{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:22:20Z","timestamp":1791285740484,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12149-019-01339-8","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T12:53:12Z","timestamp":1549457592000},"page":"317-325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Development of radiolabeled bis(zinc(II)-dipicolylamine) complexes for cell death imaging"],"prefix":"10.1007","volume":"33","author":[{"given":"Miho","family":"Aoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Odani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-7302","authenticated-orcid":false,"given":"Kazuma","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"issue":"3","key":"1339_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrc1560","volume":"5","author":"JM Brown","year":"2005","unstructured":"Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer. 2005;5(3):231\u20137.","journal-title":"Nat Rev Cancer"},{"key":"1339_CR2","doi-asserted-by":"publisher","first-page":"732603","DOI":"10.1155\/2014\/732603","volume":"2014","author":"K Ogawa","year":"2014","unstructured":"Ogawa K, Aoki M. Radiolabeled apoptosis imaging agents for early detection of response to therapy. Sci World J. 2014;2014:732603.","journal-title":"Sci World J"},{"issue":"6","key":"1339_CR3","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2967\/jnumed.109.063917","volume":"51","author":"A Reshef","year":"2010","unstructured":"Reshef A, Shirvan A, Akselrod-Ballin A, Wall A, Ziv I. Small-molecule biomarkers for clinical PET imaging of apoptosis. J Nucl Med. 2010;51(6):837\u201340.","journal-title":"J Nucl Med"},{"issue":"Suppl 2","key":"1339_CR4","doi-asserted-by":"publisher","first-page":"81S","DOI":"10.2967\/jnumed.107.045898","volume":"49","author":"FG Blankenberg","year":"2008","unstructured":"Blankenberg FG. In vivo detection of apoptosis. J Nucl Med. 2008;49(Suppl 2):81S\u201395S.","journal-title":"J Nucl Med"},{"issue":"10","key":"1339_CR5","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1021\/bc3003309","volume":"23","author":"BA Smith","year":"2012","unstructured":"Smith BA, Smith BD. Biomarkers and molecular probes for cell death imaging and targeted therapeutics. Bioconjug Chem. 2012;23(10):1989\u20132006.","journal-title":"Bioconjug Chem"},{"issue":"17","key":"1339_CR6","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.1016\/j.bmc.2005.04.071","volume":"13","author":"RG Hanshaw","year":"2005","unstructured":"Hanshaw RG, Smith BD. New reagents for phosphatidylserine recognition and detection of apoptosis. Bioorg Med Chem. 2005;13(17):5035\u201342.","journal-title":"Bioorg Med Chem"},{"issue":"11","key":"1339_CR7","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.2967\/jnumed.112.108944","volume":"53","author":"FG Blankenberg","year":"2012","unstructured":"Blankenberg FG, Strauss HW. Recent advances in the molecular imaging of programmed cell death: part I\u2014pathophysiology and radiotracers. J Nucl Med. 2012;53(11):1659\u201362.","journal-title":"J Nucl Med"},{"issue":"5","key":"1339_CR8","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","volume":"182","author":"SJ Martin","year":"1995","unstructured":"Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med. 1995;182(5):1545\u201356.","journal-title":"J Exp Med"},{"issue":"10","key":"1339_CR9","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2967\/jnumed.108.052803","volume":"49","author":"JF Tait","year":"2008","unstructured":"Tait JF. Imaging of apoptosis. J Nucl Med. 2008;49(10):1573\u20136.","journal-title":"J Nucl Med"},{"key":"1339_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/sj.cdd.4400817","volume":"8","author":"RA Schlegel","year":"2001","unstructured":"Schlegel RA, Williamson P. Phosphatidylserine, a death knell. Cell Death Differ. 2001;8:551.","journal-title":"Cell Death Differ"},{"issue":"3","key":"1339_CR11","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1158\/0008-5472.CAN-05-3000","volume":"66","author":"MF Corsten","year":"2006","unstructured":"Corsten MF, Hofstra L, Narula J, Reutelingsperger CP. Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer treatment and surveillance. Cancer Res. 2006;66(3):1255\u201360.","journal-title":"Cancer Res"},{"issue":"6","key":"1339_CR12","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00259-004-1555-4","volume":"31","author":"CM Lahorte","year":"2004","unstructured":"Lahorte CM, Vanderheyden JL, Steinmetz N, Van de Wiele C, Dierckx RA, Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging. 2004;31(6):887\u2013919.