{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:23Z","timestamp":1781719703038,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"a Grand-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science, and Technology, Japan","award":["16K10346"],"award-info":[{"award-number":["16K10346"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s12149-018-1233-4","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T03:54:34Z","timestamp":1516247674000},"page":"191-196","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The influence of elevated hormone levels on physiologic accumulation of 68Ga-DOTATOC"],"prefix":"10.1007","volume":"32","author":[{"given":"Masao","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Koyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Ishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yasoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Togashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"issue":"Suppl 2","key":"1233_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2967\/jnumed.110.085753","volume":"52","author":"V Ambrosini","year":"2011","unstructured":"Ambrosini V, Fani M, Fanti S, Forrer F, Maecke HR. Radiopeptide imaging and therapy in Europe. J Nucl Med. 2011;52(Suppl 2):42\u201355.","journal-title":"J Nucl Med"},{"key":"1233_CR2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s00261-012-9925-z","volume":"38","author":"N Naswa","year":"2013","unstructured":"Naswa N, Sharma P, Soundararajan R, Karunanithi S, Nazar AH, Kumar R, et al. Diagnostic performance of somatostatin receptor PET\/CT using 68 Ga-DOTANOC in gastrinoma patients with negative or equivocal CT findings. Abdom Imaging. 2013;38:552\u201360.","journal-title":"Abdom Imaging"},{"key":"1233_CR3","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1007\/s00330-015-3882-1","volume":"26","author":"S Binnebeek Van","year":"2016","unstructured":"Van Binnebeek S, Vanbilloen B, Baete K, Terwinghe C, Koole M, Mottaghy FM, et al. Comparison of diagnostic accuracy of 111In-pentetreotide SPECT and 68Ga-DOTATOC PET\/CT: a lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours. Eur Radiol. 2016;26:900\u20139.","journal-title":"Eur Radiol"},{"key":"1233_CR4","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/RLU.0b013e3182485110","volume":"37","author":"H Jacobsson","year":"2012","unstructured":"Jacobsson H, Larsson P, Jonsson C, Jussing E, Gryb\u00e4ck P. Normal uptake of 68 Ga-DOTA-TOC by the pancreas uncinate process mimicking malignancy at somatostatin receptor PET. Clin Nucl Med. 2012;37:362\u20135.","journal-title":"Clin Nucl Med"},{"key":"1233_CR5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00259-012-2309-3","volume":"40","author":"A Kroiss","year":"2013","unstructured":"Kroiss A, Putzer D, Decristoforo C, Uprimny C, Warwitz B, Nilica B, et al. 68 Ga-DOTA-TOC uptake in neuroendocrine tumour and healthy tissue: differentiation of physiological uptake and pathological processes in PET\/CT. Eur J Nucl Med Mol Imaging. 2013;40:514\u201323.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1233_CR6","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s00259-011-1875-0","volume":"38","author":"A Al-Ibraheem","year":"2011","unstructured":"Al-Ibraheem A, Bundschuh RA, Notni J, Buck A, Winter A, Wester HJ, et al. Focal uptake of 68 Ga-DOTATOC in the pancreas: pathological or physiological correlate in patients with neuroendocrine tumours? Eur J Nucl Med Mol Imaging. 2011;38:2005\u201313.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1233_CR7","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/jhbp.209","volume":"22","author":"M Imamura","year":"2015","unstructured":"Imamura M, Nakamoto Y, Uose S, Komoto I, Awane M, Taki Y. Diagnosis of functioning pancreaticoduodenal neuroendocrine tumors. J Hepatobiliary Pancreat Sci. 2015;22:602\u20139.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"1233_CR8","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s12149-015-0973-7","volume":"29","author":"Y Nakamoto","year":"2015","unstructured":"Nakamoto Y, Sano K, Ishimori T, Ueda M, Temma T, Saji H, et al. Additional information gained by positron emission tomography with 68Ga-DOTATOC for suspected unknown primary or recurrent neuroendocrine tumors. Ann Nucl Med. 2015;29:512\u20138.","journal-title":"Ann Nucl Med"},{"key":"1233_CR9","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s00259-011-1846-5","volume":"38","author":"D Kaemmerer","year":"2011","unstructured":"Kaemmerer D, Peter L, Lupp A, Schulz S, S\u00e4nger J, Prasad V, et al. Molecular imaging with 68Ga-SSTR PET\/CT and correlation to immunohistochemistry of somatostatin receptors in neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2011;38:1659\u201368.