{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:24:30Z","timestamp":1789615470385,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s12149-013-0725-5","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T06:34:44Z","timestamp":1365489284000},"page":"618-624","source":"Crossref","is-referenced-by-count":11,"title":["Imaging P-glycoprotein function in rats using [11C]-N-desmethyl-loperamide"],"prefix":"10.1007","volume":"27","author":[{"given":"Michael D.","family":"Farwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung A.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balu","family":"Easwaramoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ichise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"725_CR1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","volume":"53","author":"MM Gottesman","year":"2002","unstructured":"Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med. 2002;53:615\u201327.","journal-title":"Annu Rev Med"},{"key":"725_CR2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neuropharm.2008.08.032","volume":"55","author":"C Luna-Tortos","year":"2008","unstructured":"Luna-Tortos C, Fedrowitz M, Loscher W. Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008;55:1364\u201375.","journal-title":"Neuropharmacology"},{"key":"725_CR3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.0013-9580.2004.57703.x","volume":"45","author":"E Aronica","year":"2004","unstructured":"Aronica E, Gorter JA, Ramkema M, Redeker S, Ozbas-Gerceker F, van Vliet EA, et al. Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia. 2004;45:441\u201351.","journal-title":"Epilepsia"},{"key":"725_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.eplepsyres.2005.11.011","volume":"68","author":"H Kubota","year":"2006","unstructured":"Kubota H, Ishihara H, Langmann T, Schmitz G, Stieger B, Wieser HG, et al. Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis. Epilepsy Res. 2006;68:213\u201328.","journal-title":"Epilepsy Res"},{"key":"725_CR5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1528-1167.2005.54904.x","volume":"46","author":"D Schmidt","year":"2005","unstructured":"Schmidt D, Loscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia. 2005;46:858\u201377.","journal-title":"Epilepsia"},{"key":"725_CR6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1162\/15353500200504166","volume":"4","author":"HM Bigott","year":"2005","unstructured":"Bigott HM, Prior JL, Piwnica-Worms DR, Welch MJ. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94\u00a0m-sestamibi. Mol Imaging. 2005;4:30\u20139.","journal-title":"Mol Imaging"},{"key":"725_CR7","first-page":"977","volume":"53","author":"D Piwnica-Worms","year":"1993","unstructured":"Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res. 1993;53:977\u201384.","journal-title":"Cancer Res"},{"key":"725_CR8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/bjc.1998.57","volume":"77","author":"NH Hendrikse","year":"1998","unstructured":"Hendrikse NH, Franssen EJ, van der Graaf WT, Meijer C, Piers DA, Vaalburg W, et al. 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77:353\u20138.","journal-title":"Br J Cancer"},{"key":"725_CR9","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1007\/s11095-012-0776-7","volume":"29","author":"N Tournier","year":"2012","unstructured":"Tournier N, Cisternino S, Peyronneau MA, Goutal S, Dolle F, Scherrmann JM, et al. Discrepancies in the P-glycoprotein-mediated transport of (18)F-MPPF: a pharmacokinetic study in mice and non-human primates. Pharm Res. 2012;29:2468\u201376.","journal-title":"Pharm Res"},{"key":"725_CR10","first-page":"1330","volume":"44","author":"KA Kurdziel","year":"2003","unstructured":"Kurdziel KA, Kiesewetter DO, Carson RE, Eckelman WC, Herscovitch P. Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates. J Nucl Med. 2003;44:1330\u20139.","journal-title":"J Nucl Med"},{"key":"725_CR11","first-page":"1427","volume":"47","author":"A Takano","year":"2006","unstructured":"Takano A, Kusuhara H, Suhara T, Ieiri I, Morimoto T, Lee YJ, et al. Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil. J Nucl Med. 2006;47:1427\u201333.","journal-title":"J Nucl Med"},{"key":"725_CR12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.jcbfm.9600349","volume":"27","author":"M Lubberink","year":"2007","unstructured":"Lubberink M, Luurtsema G, van Berckel BN, Boellaard R, Toornvliet R, Windhorst AD, et al. Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET. J Cereb Blood Flow Metab. 2007;27:424\u201333.","journal-title":"J Cereb Blood Flow Metab"},{"key":"725_CR13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2967\/jnumed.107.047308","volume":"49","author":"SS Zoghbi","year":"2008","unstructured":"Zoghbi SS, Liow JS, Yasuno F, Hong J, Tuan E, Lazarova N, et al. 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux. J Nucl Med. 2008;49:649\u201356.","journal-title":"J Nucl Med"},{"key":"725_CR14","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1021\/jm800510m","volume":"51","author":"N Lazarova","year":"2008","unstructured":"Lazarova N, Zoghbi SS, Hong J, Seneca N, Tuan E, Gladding RL, et al. Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J Med Chem. 2008;51:6034\u201343.","journal-title":"J Med Chem"},{"key":"725_CR15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1124\/dmd.109.031161","volume":"38","author":"P Kannan","year":"2010","unstructured":"Kannan P, Brimacombe KR, Zoghbi SS, Liow JS, Morse C, Taku AK, et al. N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier. Drug Metab Dispos. 