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Demographic, clinical and radiographic data were collected from the charts, and the histological H&amp;E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4\u00a0years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12105-026-01952-w","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:03:28Z","timestamp":1784621008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8154-1702","authenticated-orcid":false,"given":"Lorena","family":"Paula de Paula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-2880","authenticated-orcid":false,"given":"Fl\u00e1via Sirotheau 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