{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:05:14Z","timestamp":1774688714047,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Tianjin Science and Technology Committee","award":["21JCYBJC01820"],"award-info":[{"award-number":["21JCYBJC01820"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-001A"],"award-info":[{"award-number":["TJYXZDXK-001A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Nucl Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12149-025-02137-1","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:57:35Z","timestamp":1766138255000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical value of clinicopathological, ultrasonographic features and fibroblast activation protein in evaluating the radioiodine treatment efficacy in papillary thyroid carcinoma"],"prefix":"10.1007","volume":"40","author":[{"given":"Dongyue","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiankai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-7394","authenticated-orcid":false,"given":"Zhaowei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"2137_CR1","first-page":"47","volume":"4","author":"BF Han","year":"2024","unstructured":"Han BF, Zheng RS, Zeng HM, Wang SM, Sun KX, Chen R, et al. Cancer incidence and mortality in China 2022. J Natl Cancer Cent. 2024;4:47\u201353.","journal-title":"J Natl Cancer Cent"},{"key":"2137_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S2213-8587(13)70215-8","volume":"2","author":"M Schlumberger","year":"2014","unstructured":"Schlumberger M, Brose M, Elisei R, Leboulleux S, Luster M, Pitoia F, et al. Definition and management of radioactive iodine-refractory differentiated thyroid cancer. Lancet Diabetes Endocrinol. 2014;2:356\u20138.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2137_CR3","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/s10238-023-00998-2","volume":"23","author":"L Zhu","year":"2023","unstructured":"Zhu L, Zhang XM, Zhang SH, Zhang QC, Cao LM, Zhang YJ, et al. Cancer-associated fibroblasts in papillary thyroid carcinoma. Clin Exp Med. 2023;23:2209\u201320.","journal-title":"Clin Exp Med"},{"key":"2137_CR4","first-page":"218","volume":"41","author":"ZR Gao","year":"2021","unstructured":"Gao ZR, Li SJ. Guidelines for radioiodine therapy of differentiated thyroid cancer (2021 edition). Chin J Nucl Med Imaging. 2021;41:218\u201341.","journal-title":"Chin J Nucl Med Imaging"},{"key":"2137_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1\u2013133.","journal-title":"Thyroid"},{"key":"2137_CR6","first-page":"55","volume":"68","author":"ND Perrier","year":"2018","unstructured":"Perrier ND, Brierley JD, Tuttle RM. Differentiated and anaplastic thyroid carcinoma: major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2018;68:55\u201363.","journal-title":"CA Cancer J Clin"},{"key":"2137_CR7","first-page":"1","volume":"25","author":"Department of Disease Control Ministry of Health, PR China","year":"2004","unstructured":"Department of Disease Control Ministry of Health, PR China. Guidelines for Prevention and Control of Overweight and Obesity in Chinese Adults (2003 Edition). Chin J Epidemiol. 2004;25:1\u201318.","journal-title":"Chin J Epidemiol"},{"key":"2137_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12020-020-02441-y","volume":"70","author":"JQ Zhou","year":"2020","unstructured":"Zhou JQ, Yin LX, Wei X, Zhang S, Song YY, Luo BM, et al. 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS. Endocrine. 2020;70:256\u201379.","journal-title":"Endocrine"},{"key":"2137_CR9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3803\/EnM.2022.1553","volume":"37","author":"CK Jung","year":"2022","unstructured":"Jung CK, Bychkov A, Kakudo K. Update from the 2022 world health organization classification of thyroid tumors: a standardized diagnostic approach. Endocrinol Metab (Seoul). 2022;37:703\u201318.","journal-title":"Endocrinol Metab (Seoul)"},{"key":"2137_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.surg.2020.04.003","volume":"169","author":"MD Bortz","year":"2021","unstructured":"Bortz MD, Kuchta K, Winchester DJ, Prinz RA, Moo TA. Extrathyroidal extension predicts negative clinical outcomes in papillary thyroid cancer. Surgery. 2021;169:2\u20136.","journal-title":"Surgery"},{"key":"2137_CR11","first-page":"717","volume":"54","author":"L Huang","year":"2019","unstructured":"Huang L, Li C, Wang W, Cai YC, Sun RH, Jiang J, et al. The significance and latest progress of extrathyroidal extension of thyroid cancer. