{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:15:09Z","timestamp":1770977709668,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s12185-009-0359-5","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T02:17:39Z","timestamp":1245637059000},"page":"13-23","source":"Crossref","is-referenced-by-count":143,"title":["Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma"],"prefix":"10.1007","volume":"90","author":[{"given":"Shigeru","family":"Kusumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"key":"359_CR1","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/nm1096-1104","volume":"2","author":"B Rehermann","year":"1996","unstructured":"Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients\u2019 recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med. 1996;2:1104\u20138. doi:\n                    10.1038\/nm1096-1104\n                    \n                  .","journal-title":"Nat Med"},{"key":"359_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1056\/NEJM200101043440120","volume":"344","author":"I Dervite","year":"2001","unstructured":"Dervite I, Hober D, Morel P. Acute hepatitis B in a patient with antibodies to hepatitis B surface antigen who was receiving rituximab. N Engl J Med. 2001;344:68\u20139. doi:\n                    10.1056\/NEJM200101043440120\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"359_CR3","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1097\/00007890-199809150-00012","volume":"66","author":"N Dhedin","year":"1998","unstructured":"Dhedin N, Douvin C, Kuentz M, Saint Marc MF, Reman O, Rieux C, et al. Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation: a retrospective study of 37 patients with pretransplant anti-HBs and anti-HBc. Transplantation. 1998;66:616\u20139. doi:\n                    10.1097\/00007890-199809150-00012\n                    \n                  .","journal-title":"Transplantation"},{"key":"359_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/j.gastro.2006.04.015","volume":"131","author":"CK Hui","year":"2006","unstructured":"Hui CK, Cheung WW, Zhang HY, Au WY, Yueng YH, Leung AY, et al. Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy. Gastroenterology. 2006;131:59\u201368. doi:\n                    10.1053\/j.gastro.2006.04.015\n                    \n                  .","journal-title":"Gastroenterology"},{"key":"359_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/sj.bmt.1700744","volume":"19","author":"GK Lau","year":"1997","unstructured":"Lau GK, Liang R, Chiu EK, Lee CK, Lam SK. Hepatic events after bone marrow transplantation in patients with hepatitis B infection: a case controlled study. Bone Marrow Transplant. 1997;19:795\u20139. doi:\n                    10.1038\/sj.bmt.1700744\n                    \n                  .","journal-title":"Bone Marrow Transplant"},{"key":"359_CR6","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1053\/j.gastro.2003.09.026","volume":"125","author":"GK Lau","year":"2003","unstructured":"Lau GK, Yiu HH, Fong DY, Cheng HC, Au WY, Lai LS, et al. Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy. Gastroenterology. 2003;125:1742\u20139. doi:\n                    10.1053\/j.gastro.2003.09.026\n                    \n                  .","journal-title":"Gastroenterology"},{"key":"359_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/0016-5085(91)90599-G","volume":"100","author":"AS Lok","year":"1991","unstructured":"Lok AS, Liang RH, Chiu EK, Wong KL, Chan TK, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy: report of a prospective study. Gastroenterology. 1991;100:182\u20138.","journal-title":"Gastroenterology"},{"key":"359_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.bmt.1703614","volume":"30","author":"P Seth","year":"2002","unstructured":"Seth P, Alrajhi AA, Kagevi I, Chaudhary MA, Colcol E, Sahovic E, et al. Hepatitis B virus reactivation with clinical flare in allogeneic stem cell transplants with chronic graft-versus-host disease. Bone Marrow Transplant. 2002;30:189\u201394. doi:\n                    10.1038\/sj.bmt.1703614\n                    \n                  .","journal-title":"Bone Marrow Transplant"},{"key":"359_CR9","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1182\/blood-2003-05-1403","volume":"102","author":"TH Westhoff","year":"2003","unstructured":"Westhoff TH, Jochimsen F, Schmittel A, Stoffler-Meilicke M, Schafer JH, Zidek W, et al. Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy. Blood. 2003;102:1930. doi:\n                    10.1182\/blood-2003-05-1403\n                    \n                  .","journal-title":"Blood"},{"key":"359_CR10","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1200\/JCO.2004.05.161","volume":"22","author":"W Yeo","year":"2004","unstructured":"Yeo W, Chan PK, Ho WM, Zee B, Lam KC, Lei KI, et al. Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy. J Clin Oncol. 