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Immunohistochemical analysis of CK13 expression and polymerase chain reaction (PCR)-based molecular investigation of specific mutations (\n                      <jats:italic>APC<\/jats:italic>\n                      E1080* and\n                      <jats:italic>KRT13<\/jats:italic>\n                      M239V and Y281H) were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CK13 expression in COC was observed in the suprabasal\/superficial layers of the cystic epithelium in 14 cases-64%; ghost cells showed positivity in 12 cases-54%. DGCT cases were negative in the epithelial proliferation but positive in ghost cells. The AA case was negative. Three CA cases demonstrated positivity in suprabasal\/central cells. None of the cases harbored the investigated mutations. However, the intronic polymorphism\n                      <jats:italic>KRT13<\/jats:italic>\n                      c.735\u2009+\u200910A\u2009&gt;\u2009G (dbSNP rs7211235) was identified in 16 COC cases, one DGCT case, one AA case, and one CA case, whereas\n                      <jats:italic>KRT13<\/jats:italic>\n                      c.735\u2009+\u20096C\u2009&gt;\u2009T (dbSNP rs181122697) was detected in one COC case. Additionally, one case harbored a previously unreported silent\/synonymous mutation,\n                      <jats:italic>KRT13<\/jats:italic>\n                      c.690G\u2009&gt;\u2009A (p.E230E), of unknown significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CK13 expression in COC and CA suggests squamous differentiation of odontogenic epithelium. The detected\n                      <jats:italic>KRT13<\/jats:italic>\n                      genetic variations are probably not associated with tumorigenic mechanisms in COC, DGCT, AA, and CA. The\n                      <jats:italic>APC<\/jats:italic>\n                      E1080* mutation was not identified in any of the entities included in the present study. Further studies are therefore required to more precisely define the genetic profile of these entities and, particularly, to clarify the potential biological relationship between dentinogenic ghost cell tumor and adenoid ameloblastoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12105-026-01938-8","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:16:30Z","timestamp":1782296190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical Expression of CK13 and Molecular Analysis of KRT13 and APC in Odontogenic Ghost Cell Lesions, Adenoid Ameloblastoma, and Conventional Ameloblastoma"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5318-5470","authenticated-orcid":false,"given":"Lucas Fabian","family":"Polti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-4617","authenticated-orcid":false,"given":"Juan Manuel","family":"Arteaga Legarrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-6866","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Sicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-5194","authenticated-orcid":false,"given":"Felipe","family":"Martins Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren","family":"Frenzel Schuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-6718","authenticated-orcid":false,"given":"Vanesa","family":"Pereira Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-9000","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Paparella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-9672","authenticated-orcid":false,"given":"Fernanda","family":"Faria Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-1172","authenticated-orcid":false,"given":"Marina","family":"Gon\u00e7alves Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-4749","authenticated-orcid":false,"given":"Silvia","family":"Ferreira de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-4547","authenticated-orcid":false,"given":"Felipe","family":"Paiva Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"1938_CR1","unstructured":"WHO Classification of Tumours Editorial Board (2022) Head and neck tumours [Internet; beta version ahead of print]. 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