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1233_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s00259-008-0944-5","volume":"36","author":"M Miederer","year":"2009","unstructured":"Miederer M, Seidl S, Buck A, Scheidhauer K, Wester HJ, Schwaiger M, et al. Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68 Ga-DOTATOC PET\/CT. Eur J Nucl Med Mol Imaging. 2009;36:48\u201352.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1233_CR11","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1007\/s00259-011-1760-x","volume":"38","author":"C Boy","year":"2011","unstructured":"Boy C, Heusner TA, Poeppel TD, Redmann-Bischofs A, Unger N, Jentzen W, et al. 68 Ga-DOTATOC PET\/CT and somatostatin receptor (sst1\u2013sst5) expression in normal human tissue: correlation of sst2 mRNA and SUVmax. Eur J Nucl Med Mol Imaging. 2011;38:1224\u201336.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1233_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1530\/JME-15-0257","volume":"56","author":"N Gallo-Payet","year":"2016","unstructured":"Gallo-Payet N. 60 years of POMC: adrenal and extra-adrenal functions of ACTH. J Mol Endocrinol. 2016;56:135\u201356.","journal-title":"J Mol Endocrinol"},{"key":"1233_CR13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000072798","volume":"78","author":"S Park","year":"2003","unstructured":"Park S, Kamegai J, Kineman RD. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Neuroendocrinology. 2003;78:163\u201375.","journal-title":"Neuroendocrinology"},{"issue":"Suppl 1","key":"1233_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000314296","volume":"92","author":"LJ Hofland","year":"2010","unstructured":"Hofland LJ, Lamberts SW, Feelders RA. Role of somatostatin receptors in normal and tumoral pituitary corticotropic cells. Neuroendocrinology. 2010;92(Suppl 1):11\u20136.","journal-title":"Neuroendocrinology"},{"key":"1233_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/JME-14-0034","volume":"53","author":"T Eigler","year":"2014","unstructured":"Eigler T, Ben-Shlomo A. Somatostatin system: molecular mechanisms regulating anterior pituitary hormones. J Mol Endocrinol. 2014;53:1\u201319.","journal-title":"J Mol Endocrinol"},{"key":"1233_CR16","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1152\/ajpendo.00004.2005","volume":"289","author":"J Hoek van der","year":"2005","unstructured":"van der Hoek J, Waaijers M, van Koetsveld PM, Sprij-Mooij D, Feelders RA, Schmid HA, et al. Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells. Am J Physiol Endocrinol Metab. 2005;289:278\u201387.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1233_CR17","doi-asserted-by":"publisher","first-page":"5070","DOI":"10.1210\/endo.136.11.7588243","volume":"136","author":"Y Xu","year":"1995","unstructured":"Xu Y, Berelowitz M, Bruno JF. Dexamethasone regulates somatostatin receptor subtype messenger ribonucleic acid expression in rat pituitary GH4C1 cells. Endocrinology. 1995;136:5070\u20135.","journal-title":"Endocrinology"},{"key":"1233_CR18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0014-5793(99)01236-3","volume":"459","author":"J Kraus","year":"1999","unstructured":"Kraus J, W\u00f6ltje M, H\u00f6llt V. Regulation of mouse somatostatin receptor type 2 gene expression by glucocorticoids. FEBS Lett. 1999;459:200\u20134.","journal-title":"FEBS Lett"},{"key":"1233_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0014-5793(98)00520-1","volume":"428","author":"J Kraus","year":"1998","unstructured":"Kraus J, W\u00f6ltje M, Sch\u00f6nwetter N, H\u00f6llt V. Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene. FEBS Lett. 1998;428:165\u201370.","journal-title":"FEBS Lett"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-018-1233-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1233-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1233-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:47:59Z","timestamp":1547754479000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-018-1233-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1233"],"URL":"https:\/\/doi.org\/10.1007\/s12149-018-1233-4","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]},"assertion":[{"value":"13 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"We have no conflict of interest to declare other than a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (16K10346).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}