{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:13:41Z","timestamp":1790878421969,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Fukushima reconstruction budget from the Japanese government in response to the Great East Japan Earthquake"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s12149-025-02065-0","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T08:50:29Z","timestamp":1750236629000},"page":"994-1013","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extended single-dose toxicity study of [211At]meta-astatobenzylguanidine in normal mice in preparation for the first-in-human clinical trial of targeted alpha therapy for pheochromocytoma and paraganglioma"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1348-4024","authenticated-orcid":false,"given":"Taiki","family":"Joho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songji","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Nishijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Ukon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komei","family":"Washino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kobayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"issue":"3","key":"2065_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s12149-018-1317-1","volume":"33","author":"M Hosono","year":"2019","unstructured":"Hosono M, Ikebuchi H, Nakamura Y, Yanagida S, Kinuya S. Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation. Ann Nucl Med. 2019;33(3):211\u201321.","journal-title":"Ann Nucl Med"},{"issue":"12","key":"2065_CR2","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.2967\/jnumed.116.178673","volume":"57","author":"C Kratochwil","year":"2016","unstructured":"Kratochwil C, Bruchertseifer F, Giesel FL, Weis M, Verburg FA, Mottaghy F, et al. 225Ac-PSMA-617 for PSMA-targeted \u03b1-radiation therapy of metastatic castration-resistant prostate cancer. J Nucl Med. 2016;57(12):1941\u20134.","journal-title":"J Nucl Med"},{"issue":"6","key":"2065_CR3","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s12149-021-01612-9","volume":"35","author":"T Watabe","year":"2021","unstructured":"Watabe T, Kaneda-Nakashima K, Ooe K, Liu Y, Kurimoto K, Murai T, et al. Extended single-dose toxicity study of [(211)At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer. Ann Nucl Med. 2021;35(6):702\u201318.","journal-title":"Ann Nucl Med"},{"issue":"6","key":"2065_CR4","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00259-017-3919-6","volume":"45","author":"Y Ohshima","year":"2018","unstructured":"Ohshima Y, Sudo H, Watanabe S, Nagatsu K, Tsuji AB, Sakashita T, et al. Antitumor effects of radionuclide treatment using alpha-emitting meta-(211)At-astato-benzylguanidine in a PC12 pheochromocytoma model. Eur J Nucl Med Mol Imaging. 2018;45(6):999\u20131010.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2065_CR5","unstructured":"Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals M3(R2). International Conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (2009)."},{"key":"2065_CR6","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.tranon.2019.04.008","volume":"12","author":"HTA Sudo","year":"2019","unstructured":"Sudo HTA, Sugyo A, Nagatsu K, Minegishi K, Ishioka NS, et al. Preclinical evaluation of the acute radiotoxicity of the \u03b1-emitting molecular-targeted therapeutic agent 211At-MABG for the treatment of malignant pheochromocytoma in normal mice. Transl Oncol. 2019;12:879\u201388.","journal-title":"Transl Oncol"},{"issue":"6","key":"2065_CR7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/bc00018a006","volume":"3","author":"G Vaidyanathan","year":"1992","unstructured":"Vaidyanathan G, Zalutsky MR. 1-(meta-[211At]Astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation. Bioconjug Chem. 1992;3(6):499\u2013503.","journal-title":"Bioconjug Chem"},{"key":"2065_CR8","unstructured":"ICH Harmonized tripartite guideline: Duration of chronic toxicity testing in animals (rodent and non rodent toxicity testing) S4. International Conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (1998)."},{"key":"2065_CR9","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"2065_CR10","first-page":"29","volume":"63","author":"AM Glass","year":"2013","unstructured":"Glass AM, Coombs W, Taffet SM. Spontaneous cardiac calcinosis in BALB\/cByJ mice. Comp Med. 2013;63(1):29\u201337.","journal-title":"Comp Med"},{"issue":"1","key":"2065_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40658-020-00326-7","volume":"7","author":"N Ukon","year":"2020","unstructured":"Ukon N, Zhao S, Washiyama K, Oriuchi N, Tan C, Shimoyama S, et al. Human dosimetry of free 211At and meta-[211At]astatobenzylguanidine (211At-MABG) estimated using preclinical biodistribution from normal mice. EJNMMI Phys. 2020;7(1):1\u201314.","journal-title":"EJNMMI Phys"},{"issue":"2","key":"2065_CR12","first-page":"33","volume":"61","author":"S Murakami","year":"2021","unstructured":"Murakami S, et al. Use of alpha rays in radiotherapy. Dental Radiology. 2021;61(2):33\u201340.","journal-title":"Dental Radiology"},{"issue":"3","key":"2065_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2174\/1874471011104030177","volume":"4","author":"MR Zalutsky","year":"2011","unstructured":"Zalutsky MR, Pruszynski M. Astatine-211: production and availability. Curr Radiopharm. 2011;4(3):177\u201385.","journal-title":"Curr Radiopharm"},{"key":"2065_CR14","unstructured":"Nonclinical Evaluation For Anticancer Pharmaceuticals (2009)."},{"key":"2065_CR15","unstructured":"Guidance for Industry Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers (2005)."}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02065-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-025-02065-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02065-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T20:52:21Z","timestamp":1757191941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-025-02065-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["2065"],"URL":"https:\/\/doi.org\/10.1007\/s12149-025-02065-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6059261\/v1","asserted-by":"object"}]},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}