{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:07:01Z","timestamp":1792598821851,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12149-019-01386-1","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T04:03:36Z","timestamp":1563336216000},"page":"755-765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Fully automated analysis for bone scintigraphy with artificial neural network: usefulness of bone scan index (BSI) in breast cancer"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-7164","authenticated-orcid":false,"given":"Anri","family":"Inaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Kinuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"issue":"2","key":"1386_CR1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S0959-8049(97)10128-9","volume":"34","author":"RD Rubens","year":"1998","unstructured":"Rubens RD. Bone metastases\u2013the clinical problem. Eur J Cancer. 1998;34(2):210\u20133.","journal-title":"Eur J Cancer"},{"issue":"6","key":"1386_CR2","doi-asserted-by":"publisher","first-page":"921","DOI":"10.2967\/jnumed.109.071571","volume":"51","author":"J Zeintl","year":"2010","unstructured":"Zeintl J, et al. Quantitative accuracy of clinical 99mTc SPECT\/CT using ordered-subset expectation maximization with 3-dimensional resolution recovery, attenuation, and scatter correction. J Nucl Med. 2010;51(6):921\u20138.","journal-title":"J Nucl Med"},{"issue":"1","key":"1386_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/RLU.0b013e3181feeb5e","volume":"36","author":"M Fukuoka","year":"2011","unstructured":"Fukuoka M, et al. Comparison of diagnostic value of I-123 MIBG and high-dose I-131 MIBG scintigraphy including incremental value of SPECT\/CT over planar image in patients with malignant pheochromocytoma\/paraganglioma and neuroblastoma. Clin Nucl Med. 2011;36(1):1\u20137.","journal-title":"Clin Nucl Med"},{"issue":"9","key":"1386_CR4","first-page":"1401","volume":"38","author":"YE Erdi","year":"1997","unstructured":"Erdi YE, et al. Quantitative bone metastases analysis based on image segmentation. J Nucl Med. 1997;38(9):1401\u20136.","journal-title":"J Nucl Med"},{"issue":"7","key":"1386_CR5","first-page":"1765","volume":"4","author":"M Imbriaco","year":"1998","unstructured":"Imbriaco M, et al. A new parameter for measuring metastatic bone involvement by prostate cancer: the Bone Scan Index. Clin Cancer Res. 1998;4(7):1765\u201372.","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1386_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MNM.0b013e328335a5ed","volume":"31","author":"AG Zafeirakis","year":"2010","unstructured":"Zafeirakis AG, Papatheodorou GA, Limouris GS. Clinical and imaging correlations of bone turnover markers in prostate cancer patients with bone only metastases. Nucl Med Commun. 2010;31(3):249\u201353.","journal-title":"Nucl Med Commun"},{"issue":"9","key":"1386_CR7","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1007\/s12149-013-0749-x","volume":"27","author":"H Wakabayashi","year":"2013","unstructured":"Wakabayashi H, et al. Bone scintigraphy as a new imaging biomarker: the relationship between bone scan index and bone metabolic markers in prostate cancer patients with bone metastases. Ann Nucl Med. 2013;27(9):802\u20137.","journal-title":"Ann Nucl Med"},{"issue":"1","key":"1386_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/2191-219X-3-83","volume":"3","author":"K Nakajima","year":"2013","unstructured":"Nakajima K, et al. Enhanced diagnostic accuracy for quantitative bone scan using an artificial neural network system: a Japanese multi-center database project. EJNMMI Res. 2013;3(1):83.","journal-title":"EJNMMI Res"},{"issue":"28","key":"1386_CR9","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1097\/MD.0000000000000269","volume":"93","author":"T Iwase","year":"2014","unstructured":"Iwase T, et al. The relationship between skeletal-related events and bone scan index for the treatment of bone metastasis with breast cancer patients. Medicine (Baltimore). 2014;93(28):e269.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"1386_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/1097-0142(19880101)61:1<195::AID-CNCR2820610133>3.0.CO;2-Y","volume":"61","author":"MS Soloway","year":"1988","unstructured":"Soloway MS, et al. Stratification of patients with metastatic prostate cancer based on extent of disease on initial bone scan. Cancer. 1988;61(1):195\u2013202.","journal-title":"Cancer"},{"key":"1386_CR11","unstructured":"Ethical Guidelines for Medical and Health Research Involving Human Subjects. Public notice of the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labour and Welfare No. 3 of 2014."},{"issue":"1","key":"1386_CR12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.eururo.2012.01.037","volume":"62","author":"D Ulmert","year":"2012","unstructured":"Ulmert D, et al. A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index. Eur Urol. 2012;62(1):78\u201384.","journal-title":"Eur Urol"},{"issue":"Pt 1","key":"1386_CR13","first-page":"664","volume":"12","author":"K Sjostrand","year":"2009","unstructured":"Sjostrand K, Ohlsson M, Edenbrandt L. Statistical regularization of deformation fields for atlas-based segmentation of bone scintigraphy images. Med Image Comput Comput Assist Interv. 2009;12(Pt 1):664\u201371.","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"2","key":"1386_CR14","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","volume":"42","author":"R Boellaard","year":"2015","unstructured":"Boellaard R, et al. FDG PET\/CT: EANM procedure guidelines for tumour imaging version 2.0. Eur J Nucl Med Mol Imaging. 2015;42(2):328\u201354.