{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:14:41Z","timestamp":1777605281735,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s12149-010-0389-3","type":"journal-article","created":{"date-parts":[[2010,6,10]],"date-time":"2010-06-10T10:00:23Z","timestamp":1276164023000},"page":"515-521","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of Tourette\u2019s syndrome by 99mTc-TRODAT-1 SPECT\/CT imaging"],"prefix":"10.1007","volume":"24","author":[{"given":"Hong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benshu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"389_CR1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10654-005-2953-z","volume":"20","author":"R Jin","year":"2005","unstructured":"Jin R, Zheng RY, Huang WW, Xu HQ, Shao B, Chen H, et al. Epidemiological survey of Tourette syndrome in children and adolescents in Wenzhou of P. R. China. Eur J Epidemiol. 2005;20:925\u20137.","journal-title":"Eur J Epidemiol"},{"key":"389_CR2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1469-8749.2003.tb00402.x","volume":"45","author":"N Khalifa","year":"2003","unstructured":"Khalifa N, von Knorring AL. Prevalence of tic disorders and Tourette syndrome in a Swedish school population. Dev Med Child Neurol. 2003;45:315\u20139.","journal-title":"Dev Med Child Neurol"},{"issue":"Suppl 1","key":"389_CR3","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0387-7604(03)90005-2","volume":"25","author":"HS Wang","year":"2003","unstructured":"Wang HS, Kuo MF. Tourette\u2019s syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei County. Brain Dev. 2003;25(Suppl 1):S29\u201331.","journal-title":"Brain Dev"},{"key":"389_CR4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1017\/S0012162200000839","volume":"42","author":"RD Freeman","year":"2000","unstructured":"Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol. 2000;42:436\u201347.","journal-title":"Dev Med Child Neurol"},{"key":"389_CR5","first-page":"651","volume":"77","author":"C Kenney","year":"2008","unstructured":"Kenney C, Kuo SH, Jimenez-Shahed J. Tourette\u2019s syndrome. Am Fam Physician. 2008;77:651\u20138.","journal-title":"Am Fam Physician"},{"key":"389_CR6","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/chi.0b013e318068fbcc","volume":"46","author":"JE Swain","year":"2007","unstructured":"Swain JE, Scahill L, Lombroso PJ, King RA, Leckman JF. Tourette syndrome and tic disorders: a decade of progress. J Am Acad Child Adolesc Psychiatry. 2007;46:947\u201368.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"389_CR7","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1056\/NEJMra010032","volume":"345","author":"J Jankovic","year":"2001","unstructured":"Jankovic J. Tourette\u2019s syndrome. N Engl J Med. 2001;345:1184\u201392.","journal-title":"N Engl J Med"},{"key":"389_CR8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(05)01012-4","volume":"4","author":"HS Singer","year":"2005","unstructured":"Singer HS. Tourette\u2019s syndrome: from behaviour to biology. Lancet Neurol. 2005;4:149\u201359.","journal-title":"Lancet Neurol"},{"key":"389_CR9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tins.2006.01.001","volume":"29","author":"RL Albin","year":"2006","unstructured":"Albin RL, Mink JW. Recent advances in Tourette syndrome research. Trends Neurosci. 2006;29:175\u201382.","journal-title":"Trends Neurosci"},{"key":"389_CR10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/08830738060210081001","volume":"21","author":"JF Leckman","year":"2006","unstructured":"Leckman JF, Bloch MH, Scahill L, King RA. Tourette syndrome: the self under siege. J Child Neurol. 2006;21:642\u20139.","journal-title":"J Child Neurol"},{"key":"389_CR11","first-page":"523","volume":"16","author":"T Pringsheim","year":"2003","unstructured":"Pringsheim T, Davenport WJ, Lang A. Tics. Curr Opin Neurol. 2003;16:523\u20137.","journal-title":"Curr Opin Neurol"},{"key":"389_CR12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ana.410300408","volume":"30","author":"HS Singer","year":"1991","unstructured":"Singer HS, Hahn IH, Moran TH. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette\u2019s syndrome. Ann Neurol. 1991;30:558\u201362.","journal-title":"Ann Neurol"},{"key":"389_CR13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/geno.1995.1265","volume":"30","author":"J Gelernter","year":"1995","unstructured":"Gelernter J, Vandenbergh D, Kruger SD, Pauls DL, Kurlan R, Pakstis AJ, et al. The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics. 1995;30:459\u201363.","journal-title":"Genomics"},{"key":"389_CR14","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1126\/science.273.5279.1225","volume":"273","author":"SS Wolf","year":"1996","unstructured":"Wolf SS, Jones DW, Knable MB, Gorey JG, Lee KS, Hyde TM, et al. Tourette syndrome: prediction of phenotypic variation in monozygotic twins by caudate nucleus D2 receptor binding. Science. 