{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:26:08Z","timestamp":1791267968442,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,26]],"date-time":"2009-12-26T00:00:00Z","timestamp":1261785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s12185-009-0459-2","type":"journal-article","created":{"date-parts":[[2009,12,25]],"date-time":"2009-12-25T06:00:30Z","timestamp":1261720830000},"page":"87-96","source":"Crossref","is-referenced-by-count":35,"title":["Methylation status of nine tumor suppressor genes in multiple myeloma"],"prefix":"10.1007","volume":"91","author":[{"given":"Esteban","family":"Braggio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Maiolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Gouveia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o T.","family":"Souto Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Garnica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana Zalcberg","family":"Renault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,26]]},"reference":[{"key":"459_CR1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMra041875","volume":"351","author":"RA Kyle","year":"2004","unstructured":"Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004;351:1860\u201373.","journal-title":"N Engl J Med"},{"key":"459_CR2","unstructured":"Ries LAG, Eisner MP, Kosary CL. SEER cancer statistics review 1975-2001. National Cancer Institute; 2004."},{"key":"459_CR3","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/sj.leu.2401041","volume":"12","author":"NV Smadja","year":"1998","unstructured":"Smadja NV, Fruchart C, Isnard F, Louvet C, Dutel JL, Cheron N, et al. Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases. Leukemia. 1998;12:960\u20139.","journal-title":"Leukemia"},{"key":"459_CR4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.leu.2402797","volume":"17","author":"C Debes-Marun","year":"2003","unstructured":"Debes-Marun C, Dewald G, Bryant S, Picken E, Santana-D\u00e1vila R, Gonz\u00e1lez-Paz N, et al. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia. 2003;17:427\u201336.","journal-title":"Leukemia"},{"key":"459_CR5","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1158\/0008-5472.CAN-03-2876","volume":"64","author":"R Fonseca","year":"2004","unstructured":"Fonseca R, Barlogie B, Bataille R, Bastard C, Bergsagel PL, Chesi M, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res. 2004;64:1546\u201358.","journal-title":"Cancer Res"},{"key":"459_CR6","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2003-02-0493","volume":"102","author":"R Fonseca","year":"2003","unstructured":"Fonseca R, Debes-Marun CS, Picken EB, Dewald GW, Bryant SC, Winkler JM, et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood. 2003;102:2562\u20137.","journal-title":"Blood"},{"key":"459_CR7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/gcc.10275","volume":"38","author":"NV Smadja","year":"2003","unstructured":"Smadja NV, Leroux D, Soulier J, Dumont S, Arnould C, Taviaux S, et al. Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases. Gene Chromosome Cancer. 2003;38:234\u20139.","journal-title":"Gene Chromosome Cancer"},{"key":"459_CR8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1600-065X.2003.00052.x","volume":"194","author":"P Bergsagel","year":"2003","unstructured":"Bergsagel P, Kuehl M. Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma. Immunol Rev. 2003;194:96\u2013104.","journal-title":"Immunol Rev"},{"key":"459_CR9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","volume":"106","author":"PL Bergsagel","year":"2005","unstructured":"Bergsagel PL, Kuehl M, Zhan F, Sawyer J, Barlogie B, Shaughnessy J. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005;106:296\u2013303.","journal-title":"Blood"},{"key":"459_CR10","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/hmg\/3.suppl_1.1487","volume":"3","author":"P Laird","year":"1994","unstructured":"Laird P, Jaenisch R. DNA methylation and cancer. Hum Mol Genet. 1994;3:1487\u201395.","journal-title":"Hum Mol Genet"},{"key":"459_CR11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg962","volume":"3","author":"P Jones","year":"2002","unstructured":"Jones P, Baylin S. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3:415\u201328.","journal-title":"Nat Rev Genet"},{"key":"459_CR12","first-page":"1724","volume":"7","author":"M Ng","year":"2001","unstructured":"Ng M, To W, Lo KW, Chan S, Tsang KS, Cheng SH, et al. Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma. Clin Cancer Res. 2001;7:1724\u20139.","journal-title":"Clin Cancer Res"},{"key":"459_CR13","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1046\/j.1365-2141.2002.03749.x","volume":"118","author":"M Mateos","year":"2002","unstructured":"Mateos M, Garc\u00eda-Sanz R, L\u00f3pez-P\u00e9rez R, Moro M, Ocio E, Hern\u00e1ndez J, et al. Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival. Br J Haematol. 2002;118:1034\u201340.","journal-title":"Br J Haematol"},{"key":"459_CR14","first-page":"476","volume":"88","author":"G Guillerm","year":"2003","unstructured":"Guillerm G, Depil S, Wolowiec D, Quesnel B. Different prognostic values of p15INK4b and p16INK4a in multiple myeloma. Haematologica. 2003;88:476\u20138.","journal-title":"Haematologica"},{"key":"459_CR15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.leukres.2003.08.008","volume":"28","author":"CS Chim","year":"2004","unstructured":"Chim CS, Kwong YL, Fung TK, Liang R. Methylation profiling in multiple myeloma. Leuk Res. 2004;28:379\u201385.","journal-title":"Leuk Res"},{"key":"459_CR16","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1182\/blood-2003-06-2007","volume":"103","author":"C Chim","year":"2004","unstructured":"Chim C, Fung T, Cheung W, Liang R, Kwong Y. SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak\/STAT pathway. Blood. 2004;103:4630\u20135.","journal-title":"Blood"},{"key":"459_CR17","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1038\/sj.leu.2403434","volume":"18","author":"O Galm","year":"2004","unstructured":"Galm O, Wilop S, Reichelt J, Jost E, Gehbauer G, Herman J, et al. DNA methylation changes in multiple myeloma. Leukemia. 2004;18:1687\u201392.","journal-title":"Leukemia"},{"key":"459_CR18","first-page":"154","volume":"89","author":"D Rossi","year":"2004","unstructured":"Rossi D, Capello D, Gloghini A, Franceschetti S, Paulli M, Bhatia K, et al. Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia. Haematologica. 2004;89:154\u201364.","journal-title":"Haematologica"},{"key":"459_CR19","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1002\/cncr.20295","volume":"100","author":"S Seidl","year":"2004","unstructured":"Seidl S, Ackermann J, Kaufmann H, Keck A, N\u00f6sslinger T, Zielinski C, et al. DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. Cancer. 2004;100:2598\u2013606.","journal-title":"Cancer"},{"key":"459_CR20","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood-2006-05-024661","volume":"109","author":"N Gonzalez-Paz","year":"2007","unstructured":"Gonzalez-Paz N, Chng W, McClure R, Blood E, Oken M, Van Ness B, et al. Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications. Blood. 2007;109:1228\u201332.","journal-title":"Blood"},{"key":"459_CR21","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","volume":"36","author":"B Durie","year":"1975","unstructured":"Durie B, Salmon S. A clinical staging sytem for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975;36:842\u201354.","journal-title":"Cancer"},{"key":"459_CR22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","volume":"121","author":"The International Myeloma Working Group","year":"2003","unstructured":"The International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003;121:749\u201357.","journal-title":"Br J Haematol"},{"key":"459_CR23","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","volume":"93","author":"J Herman","year":"1996","unstructured":"Herman J, Graff J, Myohanen S, Nelkin B, Baylin S. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996;93:9821\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"459_CR24","doi-asserted-by":"crossref","first-page":"22322","DOI":"10.1074\/jbc.272.35.22322","volume":"272","author":"J Graff","year":"1997","unstructured":"Graff J, Herman J, Myohanen S, Baylin S, Vertino P. Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem. 1997;272:22322\u20139.","journal-title":"J Biol Chem"},{"key":"459_CR25","first-page":"2515","volume":"58","author":"R Lapidus","year":"1998","unstructured":"Lapidus R, Nass S, Butash K, Parl F, Weitzman S, Graff J, et al. Mapping of ER gene CpG island methylation-specific polymerase chain reaction. Cancer Res. 1998;58:2515\u20139.","journal-title":"Cancer Res"},{"key":"459_CR26","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1182\/blood.V93.12.4347","volume":"93","author":"R Katzenellenbogen","year":"1999","unstructured":"Katzenellenbogen R, Baylin S, Herman J. Hypermethylation of the DAPKinase CpG islands is a common alteration in B cell malignancies. Blood. 1999;93:4347\u201353.","journal-title":"Blood"},{"key":"459_CR27","first-page":"6390","volume":"62","author":"T Oka","year":"2002","unstructured":"Oka T, Ouchida M, Koyama M. