{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:34:25Z","timestamp":1772120065337,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004823","name":"Nagoya University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value and the function and volume of the thyroid gland by identifying the factors that induce changes in the CT value of patients with hyperthyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study evaluated 38 patients with Graves\u2019 disease and 10 patients with Plummer disease. To obtain the mean CT value and volume of the thyroid gland, the entire thyroid gland was set as the region of interest. A test dose of 3.7\u00a0MBq I-131 was administered before initiating I-131 therapy, and the radioiodine uptake (RIU) rate was assessed after 3, 24, 96, and 168\u00a0h. An approximate curve was plotted based on the RIU values obtained, and the effective half-life (EHL) was calculated. The correlation between the mean CT value and the volume of the thyroid gland, 24-h RIU, EHL, and the free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CT value exhibited a significant positive correlation with EHL in patients with Graves\u2019 disease (r\u2009=\u20090.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) as well as patients with Plummer disease (r\u2009=\u20090.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, it did not display any correlation with the remaining parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CT value is significantly correlated with EHL, suggesting that it reflects thyroid function and is mainly related to the factors associated with iodine discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12149-024-01938-0","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:02:08Z","timestamp":1716548528000},"page":"659-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study"],"prefix":"10.1007","volume":"38","author":[{"given":"Haruna","family":"Iwanaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-9319","authenticated-orcid":false,"given":"Katsuhiko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"1938_CR1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1148\/radiology.147.3.6844615","volume":"147","author":"Y Iida","year":"1983","unstructured":"Iida Y, Konishi J, Harioka T, Misaki T, Endo K, Torizuka K. Thyroid CT number and its relationship to iodine concentration. Radiology. 1983;147:793\u20135.","journal-title":"Radiology"},{"key":"1938_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0149-936X(79)90054-7","volume":"3","author":"T Kaneko","year":"1979","unstructured":"Kaneko T, Matsumoto M, Fukui K, Hori T, Katayama K. Clinical evaluation of thyroid CT values in various thyroid conditions. J Comput Tomogr. 1979;3:1\u20134.","journal-title":"J Comput Tomogr"},{"key":"1938_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/00004728-199103000-00019","volume":"15","author":"Y Imanishi","year":"1991","unstructured":"Imanishi Y, Ehara N, Mori J, Shimokawa M, Sakuyama K, Ishikawa T, et al. Measurement of thyroid iodine by CT. J Comput Assist Tomogr. 1991;15:287\u201390.","journal-title":"J Comput Assist Tomogr"},{"key":"1938_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2214\/AJR.09.3319","volume":"195","author":"YM Han","year":"2010","unstructured":"Han YM, Kim YC, Park EK, Choe JG. Diagnostic value of CT density in patients with diffusely increased FDG uptake in the thyroid gland on PET\/CT images. AJR Am J Roentgenol. 2010;195:223\u20138.","journal-title":"AJR Am J Roentgenol"},{"key":"1938_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/00004728-200003000-00026","volume":"24","author":"Y Imanishi","year":"2000","unstructured":"Imanishi Y, Ehara N, Shinagawa T, Tsujino D, Endoh I, Baba K, et al. Correlation of CT values, iodine concentration, and histological changes in the thyroid. J Comput Assist Tomogr. 2000;24:322\u20136.","journal-title":"J Comput Assist Tomogr"},{"key":"1938_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/RCT.0000000000000360","volume":"40","author":"V Pandey","year":"2016","unstructured":"Pandey V, Reis M, Zhou YH. Correlation between computed tomography density and functional status of the thyroid gland. J Comput Assist Tomogr. 