1996;273:1225\u20137.","journal-title":"Science"},{"key":"389_CR15","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1007\/s00415-002-0746-9","volume":"249","author":"KH Krause","year":"2002","unstructured":"Krause KH, Dresel S, Krause J, Kung HF, Tatsch K, Lochmuller H. Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit\/hyperactivity disorder: positive effect of methylphenidate. J Neurol. 2002;249:1116\u20138.","journal-title":"J Neurol"},{"key":"389_CR16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/01.mnm.0000239485.53780.16","volume":"27","author":"CB Yeh","year":"2006","unstructured":"Yeh CB, Lee CH, Chou YH, Chang CJ, Ma KH, Huang WS. Evaluating dopamine transporter activity with 99mTc-TRODAT-1 SPECT in drug-naive Tourette\u2019s adults. Nucl Med Commun. 2006;27:779\u201384.","journal-title":"Nucl Med Commun"},{"key":"389_CR17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pscychresns.2007.01.003","volume":"156","author":"CB Yeh","year":"2007","unstructured":"Yeh CB, Lee CS, Ma KH, Lee MS, Chang CJ, Huang WS. Phasic dysfunction of dopamine transmission in Tourette\u2019s syndrome evaluated with 99mTc-TRODAT-1 imaging. Psychiatry Res. 2007;156:75\u201382.","journal-title":"Psychiatry Res"},{"key":"389_CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pscychresns.2007.04.006","volume":"162","author":"WJ Hwang","year":"2008","unstructured":"Hwang WJ, Yao WJ, Fu YK, Yang AS. [99mTc]TRODAT-1\/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. Psychiatry Res. 2008;162:159\u201366.","journal-title":"Psychiatry Res"},{"key":"389_CR19","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/PL00007806","volume":"247","author":"KR Muller-Vahl","year":"2000","unstructured":"Muller-Vahl KR, Berding G, Brucke T, Kolbe H, Meyer GJ, Hundeshagen H, et al. Dopamine transporter binding in Gilles de la Tourette syndrome. J Neurol. 2000;247:514\u201320.","journal-title":"J Neurol"},{"key":"389_CR20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pscychresns.2003.06.001","volume":"130","author":"KA Cheon","year":"2004","unstructured":"Cheon KA, Ryu YH, Namkoong K, Kim CH, Kim JJ, Lee JD. Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette\u2019s disorder. Psychiatry Res. 2004;130:85\u201395.","journal-title":"Psychiatry Res"},{"key":"389_CR21","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1212\/WNL.51.4.1069","volume":"51","author":"A Heinz","year":"1998","unstructured":"Heinz A, Knable MB, Wolf SS, Jones DW, Gorey JG, Hyde TM, et al. Tourette\u2019s syndrome: [I-123]beta-CIT SPECT correlates of vocal tic severity. Neurology. 1998;51:1069\u201374.","journal-title":"Neurology"},{"key":"389_CR22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0924-977X(00)00134-6","volume":"11","author":"M Stamenkovic","year":"2001","unstructured":"Stamenkovic M, Schindler SD, Asenbaum S, Neumeister A, Willeit M, Willinger U, et al. No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette\u2019s disorder patients: a [(123)I]-beta-CIT SPECT-study. Eur Neuropsychopharmacol. 2001;11:69\u201374.","journal-title":"Eur Neuropsychopharmacol"},{"key":"389_CR23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.0001-690X.2004.00214.x","volume":"109","author":"J Serra-Mestres","year":"2004","unstructured":"Serra-Mestres J, Ring HA, Costa DC, Gacinovic S, Walker Z, Lees AJ, et al. Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT\/SPECT study. Acta Psychiatr Scand. 2004;109:140\u20136.","journal-title":"Acta Psychiatr Scand"},{"key":"389_CR24","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1212\/01.WNL.0000076181.39162.FC","volume":"61","author":"RL Albin","year":"2003","unstructured":"Albin RL, Koeppe RA, Bohnen NI, Nichols TE, Meyer P, Wernette K, et al. Increased ventral striatal monoaminergic innervation in Tourette syndrome. Neurology. 2003;61:310\u20135.","journal-title":"Neurology"},{"key":"389_CR25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1212\/WNL.53.2.371","volume":"53","author":"P Meyer","year":"1999","unstructured":"Meyer P, Bohnen NI, Minoshima S, Koeppe RA, Wernette K, Kilbourn MR, et al. Striatal presynaptic monoaminergic vesicles are not increased in Tourette\u2019s syndrome. Neurology. 