{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:14:31Z","timestamp":1783754071315,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s12149-018-1241-4","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T07:56:21Z","timestamp":1518767781000},"page":"264-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic implications of 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) PET\/CT in patients with glioma"],"prefix":"10.1007","volume":"32","author":[{"given":"Akira","family":"Toriihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ohtake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Hino-Shishikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kitazume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ukihide","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"1241_CR1","first-page":"365","volume":"4","author":"E Lopci","year":"2014","unstructured":"Lopci E, Grassi I, Chiti A, Nanni C, Cicoria G, Toschi L, et al. PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence. Am J Nucl Med Mol Imaging. 2014;4:365\u2013384.","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"1241_CR2","first-page":"1155","volume":"38","author":"Y Fujibayashi","year":"1997","unstructured":"Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 1997;38:1155\u201360.","journal-title":"J Nucl Med"},{"key":"1241_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/BF02988502","volume":"15","author":"A Obata","year":"2001","unstructured":"Obata A, Yoshimi E, Waki A, Lewis JS, Oyama N, Welch MJ, et al. Retention mechanism of hypoxia selective nuclear imaging\/radiotherapeutic agent cu-diacetyl-bis (N\n                           4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells. Ann Nucl Med. 2001;15:499\u2013504.","journal-title":"Ann Nucl Med"},{"key":"1241_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3174\/ajnr.A3159","volume":"34","author":"K Tateishi","year":"2013","unstructured":"Tateishi K, Tateishi U, Sato M, Yamanaka S, Kanno H, Murata H, et al. Application of 62Cu-diacetyl-bis (N\n                           4-methylthiosemicarbazone) PET imaging to predict highly malignant tumor grades and hypoxia-inducible factor-1\u03b1 expression in patients with glioma. AJNR Am J Neuroradiol. 2013;34:92 \u2013 9.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1241_CR5","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/S0360-3016(02)04477-2","volume":"55","author":"F Dehdashti","year":"2003","unstructured":"Dehdashti F, Grigsby PW, Mintun MA, Lewis JS, Siegel BA, Welch MJ. Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report. Int J Radiat Oncol Biol Phys. 2003;55:1233\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1241_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2967\/jnumed.107.048520","volume":"49","author":"F Dehdashti","year":"2008","unstructured":"Dehdashti F, Grigsby PW, Lewis JS, Laforest R, Siegel BA, Welch MJ. Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med. 2008;49:201\u20135.","journal-title":"J Nucl Med"},{"key":"1241_CR7","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1007\/s00259-003-1130-4","volume":"30","author":"F Dehdashti","year":"2003","unstructured":"Dehdashti F, Mintun MA, Lewis JS, Bradley J, Govindan R, Laforest R, et al. In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur J Nucl Med Mol Imaging 2003;30:844\u201350.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1241_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.lungcan.2015.11.020","volume":"91","author":"T Kinoshita","year":"2016","unstructured":"Kinoshita T, Fujii H, Hayashi Y, Kamiyama I, Ohtsuka T, Asamura H. Prognostic significance of hypoxic PET using (18)F-FAZA and (62)Cu-ATSM in non-small-cell lung cancer. Lung Cancer. 2016;91:56\u201366.","journal-title":"Lung Cancer"},{"key":"1241_CR9","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1007\/s10350-008-9420-3","volume":"51","author":"DW Dietz","year":"2008","unstructured":"Dietz DW, Dehdashti F, Grigsby PW, Malyapa RS, Myerson RJ, Picus J, et al. Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study. Dis Colon Rectum. 2008;51:1641\u20138.","journal-title":"Dis Colon Rectum"},{"key":"1241_CR10","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1097\/RLU.0000000000000537","volume":"39","author":"Y Sato","year":"2014","unstructured":"Sato Y, Tsujikawa T, Oh M, Mori T, Kiyono Y, Fujieda S, et al. Assessing tumor hypoxia in head and neck cancer by PET with 62Cu-diacetyl-bis(N\n                           4-methylthiosemicarbazone). Clin Nucl Med. 2014;39:1027\u201332.","journal-title":"Clin Nucl Med"},{"key":"1241_CR11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3174\/ajnr.A3679","volume":"35","author":"K Tateishi","year":"2014","unstructured":"Tateishi K, Tateishi U, Nakanowatari S, Ohtake M, Minamimoto R, Suenaga J, et al. 62Cu-diacetyl-bis (N\n                           4-methylthiosemicarbazone) PET in human gliomas: comparative study with [18F]fluorodeoxyglucose and l-methyl-[11C]methionine PET. AJNR Am J Neuroradiol. 