{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:13:45Z","timestamp":1767906825886,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s12185-010-0615-8","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T01:08:57Z","timestamp":1276045737000},"page":"748-752","source":"Crossref","is-referenced-by-count":28,"title":["Molecular pathways to CML stem cells"],"prefix":"10.1007","volume":"91","author":[{"given":"Kristen N.","family":"Rice","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona H. M.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,10]]},"reference":[{"key":"615_CR1","doi-asserted-by":"crossref","unstructured":"Deininger M, O\u2019Brien SG, et al. International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. Blood. 2009;114 (ASH Annual Meeting Abstract 1126).","DOI":"10.1182\/blood.V114.22.1126.1126"},{"key":"615_CR2","doi-asserted-by":"crossref","unstructured":"Mahon F, Rea D, et al. Persistence of complete molecular remission in chronic myeloid leukemia after imatinib discontinuation: interim analysis of the STIM trial. J Clin Oncol 2009;27(15s) (Abstract 7084).","DOI":"10.1200\/jco.2009.27.15_suppl.7084"},{"issue":"1","key":"615_CR3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","volume":"99","author":"SM Graham","year":"2002","unstructured":"Graham SM, Jorgensen HG, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99(1):319\u201325.","journal-title":"Blood"},{"key":"615_CR4","doi-asserted-by":"crossref","unstructured":"Minami Y, Stuart SA, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. PNAS. 2008;105(46):17967\u201372.","DOI":"10.1073\/pnas.0808303105"},{"key":"615_CR5","doi-asserted-by":"crossref","unstructured":"Jamieson CHM. Chronic myeloid leukemia stem cells. Hematology. 2008. p. 436\u201342.","DOI":"10.1182\/asheducation-2008.1.436"},{"issue":"17","key":"615_CR6","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1200\/JCO.2008.17.5745","volume":"26","author":"E Kavalerchik","year":"2008","unstructured":"Kavalerchik E, Goff D, Jamieson CHM. Chronic myeloid leukemia stem cells. J Clin Oncol. 2008;26(17):2911\u20135.","journal-title":"J Clin Oncol"},{"key":"615_CR7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","volume":"367","author":"T Lapidot","year":"1994","unstructured":"Lapidot T, Sirard C, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645\u20138.","journal-title":"Nature"},{"issue":"7","key":"615_CR8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"D Bonnet","year":"1997","unstructured":"Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730\u20137.","journal-title":"Nat Med"},{"issue":"2","key":"615_CR9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1182\/blood.V95.2.404","volume":"95","author":"JC Chomel","year":"2000","unstructured":"Chomel JC, Brizard F, et al. Persistence of BCR-ABL genomic rearrangement in chronic myeloid leukemia patients in complete and sustained cytogenetic remission after interferon-alpha therapy or allogeneic bone marrow transplantation. Blood. 2000;95(2):404\u20139.","journal-title":"Blood"},{"issue":"9","key":"615_CR10","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1182\/blood.V92.9.3362","volume":"92","author":"S Bose","year":"1998","unstructured":"Bose S, Deininger M, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood. 1998;92(9):3362\u20137.","journal-title":"Blood"},{"key":"615_CR11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","volume":"247","author":"GQ Daley","year":"1990","unstructured":"Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome. Science. 1990;247:824\u201330.","journal-title":"Science"},{"issue":"4","key":"615_CR12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/j.1460-2075.1990.tb08212.x","volume":"9","author":"AG Elefanty","year":"1990","unstructured":"Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haematopoietic neoplasms in mice. EMBO J. 1990;9(4):1069\u201378.","journal-title":"EMBO J"},{"issue":"22","key":"615_CR13","doi-asserted-by":"crossref","first-page":"9072","DOI":"10.1073\/pnas.87.22.9072-a","volume":"87","author":"MA Kelliher","year":"1990","unstructured":"Kelliher MA, McLaughlin J, et al. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR\/ABL. PNAS. 1990;87(22):9072.","journal-title":"PNAS"},{"issue":"17","key":"615_CR14","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1073\/pnas.1633833100","volume":"100","author":"S Jaiswal","year":"2003","unstructured":"Jaiswal S, Traver D, et al. Expression of BCR\/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. PNAS. 2003;100(17):10002\u20137.","journal-title":"PNAS"},{"issue":"7","key":"615_CR15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","volume":"351","author":"CHM Jamieson","year":"2004","unstructured":"Jamieson CHM, Ailles LE, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast crisis CML. NEJM. 2004;351(7):657\u201367.","journal-title":"NEJM"},{"key":"615_CR16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya T, Morrison SJ, et al. Stem cells, cancer, and cancer stem cells. Nature. 