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"1339_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00395-008-0701-8","volume":"103","author":"EM Laufer","year":"2008","unstructured":"Laufer EM, Reutelingsperger CP, Narula J, Hofstra L. Annexin A5: an imaging biomarker of cardiovascular risk. Basic Res Cardiol. 2008;103(2):95\u2013104.","journal-title":"Basic Res Cardiol"},{"key":"1339_CR14","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2147\/OTT.S148684","volume":"11","author":"X Jiang","year":"2018","unstructured":"Jiang X, Li H. MiR-1180-5p regulates apoptosis of Wilms\u2019 tumor by targeting p73. OncoTargets Ther. 2018;11:823\u201331.","journal-title":"OncoTargets Ther"},{"issue":"10","key":"1339_CR15","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s002590050580","volume":"26","author":"K Ohtsuki","year":"1999","unstructured":"Ohtsuki K, Akashi K, Aoka Y, Blankenberg FG, Kopiwoda S, Tait JF, et al. Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis. Eur J Nucl Med. 1999;26(10):1251\u20138.","journal-title":"Eur J Nucl Med"},{"issue":"10","key":"1339_CR16","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.2967\/jnumed.107.050260","volume":"49","author":"T Doue","year":"2008","unstructured":"Doue T, Ohtsuki K, Ogawa K, Ueda M, Azuma A, Saji H, et al. Cardioprotective effects of erythropoietin in rats subjected to ischemia-reperfusion injury: assessment of infarct size with 99mTc-annexin V. J Nucl Med. 2008;49(10):1694\u2013700.","journal-title":"J Nucl Med"},{"issue":"11","key":"1339_CR17","first-page":"1813","volume":"47","author":"S Rottey","year":"2006","unstructured":"Rottey S, Slegers G, Van Belle S, Goethals I, Van de Wiele C. Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapy. J Nucl Med. 2006;47(11):1813\u20138.","journal-title":"J Nucl Med"},{"issue":"12","key":"1339_CR18","doi-asserted-by":"publisher","first-page":"e81191","DOI":"10.1371\/journal.pone.0081191","volume":"8","author":"K Ogawa","year":"2013","unstructured":"Ogawa K, Ohtsuki K, Shibata T, Aoki M, Nakayama M, Kitamura Y, et al. Development and evaluation of a novel 99mTc-labeled annexin A5 for early detection of response to chemotherapy. PLoS One. 2013;8(12):e81191.","journal-title":"PLoS One"},{"issue":"8","key":"1339_CR19","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s10495-013-0852-4","volume":"18","author":"H Wang","year":"2013","unstructured":"Wang H, Tang X, Tang G, Huang T, Liang X, Hu K, et al. Noninvasive positron emission tomography imaging of cell death using a novel small-molecule probe, (18)F labeled bis(zinc(II)-dipicolylamine) complex. Apoptosis. 2013;18(8):1017\u201327.","journal-title":"Apoptosis"},{"issue":"12","key":"1339_CR20","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/sj.cdd.4401315","volume":"10","author":"AV Koulov","year":"2003","unstructured":"Koulov AV, Stucker KA, Lakshmi C, Robinson JP, Smith BD. Detection of apoptotic cells using a synthetic fluorescent sensor for membrane surfaces that contain phosphatidylserine. Cell Death Differ. 2003;10(12):1357\u20139.","journal-title":"Cell Death Differ"},{"issue":"12","key":"1339_CR21","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1002\/cbic.200500149","volume":"6","author":"RG Hanshaw","year":"2005","unstructured":"Hanshaw RG, Lakshmi C, Lambert TN, Johnson JR, Smith BD. Fluorescent detection of apoptotic cells by using zinc coordination complexes with a selective affinity for membrane surfaces enriched with phosphatidylserine. ChemBioChem. 2005;6(12):2214\u201320.","journal-title":"ChemBioChem"},{"issue":"8","key":"1339_CR22","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1167\/iovs.13-13346","volume":"55","author":"JM Kwong","year":"2014","unstructured":"Kwong JM, Hoang C, Dukes RT, Yee RW, Gray BD, Pak KY, et al. Bis(zinc-dipicolylamine), Zn-DPA, a new marker for apoptosis. Investig Ophthalmol Vis Sci. 2014;55(8):4913\u201321.","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"1339_CR23","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1021\/bc500003x","volume":"25","author":"AJ Plaunt","year":"2014","unstructured":"Plaunt AJ, Harmatys KM, Wolter WR, Suckow MA, Smith BD. Library synthesis, screening, and discovery of modified zinc(II)-bis(dipicolylamine) probe for enhanced molecular imaging of cell death. Bioconjug Chem. 2014;25(4):724\u201337.","journal-title":"Bioconjug Chem"},{"issue":"11","key":"1339_CR24","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.2967\/jnumed.110.078584","volume":"51","author":"G Niu","year":"2010","unstructured":"Niu G, Chen X. Apoptosis imaging: beyond annexin V. J Nucl Med. 2010;51(11):1659\u201362.","journal-title":"J Nucl Med"},{"issue":"49","key":"1339_CR25","doi-asserted-by":"publisher","first-page":"11307","DOI":"10.1016\/j.tet.2004.08.052","volume":"60","author":"C Lakshmi","year":"2004","unstructured":"Lakshmi C, Hanshaw RG, Smith BD. Fluorophore-linked zinc(II)dipicolylamine coordination complexes as sensors for phosphatidylserine-containing membranes. Tetrahedron. 