{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:44:00Z","timestamp":1792143840679,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-026-01976-2","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:14Z","timestamp":1792140314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphoplasmacytic Lymphoma Involving Marrow-Containing Submandibular Heterotopic Ossification: A Case Report and Literature Review"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-4417","authenticated-orcid":false,"given":"Lado Lako","family":"Loro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2268-4333","authenticated-orcid":false,"given":"Frank-Jakob","family":"Sandbakk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4785-5368","authenticated-orcid":false,"given":"Camilla J\u00f8sok","family":"Nyb\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-3796","authenticated-orcid":false,"given":"Eivind Ottersen","family":"Samstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"1976_CR1","doi-asserted-by":"publisher","unstructured":"Yalcin ED, Ararat E (2020) Prevalence of soft tissue calcifications in the head and neck region: a cone-beam computed tomography study. Niger J Clin Pract 23(6):759\u2013763. https:\/\/doi.org\/10.4103\/njcp.njcp_269_19","DOI":"10.4103\/njcp.njcp_269_19"},{"issue":"8","key":"1976_CR2","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s00330-006-0525-6","volume":"17","author":"M Keberle","year":"2007","unstructured":"Keberle M, Robinson S (2007) Physiologic and pathologic calcifications and ossifications in the face and neck. Eur Radiol 17(8):2103\u20132111. https:\/\/doi.org\/10.1007\/s00330-006-0525-6","journal-title":"Eur Radiol"},{"key":"1976_CR3","doi-asserted-by":"publisher","unstructured":"Barghan S, Tahmasbi Arashlow M, Nair MK (2016) Incidental findings on cone beam computed tomography studies outside of the maxillofacial skeleton. Int J Dent 2016:9196503. https:\/\/doi.org\/10.1155\/2016\/9196503","DOI":"10.1155\/2016\/9196503"},{"key":"1976_CR4","doi-asserted-by":"publisher","unstructured":"Diniz V, Ara\u00fajo ECCB, Gon\u00e7alves BC, Fardim KAC, Manh\u00e3es Junior LRC, Tango EK et al (2020) Prevalence of soft tissue calcifications in cone beam computed tomography images in the region of head and neck. Braz Dent Sci 23(2). https:\/\/doi.org\/10.14295\/BDS.2020.V23I2.1864","DOI":"10.14295\/BDS.2020.V23I2.1864"},{"issue":"3","key":"1976_CR5","doi-asserted-by":"publisher","first-page":"393","DOI":"10.22312\/sdusbed.1120234","volume":"13","author":"E T\u00fcrk","year":"2022","unstructured":"T\u00fcrk E, Ayy\u0131ld\u0131z VA, G\u00f6rmez \u00d6 (2022) The evaluation of incidentally detected head and neck region soft tissue calcifications and ossifications on computed tomography images. S\u00fcleyman Demirel \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi 13(3):393\u2013401. https:\/\/doi.org\/10.22312\/sdusbed.1120234","journal-title":"S\u00fcleyman Demirel \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi"},{"issue":"2","key":"1976_CR6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.51122\/neudentj.2024.104","volume":"6","author":"MH Duran","year":"2024","unstructured":"Duran MH, Baybars SC (2024) Evaluation of soft tissue calcifications in the head and neck region on panoramic radiography of edentulous patients. Necmettin Erbakan Univ Dent J 6(2):208\u2013215. https:\/\/doi.org\/10.51122\/neudentj.2024.104","journal-title":"Necmettin Erbakan Univ Dent J"},{"issue":"3","key":"1976_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cden.2021.02.005","volume":"65","author":"SR Singer","year":"2021","unstructured":"Singer SR, Kim IH, Creanga AG, Mupparapu M (2021) Physiologic and pathologic calcifications of head and neck significant to the dentist. Dent Clin North Am 65(3):555\u2013577. https:\/\/doi.org\/10.1016\/j.cden.2021.02.005","journal-title":"Dent