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"3","key":"1386_CR15","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837\u201345.","journal-title":"Biometrics"},{"issue":"3","key":"1386_CR16","doi-asserted-by":"publisher","first-page":"368","DOI":"10.2967\/jnumed.108.058883","volume":"50","author":"M Sadik","year":"2009","unstructured":"Sadik M, et al. Improved classifications of planar whole-body bone scans using a computer-assisted diagnosis system: a multicenter, multiple-reader, multiple-case study. J Nucl Med. 2009;50(3):368\u201375.","journal-title":"J Nucl Med"},{"issue":"4","key":"1386_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s12149-014-0819-8","volume":"28","author":"O Tokuda","year":"2014","unstructured":"Tokuda O, et al. Investigation of computer-aided diagnosis system for bone scans: a retrospective analysis in 406 patients. Ann Nucl Med. 2014;28(4):329\u201339.","journal-title":"Ann Nucl Med"},{"issue":"Suppl 4","key":"1386_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1634\/theoncologist.9-90004-14","volume":"9","author":"RE Coleman","year":"2004","unstructured":"Coleman RE. Bisphosphonates: clinical experience. Oncologist. 2004;9(Suppl 4):14\u201327.","journal-title":"Oncologist"},{"issue":"1","key":"1386_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.juro.2010.03.034","volume":"184","author":"M Norgaard","year":"2010","unstructured":"Norgaard M, et al. Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999\u20132007). J Urol. 2010;184(1):162\u20137.","journal-title":"J Urol"},{"key":"1386_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2407-11-29","volume":"11","author":"AO Jensen","year":"2011","unstructured":"Jensen AO, et al. Incidence of bone metastases and skeletal-related events in breast cancer patients: a population-based cohort study in Denmark. BMC Cancer. 2011;11:29.","journal-title":"BMC Cancer"},{"issue":"7","key":"1386_CR21","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1200\/JCO.2012.45.9859","volume":"31","author":"JL Khatcheressian","year":"2013","unstructured":"Khatcheressian JL, et al. Breast cancer follow-up and management after primary treatment: American Society of clinical oncology clinical practice guideline update. J Clin Oncol. 2013;31(7):961\u20135.","journal-title":"J Clin Oncol"},{"issue":"8","key":"1386_CR22","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1007\/s00259-008-0721-5","volume":"35","author":"M Sadik","year":"2008","unstructured":"Sadik M, et al. Quality of planar whole-body bone scan interpretations\u2013a nationwide survey. Eur J Nucl Med Mol Imaging. 2008;35(8):1464\u201372.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"8","key":"1386_CR23","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1007\/s00330-015-3630-6","volume":"25","author":"J Krammer","year":"2015","unstructured":"Krammer J, et al. (18)F-FDG PET\/CT for initial staging in breast cancer patients\u2013Is there a relevant impact on treatment planning compared to conventional staging modalities? Eur Radiol. 2015;25(8):2460\u20139.","journal-title":"Eur Radiol"},{"issue":"5","key":"1386_CR24","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00259-015-3295-z","volume":"43","author":"D Groheux","year":"2016","unstructured":"Groheux D, et al. F-FDG PET\/CT in the early prediction of pathological response in aggressive subtypes of breast cancer: review of the literature and recommendations for use in clinical trials. Eur J Nucl Med Mol Imaging. 2016;43(5):983\u201393.","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"1386_CR25","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1186\/s40064-015-1634-y","volume":"4","author":"T Ishiba","year":"2015","unstructured":"Ishiba T, et al. Efficiency of fluorodeoxyglucose positron emission tomography\/computed tomography to predict prognosis in breast cancer patients received neoadjuvant chemotherapy. Springerplus. 2015;4:817.","journal-title":"Springerplus"},{"issue":"1","key":"1386_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1258\/ar.2011.110245","volume":"53","author":"R Murakami","year":"2012","unstructured":"Murakami R, et al. FDG-PET\/CT in the diagnosis of recurrent breast cancer. Acta Radiol. 2012;53(1):12\u20136.","journal-title":"Acta Radiol"},{"issue":"4","key":"1386_CR27","doi-asserted-by":"publisher","first-page":"878","DOI":"10.2214\/AJR.14.13906","volume":"205","author":"SH Son","year":"2015","unstructured":"Son SH, et al. Whole-body metabolic tumor volume, as determined by (18)F-FDG PET\/CT, as a prognostic factor of outcome for patients with breast cancer who have distant metastasis. AJR Am J Roentgenol. 2015;205(4):878\u201385.","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"1386_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.suronc.2013.01.002","volume":"22","author":"J Rong","year":"2013","unstructured":"Rong J, et al. Comparison of 18 FDG PET-CT and bone scintigraphy for detection of bone metastases in breast cancer patients. A meta-analysis. Surg Oncol. 2013;22(2):86\u201391.","journal-title":"Surg Oncol"},{"issue":"10","key":"1386_CR29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s12149-015-1021-3","volume":"29","author":"R Shintawati","year":"2015","unstructured":"Shintawati R, et al. Evaluation of bone scan index change over time on automated calculation in bone scintigraphy. Ann Nucl Med. 2015;29(10):911\u201320.","journal-title":"Ann Nucl Med"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-019-01386-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12149-019-01386-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-019-01386-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T19:44:40Z","timestamp":1594842280000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12149-019-01386-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1386"],"URL":"https:\/\/doi.org\/10.1007\/s12149-019-01386-1","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"assertion":[{"value":"7 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standard"}},{"value":"K. Nakajima has a collaborative research work with FUJIFILM Toyama Chemical for developing BONENAVI software. Other authors have declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}