{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:46:51Z","timestamp":1788371211945,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s12185-013-1474-x","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T08:55:31Z","timestamp":1385024131000},"page":"91-94","source":"Crossref","is-referenced-by-count":13,"title":["Treatment with dasatinib for chronic myeloid leukemia following imatinib-induced hepatotoxicity"],"prefix":"10.1007","volume":"99","author":[{"given":"Lars","family":"Harbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eray","family":"Goekkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Schafhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djordje","family":"Atanackovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"1474_CR1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/ajh.23282","volume":"87","author":"E Jabbour","year":"2012","unstructured":"Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management. Am J Hematol. 2012;87:1037\u201345.","journal-title":"Am J Hematol"},{"key":"1474_CR2","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1182\/blood-2008-07-166694","volume":"113","author":"A Quintas-Cardama","year":"2009","unstructured":"Quintas-Cardama A, Kantarjian H, Jones D, Shan J, Borthakur G, Thomas D, et al. Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy. Blood. 2009;113:6315\u201321.","journal-title":"Blood"},{"key":"1474_CR3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/leu.2008.84","volume":"22","author":"A Hochhaus","year":"2008","unstructured":"Hochhaus A, Baccarani M, Deininger M, Apperley JF, Lipton JH, Goldberg SL, et al. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia. 2008;22:1200\u20136.","journal-title":"Leukemia"},{"key":"1474_CR4","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1056\/NEJMoa1002315","volume":"362","author":"H Kantarjian","year":"2010","unstructured":"Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2010;362:2260\u201370.","journal-title":"N Engl J Med"},{"key":"1474_CR5","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1056\/NEJMoa0912614","volume":"362","author":"G Saglio","year":"2010","unstructured":"Saglio G, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Lobo C, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med. 2010;362:2251\u20139.","journal-title":"N Engl J Med"},{"key":"1474_CR6","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood-2007-07-103523","volume":"111","author":"A Hochhaus","year":"2008","unstructured":"Hochhaus A, Druker B, Sawyers C, Guilhot F, Schiffer CA, Cortes J, et al. Favorable long-term follow-up results over 6\u00a0years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-alpha treatment. Blood. 2008;111:1039\u201343.","journal-title":"Blood"},{"key":"1474_CR7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000111092","volume":"118","author":"JH Kong","year":"2007","unstructured":"Kong JH, Yoo SH, Lee KE, Nam SH, Kwon JM, Lee SM, et al. Early imatinib-mesylate-induced hepatotoxicity in chronic myelogenous leukaemia. Acta Haematol. 2007;118:205\u20138.","journal-title":"Acta Haematol"},{"key":"1474_CR8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1532\/IJH97.05034","volume":"82","author":"K Ikuta","year":"2005","unstructured":"Ikuta K, Torimoto Y, Jimbo J, Inamura J, Shindo M, Sato K, et al. Severe hepatic injury caused by imatinib mesylate administered for the treatment of chronic myeloid leukemia and the efficacy of prednisolone for its management. Int J Hematol. 2005;82:343\u20136.","journal-title":"Int J Hematol"},{"key":"1474_CR9","unstructured":"Ferrero D, Pogliani EM, Rege-Cambrin G, Fava C, Mattioli G, Dellacasa C, et al. Corticosteroids can reverse severe imatinib-induced hepatotoxicity. Haematologica 2006;91:ECR27."},{"key":"1474_CR10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1080\/10428190600593877","volume":"47","author":"R Yamazaki","year":"2006","unstructured":"Yamazaki R, Okamoto S, Chen CK, Tada S, Saito H, Shibata R, et al. Successful management of liver injury caused by imatinib mesylate in a patient with previously untreated chronic myelogenous leukemia in the chronic phase. Leuk Lymphoma. 2006;47:1427\u201330.","journal-title":"Leuk Lymphoma"},{"key":"1474_CR11","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1200\/JCO.2010.30.5359","volume":"29","author":"V Spataro","year":"2011","unstructured":"Spataro V. Nilotinib in a patient with postnecrotic liver cirrhosis related to imatinib. J Clin Oncol. 