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias\/lymphomas. Cancer Res. 2002;62:6390\u20134.","journal-title":"Cancer Res"},{"key":"459_CR28","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200011093431901","volume":"343","author":"M Esteller","year":"2000","unstructured":"Esteller M, Garcia-Foncillas J, Andion E, Goodman S, Hidalgo O, Vanaclocha V, et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med. 2000;343:1350\u20134.","journal-title":"N Engl J Med"},{"key":"459_CR29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/jnci\/94.1.26","volume":"94","author":"M Esteller","year":"2002","unstructured":"Esteller M, Gaidano G, Goodman S, Zagonel V, Capello D, Botto B, et al. Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J Natl Cancer Inst. 2002;94:26\u201332.","journal-title":"J Natl Cancer Inst"},{"key":"459_CR30","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1158\/1078-0432.CCR-03-0716","volume":"10","author":"T Takahashi","year":"2004","unstructured":"Takahashi T, Shivapurkar N, Reddy J, Shigematsu H, Miyajima K, Suzuki M, et al. DNA methylation profiles of lymphoid and hematopoietic malignancies. Clin Cancer Res. 2004;10:2928\u201335.","journal-title":"Clin Cancer Res"},{"key":"459_CR31","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.bjc.6602422","volume":"92","author":"M Murai","year":"2005","unstructured":"Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, et al. Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. Br J Cancer. 2005;92:1165\u201372.","journal-title":"Br J Cancer"},{"key":"459_CR32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/5947","volume":"21","author":"P Jones","year":"1999","unstructured":"Jones P, Laird P. Cancer epigenetics comes of age. Nat Genet. 1999;21:163\u20137.","journal-title":"Nat Genet"},{"key":"459_CR33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0168-9525(99)01971-X","volume":"16","author":"S Baylin","year":"2000","unstructured":"Baylin S, Herman J. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000;16:168\u201374.","journal-title":"Trends Genet"},{"key":"459_CR34","first-page":"3225","volume":"61","author":"M Esteller","year":"2001","unstructured":"Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res. 2001;61:3225\u20139.","journal-title":"Cancer Res"},{"key":"459_CR35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/gad.9.1.15","volume":"9","author":"L Deiss","year":"1995","unstructured":"Deiss L, Feinstein E, Berissi H, Cohen O, Kimchi A. Identification of a novel serine\/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995;9:15\u201330.","journal-title":"Genes Dev"},{"key":"459_CR36","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1182\/blood-2002-07-2009","volume":"101","author":"M Sanchez-Beato","year":"2003","unstructured":"Sanchez-Beato M, Sanchez-Aguilera A, Piris MA. Cell cycle deregulation in B-cell lymphomas. Blood. 2003;101:1220\u201335.","journal-title":"Blood"},{"key":"459_CR37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00001813-199701000-00007","volume":"8","author":"S Cote","year":"1997","unstructured":"Cote S, Momparler R. Activation of the retinoic acid receptor beta gene by 5-aza-2\u2019-deoxycytidine in human DLD-1 colon carcinoma cells. Anticancer Drugs. 1997;8:56\u201361.","journal-title":"Anticancer Drugs"},{"key":"459_CR38","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/jnci\/92.16.1303","volume":"92","author":"A Virmani","year":"2000","unstructured":"Virmani A, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, et al. Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. J Natl Cancer Inst. 2000;92:1303\u20137.","journal-title":"J Natl Cancer Inst"},{"issue":"Suppl 1","key":"459_CR39","first-page":"21","volume":"7","author":"LR Silverman","year":"1993","unstructured":"Silverman LR, Holland JF, Weinberg RS, Alter BP, Davis RB, Ellison RR, et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia. 1993;7(Suppl 1):21\u20139.","journal-title":"Leukemia"},{"key":"459_CR40","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1200\/JCO.2002.04.117","volume":"20","author":"L Silverman","year":"2002","unstructured":"Silverman L, Demakos E, Peterson B, Kornblith AB, Holland JC, Odchimar-Reissig R, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol. 2002;20:2429\u201340.","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-009-0459-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-009-0459-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-009-0459-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:15:10Z","timestamp":1590480910000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-009-0459-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,26]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["459"],"URL":"https:\/\/doi.org\/10.1007\/s12185-009-0459-2","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,26]]}}}