{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T22:28:29Z","timestamp":1748816909599},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>\nWe assessed the value of combining <jats:sup>123<\/jats:sup>I-IMP brain perfusion SPECT and <jats:sup>123<\/jats:sup>I-MIBG myocardial scintigraphy for the discrimination of dementia with Lewy bodies (DLB) from other types of dementia.\n<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We subjected 252 consecutive patients with clinically suspected DLB to both <jats:sup>123<\/jats:sup>I-IMP brain perfusion SPECT and <jats:sup>123<\/jats:sup>I-MIBG myocardial scintigraphy. Patients with Parkinson\u2019s disease were included. The 252 patients were randomly assigned to an estimation (<jats:italic>n<\/jats:italic>\u00a0=\u00a0152) or a validation group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100). Using univariate analysis, we first analyzed the relationship between various variables and the presence or absence of DLB in estimation group and then proceeded to multivariate analysis to obtain a combined index that predicted the likelihood of DLB. The diagnostic value of the index was assessed by calculating the area under the receiver operating characteristic (ROC) curve (AUC) with the cutoff value selected from the ROC curve. We then tested the predictive accuracy of the index in validation group.\n<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The combined index was an arithmetic expression that combined the age, early <jats:sup>123<\/jats:sup>I-MIBG heart-to-mediastinum uptake (E-H\/M) ratio, and the parietal lobe hypoperfusion score. Values for the AUC of the combined index, the E-H\/M ratio, the parietal lobe hypoperfusion score, and the patient age in validation group were 0.95, 0.90, 0.72, and 0.73, respectively. There was a significant difference in the AUC of the combined index among other indices (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The sensitivity, specificity, and accuracy of the combined index for a diagnosis of probable DLB in validation group were 88, 87, and 87\u00a0%, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The combinational diagnosis based on <jats:sup>123<\/jats:sup>I-IMP brain perfusion SPECT, <jats:sup>123<\/jats:sup>I-MIBG myocardial scintigraphy, and the patient age is a simple and reliable means for predicting probable DLB.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12149-013-0796-3","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T09:32:50Z","timestamp":1387531970000},"page":"203-211","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnosis of dementia with Lewy bodies: diagnostic performance of combined 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy"],"prefix":"10.1007","volume":"28","author":[{"given":"Fumi","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morikatsu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Tomiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Namimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Uetani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,21]]},"reference":[{"issue":"1","key":"796_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1474-4422(03)00619-7","volume":"3","author":"I McKeith","year":"2004","unstructured":"McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, et al. Dementia with Lewy bodies. Lancet Neurol. 2004;3(1):19\u201328.","journal-title":"Lancet Neurol"},{"issue":"Suppl 1","key":"796_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1017\/S1041610296003079","volume":"8","author":"L Burgio","year":"1996","unstructured":"Burgio L. Interventions for the behavioral complications of Alzheimer\u2019s disease: behavioral approaches. Int Psychogeriatr. 1996;8(Suppl 1):45\u201352.","journal-title":"Int Psychogeriatr"},{"issue":"2","key":"796_CR3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1532-5415.1998.tb02542.x","volume":"46","author":"DI Kaufer","year":"1998","unstructured":"Kaufer DI, Cummings JL, Christine D, Bray T, Castellon S, Masterman D, et al. Assessing the impact of neuropsychiatric symptoms in Alzheimer\u2019s disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J Am Geriatr Soc. 1998;46(2):210\u20135.","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"796_CR4","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/(SICI)1099-1166(199907)14:7<526::AID-GPS965>3.0.CO;2-0","volume":"14","author":"CA Luis","year":"1999","unstructured":"Luis CA, Barker WW, Gajaraj K, Harwood D, Petersen R, Kashuba A, et al. Sensitivity and specificity of three clinical criteria for dementia with Lewy bodies in an autopsy-verified sample. Int J Geriatr Psychiatry. 1999;14(7):526\u201333.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"5","key":"796_CR5","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1212\/WNL.54.5.1050","volume":"54","author":"IG McKeith","year":"2000","unstructured":"McKeith IG, Ballard CG, Perry RH, Ince PG, O\u2019Brien JT, Neill D, et al. Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology. 2000;54(5):1050\u20138.","journal-title":"Neurology"},{"key":"796_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1192\/bjp.174.1.45","volume":"174","author":"C Holmes","year":"1999","unstructured":"Holmes C, Cairns N, Lantos P, Mann A. Validity of current clinical criteria for Alzheimer\u2019s disease, vascular dementia and dementia with Lewy bodies. Br J Psychiatry. 1999;174:45\u201350.","journal-title":"Br J Psychiatry"},{"issue":"6","key":"796_CR7","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1212\/WNL.47.6.1403","volume":"47","author":"MS Mega","year":"1996","unstructured":"Mega MS, Masterman DL, Benson DF, Vinters HV, Tomiyasu U, Craig AH, et al. Dementia with Lewy bodies: reliability and validity of clinical and pathologic criteria. Neurology. 1996;47(6):1403\u20139.","journal-title":"Neurology"},{"issue":"8","key":"796_CR8","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/gps.1359","volume":"20","author":"MJ Firbank","year":"2005","unstructured":"Firbank MJ, Burn DJ, McKeith IG, O\u2019Brien JT. Longitudinal study of cerebral blood flow SPECT in Parkinson\u2019s disease with dementia, and dementia with Lewy bodies. Int J Geriatr Psychiatry. 