2016;40:316\u20139.","journal-title":"J Comput Assist Tomogr"},{"key":"1938_CR7","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1056\/NEJMra1510030","volume":"375","author":"TJ Smith","year":"2016","unstructured":"Smith TJ, Heged\u00fcs L. Graves\u2019 disease. N Engl J Med. 2016;375:1552\u201365.","journal-title":"N Engl J Med"},{"key":"1938_CR8","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1001\/jama.1983.03340150084036","volume":"250","author":"EM Chapman","year":"1983","unstructured":"Chapman EM. History of the discovery and early use of radioactive iodine. JAMA. 1983;250:2042\u20134.","journal-title":"JAMA"},{"issue":"1","key":"1938_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1172\/JCI101275","volume":"21","author":"S Hertz","year":"1942","unstructured":"Hertz S, Roberts A, Salter WT. Radioactive iodine as an indicator in thyroid physiology. IV. The metabolism of iodine in Graves\u2019 disease. J Clin Invest. 1942;21(1):25\u20139.","journal-title":"J Clin Invest"},{"key":"1938_CR10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1007\/s00259-002-0877-3","volume":"29","author":"MJ Reinhardt","year":"2002","unstructured":"Reinhardt MJ, Brink I, Joe AY, Von Mallek D, Ezziddin S, Palmedo H, et al. Radioiodine therapy in Graves\u2019 disease based on tissue-absorbed dose calculations: effect of pre-treatment thyroid volume on clinical outcome. Eur J Nucl Med Mol Imaging. 2002;29:1118\u201324.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1938_CR11","first-page":"218","volume":"20","author":"M Grosso","year":"2005","unstructured":"Grosso M, Traino A, Boni G, Banti E, Della Porta M, et al. Comparison of different thyroid committed doses in radioiodine therapy for Graves\u2019 hyperthyroidism. Cancer Biother Radiopharm. 2005;20:218\u201323.","journal-title":"Cancer Biother Radiopharm"},{"key":"1938_CR12","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1007\/s00259-023-06274-5","volume":"50","author":"A Campenn\u00ec","year":"2023","unstructured":"Campenn\u00ec A, Avram AM, Verburg FA, Iakovou I, H\u00e4nscheid H, de Keizer B, et al. The EANM guideline on radioiodine therapy of benign thyroid disease. Eur J Nucl Med Mol Imaging. 2023;50:3324\u201348.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1938_CR13","doi-asserted-by":"crossref","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant 2013;48:452\u20138.","DOI":"10.1038\/bmt.2012.244"},{"key":"1938_CR14","doi-asserted-by":"crossref","unstructured":"\u00a0Listewnik MH, Piwowarska-Bilska H, Jasiakiewicz K, Birkenfeld B. Influence of high tissue-absorbed dose on anti-thyroid antibodies in radioiodine therapy of Graves\u2019 disease patients. Adv Clin Exp Med 2021;30:913\u201321.","DOI":"10.17219\/acem\/137779"},{"key":"1938_CR15","doi-asserted-by":"crossref","unstructured":"\u00a0Watanabe S, Okamoto S, Akikawa K, Miyamoto N, Okamura-Kawasaki M, et al. Identification of patients with Graves\u2019 disease who benefit from high\u2011dose radioactive iodine therapy. Ann Nucl Med 2022;36:923\u201330.","DOI":"10.1007\/s12149-022-01781-1"},{"key":"1938_CR16","doi-asserted-by":"crossref","unstructured":"Lu L, Gao C, Zhang N. Age moderates the associations between TRAbs, free T3 and outcomes of Graves\u2019 disease patients with radioactive iodine treatment. Clin Endocrinol 2021;94:303\u20139.","DOI":"10.1111\/cen.14301"},{"key":"1938_CR17","doi-asserted-by":"crossref","unstructured":"Bano A, Gan E, Addison C, Narayanan K, Weaver JU, Tsatlidis V, et al. Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients With Graves disease. J Clin Endocrinol 2019;104:1378\u201385.","DOI":"10.1210\/jc.2018-01738"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-024-01938-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-024-01938-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-024-01938-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T17:19:17Z","timestamp":1722014357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-024-01938-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1938"],"URL":"https:\/\/doi.org\/10.1007\/s12149-024-01938-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3881795\/v1","asserted-by":"object"}]},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"19 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethical Review Committee of Nagoya University Hospital and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Ethical Review Committee of Nagoya University Hospital (application no. 20-0033). As this study analysed clinical data retrospectively, we did not obtain informed consent directly from each patient. Instead of direct informed consent, we published the research contents on the university web page and provided an opt-out opportunity.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}