2011;29:e50\u20132.","journal-title":"J Clin Oncol"},{"key":"1474_CR12","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1016\/j.leukres.2009.06.012","volume":"33","author":"GF Perini","year":"2009","unstructured":"Perini GF, Santos FP, Funke V, Ruiz J, Neto BH, Hamerschlak N. Nilotinib post-liver transplantation for acute hepatic failure related to imatinib. Leuk Res. 2009;33:e234\u20135.","journal-title":"Leuk Res"},{"key":"1474_CR13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ajh.20486","volume":"81","author":"TJ Cross","year":"2006","unstructured":"Cross TJ, Bagot C, Portmann B, Wendon J, Gillett D. Imatinib mesylate as a cause of acute liver failure. Am J Hematol. 2006;81:189\u201392.","journal-title":"Am J Hematol"},{"key":"1474_CR14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/asheducation-2011.1.128","volume":"2011","author":"A Hochhaus","year":"2011","unstructured":"Hochhaus A. Educational session: managing chronic myeloid leukemia as a chronic disease. Hematol Am Soc Hematol Educ Program. 2011;2011:128\u201335.","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"1474_CR15","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/leu.2009.168","volume":"23","author":"MC Muller","year":"2009","unstructured":"Muller MC, Cross NC, Erben P, Schenk T, Hanfstein B, Ernst T, et al. Harmonization of molecular monitoring of CML therapy in Europe. Leukemia. 2009;23:1957\u201363.","journal-title":"Leukemia"},{"issue":"122","key":"1474_CR16","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","volume":"8","author":"M Baccarani","year":"2013","unstructured":"Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013;8(122):872\u201384.","journal-title":"Blood"},{"key":"1474_CR17","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1080\/10428190412331272721","volume":"45","author":"S Kikuchi","year":"2004","unstructured":"Kikuchi S, Muroi K, Takahashi S, Kawano-Yamamoto C, Takatoku M, Miyazato A, et al. Severe hepatitis and complete molecular response caused by imatinib mesylate: possible association of its serum concentration with clinical outcomes. Leuk Lymphoma. 2004;45:2349\u201351.","journal-title":"Leuk Lymphoma"},{"key":"1474_CR18","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1158\/1078-0432.CCR-07-0346","volume":"13","author":"NP Erp van","year":"2007","unstructured":"van Erp NP, Gelderblom H, Karlsson MO, Li J, Zhao M, Ouwerkerk J, et al. Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib. Clin Cancer Res. 2007;13:7394\u2013400.","journal-title":"Clin Cancer Res"},{"key":"1474_CR19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1200\/JCO.2007.11.0304","volume":"26","author":"RK Ramanathan","year":"2008","unstructured":"Ramanathan RK, Egorin MJ, Takimoto CH, Remick SC, Doroshow JH, LoRusso PA, et al. Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group. J Clin Oncol. 2008;26:563\u20139.","journal-title":"J Clin Oncol"},{"key":"1474_CR20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1182\/blood-2011-08-376087","volume":"119","author":"HM Kantarjian","year":"2012","unstructured":"Kantarjian HM, Shah NP, Cortes JE, Baccarani M, Agarwal MB, Undurraga MS, et al. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood. 2012;119:1123\u20139.","journal-title":"Blood"},{"key":"1474_CR21","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1002\/cncr.24504","volume":"115","author":"H Kantarjian","year":"2009","unstructured":"Kantarjian H, Pasquini R, L\u00e9vy V, Jootar S, Holowiecki J, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: two-year follow-up of a randomized phase study (START-R). Cancer. 2009;115:4136\u201347.","journal-title":"Cancer"},{"key":"1474_CR22","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1182\/blood-2006-09-047266","volume":"109","author":"A Hochhaus","year":"2007","unstructured":"Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood. 2007;109:2303\u20139.","journal-title":"Blood"},{"key":"1474_CR23","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1161\/CIRCULATIONAHA.111.079921","volume":"125","author":"D Montani","year":"2012","unstructured":"Montani D, Bergot E, G\u00fcnther S, Savale L, Bergeron A, Bourdin A, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation. 2012;125:2128\u201337.","journal-title":"Circulation"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-013-1474-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-013-1474-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-013-1474-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T05:11:15Z","timestamp":1559452275000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-013-1474-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["1474"],"URL":"https:\/\/doi.org\/10.1007\/s12185-013-1474-x","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}