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The phantom was scanned for 10\u00a0min in list mode with the spheres at the center and periphery of each detector and reconstructed at 1\u201310\u00a0min. Visual and quantitative evaluations were performed using the coefficient of variation of the background (CV\n                      <jats:sub>BG<\/jats:sub>\n                      ), detection index (DI), and contrast recovery coefficient (CRC). Representative clinical images of three lesion types, namely, mass uptake near the nipple, mass uptake close to the chest wall, and non-mass uptake, were also assessed using visual evaluation and the tumor-to-background ratio (TBR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Phantom images with SBRs of 2:1 and 4:1 did not sufficiently visualize the small spheres; therefore, an 8:1 ratio was chosen for the analysis. dbPET was capable of visualizing smaller spheres compared with PEM. At the periphery, image quality was reduced for all systems, while all systems were able to identify spheres\u2009\u2265\u20097.5\u00a0mm in diameter at a contrast ratio of 1:8 under clinical imaging protocols. The DI decreased with shorter acquisition time, while the CRC remained relatively stable. The CV\n                      <jats:sub>BG<\/jats:sub>\n                      increased, especially in dbPET2. Clinical evaluation confirmed the acquisition-time dependence of image quality in both PEM and dbPET systems, providing practical insight into their appropriate use under routine clinical conditions. TBR analysis supported the consistency between the phantom study results and the clinical evaluations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that all breast-specific PET systems can achieve image quality capable of identifying sub-centimeter lesions within clinically feasible scan times. These findings provide the foundation for harmonizing protocols across systems and optimizing their clinical application in breast cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12149-026-02165-5","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:58:11Z","timestamp":1770447491000},"page":"641-653","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of image quality of breast-specific positron emission tomography between opposite-type and ring-shaped systems: insights from Phantom and clinical studies in a Japanese multicenter trial"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-0906","authenticated-orcid":false,"given":"Yoko","family":"Satoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoe","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Itagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Naoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae K.","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Inaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"2165_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s00259-013-2553-1","volume":"41","author":"JE Kalinyak","year":"2014","unstructured":"Kalinyak JE, Berg WA, Schilling K, Madsen KS, Narayanan D, Tartar M. 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The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}