2010;38:917\u201322.","journal-title":"Drug Metab Dispos"},{"key":"725_CR16","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.1014641108","volume":"108","author":"P Kannan","year":"2011","unstructured":"Kannan P, Brimacombe KR, Kreisl WC, Liow JS, Zoghbi SS, Telu S, et al. Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. PNAS. 2011;108:2593\u20138.","journal-title":"PNAS"},{"key":"725_CR17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2967\/jnumed.108.056226","volume":"50","author":"JS Liow","year":"2009","unstructured":"Liow JS, Kreisl W, Zoghbi SS, Lazarova N, Seneca N, Gladding RL, et al. P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys. J Nucl Med. 2009;50:108\u201315.","journal-title":"J Nucl Med"},{"key":"725_CR18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2967\/jnumed.109.070151","volume":"51","author":"WC Kreisl","year":"2010","unstructured":"Kreisl WC, Liow JS, Kimura N, Seneca N, Zoghbi SS, Morse CL, et al. P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide. J Nucl Med. 2010;51:559\u201366.","journal-title":"J Nucl Med"},{"key":"725_CR19","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2967\/jnumed.108.058453","volume":"50","author":"N Seneca","year":"2009","unstructured":"Seneca N, Zoghbi SS, Liow JS, Kreisl W, Herscovitch P, Jenko K, et al. Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. J Nucl Med. 2009;50:807\u201313.","journal-title":"J Nucl Med"},{"key":"725_CR20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eplepsyres.2010.12.013","volume":"94","author":"L Moerman","year":"2011","unstructured":"Moerman L, Wyffels L, Slaets D, Raedt R, Boon P, De Vos F. Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethyl loperamide. Epilepsy Res. 2011;94:18\u201325.","journal-title":"Epilepsy Res"},{"key":"725_CR21","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1523\/JNEUROSCI.6616-10.2011","volume":"31","author":"JP Bankstahl","year":"2011","unstructured":"Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, et al. A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier. J Neurosci. 2011;31:8803\u201311.","journal-title":"J Neurosci"},{"key":"725_CR22","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.neuroimage.2009.09.048","volume":"49","author":"C Fougere la","year":"2010","unstructured":"la Fougere C, Boning G, Bartmann H, Wangler B, Nowak S, Just T, et al. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. NeuroImage. 2010;49:1406\u201315.","journal-title":"NeuroImage"},{"key":"725_CR23","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.2967\/jnumed.108.051235","volume":"49","author":"JP Bankstahl","year":"2008","unstructured":"Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, et al. Tariquidar-induced P-glycoprotein inhibition at the rat blood\u2013brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med. 2008;49:1328\u201335.","journal-title":"J Nucl Med"},{"key":"725_CR24","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S1053-8119(03)00405-1","volume":"20","author":"J Bart","year":"2003","unstructured":"Bart J, Willemsen AT, Groen HJ, van der Graaf WT, Wegman TD, Vaalburg W, et al. Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET. NeuroImage. 2003;20:1775\u201382.","journal-title":"NeuroImage"},{"key":"725_CR25","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00259-009-1332-5","volume":"37","author":"C Kuntner","year":"2010","unstructured":"Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, et al. Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET. Eur J Nucl Med Mol Imag. 2010;37:942\u201353.","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"725_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2342-11-1","volume":"11","author":"S Syvanen","year":"2011","unstructured":"Syvanen S, Luurtsema G, Molthoff CF, Windhorst AD, Huisman MC, Lammertsma AA, et al. (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus. BMC Med Imaging. 2011;11:1.","journal-title":"BMC Med Imaging"},{"key":"725_CR27","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1021\/jm900485a","volume":"52","author":"A Waarde van","year":"2009","unstructured":"van Waarde A, Ramakrishnan NK, Rybczynska AA, Elsinga PH, Berardi F, de Jong JR, et al. Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression. J Med Chem. 2009;52:4524\u201332.","journal-title":"J Med Chem"},{"key":"725_CR28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2967\/jnumed.108.059162","volume":"50","author":"M Muzi","year":"2009","unstructured":"Muzi M, Mankoff DA, Link JM, Shoner S, Collier AC, Sasongko L, et al. Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans. J Nucl Med. 2009;50:1267\u201375.","journal-title":"J Nucl Med"},{"key":"725_CR29","first-page":"72","volume":"26","author":"HB Lee","year":"1985","unstructured":"Lee HB, Blaufox MD. Blood volume in the rat. J Nucl Med. 1985;26:72\u20136.","journal-title":"J Nucl Med"},{"key":"725_CR30","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/sj.bjp.0701979","volume":"124","author":"NH Hendrikse","year":"1998","unstructured":"Hendrikse NH, Schinkel AH, de Vries EG, Fluks E, Van der Graaf WT, Willemsen AT, et al. Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography. Br J Pharmacol. 1998;124:1413\u20138.","journal-title":"Br J Pharmacol"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-013-0725-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-013-0725-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-013-0725-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T01:44:48Z","timestamp":1562895888000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-013-0725-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["725"],"URL":"https:\/\/doi.org\/10.1007\/s12149-013-0725-5","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]}}}