2004;22:927\u201334. doi:\n                    10.1200\/JCO.2004.05.161\n                    \n                  .","journal-title":"J Clin Oncol"},{"key":"359_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1200\/JCO.2008.18.0182","volume":"27","author":"W Yeo","year":"2009","unstructured":"Yeo W, Chan TC, Leung NW, Lam WY, Mo FK, Chu MT, et al. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab. J Clin Oncol. 2009;27:605\u201311. doi:\n                    10.1200\/JCO.2008.18.0182\n                    \n                  .","journal-title":"J Clin Oncol"},{"key":"359_CR12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/hep.21051","volume":"43","author":"W Yeo","year":"2006","unstructured":"Yeo W, Johnson PJ. Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology. 2006;43:209\u201320. doi:\n                    10.1002\/hep.21051\n                    \n                  .","journal-title":"Hepatology"},{"key":"359_CR13","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1053\/jhep.2003.50220","volume":"37","author":"AL Cheng","year":"2003","unstructured":"Cheng AL, Hsiung CA, Su IJ, Chen PJ, Chang MC, Tsao CJ, et al. Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma. Hepatology. 2003;37:1320\u20138. doi:\n                    10.1053\/jhep.2003.50220\n                    \n                  .","journal-title":"Hepatology"},{"key":"359_CR14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/sj.bmt.1703826","volume":"31","author":"A Locasciulli","year":"2003","unstructured":"Locasciulli A, Bruno B, Alessandrino EP, Meloni G, Arcese W, Bandini G, et al. Hepatitis reactivation and liver failure in haemopoietic stem cell transplants for hepatitis B virus (HBV)\/hepatitis C virus (HCV) positive recipients: a retrospective study by the Italian Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2003;31:295\u2013300. doi:\n                    10.1038\/sj.bmt.1703826\n                    \n                  .","journal-title":"Bone Marrow Transplant"},{"key":"359_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/1096-9071(200011)62:3<299::AID-JMV1>3.0.CO;2-0","volume":"62","author":"W Yeo","year":"2000","unstructured":"Yeo W, Chan PK, Zhong S, Ho WM, Steinberg JL, Tam JS, et al. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol. 2000;62:299\u2013307. doi:\n                    10.1002\/1096-9071(200011)62:3<299::AID-JMV1>3.0.CO;2-0\n                    \n                  .","journal-title":"J Med Virol"},{"key":"359_CR16","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/sj.bjc.6601699","volume":"90","author":"W Yeo","year":"2004","unstructured":"Yeo W, Zee B, Zhong S, Chan PK, Wong WL, Ho WM, et al. Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy. Br J Cancer. 2004;90:1306\u201311. doi:\n                    10.1038\/sj.bjc.6601699\n                    \n                  .","journal-title":"Br J Cancer"},{"issue":"Pt 10","key":"359_CR17","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1099\/0022-1317-69-10-2575","volume":"69","author":"H Okamoto","year":"1988","unstructured":"Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988;69(Pt 10):2575\u201383. doi:\n                    10.1099\/0022-1317-69-10-2575\n                    \n                  .","journal-title":"J Gen Virol"},{"key":"359_CR18","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1053\/jhep.2002.33161","volume":"35","author":"CJ Chu","year":"2002","unstructured":"Chu CJ, Lok AS. Clinical significance of hepatitis B virus genotypes. Hepatology. 2002;35:1274\u20136. doi:\n                    10.1053\/jhep.2002.33161\n                    \n                  .","journal-title":"Hepatology"},{"key":"359_CR19","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1086\/590968","volume":"47","author":"T Umemura","year":"2008","unstructured":"Umemura T, Tanaka E, Kiyosawa K, Kumada H. Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan. Clin Infect Dis. 2008;47:e52\u20136. doi:\n                    10.1086\/590968\n                    \n                  .","journal-title":"Clin Infect Dis"},{"key":"359_CR20","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/hep.21249","volume":"44","author":"A Ozasa","year":"2006","unstructured":"Ozasa A, Tanaka Y, Orito E, Sugiyama M, Kang JH, Hige S, et al. Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection. Hepatology. 