{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:33:07Z","timestamp":1771630387242,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Youth Science Project of Wuxi Health Committee","award":["Q202436"],"award-info":[{"award-number":["Q202436"]}]},{"name":"Soft Science Research Project of Wuxi Science and Technology Association","award":["KX-24-B83"],"award-info":[{"award-number":["KX-24-B83"]}]},{"name":"Jiangsu Provincial Medical Key Disciplin","award":["ZDXYS202211"],"award-info":[{"award-number":["ZDXYS202211"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12149-025-02112-w","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:17:56Z","timestamp":1759324676000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative analysis of striatal subregional asymmetry on 99mTc-TRODAT-1 SPECT and clinical correlations with UPDRS subscales in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"40","author":[{"given":"Danping","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanfu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1932-973X","authenticated-orcid":false,"given":"Wanzhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2112_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080952","volume":"388","author":"D Su","year":"2025","unstructured":"Su D, Cui Y, He C, Yin P, Bai R, Zhu J, et al. Projections for prevalence of Parkinson\u2019s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021. BMJ. 2025;388:e080952.","journal-title":"BMJ"},{"issue":"27","key":"2112_CR2","doi-asserted-by":"publisher","first-page":"24404","DOI":"10.1021\/acsnano.5c04662","volume":"19","author":"M Salehirozveh","year":"2025","unstructured":"Salehirozveh M, Dehghani P, Mijakovic I. Nanopore-based neurotransmitter detection: advances, challenges, and future perspectives. ACS Nano. 2025;19(27):24404\u201324.","journal-title":"ACS Nano"},{"issue":"6","key":"2112_CR3","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S1474-4422(25)00125-5","volume":"24","author":"W Graham","year":"2025","unstructured":"Graham W, Natasha K, Per S, Ashwani J, Michael GK. Gene therapy for Parkinson\u2019s disease: trials and technical advances. Lancet Neurol. 2025;24(6):548\u201356.","journal-title":"Lancet Neurol"},{"issue":"6","key":"2112_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.tins.2025.04.005","volume":"48","author":"F Anastasia","year":"2025","unstructured":"Anastasia F, YuHong F, Miquel V, Glenda MH. Neuromelanin and selective neuronal vulnerability to Parkinson\u2019s disease. Trends Neurosci. 2025;48(6):445\u201359.","journal-title":"Trends Neurosci"},{"key":"2112_CR5","doi-asserted-by":"publisher","unstructured":"Barker RA, Lao-Kaim NP, Guzman NV, Athauda D, Bjartmarz H, Bj\u00f6rklund A, et al. The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson\u2019s disease. Nat Biotechnol. 2025 May 2. https:\/\/doi.org\/10.1038\/s41587-025-02567-2. Epub ahead of print.","DOI":"10.1038\/s41587-025-02567-2"},{"key":"2112_CR6","doi-asserted-by":"publisher","unstructured":"Chuyu C, Meghan M, Nathaniel S, Vanessa P, Giulia T, Daniel A, et al. LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. Mol Psychiatry. 2025 Apr 23. https:\/\/doi.org\/10.1038\/s41380-025-03030-z. Epub ahead of print.","DOI":"10.1038\/s41380-025-03030-z"},{"issue":"7","key":"2112_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70435","volume":"21","author":"S Ellen Hanna","year":"2025","unstructured":"Ellen Hanna S, Niklas M-C, Alexa PB, Erik S, Olof S, Sebastian P, et al. Longitudinal tau aggregation, atrophy, and cognitive decline in Alzheimer\u2019s disease. Alzheimers Dement. 2025;21(7):e70435.","journal-title":"Alzheimers Dement"},{"issue":"3","key":"2112_CR8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s12149-020-01444-z","volume":"34","author":"Y Sun","year":"2020","unstructured":"Sun Y, Chen Z, Liu C, Tang J, Wang Y, Zhang G, et al. Phase I clinical study with different doses of (99m)Tc-TRODAT-1 in healthy adults. Ann Nucl Med. 2020;34(3):212\u20139.","journal-title":"Ann Nucl Med"},{"issue":"1","key":"2112_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12149-019-01412-2","volume":"34","author":"Y Sun","year":"2020","unstructured":"Sun Y, Liu C, Chen Z, Li B, Lv Z, Lou J, et al. A phase 2, open-label, multi-center study to evaluate the efficacy and safety of (99m)Tc-TRODAT-1 SPECT to detect Parkinson\u2019s disease. Ann Nucl Med. 2020;34(1):31\u20137.","journal-title":"Ann Nucl Med"},{"issue":"4","key":"2112_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13139-024-00840-x","volume":"58","author":"C Sung","year":"2024","unstructured":"Sung C, Oh SJ, Kim JS. Imaging procedure and clinical studies of [(18)F]FP-CIT PET. Nucl Med Mol Imaging. 2024;58(4):185\u2013202.","journal-title":"Nucl Med Mol Imaging"},{"issue":"1","key":"2112_CR11","doi-asserted-by":"publisher","first-page":"12297","DOI":"10.1038\/s41598-021-91891-z","volume":"11","author":"YS An","year":"2021","unstructured":"An YS, Yoon JH, Son SJ, Hong CH, Lee SJ, Yoon JK. Early-phase (18)F-FP-CIT and (18)F-flutemetamol PET were significantly correlated. Sci Rep. 2021;11(1):12297.","journal-title":"Sci Rep"},{"issue":"10","key":"2112_CR12","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.neuron.2023.02.017","volume":"111","author":"XN Zhu","year":"2023","unstructured":"Zhu XN, Li J, Qiu GL, Wang L, Lu C, Guo YG, et al. