{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:55:21Z","timestamp":1784069721597,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s12149-018-1239-y","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T04:33:17Z","timestamp":1517805197000},"page":"250-255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biochemical and pathologic factors affecting technetium-99m-methoxyisobutylisonitrile imaging results in patients with primary hyperparathyroidism"],"prefix":"10.1007","volume":"32","author":[{"given":"Aysenur","family":"Ozderya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-755X","authenticated-orcid":false,"given":"Sule","family":"Temizkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin Ege","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Ozugur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadriye","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"1239_CR1","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1007\/s00198-016-3716-2","volume":"28","author":"AA Khan","year":"2017","unstructured":"Khan AA, Hanley DA, Rizzoli R, Bollerslev J, Young JE, Rejnmark L, et al. Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus. Osteoporos Int. 2017;28:01\u201319.","journal-title":"Osteoporos Int"},{"key":"1239_CR2","first-page":"5","volume":"4","author":"L Bandeira","year":"2016","unstructured":"Bandeira L, Bilezikian J. Primary Hyperparathyroidism F1000Res. 2016;4:5.","journal-title":"Primary Hyperparathyroidism F1000Res"},{"key":"1239_CR3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5694\/j.1326-5377.2002.tb04756.x","volume":"177","author":"MS Sywak","year":"2002","unstructured":"Sywak MS, Robinson BG, Clifton-Bligh P, Reeve TS, Barraclough BH, Fick GH, et al. Increase in presentations and procedure rates for hyperparathyroidism in Northern Sydney and New South Wales. Med J Aust. 2002;177:246\u20139.","journal-title":"Med J Aust"},{"key":"1239_CR4","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1001\/archsurg.137.9.1055","volume":"137","author":"WR Sackett","year":"2002","unstructured":"Sackett WR, Barraclough B, Reeve TS, Delbridge LW. Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg. 2002;137:1055\u20139.","journal-title":"Arch Surg"},{"key":"1239_CR5","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1210\/jc.2014-2000","volume":"99","author":"R Udelsman","year":"2014","unstructured":"Udelsman R, \u00c5kerstr\u00f6m G, Biagini C, Duh QY, Miccoli P, Niederle B, et al. The surgical management of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99:3595\u20133606.","journal-title":"J Clin Endocrinol Metab"},{"key":"1239_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/00000658-200205000-00008","volume":"235","author":"R Udelsman","year":"2002","unstructured":"Udelsman R. Six hundred fifty-six consecutive explorations for primary hyperparathyroidism. Ann Surg. 2002;235:665\u201370.","journal-title":"Ann Surg"},{"key":"1239_CR7","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/SLA.0b013e318208fed9","volume":"253","author":"R Udelsman","year":"2011","unstructured":"Udelsman R, Lin Z, Donovan P. The superiority of minimally invasive parathyroidectomy based on 1650 consecutive patients with primary hyperparathyroidism. Ann Surg. 2011;253:585\u201391.","journal-title":"Ann Surg"},{"key":"1239_CR8","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1097\/SLA.0b013e318288836b","volume":"257","author":"SB Leder","year":"2013","unstructured":"Leder SB, Donovan P, Acton LM, Warner HL, Carling T, Alian AA, et al. Laryngeal physiology and voice acoustics are maintained after minimally invasive parathyroidectomy. Ann Surg. 2013;257:968 \u2013 270.","journal-title":"Ann Surg"},{"key":"1239_CR9","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00423-009-0524-6","volume":"394","author":"M Thier","year":"2009","unstructured":"Thier M, Nordenstr\u00f6m E, Bergenfelz A, Westerdahl J. Surgery for patients with primary hyperparathyroidism and negative sestamibi scintigraphy\u2013a feasibility study. Langenbecks Arch Surg. 2009;394:881\u20134.","journal-title":"Langenbecks Arch Surg"},{"key":"1239_CR10","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00000658-200211000-00001","volume":"236","author":"A Bergenfelz","year":"2002","unstructured":"Bergenfelz A, Lindblom P, Tibblin S, Westerdahl J. Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial. Ann Surg. 2002;236:543\u201351.","journal-title":"Ann Surg"},{"key":"1239_CR11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00423-008-0408-1","volume":"393","author":"A Slepavicius","year":"2008","unstructured":"Slepavicius A, Beisa V, Janusonis V, Strupas K. Focused versus conventional parathyroidectomy for primary hyperparathyroidism: a prospective, randomized, blinded trial. Langenbecks Arch Surg. 2008;393:659\u201366.","journal-title":"Langenbecks Arch Surg"},{"key":"1239_CR12","first-page":"1443","volume":"44","author":"G Mariani","year":"2003","unstructured":"Mariani G, Gulec SA, Rubello D, Boni G, Puccini M, Pelizzo MR, et al. Preoperative localization and radioguided parathyroid surgery. J Nucl Med. 2003;44:1443\u201358.","journal-title":"J Nucl Med"},{"key":"1239_CR13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/MNM.0000000000000621","volume":"38","author":"M Araz","year":"2017","unstructured":"Araz M, \u00c7ayir D, Erdo\u011fan M, U\u00e7an B, \u00c7akal E. Factors affecting the sensitivity of Tc-99m methoxyisobutylisonitrile dual-phase parathyroid single photon emission computed tomography in primary hyperparathyroidism. Nucl Med Commun. 2017;38:117\u201323.","journal-title":"Nucl Med Commun"},{"key":"1239_CR14","first-page":"2639","volume":"7","author":"N Khorasani","year":"2014","unstructured":"Khorasani N, Mohammadi A. Effective factors on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism. Int J Clin Exp Med. 2014;7:2639\u201344.","journal-title":"Int J Clin Exp Med"},{"key":"1239_CR15","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.5858\/2009-0578-CCR.1","volume":"134","author":"D Carlson","year":"2010","unstructured":"Carlson D. Parathyroid pathology: hyperparathyroidism and parathyroid tumors. Arch Pathol Lab Med. 2010;134:1639\u201344.","journal-title":"Arch Pathol Lab Med"},{"key":"1239_CR16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/archotol.131.6.493","volume":"131","author":"NY Mehta","year":"2005","unstructured":"Mehta NY, Ruda JM, Kapadia S, Boyer PJ, Hollenbeak CS, Stack BC Jr, et al. Relationship of technetium Tc 99 m sestamibi scans to histopathological features of hyperfunctioning parathyroid tissue. Arch Otolaryngol Head Neck Surg. 2005;131:493\u20138.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1239_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.amjsurg.2007.01.040","volume":"195","author":"Y Erbil","year":"2008","unstructured":"Erbil Y, Kapran Y, I\u015fsever H, Barbaros U, Adalet I, Dizdaro\u011flu F, et al. The positive effect of adenoma weight and oxyphil cell content on preoperative localization with 99mTc-sestamibi scanning for primary hyperparathyroidism. Am J Surg. 2008;195:34\u20139.","journal-title":"Am J Surg"},{"key":"1239_CR18","first-page":"241","volume":"36","author":"F B\u00e9nard","year":"1995","unstructured":"B\u00e9nard F, Lefebvre B, Beuvon F, Langlois MF, Bisson G. Rapid washout of technetium-99m-MIBI from a large parathyroid adenoma. J Nucl Med. 1995;36:241\u20133.","journal-title":"J Nucl Med"},{"key":"1239_CR19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1055\/s-0028-1105925","volume":"117","author":"FH Jorna","year":"2009","unstructured":"Jorna FH, Hollema H, Hendrikse HN, Bart J, Brouwers AH, Plukker JT, et al. P-gp and MRP1 expression in parathyroid tumors related to histology, weight and (99 m) Tc-sestamibi imaging results. Exp Clin Endocrinol Diabetes. 2009;117:406\u201312.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1239_CR20","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1002\/bjs.5882","volume":"94","author":"Y Gupta","year":"2007","unstructured":"Gupta Y, Ahmed R, Happerfield L, Pinder SE, Balan KK, Wishart GC, et al. P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism. Br J Surg. 2007;94:1491\u20135.","journal-title":"Br J Surg"},{"key":"1239_CR21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1089\/cbr.2006.21.579","volume":"21","author":"B Turgut","year":"2006","unstructured":"Turgut B, Elagoz S, Erselcan T, Koyuncu A, Dokmetas HS, Hasbek Z, et al. Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. Cancer Biother Radiopharm. 2006;21:579\u201390.","journal-title":"Cancer Biother Radiopharm"},{"key":"1239_CR22","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s00259-002-0817-2","volume":"29","author":"A Kao","year":"2002","unstructured":"Kao A, Shiau YC, Tsai SC, Wang JJ, Ho ST. Technetium-99m methoxyisobutylisonitrile imaging for parathyroid adenoma: relationship to P-glycoprotein or multidrug resistance-related protein expression. Eur J Nucl Med Mol Imaging. 2002;29:1012\u20135.