2005;20(8):776\u201382.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"3","key":"796_CR9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s00259-005-1921-x","volume":"33","author":"H Hanyu","year":"2006","unstructured":"Hanyu H, Shimizu S, Hirao K, Kanetaka H, Iwamoto T, Chikamori T, et al. Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging. 2006;33(3):248\u201353.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"796_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1159\/000165918","volume":"26","author":"M Tateno","year":"2008","unstructured":"Tateno M, Kobayashi S, Shirasaka T, Furukawa Y, Fujii K, Morii H, et al. Comparison of the usefulness of brain perfusion SPECT and MIBG myocardial scintigraphy for the diagnosis of dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2008;26(5):453\u20137.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3 Suppl","key":"796_CR11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3233\/JAD-2006-9S347","volume":"9","author":"IG McKeith","year":"2006","unstructured":"McKeith IG. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. J Alzheimers Dis. 2006;9(3 Suppl):417\u201323.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"796_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s002590050505","volume":"27","author":"N Hattori","year":"2000","unstructured":"Hattori N, Schwaiger M. Metaiodobenzylguanidine scintigraphy of the heart: what have we learnt clinically? Eur J Nucl Med. 2000;27(1):1\u20136.","journal-title":"Eur J Nucl Med"},{"issue":"8","key":"796_CR13","first-page":"1579","volume":"33","author":"S Minoshima","year":"1992","unstructured":"Minoshima S, Berger KL, Lee KS, Mintun MA. An automated method for rotational correction and centering of three-dimensional functional brain images. J Nucl Med. 1992;33(8):1579\u201385.","journal-title":"J Nucl Med"},{"issue":"7","key":"796_CR14","first-page":"1238","volume":"36","author":"S Minoshima","year":"1995","unstructured":"Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer\u2019s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med. 1995;36(7):1238\u201348.","journal-title":"J Nucl Med"},{"issue":"4","key":"796_CR15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF02988523","volume":"17","author":"S Mizumura","year":"2003","unstructured":"Mizumura S, Kumita S, Cho K, Ishihara M, Nakajo H, Toba M, et al. Development of quantitative analysis method for stereotactic brain image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med. 2003;17(4):289\u201395.","journal-title":"Ann Nucl Med"},{"issue":"5","key":"796_CR16","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s00415-003-1029-9","volume":"250","author":"Y Horimoto","year":"2003","unstructured":"Horimoto Y, Matsumoto M, Akatsu H, Ikari H, Kojima K, Yamamoto T, et al. Autonomic dysfunctions in dementia with Lewy bodies. J Neurol. 2003;250(5):530\u20133.","journal-title":"J Neurol"},{"issue":"5","key":"796_CR17","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1212\/WNL.56.5.643","volume":"56","author":"K Lobotesis","year":"2001","unstructured":"Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, et al. Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology. 2001;56(5):643\u20139.","journal-title":"Neurology"},{"issue":"10","key":"796_CR18","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1007\/s00259-002-0919-x","volume":"29","author":"J Pasquier","year":"2002","unstructured":"Pasquier J, Michel BF, Brenot-Rossi I, Hassan-Sebbag N, Sauvan R, Gastaut JL. Value of (99m)Tc-ECD SPET for the diagnosis of dementia with Lewy bodies. Eur J Nucl Med Mol Imaging. 2002;29(10):1342\u20138.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"796_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/jnnp.71.5.583","volume":"71","author":"M Yoshita","year":"2001","unstructured":"Yoshita M, Taki J, Yamada M. A clinical role for [(123)I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer\u2019s-type and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2001;71(5):583\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"796_CR20","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1007\/s00259-008-0828-8","volume":"35","author":"M Estorch","year":"2008","unstructured":"Estorch M, Camacho V, Paredes P, Rivera E, Rodriguez-Revuelto A, Flotats A, et al. Cardiac (123)I-metaiodobenzylguanidine imaging allows early identification of dementia with Lewy bodies during life. Eur J Nucl Med Mol Imaging. 2008;35(9):1636\u201341.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"796_CR21","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","volume":"47","author":"IG McKeith","year":"1996","unstructured":"McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47(5):1113\u201324.","journal-title":"Neurology"},{"issue":"1","key":"796_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1750-3639.2006.00032.x","volume":"17","author":"S Orimo","year":"2007","unstructured":"Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson\u2019s disease. Brain Pathol. 2007;17(1):24\u201330.","journal-title":"Brain Pathol"},{"issue":"11","key":"796_CR23","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1212\/01.wnl.0000256715.13907.d3","volume":"68","author":"CF Lippa","year":"2007","unstructured":"Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 2007;68(11):812\u20139.","journal-title":"Neurology"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-013-0796-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-013-0796-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-013-0796-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-013-0796-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:24:13Z","timestamp":1630549453000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-013-0796-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,21]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1007\/s12149-013-0796-3","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,21]]},"assertion":[{"value":"22 July 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}