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019;54:717\u201320.","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"2137_CR12","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1089\/thy.2016.0132","volume":"27","author":"LM Youngwirth","year":"2017","unstructured":"Youngwirth LM, Adam MA, Scheri RP, Roman SA, Sosa JA. Extrathyroidal extension is associated with compromised survival in patients with thyroid cancer. Thyroid. 2017;27:626\u201331.","journal-title":"Thyroid"},{"key":"2137_CR13","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1089\/thy.2017.0513","volume":"28","author":"S Tam","year":"2018","unstructured":"Tam S, Amit M, Boonsripitayanon M, Busaidy NL, Cabanilas ME, Waguespack SG, et al. Effect of tumor size and minimal extrathyroidal extension in patients with differentiated thyroid cancer. Thyroid. 2018;28:982\u201390.","journal-title":"Thyroid"},{"key":"2137_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.amjsurg.2020.02.020","volume":"220","author":"CH Shin","year":"2020","unstructured":"Shin CH, Roh JL, Song DE, Cho KJ, Choi SH, Nam SY, et al. Prognostic value of tumor size and minimal extrathyroidal extension in papillary thyroid carcinoma. Am J Surg. 2020;220:925\u201331.","journal-title":"Am J Surg"},{"key":"2137_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.930180","author":"JY Chai","year":"2022","unstructured":"Chai JY, Zhang RG, Zheng W, Zhang GZ, Jia Q, Tan J, et al. Predictive value of clinical and pathological characteristics for metastatic radioactive iodine-refractory differentiated thyroid carcinoma: a 16-year retrospective study. Front Endocrinol (Lausanne). 2022. https:\/\/doi.org\/10.3389\/fendo.2022.930180.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2137_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152243","author":"W Liu","year":"2024","unstructured":"Liu W, Jiang BB, Xue JL, Liu R, Wei Y, Li P. Clinicopathological features of differentiated thyroid carcinoma as predictors of the effects of radioactive iodine therapy. Ann Diagn Pathol. 2024. https:\/\/doi.org\/10.1016\/j.anndiagpath.2023.152243.","journal-title":"Ann Diagn Pathol"},{"key":"2137_CR17","doi-asserted-by":"publisher","first-page":"5448","DOI":"10.1002\/cam4.1794","volume":"7","author":"GP Li","year":"2018","unstructured":"Li GP, Lei JY, Song LL, Jiang K, Wei T, Li ZH, et al. Radioiodine refractoriness score: a multivariable prediction model for postoperative radioiodine-refractory differentiated thyroid carcinomas. Cancer Med. 2018;7:5448\u201356.","journal-title":"Cancer Med"},{"key":"2137_CR18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.22551\/2021.33.0804.10190","volume":"8","author":"CA Silaghi","year":"2021","unstructured":"Silaghi CA, Oana SP, Silaghi H, Piciu D, Georgescu CE. Rationale for therapeutic decision-making in locally advanced and metastatic radioactive iodine (RAI)-refractory differentiated thyroid cancer, starting from a clinical case. Arch Clin Cases. 2021;8:72\u201383.","journal-title":"Arch Clin Cases"},{"key":"2137_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.720723","author":"T Fullmer","year":"2021","unstructured":"Fullmer T, Cabanillas ME, Zafereo M. Novel therapeutics in radioactive iodine-resistant thyroid cancer. Front Endocrinol (Lausanne). 2021. https:\/\/doi.org\/10.3389\/fendo.2021.720723.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2137_CR20","doi-asserted-by":"publisher","unstructured":"Yu F, Wu WY, Zhang LT, Li SH, Yao XC, Wang J, et al. Cervical lymph node metastasis prediction of postoperative papillary thyroid carcinoma before 131I therapy based on clinical and ultrasound characteristics. Front Endocrinol (Lausanne). 2023. https:\/\/doi.org\/10.3389\/fendo.2023.1122517.","DOI":"10.3389\/fendo.2023.1122517"},{"key":"2137_CR21","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.actbio.2021.12.014","volume":"140","author":"H Jian","year":"2022","unstructured":"Jian H, Wang XB, Song PP, Wu XQ, Zheng RX, Wang YJ, et al. Tumor microcalcification-mediated relay drug delivery for photodynamic immunotherapy of breast cancer. Acta Biomater. 2022;140:518\u201329.","journal-title":"Acta Biomater"},{"key":"2137_CR22","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-23-0108","author":"AB Bah\u00e7ecio\u011flu","year":"2023","unstructured":"Bah\u00e7ecio\u011flu AB, G\u00fcrsoy A, Sak SD, Ilgan S, Bilezik\u00e7i B, Erdo\u011fan MF. The sonographer\u2019s and pathologist\u2019s perspective of echogenic microfoci in papillary thyroid carcinoma. Eur Thyroid J. 2023. https:\/\/doi.org\/10.1530\/ETJ-23-0108.","journal-title":"Eur Thyroid J"},{"key":"2137_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/10732748241295347","author":"H Chen","year":"2024","unstructured":"Chen H, Zhu L, Zhuang Y, Ye X, Chen F, Zeng J. Prediction model of cervical lymph node metastasis in papillary thyroid carcinoma. Cancer Control. 