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron. 2023;111(10):1626-36.e6.","journal-title":"Neuron"},{"key":"2112_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fneur.2017.00037","volume":"8","author":"CD Rietdijk","year":"2017","unstructured":"Rietdijk CD, Perez-Pardo P, Garssen J, van Wezel RJ, Kraneveld AD. Exploring Braak\u2019s hypothesis of Parkinson\u2019s disease. Front Neurol. 2017;8:37.","journal-title":"Front Neurol"},{"issue":"1","key":"2112_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1176\/appi.ajp.2020.20111601","volume":"178","author":"WK Goodman","year":"2021","unstructured":"Goodman WK, Storch EA, Sheth SA. Harmonizing the neurobiology and treatment of obsessive-compulsive disorder. Am J Psychiatry. 2021;178(1):17\u201329.","journal-title":"Am J Psychiatry"},{"issue":"3","key":"2112_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/HRP.0000000000000429","volume":"33","author":"MD Hall","year":"2025","unstructured":"Hall MD, Gipson KS, Gipson SYT, Colvin MK, Nguyen STT, Greenberg E. Disrupted cortico-striato-thalamo-cortical circuitry and sleep disturbances in obsessive-compulsive spectrum, chronic tic, and attention-deficit\/hyperactivity disorders. Harv Rev Psychiatry. 2025;33(3):114\u201326.","journal-title":"Harv Rev Psychiatry"},{"key":"2112_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1746540","volume":"2022","author":"G Fabiani","year":"2022","unstructured":"Fabiani G, Camargo CHF, Filho RM, Froehner GS, Teive HAG. Evaluation of brain SPECT with (99m)Tc-TRODAT-1 in the differential diagnosis of Parkinsonism. Parkinsons Dis. 2022;2022:1746540.","journal-title":"Parkinsons Dis"},{"issue":"2","key":"2112_CR17","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/biomedicines11020296","volume":"11","author":"AM Coutinho","year":"2023","unstructured":"Coutinho AM, Ghilardi MG, Campos ACP, Etchebehere E, Fonoff FC, Cury RG, et al. Does TRODAT-1 SPECT uptake correlate with cerebrospinal fluid \u03b1-synuclein levels in mid-stage Parkinson\u2019s disease? Biomedicines. 2023;11(2):296.","journal-title":"Biomedicines"},{"issue":"8","key":"2112_CR18","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1007\/s00259-020-04817-8","volume":"47","author":"S Morbelli","year":"2020","unstructured":"Morbelli S, Esposito G, Arbizu J, Barthel H, Boellaard R, Bohnen NI, et al. EANM practice guideline\/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0. Eur J Nucl Med Mol Imaging. 2020;47(8):1885\u2013912.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"9","key":"2112_CR19","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1097\/RLU.0000000000004311","volume":"47","author":"FA Pitella","year":"2022","unstructured":"Pitella FA, Trevisan AC, Alexandre-Santos L, Kato M, Macruz Brito MMC, Tumas V, et al. Reference values for dopamine transporter imaging with 99m Tc-TRODAT-1 in healthy subjects and Parkinson\u2019s disease patients. Clin Nucl Med. 2022;47(9):794\u20139.","journal-title":"Clin Nucl Med"},{"issue":"4","key":"2112_CR20","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s13311-020-00889-4","volume":"17","author":"SD Aradi","year":"2020","unstructured":"Aradi SD, Hauser RA. Medical management and prevention of motor complications in Parkinson\u2019s disease. Neurotherapeutics. 2020;17(4):1339\u201365.","journal-title":"Neurotherapeutics"},{"issue":"1","key":"2112_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s41824-018-0028-0","volume":"2","author":"KJ Nichols","year":"2018","unstructured":"Nichols KJ, Chen B, Tomas MB, Palestro CJ. Interpreting (123)I-ioflupane dopamine transporter scans using hybrid scores. Eur J Hybrid Imaging. 2018;2(1):10.","journal-title":"Eur J Hybrid Imaging"},{"issue":"10","key":"2112_CR22","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.1097\/RLU.0000000000002605","volume":"44","author":"CK Chiu","year":"2019","unstructured":"Chiu CK, Sun SS, Kao CH, Wu YC, Hsieh TC. Brain lymphoma on 99mTc-TRODAT-1 SPECT. Clin Nucl Med. 2019;44(10):e590-2.","journal-title":"Clin Nucl Med"},{"issue":"4","key":"2112_CR23","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00702-018-1898-9","volume":"126","author":"KA Jellinger","year":"2019","unstructured":"Jellinger KA. Is Braak staging valid for all types of Parkinson\u2019s disease? J Neural Transm (Vienna). 2019;126(4):423\u201331.","journal-title":"J Neural Transm (Vienna)"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02112-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-025-02112-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02112-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:20:21Z","timestamp":1771586421000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-025-02112-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2112"],"URL":"https:\/\/doi.org\/10.1007\/s12149-025-02112-w","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"30 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethic Committee of our institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}