{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:21:15Z","timestamp":1761895275172},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s12185-011-0854-3","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T03:19:53Z","timestamp":1303787993000},"page":"806-810","source":"Crossref","is-referenced-by-count":14,"title":["Coexistence of inversion 16 and the Philadelphia chromosome comprising P190 BCR\/ABL in chronic myeloid leukemia blast crisis"],"prefix":"10.1007","volume":"93","author":[{"given":"Soranobu","family":"Ninomiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Kanemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senji","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"854_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","volume":"306","author":"CR Bartram","year":"1983","unstructured":"Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts van Kessel A, Bootsma D, et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983;306:277\u201380.","journal-title":"Nature"},{"key":"854_CR2","first-page":"2343","volume":"61","author":"E Laurent","year":"2001","unstructured":"Laurent E, Talpaz M, Kantarjian H, Kurzrock R. The BCR gene and Philadelphia chromosome-positive leukemogenesis. Cancer Res. 2001;61:2343\u201355.","journal-title":"Cancer Res"},{"key":"854_CR3","doi-asserted-by":"publisher","first-page":"819","DOI":"10.7326\/0003-4819-138-10-200305200-00010","volume":"138","author":"R Kurzrock","year":"2003","unstructured":"Kurzrock R, Kantarjian HM, Druker BJ, Talpaz M. Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. Ann Intern Med. 2003;138:819\u201330.","journal-title":"Ann Intern Med"},{"key":"854_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0002-9343(87)90754-6","volume":"83","author":"HM Kantarjian","year":"1987","unstructured":"Kantarjian HM, Keating MJ, Talpaz M, Walters RS, Smith TL, Cork A, et al. Chronic myelogenous leukemia in blast crisis. Analysis of 242 patients. Am J Med. 1987;83:445\u201354.","journal-title":"Am J Med"},{"key":"854_CR5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s002770050233","volume":"73","author":"M Griesshammer","year":"1996","unstructured":"Griesshammer M, Heinze B, Hellmann A, Popp C, Anger B, Heil G, et al. Chronic myelogenous leukemia in blast crisis: retrospective analysis of prognostic factors in 90 patients. Ann Hematol. 1996;73:225\u201330.","journal-title":"Ann Hematol"},{"key":"854_CR6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/0165-4608(94)00219-2","volume":"81","author":"P Ruff","year":"1995","unstructured":"Ruff P, Saragas E, Poulos M, Weaving A. Patterns of clonal evolution in transformed chronic myelogenous leukemia. Cancer Genet Cytogenet. 1995;81:182\u20134.","journal-title":"Cancer Genet Cytogenet"},{"key":"854_CR7","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1309\/F0MX5CL8CEDY3W86","volume":"125","author":"Y Wu","year":"2006","unstructured":"Wu Y, Slovak ML, Snyder DS, Arber DA. Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias: report of six cases and review of literature. Am J Clin Pathol. 2006;125:260\u20136.","journal-title":"Am J Clin Pathol"},{"key":"854_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1309\/3HFE16DKMB1DBFMN","volume":"124","author":"M Merzianu","year":"2005","unstructured":"Merzianu M, Medeiros LJ, Cortes J, Yin C, Lin P, Jones D, et al. inv(16)(p13q22) in chronic myelogenous leukemia in blast phase: a clinicopathologic, cytogenetic, and molecular study of five cases. Am J Clin Pathol. 2005;124:807\u201314.","journal-title":"Am J Clin Pathol"},{"key":"854_CR9","first-page":"628","volume":"9","author":"J Anastasi","year":"1995","unstructured":"Anastasi J, Feng J, Le Beau MM, Larson RA, Rowley JD, Vardiman JW. The relationship between secondary chromosomal abnormalities and blast transformation in chronic myelogenous leukemia. Leukemia. 