{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:05:54Z","timestamp":1787763954517,"version":"build-2784847793"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"HKU Seed Funding Programme for Basic Research","award":["200811159211"],"award-info":[{"award-number":["200811159211"]}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["02132436"],"award-info":[{"award-number":["02132436"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s12185-016-2075-2","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T11:07:11Z","timestamp":1471345631000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo"],"prefix":"10.1007","volume":"105","author":[{"given":"Yuk Man","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Fan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Chong","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray Kit","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"2075_CR1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MOP.0000000000000065","volume":"26","author":"MC Yoder","year":"2014","unstructured":"Yoder MC. Cord blood banking and transplantation: advances and controversies. Curr Opin Pediatr. 2014;26:163\u20138.","journal-title":"Curr Opin Pediatr"},{"key":"2075_CR2","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1207285","volume":"367","author":"M Lima de","year":"2012","unstructured":"de Lima M, McNiece I, Robinson SN, Munsell M, Eapen M, Horowitz M, et al. Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med. 2012;367:2305\u201315.","journal-title":"N Engl J Med"},{"key":"2075_CR3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/sj.bmt.1705258","volume":"37","author":"SN Robinson","year":"2006","unstructured":"Robinson SN, Ng J, Niu T, Yang H, McMannis JD, Karandish S, et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant. 2006;37:359\u201366.","journal-title":"Bone Marrow Transplant"},{"key":"2075_CR4","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1182\/blood.V87.4.1261.bloodjournal8741261","volume":"87","author":"DL DiGiusto","year":"1996","unstructured":"DiGiusto DL, Lee R, Moon J, Moss K, O\u2019Toole T, Voytovich A, et al. Hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood progenitor cells evaluated in vitro and in vivo. Blood. 1996;87:1261\u201371.","journal-title":"Blood"},{"key":"2075_CR5","first-page":"166","volume":"90","author":"K Levac","year":"2005","unstructured":"Levac K, Karanu F, Bhatia M. Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica. 2005;90:166\u201372.","journal-title":"Haematologica"},{"key":"2075_CR6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/bbmt.2002.v8.pm12171483","volume":"8","author":"EJ Shpall","year":"2002","unstructured":"Shpall EJ, Quinones R, Giller R, Zeng C, Baron AE, Jones RB, et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant. 2002;8:368\u201376.","journal-title":"Biol Blood Marrow Transplant"},{"key":"2075_CR7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nm.2080","volume":"16","author":"C Delaney","year":"2010","unstructured":"Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16:232\u20136.","journal-title":"Nat Med"},{"key":"2075_CR8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.bmt.1705538","volume":"39","author":"CC Hofmeister","year":"2007","unstructured":"Hofmeister CC, Zhang J, Knight KL, Le P, Stiff PJ. Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant. 2007;39:11\u201323.","journal-title":"Bone Marrow Transplant"},{"key":"2075_CR9","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1182\/blood-2001-12-0290","volume":"101","author":"J Jaroscak","year":"2003","unstructured":"Jaroscak J, Goltry K, Smith A, Waters-Pick B, Martin PL, Driscoll TA, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. Blood. 2003;101:5061\u20137.","journal-title":"Blood"},{"key":"2075_CR10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/sj.bmt.1702222","volume":"25","author":"AL Pecora","year":"2000","unstructured":"Pecora AL, Stiff P, Jennis A, Goldberg S, Rosenbluth R, Price P, et al. Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplant. 2000;25:797\u20139.","journal-title":"Bone Marrow Transplant"},{"key":"2075_CR11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","volume":"128","author":"PA Jones","year":"2007","unstructured":"Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683\u201392.","journal-title":"Cell"},{"key":"2075_CR12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.exphem.2005.10.002","volume":"34","author":"H Araki","year":"2006","unstructured":"Araki H, Mahmud N, Milhem M, Nunez R, Xu M, Beam CA, et al. Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol. 2006;34:140\u20139.","journal-title":"Exp Hematol"},{"key":"2075_CR13","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1182\/blood-2006-07-035287","volume":"109","author":"H Araki","year":"2007","unstructured":"Araki H, Yoshinaga K, Boccuni P, Zhao Y, Hoffman R, Mahmud N. Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. Blood. 2007;109:3570\u20138.","journal-title":"Blood"},{"key":"2075_CR14","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1172\/JCI70313","volume":"124","author":"P Chaurasia","year":"2014","unstructured":"Chaurasia P, Gajzer DC, Schaniel C, D\u2019Souza S, Hoffman R. Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest. 2014;124:2378\u201395.","journal-title":"J Clin Invest"},{"key":"2075_CR15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.bbmt.2013.12.562","volume":"20","author":"N Mahmud","year":"2014","unstructured":"Mahmud N, Petro B, Baluchamy S, Li X, Taioli S, Lavelle D, et al. Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem\/progenitor cells. Biol Blood Marrow Transplant. 2014;20:480\u20139.","journal-title":"Biol Blood Marrow Transplant"},{"key":"2075_CR16","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.2174\/092986707782023271","volume":"14","author":"AF Holloway","year":"2007","unstructured":"Holloway AF, Oakford PC. Targeting epigenetic modifiers in cancer. Curr Med Chem. 2007;14:2540\u20137.","journal-title":"Curr Med Chem"},{"key":"2075_CR17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/leu.2010.276","volume":"25","author":"A Quintas-Cardama","year":"2011","unstructured":"Quintas-Cardama A, Santos FP, Garcia-Manero G. Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia. Leukemia. 2011;25:226\u201335.","journal-title":"Leukemia"},{"key":"2075_CR18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ajh.20273","volume":"78","author":"TE Coyle","year":"2005","unstructured":"Coyle TE, Bair AK, Stein C, Vajpayee N, Mehdi S, Wright J. Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? Am J Hematol. 2005;78:256\u201360.","journal-title":"Am J Hematol"},{"key":"2075_CR19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","volume":"150","author":"MA Dawson","year":"2012","unstructured":"Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12\u201327.","journal-title":"Cell"},{"key":"2075_CR20","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1038\/sj.onc.1204639","volume":"20","author":"PM Ayton","year":"2001","unstructured":"Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene. 2001;20:5695\u2013707.","journal-title":"Oncogene"},{"key":"2075_CR21","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood.V90.12.4699","volume":"90","author":"K Ida","year":"1997","unstructured":"Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, et al. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood. 1997;90:4699\u2013704.","journal-title":"Blood"},{"key":"2075_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2014.04.008","volume":"68","author":"WC Lui","year":"2014","unstructured":"Lui WC, Chan YF, Chan LC, Ng RK. Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic stem cells. Cytokine. 2014;68:127\u201332.","journal-title":"Cytokine"},{"key":"2075_CR23","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1158\/1541-7786.MCR-11-0220","volume":"9","author":"A Borriello","year":"2011","unstructured":"Borriello A, Caldarelli I, Bencivenga D, Criscuolo M, Cucciolla V, Tramontano A, et al. p57(Kip2) and cancer: time for a critical appraisal. Mol Cancer Res. 2011;9:1269\u201384.","journal-title":"Mol Cancer Res"},{"key":"2075_CR24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2119\/2007-00084.Bokelmann","volume":"14","author":"I Bokelmann","year":"2008","unstructured":"Bokelmann I, Mahlknecht U. Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol Med. 2008;14:20\u20137.","journal-title":"Mol Med"},{"key":"2075_CR25","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0145-2126(01)00151-5","volume":"26","author":"R Kawagoe","year":"2002","unstructured":"Kawagoe R, Kawagoe H, Sano K. Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways. Leuk Res. 2002;26:495\u2013502.","journal-title":"Leuk Res"},{"key":"2075_CR26","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.exphem.2007.06.014","volume":"35","author":"L Lagneaux","year":"2007","unstructured":"Lagneaux L, Gillet N, Stamatopoulos B, Delforge A, Dejeneffe M, Massy M, et al. Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response. Exp Hematol. 2007;35:1527\u201337.","journal-title":"Exp Hematol"},{"key":"2075_CR27","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1182\/blood-2005-05-2003","volume":"106","author":"HJ Lawrence","year":"2005","unstructured":"Lawrence HJ, Christensen J, Fong S, Hu YL, Weissman I, Sauvageau G, et al. Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood. 2005;106:3988\u201394.","journal-title":"Blood"},{"key":"2075_CR28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1182\/blood.V99.1.121","volume":"99","author":"U Thorsteinsdottir","year":"2002","unstructured":"Thorsteinsdottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, et al. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 2002;99:121\u20139.","journal-title":"Blood"},{"key":"2075_CR29","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1128\/MCB.00545-09","volume":"29","author":"YL Hu","year":"2009","unstructured":"Hu YL, Fong S, Ferrell C, Largman C, Shen WF. HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis. Mol Cell Biol. 2009;29:5181\u201392.","journal-title":"Mol Cell Biol"},{"key":"2075_CR30","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.1073\/pnas.1402238111","volume":"111","author":"C Collins","year":"2014","unstructured":"Collins C, Wang J, Miao H, Bronstein J, Nawer H, Xu T, et al. C\/EBPalpha is an essential collaborator in Hoxa9\/Meis1-mediated leukemogenesis. Proc Natl Acad Sci USA. 2014;111:9899\u2013904.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2075_CR31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1084\/jem.20130932","volume":"211","author":"E Ohlsson","year":"2014","unstructured":"Ohlsson E, Hasemann MS, Willer A, Lauridsen FK, Rapin N, Jendholm J, et al. Initiation of MLL-rearranged AML is dependent on C\/EBPalpha. J Exp Med. 2014;211:5\u201313.","journal-title":"J Exp Med"},{"key":"2075_CR32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nrc3536","volume":"13","author":"MH Barcellos-Hoff","year":"2013","unstructured":"Barcellos-Hoff MH, Lyden D, Wang TC. The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer. 2013;13:511\u20138.","journal-title":"Nat Rev Cancer"},{"key":"2075_CR33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1182\/blood-2007-03-080523","volume":"110","author":"M Heuser","year":"2007","unstructured":"Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110:1639\u201347.","journal-title":"Blood"},{"key":"2075_CR34","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1093\/emboj\/cdg315","volume":"22","author":"OH Kramer","year":"2003","unstructured":"Kramer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, et al. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J. 2003;22:3411\u201320.","journal-title":"EMBO J"},{"key":"2075_CR35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3324\/haematol.2013.092643","volume":"99","author":"MR Heideman","year":"2014","unstructured":"Heideman MR, Lancini C, Proost N, Yanover E, Jacobs H, Dannenberg JH. Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis. Haematologica. 2014;99:1292\u2013303.","journal-title":"Haematologica"},{"key":"2075_CR36","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1172\/JCI60806","volume":"123","author":"AR Summers","year":"2013","unstructured":"Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, et al. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Investig. 2013;123:3112\u201323.","journal-title":"J Clin Investig"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2075-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-016-2075-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2075-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2075-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T02:04:42Z","timestamp":1657073082000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-016-2075-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,16]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["2075"],"URL":"https:\/\/doi.org\/10.1007\/s12185-016-2075-2","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,16]]}}}