2004;60(49):11307\u201315.","journal-title":"Tetrahedron"},{"issue":"4","key":"1339_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1021\/bc040249w","volume":"16","author":"K Ogawa","year":"2005","unstructured":"Ogawa K, Mukai T, Arano Y, Ono M, Hanaoka H, Ishino S, et al. Development of a rhenium-186-labeled MAG3-conjugated bisphosphonate for the palliation of metastatic bone pain based on the concept of bifunctional radiopharmaceuticals. Bioconjug Chem. 2005;16(4):751\u20137.","journal-title":"Bioconjug Chem"},{"issue":"6","key":"1339_CR27","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1248\/cpb.c18-00081","volume":"66","author":"K Ogawa","year":"2018","unstructured":"Ogawa K, Takeda T, Yokokawa M, Yu J, Makino A, Kiyono Y, et al. Comparison of radioiodine- or radiobromine-labeled RGD peptides between direct and indirect labeling methods. Chem Pharm Bull (Tokyo). 2018;66(6):651\u20139.","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"12","key":"1339_CR28","first-page":"2042","volume":"47","author":"K Ogawa","year":"2006","unstructured":"Ogawa K, Mukai T, Inoue Y, Ono M, Saji H. Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. J Nucl Med. 2006;47(12):2042\u20137.","journal-title":"J Nucl Med"},{"issue":"11","key":"1339_CR29","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1111\/j.1349-7006.2009.01279.x","volume":"100","author":"K Ogawa","year":"2009","unstructured":"Ogawa K, Shiba K, Akhter N, Yoshimoto M, Washiyama K, Kinuya S, et al. Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy. Cancer Sci. 2009;100(11):2188\u201392.","journal-title":"Cancer Sci"},{"issue":"4","key":"1339_CR30","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0883-2897(86)90027-9","volume":"13","author":"E Deutsch","year":"1986","unstructured":"Deutsch E, Libson K, Vanderheyden JL, Ketring AR, Maxon HR. The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine. Int J Radiat Appl Instrum Part B Nucl Med Biol. 1986;13(4):465\u201377.","journal-title":"Int J Radiat Appl Instrum Part B Nucl Med Biol"},{"issue":"8","key":"1339_CR31","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1021\/ja038277x","volume":"126","author":"A Ojida","year":"2004","unstructured":"Ojida A, Mito-oka Y, Sada K, Hamachi I. Molecular recognition and fluorescence sensing of monophosphorylated peptides in aqueous solution by bis(zinc(II)-dipicolylamine)-based artificial receptors. J Am Chem Soc. 2004;126(8):2454\u201363.","journal-title":"J Am Chem Soc"},{"issue":"8","key":"1339_CR32","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1021\/am508838z","volume":"7","author":"Q Hu","year":"2015","unstructured":"Hu Q, Gao M, Feng G, Chen X, Liu B. A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics. ACS Appl Mater Interfaces. 2015;7(8):4875\u201382.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"1339_CR33","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1016\/j.bmc.2011.04.029","volume":"19","author":"L Wyffels","year":"2011","unstructured":"Wyffels L, Gray BD, Barber C, Moore SK, Woolfenden JM, Pak KY, et al. Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents. Bioorg Med Chem. 2011;19(11):3425\u201333.","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"1339_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s11307-014-0758-8","volume":"17","author":"DR Rice","year":"2015","unstructured":"Rice DR, Plaunt AJ, Turkyilmaz S, Smith M, Wang Y, Rusckowski M, et al. Evaluation of [111In]-labeled zinc-dipicolylamine tracers for SPECT imaging of bacterial infection. Mol Imaging Biol. 2015;17(2):204\u201313.","journal-title":"Mol Imaging Biol"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-019-01339-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-019-01339-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-019-01339-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T19:25:07Z","timestamp":1580930707000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-019-01339-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1339"],"URL":"https:\/\/doi.org\/10.1007\/s12149-019-01339-8","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]},"assertion":[{"value":"25 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}