{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:36:42Z","timestamp":1780360602913,"version":"3.54.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (\u0394SUVmax).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>\u0394SUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median \u0394SUVmax of 2.6 (0\u20137\u00a0days), 0.8 (8\u201314\u00a0days), and 0.3 (&gt;\u200914\u00a0days), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Consideration should be given to performing FDG PET at least 2\u00a0weeks after the COVID-19 vaccine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12149-021-01675-8","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:02:49Z","timestamp":1630404169000},"page":"1264-1269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients"],"prefix":"10.1007","volume":"35","author":[{"given":"Pooja","family":"Advani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Chumsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmayi","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-570X","authenticated-orcid":false,"given":"Ephraim","family":"Parent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"1675_CR1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.25728","author":"LJ McIntosh","year":"2021","unstructured":"McIntosh LJ, Bankier AA, Vijayaraghavan GR, Licho R, Rosen MP. COVID-19 vaccination-related uptake on FDG PET\/CT: an emerging dilemma and suggestions for management. AJR Am J Roentgenol. 2021. https:\/\/doi.org\/10.2214\/AJR.21.25728.","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"1675_CR2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/RLU.0000000000003634","volume":"46","author":"M Doss","year":"2021","unstructured":"Doss M, Nakhoda SK, Li Y, Yu JQ. COVID-19 vaccine-related local FDG uptake. Clin Nucl Med. 2021;46(5):439\u201341.","journal-title":"Clin Nucl Med"},{"issue":"3","key":"1675_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s12149-011-0568-x","volume":"26","author":"N Shirone","year":"2012","unstructured":"Shirone N, Shinkai T, Yamane T, Uto F, Yoshimura H, Tamai H, et al. Axillary lymph node accumulation on FDG-PET\/CT after influenza vaccination. 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R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria: R Foundation for Statistical Computing. 2019. https:\/\/www.R-project.org\/. Accessed 2 Aug 2021."},{"issue":"5","key":"1675_CR7","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s00330-010-1719-5","volume":"20","author":"E Panagiotidis","year":"2010","unstructured":"Panagiotidis E, Exarhos D, Housianakou I, Bournazos A, Datseris I. FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1). Eur Radiol. 2010;20(5):1251\u20133.","journal-title":"Eur Radiol"},{"key":"1675_CR8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021210886:210886","author":"Y Eshet","year":"2021","unstructured":"Eshet Y, Tau N, Alhoubani Y, Kanana N, Domachevsky L, Eifer M. Prevalence of increased FDG PET\/CT axillary lymph node uptake beyond 6 weeks after mRNA COVID-19 vaccination. Radiology. 2021. https:\/\/doi.org\/10.1148\/radiol.2021210886:210886.","journal-title":"Radiology"},{"key":"1675_CR9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.25928","author":"DG Schroeder","year":"2021","unstructured":"Schroeder DG, Jang S, Johnson DR, Takahashi H, Navin PJ, Broski SM, et al. Frequency and characteristics of nodal and deltoid FDG and 11C-choline uptake on PET imaging performed after COVID-19 vaccination. AJR Am J Roentgenol. 2021. https:\/\/doi.org\/10.2214\/AJR.21.25928.","journal-title":"AJR Am J Roentgenol"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-021-01675-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-021-01675-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-021-01675-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:12:28Z","timestamp":1633651948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-021-01675-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1675"],"URL":"https:\/\/doi.org\/10.1007\/s12149-021-01675-8","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"assertion":[{"value":"15 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No funding was obtained for this study. Dr. Pooja Advani received research funding from Genentech. Dr. Saranya Chumsri receives research funding from Merck and Pfizer. Dr. Ephraim Parent receives research funding from Blue Earth Diagnostics. The other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The recruitment protocol was approved by the Institutional Review Board (IRB) and complied with the Health Insurance Portability and Accountability Act (HIPPA). Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}