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Although hypoglycemia has been studied from a biomedical perspective, there is limited research related to the meaning construction and affective regulation processes associated with it. The present study aims to understand the affective-semiotic processes involved in the hypoglycemic symptom of T1DM by analyzing its dynamic organization and affective-semiotic regulation. Methodologically, an idiographic perspective was chosen through the microgenetic analysis of in-depth interviews in a case study. The main results indicate that the initial sensation of physical discomfort is merely the starting point of a wider semiotic network that hyper-generalizes and expands itself towards broader aspects of life and identity. Life projections, whether short- or long-term, are mediated by the fear of the symptom, which, in turn, can shape one\u00b4s perception of life priorities in life and involves the potential to shape one\u2019s future in terms of the ability to maintain health. It is proposed that the hypoglycemic symptom, as a set of experiences with the capacity to destabilize the individual, should be considered in order to: (a) Evaluate how each one is affected through affective-semiotic fields of meaning directly linked to the perception of oneself as a subject, (b) Reduce the uncertainty associated with the body\u2019s vulnerability and contingency and, (c) Foster a greater personal empowerment with respect to the disease.<\/jats:p>","DOI":"10.1007\/s12124-024-09889-x","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T09:29:43Z","timestamp":1739784583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Affective Semiosis of the Hypoglycemic Symptom in Type 1 Diabetes Mellitus"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-8137","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Cleves-Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-9840","authenticated-orcid":false,"given":"M\u00f3nica","family":"Roncancio-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-1707","authenticated-orcid":false,"given":"Angela Uchoa","family":"Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"9889_CR1","doi-asserted-by":"publisher","unstructured":"American Diabetes Association. 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