1999;53:371\u20134.","journal-title":"Neurology"},{"key":"389_CR26","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1176\/appi.ajp.159.8.1329","volume":"159","author":"HS Singer","year":"2002","unstructured":"Singer HS, Szymanski S, Giuliano J, Yokoi F, Dogan AS, Brasic JR, et al. Elevated intrasynaptic dopamine release in Tourette\u2019s syndrome measured by PET. Am J Psychiatry. 2002;159:1329\u201336.","journal-title":"Am J Psychiatry"},{"key":"389_CR27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00004583-198907000-00015","volume":"28","author":"JF Leckman","year":"1989","unstructured":"Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, et al. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry. 1989;28:566\u201373.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"389_CR28","first-page":"207","volume":"45","author":"WJ Hwang","year":"2004","unstructured":"Hwang WJ, Yao WJ, Wey SP, Ting G. Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson\u2019s disease. J Nucl Med. 2004;45:207\u201313.","journal-title":"J Nucl Med"},{"key":"389_CR29","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/BF01254479","volume":"23","author":"HF Kung","year":"1996","unstructured":"Kung HF, Kim HJ, Kung MP, Meegalla SK, Plossl K, Lee HK. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med. 1996;23:1527\u201330.","journal-title":"Eur J Nucl Med"},{"key":"389_CR30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.nucmedbio.2007.03.010","volume":"34","author":"HF Kung","year":"2007","unstructured":"Kung HF, Kung MP, Wey SP, Lin KJ, Yen TC. Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT. Nucl Med Biol. 2007;34:787\u20139.","journal-title":"Nucl Med Biol"},{"key":"389_CR31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpedi.160.1.65","volume":"160","author":"MH Bloch","year":"2006","unstructured":"Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, et al. Adulthood outcome of tic and obsessive\u2013compulsive symptom severity in children with Tourette syndrome. Arch Pediatr Adolesc Med. 2006;160:65\u20139.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"389_CR32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.102.1.14","volume":"102","author":"JF Leckman","year":"1998","unstructured":"Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, et al. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics. 1998;102:14\u20139.","journal-title":"Pediatrics"},{"key":"389_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/brain\/awm278","volume":"131","author":"CL Baym","year":"2008","unstructured":"Baym CL, Corbett BA, Wright SB, Bunge SA. Neural correlates of tic severity and cognitive control in children with Tourette syndrome. Brain. 2008;131:165\u201379.","journal-title":"Brain"},{"key":"389_CR34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1176\/ajp.2007.164.6.955","volume":"164","author":"R Marsh","year":"2007","unstructured":"Marsh R, Zhu H, Wang Z, Skudlarski P, Peterson BS. A developmental fMRI study of self-regulatory control in Tourette\u2019s syndrome. Am J Psychiatry. 2007;164:955\u201366.","journal-title":"Am J Psychiatry"},{"key":"389_CR35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/1098-2396(200102)39:2<101::AID-SYN1>3.0.CO;2-1","volume":"39","author":"J Booij","year":"2001","unstructured":"Booij J, Bergmans P, Winogrodzka A, Speelman JD, Wolters EC. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson\u2019s disease. Synapse. 2001;39:101\u20138.","journal-title":"Synapse"},{"key":"389_CR36","first-page":"1079","volume":"22","author":"F Dong","year":"2006","unstructured":"Dong F, Liu XH, Tan J, Zhang BS, Sun F. 99mTc-TRODAT-1 SPECT imaging for diagnosis and scaling of Parkinson\u2019s disease. Chin J Med Imaging Technol. 2006;22:1079\u201382 (in Chinese).","journal-title":"Chin J Med Imaging Technol"},{"key":"389_CR37","first-page":"1804","volume":"46","author":"W Koch","year":"2005","unstructured":"Koch W, Hamann C, Welsch J, Popperl G, Radau PE, Tatsch K. Is iterative reconstruction an alternative to filtered backprojection in routine processing of dopamine transporter SPECT studies? J Nucl Med. 2005;46:1804\u201311.","journal-title":"J Nucl Med"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-010-0389-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-010-0389-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-010-0389-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T04:41:17Z","timestamp":1559450477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-010-0389-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,11]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["389"],"URL":"https:\/\/doi.org\/10.1007\/s12149-010-0389-3","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,11]]}}}