Clin North Am"},{"issue":"2","key":"1976_CR8","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cden.2023.10.002","volume":"68","author":"AZ Syed","year":"2024","unstructured":"Syed AZ (2024) Soft Tissue Calcifications in the Head and Neck Region. Dent Clin North Am 68(2):375\u2013391. https:\/\/doi.org\/10.1016\/j.cden.2023.10.002","journal-title":"Dent Clin North Am"},{"issue":"4","key":"1976_CR9","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1136\/jramc-2014-000277","volume":"161","author":"DS Edwards","year":"2015","unstructured":"Edwards DS, Clasper JC (2015) Heterotopic ossification: a systematic review. J R Army Med Corps 161(4):315\u2013321. https:\/\/doi.org\/10.1136\/jramc-2014-000277","journal-title":"J R Army Med Corps"},{"issue":"4","key":"1976_CR10","doi-asserted-by":"publisher","first-page":"e10172","DOI":"10.1002\/jbm4.10172","volume":"3","author":"C Meyers","year":"2019","unstructured":"Meyers C, Lisiecki J, Miller S, Levin A, Fayad L, Ding C, Sono T, McCarthy E, Levi B, James AW (2019) Heterotopic ossification: a comprehensive review. JBMR Plus 3(4):e10172. https:\/\/doi.org\/10.1002\/jbm4.10172","journal-title":"JBMR Plus"},{"issue":"7","key":"1976_CR11","first-page":"666","volume":"120","author":"S Haque","year":"1996","unstructured":"Haque S, Eisen RN, West AB (1996) Heterotopic bone formation in the gastrointestinal tract. Arch Pathol Lab Med 120(7):666\u2013670","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"1976_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2478\/raon-2019-0039","volume":"53","author":"B Mujtaba","year":"2019","unstructured":"Mujtaba B, Taher A, Fiala MJ, Nassar S, Madewell JE, Hanafy AK, Aslam R (2019) Heterotopic ossification: radiological and pathological review. Radiol Oncol 53(3):275\u2013284. https:\/\/doi.org\/10.2478\/raon-2019-0039","journal-title":"Radiol Oncol"},{"issue":"1","key":"1976_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13005-018-0180-6","volume":"14","author":"M Hanisch","year":"2018","unstructured":"Hanisch M, Hanisch L, Fr\u00f6hlich LF, Werkmeister R, Bohner L, Kleinheinz J (2018) Myositis ossificans traumatica of the masticatory muscles: etiology, diagnosis and treatment. Head Face Med 14(1):23. https:\/\/doi.org\/10.1186\/s13005-018-0180-6","journal-title":"Head Face Med"},{"issue":"12","key":"1976_CR14","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1016\/j.ijom.2017.06.016","volume":"46","author":"LG Mercuri","year":"2017","unstructured":"Mercuri LG, Saltzman BM (2017) Acquired heterotopic ossification of the temporomandibular joint. Int J Oral Maxillofac Surg 46(12):1562\u20131568. https:\/\/doi.org\/10.1016\/j.ijom.2017.06.016","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"1976_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/jcm10010109","volume":"10","author":"M Knitschke","year":"2020","unstructured":"Knitschke M, Siu K, B\u00e4cker C, Attia S, Howaldt HP, B\u00f6ttger S (2020) Heterotopic ossification of the vascular pedicle after maxillofacial reconstructive surgery using fibular free flap: introducing new classification and retrospective analysis. J Clin Med 10(1):109. https:\/\/doi.org\/10.3390\/jcm10010109","journal-title":"J Clin Med"},{"issue":"14","key":"1976_CR16","doi-asserted-by":"publisher","first-page":"e158996","DOI":"10.1172\/jci.insight.158996","volume":"7","author":"CD Hwang","year":"2022","unstructured":"Hwang CD, Pagani CA, Nunez JH, Cherief M, Qin Q, Gomez-Salazar M, Kadaikal B, Kang H, Chowdary AR, Patel N, James AW, Levi B (2022) Contemporary perspectives on heterotopic ossification. JCI Insight 7(14):e158996. https:\/\/doi.org\/10.1172\/jci.insight.158996","journal-title":"JCI Insight"},{"issue":"3","key":"1976_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.5624\/isd.20230069","volume":"53","author":"GD