2014;35:278 \u2013 84.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1241_CR12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"1241_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/jon.12386","volume":"27","author":"GC Chiang","year":"2017","unstructured":"Chiang GC, Galla N, Ferraro R, Kovanlikaya I. The added prognostic value of metabolic tumor size on FDG-PET at first suspected recurrence of glioblastoma multiforme. J Neuroimaging. 2017;27:243\u20137.","journal-title":"J Neuroimaging"},{"key":"1241_CR14","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1148\/radiol.2016161172","volume":"283","author":"C Leiva-Salinas","year":"2017","unstructured":"Leiva-Salinas C, Schiff D, Flors L, Patrie JT, Rehm PK. FDG PET\/MR imaging coregistration helps predict survival in patients with glioblastoma and radiologic progression after standard of care treatment. Radiology. 2017;283:508 \u2013 14.","journal-title":"Radiology"},{"key":"1241_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s11060-011-0771-6","volume":"107","author":"C Colavolpe","year":"2012","unstructured":"Colavolpe C, Metellus P, Mancini J, Barrie M, Bequet-Boucard C, Figarella-Branger D, et al. Independent prognostic value of pre-treatment 18-FDG-PET in high-grade gliomas. J Neurooncol. 2012;107:527 \u2013 35.","journal-title":"J Neurooncol"},{"key":"1241_CR16","first-page":"1667","volume":"42","author":"KS Tralins","year":"2002","unstructured":"Tralins KS, Douglas JG, Stelzer KJ, Mankoff DA, Silbergeld DL, Rostomilly R, et al. Volumetric analysis of 18F-FDG PET in glioblastoma multiforme: prognostic information and possible role in definition of target volumes in radiation dose escalation. J Nucl Med. 2002;42:1667\u201373.","journal-title":"J Nucl Med"},{"key":"1241_CR17","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00259-016-3541-z","volume":"44","author":"T Toyonaga","year":"2017","unstructured":"Toyonaga T, Yamaguchi S, Hirata K, Kobayashi K, Manabe O, Watanabe S, et al. Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor. Eur J Nucl Med Mol Imaging. 2017;44:611\u20139.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1241_CR18","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1007\/s00259-014-2776-9","volume":"41","author":"N Kawai","year":"2014","unstructured":"Kawai N, Lin W, Cao WD, Ogawa D, Miyake K, Haba R, et al. Correlation between 18F-fluoromisonidazole PET and expression of HIF-1\u03b1 and VEGF in newly diagnosed and recurrent malignant gliomas. Eur J Nucl Med Mol Imaging. 2014;41:1870\u20138.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1241_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2967\/jnumed.108.055467","volume":"50","author":"KR Swanson","year":"2009","unstructured":"Swanson KR, Chakraborty G, Wang CH, Rockne R, Harpold HLP, Muzi M, et al. Complementary but distinct roles for MRI and 18F-fluoromisonidazole PET in the assessment of human glioblastomas. J Nucl Med. 2009;50:36\u201344.","journal-title":"J Nucl Med"},{"key":"1241_CR20","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1158\/1078-0432.CCR-07-4995","volume":"14","author":"AM Spence","year":"2008","unstructured":"Spence AM, Muzi M, Swanson KR, O\u2019Sullivan F, Rockhill JK, Rajendran JG, et al. Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival. Clin Cancer Res. 2008;14:2623\u201330.","journal-title":"Clin Cancer Res"},{"key":"1241_CR21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2967\/jnumed.113.126615","volume":"55","author":"S Carlin","year":"2014","unstructured":"Carlin S, Zhang H, Reese M, Ramos NN, Chen Q, Ricketts SA. A comparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers. J Nucl Med. 2014;55:515 \u2013 21.","journal-title":"J Nucl Med"},{"key":"1241_CR22","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.ijrobp.2004.12.057","volume":"61","author":"JA O\u2019Donoghue","year":"2005","unstructured":"O\u2019Donoghue JA, Zanzonico P, Pugachev A, Wen B, Smith-Jones P, Cai S, et al. Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N\n                           4-methylthiosemicarbazone) positron emission tomography: comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys. 2005;61:1493\u2013502.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1241_CR23","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3892\/or.2015.4079","volume":"34","author":"T Furukawa","year":"2015","unstructured":"Furukawa T, Yuan Q, Jin ZH, Aung W, Yoshii Y, Hasegawa S, et al. A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-\u03b1-d-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]. Oncol Rep. 2015;34:1379\u201387.","journal-title":"Oncol Rep"},{"key":"1241_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.radonc.2006.07.023","volume":"80","author":"EG Troost","year":"2006","unstructured":"Troost EG, Laverman P, Kaanders JH, Philippens M, Lok J, Oyen WJ, et al. Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors. Radiother Oncol. 2006;80:157 \u2013 64.","journal-title":"Radiother Oncol"},{"key":"1241_CR25","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s00259-012-2258-x","volume":"40","author":"M Busk","year":"2013","unstructured":"Busk M, Mortensen LS, Nordsmark M, Overgaard J, Jakobsen S, Hansen KV, et al. PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice. Eur J Nucl Med Mol Imaging. 2013;40:186 \u2013 97.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1241_CR26","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2967\/jnumed.115.155663","volume":"57","author":"F Li","year":"2016","unstructured":"Li F, Jorgensen JT, Forman J, Hansen AE, Kjaer A. 64Cu-ATSM reflects pO2 levels in human head and neck cancer xenografts but not in colorectal cancer xenografts: comparison with 64CuCl2. J Nucl Med. 2016;57:437 \u2013 43.","journal-title":"J Nucl Med"},{"key":"1241_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fmed.2015.00058","volume":"2","author":"M Colombie","year":"2015","unstructured":"Colombie M, Gouard S, Frindel M, Vidal A, Cherel M, Kraeber-Bodere F, et al. Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging. Front Med (Lausanne). 2015;2:58. \n                    https:\/\/doi.org\/10.3389\/fmed.2015.00058\n                    \n                  .","journal-title":"Front Med (Lausanne)"},{"key":"1241_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/jmri.24756","volume":"42","author":"D Bonekamp","year":"2015","unstructured":"Bonekamp D, Deike K, Wiestler B, Wick W, Bendszus M, Radbruch A, et al. Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: comparison of intraindividually matched T1- and T2\n                           *-based bolus techniques. J Magn Reson Imaging. 2015;42:87\u201396.","journal-title":"J Magn Reson Imaging"},{"key":"1241_CR29","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3174\/ajnr.A4284","volume":"36","author":"G Coban","year":"2015","unstructured":"Coban G, Mohan S, Kural F, Wang S, O\u2019Rourke DM, Poptani H. Prognostic value of dynamic susceptibility contrast-enhanced and diffusion-weighted MR imaging in patients with glioblastomas. AJNR Am J Neuroradiol. 2015;36:1247\u201352.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1241_CR30","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJMra061808","volume":"355","author":"CT Jordan","year":"2006","unstructured":"Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355:1253\u201361.","journal-title":"N Engl J Med"},{"key":"1241_CR31","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.nucmedbio.2009.12.011","volume":"37","author":"Y Yoshii","year":"2010","unstructured":"Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Waki A, Mori T, et al. Copper-64-diacetyl-bis (N\n                           4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma. Nucl Med Biol. 2010;37:395\u2013404.","journal-title":"Nucl Med Biol"},{"key":"1241_CR32","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1212\/WNL.0000000000001588","volume":"84","author":"M Ikawa","year":"2015","unstructured":"Ikawa M, Okazawa H, Tsujikawa T, Matsunaga A, Yamamura O, Mori T, et al. Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study. Neurology. 2015;84:2033\u20139.","journal-title":"Neurology"},{"key":"1241_CR33","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","volume":"7","author":"HP Indo","year":"2007","unstructured":"Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, et al. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion. 2007;7:106 \u2013 18.","journal-title":"Mitochondrion"},{"key":"1241_CR34","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.phrs.2015.06.013","volume":"100","author":"IS Okon","year":"2015","unstructured":"Okon IS, Zou MH. Mitochondrial ROS and cancer drug resistance: implications for therapy. Phamacol Res. 2015;100:170\u20134.","journal-title":"Phamacol Res"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-018-1241-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1241-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-018-1241-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T02:52:12Z","timestamp":1550371932000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-018-1241-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["1241"],"URL":"https:\/\/doi.org\/10.1007\/s12149-018-1241-4","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"assertion":[{"value":"19 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}