2001;414:105\u201311.","journal-title":"Nature"},{"key":"615_CR17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","volume":"423","author":"T Reya","year":"2003","unstructured":"Reya T, Duncan AW, et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature. 2003;423:409\u201314.","journal-title":"Nature"},{"issue":"Suppl 1","key":"615_CR18","doi-asserted-by":"crossref","first-page":"11842","DOI":"10.1073\/pnas.2034201100","volume":"100","author":"E Passegue","year":"2003","unstructured":"Passegue E, Jamieson CHM, et al. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? PNAS. 2003;100(Suppl 1):11842\u20139.","journal-title":"PNAS"},{"key":"615_CR19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","volume":"434","author":"T Reya","year":"2005","unstructured":"Reya T, Clevers H. Wnt signaling in stem cells and cancer. Nature. 2005;434:843\u201350.","journal-title":"Nature"},{"issue":"3","key":"615_CR20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ni1164","volume":"6","author":"AW Duncan","year":"2005","unstructured":"Duncan AW, Rattis FM, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314\u201322.","journal-title":"Nat Immunol"},{"issue":"10","key":"615_CR21","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1073\/pnas.0900189106","volume":"106","author":"AE Abrahamsson","year":"2009","unstructured":"Abrahamsson AE, Geron I, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. PNAS. 2009;106(10):3925\u20139.","journal-title":"PNAS"},{"issue":"11","key":"615_CR22","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/81390","volume":"6","author":"B Varnum-Finney","year":"2000","unstructured":"Varnum-Finney B, Xu L, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6(11):1278\u201381.","journal-title":"Nat Med"},{"key":"615_CR23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","volume":"306","author":"AP Weng","year":"2004","unstructured":"Weng AP, Ferrando AA, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269\u201371.","journal-title":"Science"},{"key":"615_CR24","doi-asserted-by":"crossref","unstructured":"Deangelo DJ, Stone RM, et al. A phase I clinical trial of the notch inhibitor MK-0752 in patients with T-cell acute lymphoblastic leukemia\/lymphoma T-ALL and other leukemias. J Clin Oncol. 2006;24(18S):658S (ASCO annual meeting proceedings).","DOI":"10.1200\/jco.2006.24.18_suppl.6585"},{"key":"615_CR25","doi-asserted-by":"crossref","unstructured":"Nakahara F, Sakata-Yanagimoto M, et al. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood. 2010;115(14):2872\u201381.","DOI":"10.1182\/blood-2009-05-222836"},{"key":"615_CR26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/35077219","volume":"411","author":"J Taipale","year":"2001","unstructured":"Taipale J, Beachy PA. The Hedgehog and Wnt signaling pathways in cancer. Nature. 2001;411:349\u201354.","journal-title":"Nature"},{"key":"615_CR27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35069099","volume":"410","author":"Y Zhang","year":"2001","unstructured":"Zhang Y, Kalderon D. Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature. 2001;410:599\u2013604.","journal-title":"Nature"},{"key":"615_CR28","doi-asserted-by":"crossref","unstructured":"Hofmann I, Stover EH, et al. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009;4(6):559\u201367.","DOI":"10.1016\/j.stem.2009.03.016"},{"key":"615_CR29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature07737","volume":"458","author":"C Zhao","year":"2009","unstructured":"Zhao C, Chen A, et al. Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukemia. Nature. 2009;458:776\u20139.","journal-title":"Nature"},{"key":"615_CR30","doi-asserted-by":"crossref","unstructured":"Abrahamsson-Schairer AE, Shih A, et al. Smoothening the way for human leukemia stem cell inhibition in chronic myeloid leukemia. American Association for Cancer Research 2010 Annual Meeting Abstract LB-258.","DOI":"10.1158\/1538-7445.AM10-LB-258"},{"issue":"5","key":"615_CR31","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1182\/blood.V83.5.1179.1179","volume":"83","author":"A McGahon","year":"1994","unstructured":"McGahon A, Bissonnette R, et al. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood. 1994;83(5):1179\u201387.","journal-title":"Blood"},{"issue":"12","key":"615_CR32","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1073\/pnas.92.12.5287","volume":"92","author":"I Sanchez-Garcia","year":"1995","unstructured":"Sanchez-Garcia I, Grutz G. Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. PNAS. 1995;92(12):5287\u201391.","journal-title":"PNAS"},{"issue":"3","key":"615_CR33","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1182\/blood.V86.3.1148.1148","volume":"86","author":"A Bedi","year":"1995","unstructured":"Bedi A, Barber JP, et al. BCR-ABL-mediated inhibition of apoptosis with delay of G2\/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. Blood. 1995;86(3):1148\u201358.","journal-title":"Blood"},{"issue":"10","key":"615_CR34","first-page":"225","volume":"13","author":"K Nishii","year":"1996","unstructured":"Nishii K, Kabarowski JH, et al. BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block. Oncogene. 1996;13(10):225\u201334.","journal-title":"Oncogene"},{"issue":"8","key":"615_CR35","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1182\/blood.V83.8.2038.2038","volume":"83","author":"A Bedi","year":"1994","unstructured":"Bedi A, Zehnbauer BA, et al. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood. 1994;83(8):2038\u201344.","journal-title":"Blood"},{"issue":"6","key":"615_CR36","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1182\/blood.V86.6.2371.bloodjournal8662371","volume":"86","author":"A Gaiger","year":"1995","unstructured":"Gaiger A, Henn T, et al. Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression. Blood. 1995;86(6):2371\u20138.","journal-title":"Blood"},{"issue":"3","key":"615_CR37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/sj.onc.1201490","volume":"16","author":"N Cambier","year":"1998","unstructured":"Cambier N, Chopra R, et al. BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner. Oncogene. 1998;16(3):335\u201348.","journal-title":"Oncogene"},{"issue":"6","key":"615_CR38","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.V96.6.2269","volume":"96","author":"F Gesbert","year":"2000","unstructured":"Gesbert F, Griffin JD. Bcr\/Abl activates transcription of the Bcl-X gene through STAT5. Blood. 2000;96(6):2269\u201376.","journal-title":"Blood"},{"issue":"6","key":"615_CR39","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.191.6.977","volume":"191","author":"M Horita","year":"2000","unstructured":"Horita M, Andreu EJ, et al. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL. J Exp Med. 2000;191(6):977\u201384.","journal-title":"J Exp Med"},{"issue":"5","key":"615_CR40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/mcbr.2000.0231","volume":"3","author":"RP Groot De","year":"2000","unstructured":"De Groot RP, Raaijmakers JA, et al. STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells. Mol Cell Biol Res Commun. 2000;3(5):299\u2013305.","journal-title":"Mol Cell Biol Res Commun"},{"key":"615_CR41","doi-asserted-by":"crossref","unstructured":"Goff DJ, Abrahamsson-Schairer A, et al. The broad spectrum Bcl-2 inhibitor apogossypol induces apoptosis and differentiation of blast crisis chronic myeloid leukemia stem cells. 2009 (American Society of Hematology Annual Meeting Poster 3275).","DOI":"10.1182\/blood.V114.22.3275.3275"},{"issue":"2","key":"615_CR42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","volume":"138","author":"S Jaiswal","year":"2009","unstructured":"Jaiswal S, Jamieson CHM, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138(2):271\u201385.","journal-title":"Cell"},{"issue":"2","key":"615_CR43","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","volume":"138","author":"R Majeti","year":"2009","unstructured":"Majeti R, Chao MP, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009;138(2):286\u201399.","journal-title":"Cell"},{"key":"615_CR44","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/sj.leu.2404657","volume":"21","author":"A Sengupta","year":"2007","unstructured":"Sengupta A, Banergee D, et al. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox, and Notch signaling in chronic myeloid leukemia progression. Leukemia. 2007;21:949\u201355.","journal-title":"Leukemia"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-010-0615-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-010-0615-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-010-0615-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T03:18:51Z","timestamp":1635477531000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-010-0615-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["615"],"URL":"https:\/\/doi.org\/10.1007\/s12185-010-0615-8","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}