Jo","year":"2023","unstructured":"Jo GD, Kang JH, Kim JE, Yi WJ, Heo MS, Lee SS, Huh KH (2023) Head and neck manifestations of fibrodysplasia ossificans progressiva: clinical and imaging findings in 2 cases. Imaging Sci Dent 53(3):257\u2013264. https:\/\/doi.org\/10.5624\/isd.20230069","journal-title":"Imaging Sci Dent"},{"issue":"2","key":"1976_CR18","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3892\/ol.2026.15718","volume":"32","author":"Y Fukuma","year":"2026","unstructured":"Fukuma Y, Ishida M, Sasaki A, Jinnin T, Terada T, Haginomori SI, Hirose Y (2026) Salivary duct carcinoma with heterotopic ossification in the parotid gland: a case report. Oncol Lett 32(2):363. https:\/\/doi.org\/10.3892\/ol.2026.15718","journal-title":"Oncol Lett"},{"issue":"3 Suppl","key":"1976_CR19","first-page":"871","volume":"54","author":"M Munteanu","year":"2013","unstructured":"Munteanu M, Munteanu G, Giuri S, Zolog I, Motoc AG (2013) Ossification of the choroid: three clinical cases and literature review of the pathogenesis of intraocular ossification. Rom J Morphol Embryol 54(3 Suppl):871\u2013877","journal-title":"Rom J Morphol Embryol"},{"key":"1976_CR20","unstructured":"Udoji WC, Krohn NJ (1979) Myelofibrosis and myeloma in heterotopic bone marrow. Arch Pathol Lab Med 103(6):315-6"},{"issue":"1","key":"1976_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13256-020-02430-9","volume":"14","author":"A Borgia","year":"2020","unstructured":"Borgia A, Manara S, Balzarotti M, Vinciguerra P, Di Maria A (2020) Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report. J Med Case Rep 14(1):92. https:\/\/doi.org\/10.1186\/s13256-020-02430-9","journal-title":"J Med Case Rep"},{"key":"1976_CR22","doi-asserted-by":"publisher","unstructured":"Meyer PN, Al-Masri H, Alkan S (2007) Osseous metaplasia in diffuse large B-cell lymphoma of the kidney. Am J Hematol 82(4):321-4. https:\/\/doi.org\/10.1002\/ajh.20806","DOI":"10.1002\/ajh.20806"},{"key":"1976_CR23","doi-asserted-by":"publisher","unstructured":"Mokhtari M, Kumar PV (2012) Osseous metaplasia in Castleman\u2019s disease: a case report. Case Rep Med 2012:674870. https:\/\/doi.org\/10.1155\/2012\/674870","DOI":"10.1155\/2012\/674870"},{"key":"1976_CR24","doi-asserted-by":"publisher","unstructured":"Egan KP, Duque G, Keenan MA, Pignolo RJ (2018) Circulating osteogentic precursor cells in non-hereditary heterotopic ossification. Bone 109:61\u201364. https:\/\/doi.org\/10.1016\/j.bone.2017.12.028","DOI":"10.1016\/j.bone.2017.12.028"},{"issue":"3","key":"1976_CR25","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jhsa.2013.09.029","volume":"39","author":"LM Reichel","year":"2014","unstructured":"Reichel LM, Salisbury E, Moustoukas MJ, Davis AR, Olmsted-Davis E (2014) Molecular mechanisms of heterotopic ossification. J Hand Surg Am 39(3):563\u2013566. https:\/\/doi.org\/10.1016\/j.jhsa.2013.09.029","journal-title":"J Hand Surg Am"},{"issue":"2","key":"1976_CR26","doi-asserted-by":"publisher","first-page":"544","DOI":"10.7150\/ijbs.102297","volume":"21","author":"JX Li","year":"2025","unstructured":"Li JX, Dang YM, Liu MC, Gao LQ, Lin H (2025) Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets. Int J Biol Sci 21(2):544\u2013564. https:\/\/doi.org\/10.7150\/ijbs.102297","journal-title":"Int J Biol Sci"},{"key":"1976_CR27","doi-asserted-by":"publisher","unstructured":"Dogliotti I, Jim\u00e9nez C, Varettoni M, Talaulikar D, Bagratuni T, Ferrante M et al (2023) Diagnostics in Waldenstr\u00f6m\u2019s macroglobulinemia: a consensus statement of the European Consortium for Waldenstr\u00f6m\u2019s Macroglobulinemia. Leukemia 37(2):388\u2013395. https:\/\/doi.org\/10.1038\/s41375-022-01762-3","DOI":"10.1038\/s41375-022-01762-3"},{"key":"1976_CR28","doi-asserted-by":"publisher","unstructured":"Gertz MA (2023) Waldenstr\u00f6m macroglobulinemia: 2023 update on diagnosis, risk