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The study was performed using simulation with the assumption that all patients received RT. The clinical target volume (CTV) was contoured using the Gd-enhanced region (CTV(Gd)), the tumor\/normal tissue (T\/N) ratios of\n                      <jats:sup>11<\/jats:sup>\n                      C-MET PET of 1.3 and 2.0 (CTV (T\/N 1.3), CTV (T\/N 2.0)), and the PET-edge method (CTV(P-E)) for stereotactic RT planning. Differences among CTVs were evaluated. The brain dose at each CTV and the dose at each CTV defined by\n                      <jats:sup>11<\/jats:sup>\n                      C-MET PET using MRI as the reference were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Jaccard index (JI) for concordance of CTV (Gd) with CTVs using\n                      <jats:sup>11<\/jats:sup>\n                      C-MET PET was highest for CTV (T\/N 2.0), with a value of 0.7. In a comparison of pixel values of MRI and PET, the correlation coefficient for cases with higher JI was significantly greater than that for lower JI cases (0.37 vs. 0.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007). D50% of the brain in RT planning using each CTV differed significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03) and that using CTV (T\/N 1.3) were higher than with use of CTV (Gd). V90% and V95% for each CTV differed in a simulation study for actual treatment using CTV (Gd) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a01.0\u00a0\u00d7\u00a010\n                      <jats:sup>\u20137<\/jats:sup>\n                      and 3.0\u00a0\u00d7\u00a010\n                      <jats:sup>\u20139<\/jats:sup>\n                      , respectively) and those using CTV (T\/N 1.3) and CTV (P-E) were lower than with CTV (Gd).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The region of\n                      <jats:sup>11<\/jats:sup>\n                      C-MET accumulation is not necessarily consistent with and larger than the Gd-enhanced region. A change of the tumor boundary using\n                      <jats:sup>11<\/jats:sup>\n                      C-MET PET can cause significant changes in doses to the brain and the CTV.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12149-024-01901-z","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:02:21Z","timestamp":1707912141000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Methyl-11C-L-methionine positron emission tomography for radiotherapy planning for recurrent malignant glioma"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-254X","authenticated-orcid":false,"given":"Hikaru","family":"Niitsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Fukumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mizumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kamizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"1901_CR1","doi-asserted-by":"crossref","unstructured":"Narita Y, Shibui S. 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