2024. https:\/\/doi.org\/10.1177\/10732748241295347.","journal-title":"Cancer Control"},{"key":"2137_CR24","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051568","author":"J Yang","year":"2022","unstructured":"Yang J, Zhang F, Qiao Y. Diagnostic accuracy of ultrasound, CT and their combination in detecting cervical lymph node metastasis in patients with papillary thyroid cancer: a systematic review and meta-analysis. BMJ Open. 2022. https:\/\/doi.org\/10.1136\/bmjopen-2021-051568.","journal-title":"BMJ Open"},{"key":"2137_CR25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12957-024-03566-4","volume":"22","author":"F Liu","year":"2024","unstructured":"Liu F, Han F, Lu L, Chen Y, Guo Z, Yao J. Meta-analysis of prediction models for predicting lymph node metastasis in thyroid cancer. World J Surg Oncol. 2024;22:278\u201394.","journal-title":"World J Surg Oncol"},{"key":"2137_CR26","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s12885-022-09550-z","volume":"22","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zhang X, Yin YF, Zhao SS, Wang KK, Shang MY, et al. Integrating BRAFV600E mutation, ultrasonic and clinicopathologic characteristics for predicting the risk of cervical central lymph node metastasis in papillary thyroid carcinoma. BMC Cancer. 2022;22:461\u201370.","journal-title":"BMC Cancer"},{"key":"2137_CR27","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.7150\/thno.57689","volume":"11","author":"JM Oh","year":"2021","unstructured":"Oh JM, Ahn BC. Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS. Theranostics. 2021;11:6251\u201377.","journal-title":"Theranostics"},{"key":"2137_CR28","doi-asserted-by":"publisher","first-page":"4700","DOI":"10.1172\/JCI46382","volume":"121","author":"D Chakravarty","year":"2011","unstructured":"Chakravarty D, Santos E, Ryder M, Knauf JA, Liao XH, West BL, et al. Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest. 2011;121:4700\u201311.","journal-title":"J Clin Invest"},{"key":"2137_CR29","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1089\/thy.2023.0157","volume":"33","author":"X Xiao","year":"2023","unstructured":"Xiao X, Chen MK, Sang Y, Xue JY, Jiang K, Chen YL, et al. Methylation-mediated silencing of ATF3 promotes thyroid cancer progression by regulating prognostic genes in the MAPK and PI3K\/AKT pathways. Thyroid. 2023;33:1441\u201354.","journal-title":"Thyroid"},{"key":"2137_CR30","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.23500","author":"GD Fu","year":"2023","unstructured":"Fu GD, Chazen RS, Monteiro E, Vescan A, Freeman JL, Witterick IJ, et al. Facilitation of definitive cancer diagnosis with quantitative molecular assays of BRAF V600E and TERT promoter variants in patients with thyroid nodules. JAMA Netw Open. 2023. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.23500.","journal-title":"JAMA Netw Open"},{"key":"2137_CR31","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1530\/ERC-13-0399","volume":"21","author":"ZJ Zhang","year":"2014","unstructured":"Zhang ZJ, Liu DX, Murugan AK, Liu ZM, Xing MZ. Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Endocr Relat Cancer. 2014;21:161\u201373.","journal-title":"Endocr Relat Cancer"},{"key":"2137_CR32","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17488","author":"S Jafri","year":"2021","unstructured":"Jafri S, Yaqub A. Redifferentiation of BRAF V600E-mutated radioiodine refractory metastatic papillary thyroid cancer after treatment with dabrafenib and trametinib. Cureus. 2021. https:\/\/doi.org\/10.7759\/cureus.17488.","journal-title":"Cureus"},{"key":"2137_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s12149-020-01546-8","volume":"35","author":"K Konishi","year":"2021","unstructured":"Konishi K, Ishiba R, Ikenohira T, Asao T, Hirata M, Ohira K, et al. The relationship between the quantitative evaluation of thyroid bed uptake and the disappearance of accumulation in adjuvant radioactive iodine therapy for differentiated thyroid cancer. Ann Nucl Med. 2021;35:159\u201366.","journal-title":"Ann Nucl Med"},{"key":"2137_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2024.109075","author":"N Oguri","year":"2024","unstructured":"Oguri N, Gi T, Nakamura E, Furukoji E, Goto H, Maekawa K, et al. Expression of fibroblast activation protein-\u03b1 in human deep vein thrombosis. Thromb Res. 2024. https:\/\/doi.org\/10.1016\/j.thromres.2024.109075.","journal-title":"Thromb Res"},{"key":"2137_CR35","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s10555-020-09909-3","volume":"39","author":"AA Fitzgerald","year":"2020","unstructured":"Fitzgerald AA, Weiner LM. The role of fibroblast activation protein in health and malignancy. Cancer Metastasis Rev. 2020;39:783\u2013803.","journal-title":"Cancer Metastasis Rev"},{"key":"2137_CR36","doi-asserted-by":"publisher","first-page":"S1064","DOI":"10.1016\/S0007-4551(24)00409-0","volume":"111","author":"C Renaud","year":"2024","unstructured":"Renaud C, Camila N, Agathe E, Bardet S. M\u00e9decine nucl\u00e9aire et cancers de La thyro\u00efde En 2024: iode 131, TEP et nouvelles approches th\u00e9ranostiques. Bull Cancer. 