{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:04:20Z","timestamp":1792173860463,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The aim of this study was to investigate the differences between voxel-based dosimetry and the mean absorbed doses calculated with pre-treatment Tc-99\u00a0m-MAA SPECT\/CT and post-treatment Y-90 PET\/MR images. We also sought to present a detailed comparison of dose-volume histograms (DVHs) calculated from pre- and post-treatment imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A total of 47 treatments and 41 patients were included in the analysis as six of the treatments were retreatments of the six patients. Multicompartment and voxel-based dosimetry were performed with pre-treatment Tc-99m-MAA SPECT\/CT and Y-90 PET\/MRI. Correlation coefficients between the two imaging methods for the mean absorbed dose of tumor, whole liver normal tissue, perfused normal tissue, T\/N ratio and tumor D10, D50 and D90 values were calculated. Additionally, differences between these values were also evaluated with Bland\u2013Altman plots.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Pre-treatment Tc-99m-MAA SPECT\/CT accurately predicted the dose values for healthy liver parenchyma calculated with Y-90 PET\/MRI but showed lower accuracy in predicting T\/N ratio and tumor doses. There were significant variations in tumor-absorbed doses for both glass and resin microspheres. Additionally, D90 values were higher when calculated with SPECT\/CT than with PET\/MRI, whereas D10 values were higher in PET\/MRI compared to SPECT\/CT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The findings in our study suggest that Tc-99m-MAA SPECT\/CT had higher accuracy in predicting the dose to the healthy liver parenchyma compared to the tumor, maintaining its importance in treatment planning.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12149-025-02052-5","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:23:39Z","timestamp":1745389419000},"page":"716-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative voxel-based dosimetry with pre-treatment Tc-99m SPECT\/CT and post-treatment Y-90 PET\/MRI for radioembolization with Y-90 microspheres"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-9988","authenticated-orcid":false,"given":"Burak","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriye Ozlem","family":"Kucuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Soydal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre Can","family":"Celebioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Inal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecenur","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sad\u0131k","family":"Bilgic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digdem","family":"Kuru Oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla Halil","family":"Elhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal Metin","family":"Kir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"2052_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. 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Approval was granted by the Ethics Committee of Ankara University (21.04.2022\/No. \u013004-203\u201322).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants prospectively included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}