1995;9:628\u201333.","journal-title":"Leukemia"},{"key":"854_CR10","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S0145-2126(01)00199-0","volume":"26","author":"K Tsuboi","year":"2002","unstructured":"Tsuboi K, Komatsu H, Miwa H, Iida S, Banno S, Wakita A, et al. Lymphoid blastic crisis of chronic myelogenous leukaemia with inv(16)(p13;q22). Leuk Res. 2002;26:771\u20134.","journal-title":"Leuk Res"},{"key":"854_CR11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0145-2126(97)00070-2","volume":"21","author":"H Myint","year":"1997","unstructured":"Myint H, Ross FM, Hall JL, Hamblin TJ. Early transformation to acute myeloblastic leukaemia with the acquisition of inv(16) in Ph positive chronic granulocytic leukaemia. Leuk Res. 1997;21:473\u20134.","journal-title":"Leuk Res"},{"key":"854_CR12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/0165-4608(92)90251-3","volume":"62","author":"JP Evers","year":"1992","unstructured":"Evers JP, Bagg A, Himoe E, Zwiebel JA, Jacobson RJ. Temporal association of marrow eosinophilia with inversion of chromosome 16 in recurrent blast crises of chronic myelogenous leukemia. Cancer Genet Cytogenet. 1992;62:134\u20139.","journal-title":"Cancer Genet Cytogenet"},{"key":"854_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0165-4608(92)90086-N","volume":"61","author":"N Asou","year":"1992","unstructured":"Asou N, Sanada I, Tanaka K, Hidaka M, Suzushima H, Matsuzaki H, et al. Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia. Cancer Genet Cytogenet. 1992;61:197\u2013200.","journal-title":"Cancer Genet Cytogenet"},{"key":"854_CR14","first-page":"381","volume":"6","author":"H Enright","year":"1992","unstructured":"Enright H, Weisdorf D, Peterson L, Rydell RE, Kaplan ME, Arthur DC. Inversion of chromosome 16 and dysplastic eosinophils in accelerated phase of chronic myeloid leukemia. Leukemia. 1992;6:381\u20134.","journal-title":"Leukemia"},{"key":"854_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0165-4608(92)90154-Z","volume":"59","author":"S Heim","year":"1992","unstructured":"Heim S, Christensen BE, Fioretos T, Sorensen AG, Pedersen NT. Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia. Cancer Genet Cytogenet. 1992;59:35\u20138.","journal-title":"Cancer Genet Cytogenet"},{"key":"854_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0165-4608(92)90129-V","volume":"58","author":"LM Secker-Walker","year":"1992","unstructured":"Secker-Walker LM, Morgan GJ, Min T, Swansbury GJ, Craig J, Yamada T, et al. Inversion of chromosome 16 with the Philadelphia chromosome in acute myelomonocytic leukemia with eosinophilia. Report of two cases. Cancer Genet Cytogenet. 1992;58:29\u201334.","journal-title":"Cancer Genet Cytogenet"},{"key":"854_CR17","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1365-2141.1988.tb02422.x","volume":"69","author":"YS Li","year":"1988","unstructured":"Li YS, Hayhoe FG. Ph1 chromosome positive acute myelomonocytic leukaemia with inverted chromosome 16. Br J Haematol. 1988;69:576.","journal-title":"Br J Haematol"},{"key":"854_CR18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/ajh.2830450118","volume":"45","author":"I Miura","year":"1994","unstructured":"Miura I, Takatsu H, Yamaguchi A, Hashimoto K, Nimura T, Nishinari T, et al. Standard Ph chromosome, t(9;22)(q34;q11), as an additional change in a patient with acute myelomonocytic leukemia (M4Eo) associated with inv(16)(p13q22). Am J Hematol. 1994;45:94\u20136.","journal-title":"Am J Hematol"},{"key":"854_CR19","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/sj.leu.2402159","volume":"15","author":"G Marcucci","year":"2001","unstructured":"Marcucci G, Caligiuri MA, Dohner H, Archer KJ, Schlenk RF, Dohner K, et al. Quantification of CBFbeta\/MYH11 fusion transcript by real time RT-PCR in patients with INV(16) acute myeloid leukemia. Leukemia. 2001;15:1072\u201380.","journal-title":"Leukemia"},{"key":"854_CR20","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1080\/10428190290021434","volume":"43","author":"AD Siddiqui","year":"2002","unstructured":"Siddiqui AD, Sheikh ZS, Liu D, Seiter K. Coexistence of inversion 16 and the Philadelphia chromosome in patients with acute myelogenous leukemia. Leuk Lymphoma. 2002;43:1137\u201340.","journal-title":"Leuk Lymphoma"},{"key":"854_CR21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cancergencyto.2010.03.001","volume":"200","author":"CA Tirado","year":"2010","unstructured":"Tirado CA, Valdez F, Klesse L, Karandikar NJ, Uddin N, Arbini A, et al. Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3\u2032CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review. Cancer Genet Cytogenet. 2010;200:54\u20139.","journal-title":"Cancer Genet Cytogenet"},{"issue":"3","key":"854_CR22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3109\/10428194.2010.538941","volume":"52","author":"CG Roth","year":"2011","unstructured":"Roth CG, Contis L, Gupta S, Agha M, Safyan E. De novo acute myeloid leukemia with Philadelphia chromosome (BCR-ABL) and inversion 16 (CBFB-MYH11): report of two cases and review of the literature. Leuk Lymphoma. 