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1239_CR23","first-page":"1617","volume":"39","author":"A Bhatnagar","year":"1998","unstructured":"Bhatnagar A, Vezza PR, Bryan JA, Atkins FB, Ziessman HA. Technetium-99m-sestamibi parathyroid scintigraphy: effect of P-glycoprotein, histology and tumor size on detectability. J Nucl Med. 1998;39:1617\u201320.","journal-title":"J Nucl Med"},{"key":"1239_CR24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00268-001-0177-2","volume":"26","author":"S Yamaguchi","year":"2002","unstructured":"Yamaguchi S, Yachiku S, Hashimoto H, Kaneko S, Nishihara M, Niibori D, et al. Relation between technetium 99 m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands. World J Surg. 2002;26:29\u201334.","journal-title":"World J Surg"},{"key":"1239_CR25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/000313480306900507","volume":"69","author":"M Parikshak","year":"2003","unstructured":"Parikshak M, Castillo ED, Conrad MF, Talpos GB. Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism. Am Surg. 2003;69:393\u20138.","journal-title":"Am Surg"},{"key":"1239_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1475-097X.2011.01048.x","volume":"32","author":"DS Mshelia","year":"2012","unstructured":"Mshelia DS, Hatutale AN, Mokgoro NP, Nchabaleng ME, Buscombe JR, Sathekge MM, et al. Correlation between serum calcium levels and dual-phase (99 m) Tc-sestamibi parathyroid scintigraphy in primary hyperparathyroidism. Clin Physiol Funct Imaging. 2012;32:19\u201324.","journal-title":"Clin Physiol Funct Imaging"},{"key":"1239_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00423-010-0724-0","volume":"396","author":"AO Bergenfelz","year":"2011","unstructured":"Bergenfelz AO, Wallin G, Jansson S, Eriksson H, M\u00e5rtensson H, Christiansen P, et al. Results of surgery for sporadic primary hyperparathyroidism in patients with preoperatively negative sestamibi scintigraphy and ultrasound. Langenbecks Arch Surg. 2011;396:83\u201390.","journal-title":"Langenbecks Arch Surg"},{"key":"1239_CR28","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1245\/s10434-012-2325-3","volume":"19","author":"BM Dy","year":"2012","unstructured":"Dy BM, Richards ML, Vazquez BJ, Thompson GB, Farley DR, Grant CS, et al. Primary hyperparathyroidism and negative Tc99 sestamibi imaging: to operate or not? Ann Surg Oncol. 2012;19:2272\u20138.","journal-title":"Ann Surg Oncol"},{"key":"1239_CR29","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.surg.2011.09.016","volume":"150","author":"TS Wang","year":"2011","unstructured":"Wang TS, Cheung K, Farrokhyar F, Roman SA, Sosa JA. Would scan, but which scan? A cost-utility analysis to optimize preoperative imaging for primary hyperparathyroidism. Surgery. 2011;150:1286\u201394.","journal-title":"Surgery"},{"key":"1239_CR30","first-page":"215","volume":"16","author":"W Chudzinski","year":"2005","unstructured":"Chudzinski W, Niderla J, Lasiecka Z, Wilczynski G, Gornicka B, Wasiutynski A, et al. P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism. Int J Mol Med. 2005;16:215\u20139.","journal-title":"Int J Mol Med"},{"key":"1239_CR31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/BF00296351","volume":"56","author":"CA Axiotis","year":"1995","unstructured":"Axiotis CA, Bani D, Bianchi S, Pioli P, Tanini A, Brandi ML, et al. P-glycoprotein is expressed in parathyroid epithelium and is regulated by calcium. Calcif Tissue Int. 1995;56:170\u20134.","journal-title":"Calcif Tissue Int"},{"key":"1239_CR32","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/BF03027403","volume":"19","author":"TF Cermik","year":"2005","unstructured":"Cermik TF, Puyan FO, Sezer A, Firat MF, Berkarda S. Relation between Tc-99m sestamibi uptake and biological factors in hyperparathyroidism. Ann Nucl Med. 2005;19:387\u201392.","journal-title":"Ann Nucl Med"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-018-1239-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1239-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1239-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T21:14:21Z","timestamp":1693516461000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-018-1239-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["1239"],"URL":"https:\/\/doi.org\/10.1007\/s12149-018-1239-y","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]},"assertion":[{"value":"6 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None of the authors have any potential conflicts of interest associated with this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Ethics Committee of Kartal Dr. Lutfi Kirdar Training and Research Hospital and the study procedures were conducted in accordance with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}