stratification, and management. Am J Hematol 98(2):348\u2013358. https:\/\/doi.org\/10.1002\/ajh.26796","DOI":"10.1002\/ajh.26796"},{"key":"1976_CR29","doi-asserted-by":"publisher","first-page":"105708","DOI":"10.1016\/j.humpath.2024.105708","volume":"156","author":"L Qiu","year":"2025","unstructured":"Qiu L, Lin P (2025) Lymphoplasmacytic lymphoma and Waldenstr\u00f6m macroglobulinemia, a decade after the discovery of MYD88L265P. Hum Pathol 156:105708. https:\/\/doi.org\/10.1016\/j.humpath.2024.105708","journal-title":"Hum Pathol"},{"key":"1976_CR30","doi-asserted-by":"publisher","unstructured":"Lee EI, Ch\u00e9vez-Barrios P, Soparkar CN (2010) Mar-Apr;26(2):120-2 Metaplastic bone formation in the orbit. Ophthalmic Plast Reconstr Surg. https:\/\/doi.org\/10.1097\/IOP.0b013e3181b8e65b","DOI":"10.1097\/IOP.0b013e3181b8e65b"},{"issue":"6","key":"1976_CR31","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1097\/SCS.0b013e318231e549","volume":"22","author":"CS Francis","year":"2011","unstructured":"Francis CS, Kim D, Chaudhry O, Rizvi M, Urata MM, Hammoudeh JA (2011) Nasofrontal heterotopic ossification following lymphangioma resection. J Craniofac Surg 22(6):2381\u20132384. https:\/\/doi.org\/10.1097\/SCS.0b013e318231e549","journal-title":"J Craniofac Surg"},{"issue":"1","key":"1976_CR32","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1097\/SCS.0b013e3182710348","volume":"24","author":"I K\u00fc\u00e7\u00fcker","year":"2013","unstructured":"K\u00fc\u00e7\u00fcker I, Sakrak T, Demirba\u011f E (2013) Heterotopic ossification in orbital roof, frontal sinus, and ethmoidal cells leading to hypoglobus and upward-gaze deficit. J Craniofac Surg 24(1):e83\u2013e85. https:\/\/doi.org\/10.1097\/SCS.0b013e3182710348","journal-title":"J Craniofac Surg"},{"issue":"8","key":"1976_CR33","doi-asserted-by":"publisher","first-page":"e182377","DOI":"10.1001\/jamaophthalmol.2018.2377","volume":"136","author":"BM Lawson","year":"2018","unstructured":"Lawson BM, Reddy SG, Jody NM (2018) Extensive intraocular osseous metaplasia with bone marrow formation. JAMA Ophthalmol 136(8):e182377. https:\/\/doi.org\/10.1001\/jamaophthalmol.2018.2377","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"1976_CR34","doi-asserted-by":"publisher","first-page":"NP143","DOI":"10.1177\/11206721221137150","volume":"33","author":"S Dore","year":"2023","unstructured":"Dore S, Deiana A, Serra R, Turtas V, Boscia G, Pinna A (2023) Intraocular osseous metaplasia with formation of hematopoietic bone marrow in a blind eye from birth. Eur J Ophthalmol 33(3):NP143\u2013NP144. https:\/\/doi.org\/10.1177\/11206721221137150","journal-title":"Eur J Ophthalmol"},{"issue":"11","key":"1976_CR35","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1136\/jclinpath-2011-200633","volume":"65","author":"F Forest","year":"2012","unstructured":"Forest F, Molina L, Stefani L, Peoc\u2019h M (2012) Marginal zone B-cell lymphoma in true trilineage haematopoietic tissue within heterotopic ossification of a surgical scar. J Clin Pathol 65(11):1055\u20131056. https:\/\/doi.org\/10.1136\/jclinpath-2011-200633","journal-title":"J Clin Pathol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-026-01976-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-026-01976-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-026-01976-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:16Z","timestamp":1792140316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-026-01976-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1976"],"URL":"https:\/\/doi.org\/10.1007\/s12105-026-01976-2","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"1 September 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent for publication was obtained for the person\u2019s data included in this case report.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"105"}}