{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T12:40:09Z","timestamp":1745325609329,"version":"3.40.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>We planned this retrospective study to evaluate the effect of the central vs peripheral location effect on the success of selective internal radiation therapy (SIRT) with <jats:sup>90<\/jats:sup>Yttrium-90 (<jats:sup>90<\/jats:sup>Y) glass microspheres in hepatocellular carcinomas (HCC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Material and methods<\/jats:title>\n            <jats:p>Thirty-eight patients diagnosed with HCC who were eligible for SIRT with <jats:sup>90<\/jats:sup>Y glass microspheres were included in this study. The location being central versus peripheral was defined as explained: Straight lines through the bifurcation of the right and left branches of the portal vein to the center of the HCC and the peripheral surface of the liver were traced on the same plane. The coefficient was determined as a ratio of the center of the HCC to the distance from the hilum of the liver at the portal vein bifurcation. Value under \u00bd accepted as central location (Group 1, <jats:italic>n<\/jats:italic>\u2009=\u200917), over \u00bd values are accepted as peripheral location (Group 2, <jats:italic>n<\/jats:italic>\u2009=\u200921). Treatment responses were analyzed after 2\u00a0months of the treatment with magnetic resonance imaging, and 2-deoxy-2-[<jats:sup>18<\/jats:sup>F]fluoro-D-glucose positron emission tomography\/computed tomography ([<jats:sup>18<\/jats:sup>F]FDG PET\/CT) for FDG-avid ones. Differences in treatment responses rates, treatment approach, the absorbed doses and the volumes of each liver segments between groups were investigated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In Group 1; mean age was 67. In 5 cases split infusion, in 10 cases tumor selective treatment approach were applied. According to PERCIST\/mRECIST criteria treatment responses categories: complete response in 2\/1 cases, partial response in 7\/9 cases, stable disease in 3\/4 cases, progressive diseases in 2\/3 cases; respectively. AFP value decreased in 2 cases, increased in 7 cases, and was stable in 1 case. Mean absorbed doses were 347.9\u00a0Gy for tumor, 140.6\u00a0Gy for perfused normal tissue, and 26.1\u00a0Gy for the normal liver. In Group 2; the mean age was 71.5. In 5 cases split infusion, and in 1 case non-selective treatment approach were applied. According to PERCIST\/mRECIST criteria treatment responses categories: complete response in 7\/6 cases, partial response in 7\/10 cases, stable disease in 2\/2 cases, and progressive diseases in 3\/3 cases; respectively. AFP value decreased in 9 cases, increased in 2 cases, and was stable in 2 cases. Mean absorbed doses were 495.9\u00a0Gy for tumor, 134\u00a0Gy for perfused normal tissue, and 17.3\u00a0Gy for the normal liver.There is no statistically significant difference in terms of gender, treatment response rates, tumor volumes, perfuse tissue volumes between 2 groups. However, tumor-selective approach and absorbed doses of the perfused normal tissue and the tumor were significantly higher in Group 2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.007, 0.04, and 0.02; respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Contrary to expectation, centrally located HCCs could be treated as successfully as peripherally located HCCs. However, the complete response rate in the peripheral located tumor is more frequent than centrally located ones.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12149-025-02028-5","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:12:21Z","timestamp":1740751941000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is there any effect of hcc location on selective internal radiation therapy with 90yttrium response?"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-9749","authenticated-orcid":false,"given":"Elife","family":"Akgun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagr\u0131","family":"Erdim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu","family":"Ibicioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tevfik","family":"Guzelbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu Esen","family":"Akkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"K\u0131l\u0131ckesmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"2028_CR1","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1053\/j.gastro.2019.12.053","volume":"158","author":"R Loomba","year":"2020","unstructured":"Loomba R, Lim JK, Patton H, et al. AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: expert Review. Gastroenterology. 2020;158:1822\u201330.","journal-title":"Gastroenterology"},{"key":"2028_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca a Cancer J Clinicians. 2018;68:394\u2013424.","journal-title":"Ca a Cancer J Clinicians"},{"key":"2028_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-0030-1247132","volume":"30","author":"R Lencioni","year":"2010","unstructured":"Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010;30:52\u201360.","journal-title":"Semin Liver Dis"},{"key":"2028_CR4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1148\/radiol.2016142043","volume":"280","author":"O Jh","year":"2016","unstructured":"Jh O, Lodge MA, Wahl RL. Practical PERCIST: a simplified guide to PET response criteria in solid tumors 10. Radiology. 2016;280:576\u201384.","journal-title":"Radiology"},{"key":"2028_CR5","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1055\/s-0041-1735569","volume":"38","author":"M Rice","year":"2021","unstructured":"Rice M, Krosin M, Haste P. Post Yttrium-90 imaging. Semin Intervent Radiol. 2021;38:460\u20135.","journal-title":"Semin Intervent Radiol"},{"key":"2028_CR6","first-page":"9926704","volume":"22","author":"A Villalobos","year":"2021","unstructured":"Villalobos A, Wagstaff W, Guo M, et al. Predictors of successful Yttrium-90 radioembolization bridging or downstaging in patients with hepatocellular carcinoma. 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Unresectable HCC: The LEGACY Study Hepatol. 2021;74:2342\u201352.","journal-title":"Unresectable HCC: The LEGACY Study Hepatol"},{"key":"2028_CR9","first-page":"1673","volume":"41","author":"JE Dancey","year":"2000","unstructured":"Dancey JE, Shepherd FA, Paul K, et al. Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y-microspheres. J Nucl Med. 2000;41:1673\u201381.","journal-title":"J Nucl Med"},{"key":"2028_CR10","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1007\/s00259-020-04845-4","volume":"47","author":"C Chiesa","year":"2020","unstructured":"Chiesa C, Mira M, Bhoori S, et al. Radioembolization of hepatocarcinoma with (90)Y glass microspheres: treatment optimization using the dose-toxicity relationship. 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World J Gastroenterol. 2017;23:6437\u201347.","journal-title":"World J Gastroenterol"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02028-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-025-02028-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02028-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:59:54Z","timestamp":1745323194000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-025-02028-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["2028"],"URL":"https:\/\/doi.org\/10.1007\/s12149-025-02028-5","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"type":"print","value":"0914-7187"},{"type":"electronic","value":"1864-6433"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"8 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}