{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:44:59Z","timestamp":1764783899253,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ck0106064h0002"],"award-info":[{"award-number":["15ck0106064h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s12185-016-2137-5","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T07:50:49Z","timestamp":1479196249000},"page":"335-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia"],"prefix":"10.1007","volume":"105","author":[{"given":"Makiko","family":"Morita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Nishinaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Saida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kamikubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Heike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsutoshi","family":"Nakahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souichi","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"2137_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.immunol.22.012703.104753","volume":"22","author":"S Wong","year":"2004","unstructured":"Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu Rev Immunol. 2004;22:247\u2013306.","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"2137_CR2","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1182\/blood-2008-02-140665","volume":"112","author":"K Porkka","year":"2008","unstructured":"Porkka K, Koskenvesa P, Lundan T, Rimpilainen J, Mustjoki S, Smykla R, et al. Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. Blood. 2008;112(4):1005\u201312.","journal-title":"Blood"},{"issue":"6","key":"2137_CR3","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1182\/blood-2010-12-326843","volume":"119","author":"A Hamilton","year":"2012","unstructured":"Hamilton A, Helgason GV, Schemionek M, Zhang B, Myssina S, Allan EK, et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood. 2012;119(6):1501\u201310.","journal-title":"Blood"},{"issue":"11","key":"2137_CR4","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nrc1738","volume":"5","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, J\u00e4\u00e4ttel\u00e4 M. Lysosomes and autophagy in cell death control. Nat Rev Cancer. 2005;5(11):886\u201397.","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"2137_CR5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrm2245","volume":"8","author":"DJ Klionsky","year":"2007","unstructured":"Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8(11):931\u20137.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2137_CR6","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1182\/blood-2003-05-1605","volume":"103","author":"M Okada","year":"2004","unstructured":"Okada M, Adachi S, Imai T, Watanabe K, Toyokuni S, Ueno M, et al. A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity. Blood. 2004;103(6):2299\u2013307.","journal-title":"Blood"},{"issue":"5","key":"2137_CR7","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1172\/JCI35660","volume":"119","author":"C Bellodi","year":"2009","unstructured":"Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest. 2009;119(5):1109\u201323.","journal-title":"J Clin Invest"},{"issue":"8","key":"2137_CR8","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1182\/blood-2011-01-330621","volume":"118","author":"GV Helgason","year":"2011","unstructured":"Helgason GV, Karvela M, Holyoake TL. Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML. Blood. 2011;118(8):2035\u201343.","journal-title":"Blood"},{"issue":"1","key":"2137_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1189\/jlb.4A0813-422RRR","volume":"98","author":"H Itoh","year":"2015","unstructured":"Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, et al. Enhancement of neutrophil autophagy by an IVIG preparation against multidrug-resistant bacteria as well as drug-sensitive strains. J Leukoc Biol. 2015;98(1):107\u201317.","journal-title":"J Leukoc Biol"},{"issue":"9","key":"2137_CR10","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","volume":"100","author":"M Ito","year":"2002","unstructured":"Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, et al. NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100(9):3175\u201382.","journal-title":"Blood"},{"issue":"3","key":"2137_CR11","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1182\/blood-2002-09-2755","volume":"102","author":"H Hiramatsu","year":"2003","unstructured":"Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K, et al. Complete reconstitution of human lymphocytes from cord blood CD34+\u00a0cells using the NOD\/SCID\/gammacnull mice model. Blood. 2003;102(3):873\u201380.","journal-title":"Blood"},{"issue":"11","key":"2137_CR12","doi-asserted-by":"publisher","first-page":"e27042","DOI":"10.1371\/journal.pone.0027042","volume":"6","author":"I Kato","year":"2011","unstructured":"Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, et al. Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1\/CXCR4 axis. PLoS One. 2011;6(11):e27042.","journal-title":"PLoS One"},{"issue":"5","key":"2137_CR13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/ajh.23419","volume":"88","author":"P Simara","year":"2013","unstructured":"Simara P, Stejskal S, Koutna I, Potesil D, Tesarova L, Potesilova M, et al. Apoptosis in chronic myeloid leukemia cells transiently treated with imatinib or dasatinib is caused by residual BCR\u2014ABL kinase inhibition. Am J Hematol. 2013;88(5):385\u201393.","journal-title":"Am J Hematol"},{"issue":"20","key":"2137_CR14","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1182\/blood-2013-05-499970","volume":"123","author":"MTS Williams","year":"2014","unstructured":"Williams MTS, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, et al. Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood. 2014;123(20):3116\u201327.","journal-title":"Blood"},{"issue":"3","key":"2137_CR15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1182\/blood-2010-09-307330","volume":"118","author":"M Holland","year":"2011","unstructured":"Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, et al. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 2011;118(3):638\u201349.","journal-title":"Blood"},{"issue":"11","key":"2137_CR16","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/cdd.2008.107","volume":"15","author":"Y Kamitsuji","year":"2008","unstructured":"Kamitsuji Y, Kuroda J, Kimura S, Toyokuni S, Watanabe K, Ashihara E, et al. The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias. Cell Death Differ. 2008;15(11):1712\u201322.","journal-title":"Cell Death Differ"},{"issue":"6","key":"2137_CR17","doi-asserted-by":"publisher","first-page":"e0129663","DOI":"10.1371\/journal.pone.0129663","volume":"10","author":"B Chen","year":"2015","unstructured":"Chen B, Xu X, Luo J, Wang H, Zhou S. Rapamycin enhances the anti-cancer effect of dasatinib by suppressing Src\/PI3\u00a0K\/mTOR pathway in NSCLC Cells. PLoS One. 2015;10(6):e0129663.","journal-title":"PLoS One"},{"issue":"12","key":"2137_CR18","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1182\/blood-2003-03-0960","volume":"102","author":"BZ Carter","year":"2003","unstructured":"Carter BZ, Kornblau SM, Tsao T, Wang RY, Schober WD, Milella M, et al. Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood. 2003;102(12):4179\u201386.","journal-title":"Blood"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2137-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-016-2137-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2137-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T09:55:30Z","timestamp":1589450130000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-016-2137-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["2137"],"URL":"https:\/\/doi.org\/10.1007\/s12185-016-2137-5","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"type":"print","value":"0925-5710"},{"type":"electronic","value":"1865-3774"}],"subject":[],"published":{"date-parts":[[2016,11,15]]},"assertion":[{"value":"13 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}