2006;44:326\u201334. doi:\n                    10.1002\/hep.21249\n                    \n                  .","journal-title":"Hepatology"},{"key":"359_CR21","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1056\/NEJM199106133242404","volume":"324","author":"M Omata","year":"1991","unstructured":"Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med. 1991;324:1699\u2013704.","journal-title":"N Engl J Med"},{"key":"359_CR22","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1056\/NEJM199106133242405","volume":"324","author":"TJ Liang","year":"1991","unstructured":"Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben-Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med. 1991;324:1705\u20139.","journal-title":"N Engl J Med"},{"key":"359_CR23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1172\/JCI117006","volume":"93","author":"TJ Liang","year":"1994","unstructured":"Liang TJ, Hasegawa K, Munoz SJ, Shapiro CN, Yoffe B, McMahon BJ, et al. Hepatitis B virus precore mutation and fulminant hepatitis in the United States: a polymerase chain reaction-based assay for the detection of specific mutation. J Clin Invest. 1994;93:550\u20135. doi:\n                    10.1172\/JCI117006\n                    \n                  .","journal-title":"J Clin Invest"},{"key":"359_CR24","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.jhep.2005.01.018","volume":"42","author":"CK Hui","year":"2005","unstructured":"Hui CK, Sun J, Au WY, Lie AK, Yueng YH, Zhang HY, et al. Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area. J Hepatol. 2005;42:813\u20139. doi:\n                    10.1016\/j.jhep.2005.01.018\n                    \n                  .","journal-title":"J Hepatol"},{"key":"359_CR25","doi-asserted-by":"publisher","first-page":"747","DOI":"10.2169\/internalmedicine.45.0158","volume":"45","author":"T Umemura","year":"2006","unstructured":"Umemura T, Kiyosawa K. Fatal HBV reactivation in a subject with anti-HBs and anti-HBc. Intern Med. 2006;45:747\u20138. doi:\n                    10.2169\/internalmedicine.45.0158\n                    \n                  .","journal-title":"Intern Med"},{"key":"359_CR26","doi-asserted-by":"publisher","first-page":"519","DOI":"10.7326\/0003-4819-148-7-200804010-00008","volume":"148","author":"R Loomba","year":"2008","unstructured":"Loomba R, Rowley A, Wesley R, Liang TJ, Hoofnagle JH, Pucino F, et al. Systematic review: the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy. Ann Intern Med. 2008;148:519\u201328.","journal-title":"Ann Intern Med"},{"key":"359_CR27","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1136\/gut.2005.070763","volume":"54","author":"CK Hui","year":"2005","unstructured":"Hui CK, Cheung WW, Au WY, Lie AK, Zhang HY, Yueng YH, et al. Hepatitis B reactivation after withdrawal of pre-emptive lamivudine in patients with haematological malignancy on completion of cytotoxic chemotherapy. Gut. 2005;54:1597\u2013603. doi:\n                    10.1136\/gut.2005.070763\n                    \n                  .","journal-title":"Gut"},{"key":"359_CR28","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.hepres.2006.08.005","volume":"36","author":"N Shinkai","year":"2006","unstructured":"Shinkai N, Tanaka Y, Orito E, Ito K, Ohno T, Hirashima N, et al. Measurement of hepatitis B virus core-related antigen as predicting factor for relapse after cessation of lamivudine therapy for chronic hepatitis B virus infection. Hepatol Res. 2006;36:272\u20136. doi:\n                    10.1016\/j.hepres.2006.08.005\n                    \n                  .","journal-title":"Hepatol Res"},{"key":"359_CR29","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1128\/JCM.00366-07","volume":"45","author":"DK Wong","year":"2007","unstructured":"Wong DK, Tanaka Y, Lai CL, Mizokami M, Fung J, Yuen MF. Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J Clin Microbiol. 2007;45:3942\u20137. doi:\n                    10.1128\/JCM.00366-07\n                    \n                  .","journal-title":"J Clin Microbiol"},{"key":"359_CR30","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1056\/NEJMoa033364","volume":"351","author":"YF Liaw","year":"2004","unstructured":"Liaw YF, Sung JJ, Chow WC, Farrell G, Lee CZ, Yuen H, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004;351:1521\u201331. doi:\n                    10.1056\/NEJMoa033364\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"359_CR31","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1053\/j.gastro.2003.09.033","volume":"125","author":"AS Lok","year":"2003","unstructured":"Lok AS, Lai CL, Leung N, Yao GB, Cui ZY, Schiff ER, et al. Long-term safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology. 2003;125:1714\u201322. doi:\n                    10.1053\/j.gastro.2003.09.033\n                    \n                  .","journal-title":"Gastroenterology"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-009-0359-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-009-0359-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-009-0359-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-009-0359-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T05:01:26Z","timestamp":1559451686000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-009-0359-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,23]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1007\/s12185-009-0359-5","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,23]]}}}