2011;52(3):531\u20135.","journal-title":"Leuk Lymphoma"},{"key":"854_CR23","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1056\/NEJM198309153091103","volume":"309","author":"MM Le Beau","year":"1983","unstructured":"Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association. N Engl J Med. 1983;309:630\u20136.","journal-title":"N Engl J Med"},{"key":"854_CR24","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1182\/blood.V85.3.772.bloodjournal853772","volume":"85","author":"P Marlton","year":"1995","unstructured":"Marlton P, Claxton DF, Liu P, Estey EH, Beran M, LeBeau M, et al. Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis. Blood. 1995;85:772\u20139.","journal-title":"Blood"},{"key":"854_CR25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2141.1992.tb06480.x","volume":"82","author":"C Preudhomme","year":"1992","unstructured":"Preudhomme C, Lai JL, Plantier I, Demory JL, Zandecki M, Fenaux P. Cytogenetic and molecular remission in a case of acute myeloid leukaemia(AML) with inversion of chromosome 16 (Inv(16)) and Philadelphia chromosome (Ph). Br J Haematol. 1992;82:623\u20136.","journal-title":"Br J Haematol"},{"key":"854_CR26","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood.V88.7.2375.bloodjournal8872375","volume":"88","author":"JV Melo","year":"1996","unstructured":"Melo JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood. 1996;88:2375\u201384.","journal-title":"Blood"},{"key":"854_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0145-2126(03)00161-9","volume":"28","author":"M Cividin","year":"2004","unstructured":"Cividin M, Brizard F, Sorel N, Renaud M, Guilhot F, Brizard A. p190(BCR-ABL) rearrangement as a secondary change in a case of acute myelo-monocytic leukemia with inv(16)(p13q22). Leuk Res. 2004;28:97\u20139.","journal-title":"Leuk Res"},{"key":"854_CR28","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1182\/blood.V99.10.3530","volume":"99","author":"CL Sawyers","year":"2002","unstructured":"Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, Ottmann OG, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002;99:3530\u20139.","journal-title":"Blood"},{"key":"854_CR29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S1535-6108(02)00096-X","volume":"2","author":"NP Shah","year":"2002","unstructured":"Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (ST1571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2:117\u201325.","journal-title":"Cancer Cell"},{"key":"854_CR30","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1182\/blood-2006-09-046888","volume":"109","author":"J Cortes","year":"2007","unstructured":"Cortes J, Rousselot P, Kim DW, Ritchie E, Hamerschlak N, Coutre S, et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood. 2007;109:3207\u201313.","journal-title":"Blood"},{"key":"854_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12185-008-0032-4","volume":"87","author":"Y Wang","year":"2008","unstructured":"Wang Y, Wu D, Sun A, Jin Z, Qiu H, Miao M, et al. Allogeneic hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in second chronic phase attained by imatinib after onset of blast crisis. Int J Hematol. 2008;87:167\u201371.","journal-title":"Int J Hematol"},{"key":"854_CR32","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1182\/blood-2009-02-204693","volume":"114","author":"D Verma","year":"2009","unstructured":"Verma D, Kantarjian HM, Jones D, Luthra R, Borthakur G, Verstovsek S, et al. Chronic myeloid leukemia (CML) with P190 BCR-ABL: analysis of characteristics, outcomes, and prognostic significance. Blood. 2009;114:2232\u20135.","journal-title":"Blood"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-011-0854-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-011-0854-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-011-0854-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-011-0854-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T16:28:16Z","timestamp":1592497696000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-011-0854-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["854"],"URL":"https:\/\/doi.org\/10.1007\/s12185-011-0854-3","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}