2024;111:S1064\u201372.","journal-title":"Bull Cancer"},{"key":"2137_CR37","first-page":"1973","volume":"6","author":"M Yang","year":"2020","unstructured":"Yang M, Li J, Gu P, Fan X. The application of nanoparticles in cancer immunotherapy: targeting tumor microenvironment. Bioact Mater. 2020;6:1973\u201387.","journal-title":"Bioact Mater"},{"key":"2137_CR38","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1158\/1078-0432.CCR-23-3841","volume":"30","author":"M Wehrli","year":"2024","unstructured":"Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson RC, et al. Mesothelin CAR T cells secreting anti-FAP\/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma. Clin Cancer Res. 2024;30:1859\u201377.","journal-title":"Clin Cancer Res"},{"key":"2137_CR39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12967-024-06064-z","volume":"23","author":"G Wei","year":"2025","unstructured":"Wei G, Nie Y, Sun M, Zhou W, Zhao H, Chen F, et al. Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer. J Transl Med. 2025;23:42\u201356.","journal-title":"J Transl Med"},{"key":"2137_CR40","doi-asserted-by":"publisher","first-page":"465","DOI":"10.7150\/ijbs.72218","volume":"19","author":"HT Wu","year":"2023","unstructured":"Wu HT, Xiang ZX, Huang GQ, He QM, Song JL, Dou RZ, et al. BGN\/FAP\/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer. Int J Biol Sci. 2023;19:465\u201383.","journal-title":"Int J Biol Sci"},{"key":"2137_CR41","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1089\/105072501300176435","volume":"11","author":"U Feldt-Rasmussen","year":"2001","unstructured":"Feldt-Rasmussen U. Iodine and cancer. Thyroid. 2001;11:483\u20136.","journal-title":"Thyroid"},{"key":"2137_CR42","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12967-023-04080-z","volume":"21","author":"YF Liu","year":"2023","unstructured":"Liu YF, Sun YS, Wang P, Li SL, Dong YW, Zhou M, et al. FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer. J Transl Med. 2023;21:255\u201372.","journal-title":"J Transl Med"},{"key":"2137_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.980582","author":"J Li","year":"2022","unstructured":"Li J, Zhang Y, Sun F, Xing L, Sun X. Towards an era of precise diagnosis and treatment: role of novel molecular modification-based imaging and therapy for dedifferentiated thyroid cancer. Front Endocrinol (Lausanne). 2022. https:\/\/doi.org\/10.3389\/fendo.2022.980582.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2137_CR44","doi-asserted-by":"crossref","unstructured":"Wang Y, Liu Y, Geng H, Zhang W. Advancements in theranostic applications: exploring the role of fibroblast activation protein Inhibition tracers in enhancing thyroid health assessment. EJNMMI Res. 2023;13:109.","DOI":"10.1186\/s13550-023-01060-8"},{"key":"2137_CR45","doi-asserted-by":"publisher","first-page":"716","DOI":"10.3390\/ph17060716","volume":"17","author":"D Albano","year":"2024","unstructured":"Albano D, Rizzo A, Slart RHJ, Hess S, Edel N, Cristina GW, et al. The role of fibroblast activation protein inhibitor positron emission tomography in inflammatory and infectious diseases: an updated systematic review. Pharmaceuticals (Basel). 2024;17:716.","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Annals of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02137-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12149-025-02137-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12149-025-02137-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:36:42Z","timestamp":1774687002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12149-025-02137-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2137"],"URL":"https:\/\/doi.org\/10.1007\/s12149-025-02137-1","relation":{},"ISSN":["0914-7187","1864-6433"],"issn-type":[{"value":"0914-7187","type":"print"},{"value":"1864-6433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"6 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}