{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:25:34Z","timestamp":1759962334762},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s12185-016-2175-z","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T11:08:20Z","timestamp":1485860900000},"page":"668-675","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever"],"prefix":"10.1007","volume":"105","author":[{"given":"Jesus","family":"Reyna-Figueroa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Lagunas-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Galindo-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Fernanda","family":"Fern\u00e1ndez-Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Guadalupe","family":"Castro-Oteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Mart\u00ednez-Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Melchy","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Rosenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Elena","family":"Lim\u00f3n-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Javier","family":"Ortiz-Ibarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Madrid-Marina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"2175_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1189\/jlb.0105017","volume":"78","author":"D Wesche","year":"2005","unstructured":"Wesche D, Lomas NJ, Perl M, Shiang C, Ayala A. Leukocyte apoptosis and its significance in sepsis shock. J Leukoc Biol. 2005;78:325\u201337.","journal-title":"J Leukoc Biol"},{"key":"2175_CR2","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1046\/j.1365-2044.2000.01554.x","volume":"55","author":"P Kam","year":"2000","unstructured":"Kam P, Ferch N. Apoptosis: mechanism and clinical implications. Anaesthesia. 2000;55:1081\u201398.","journal-title":"Anaesthesia"},{"issue":"3","key":"2175_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/carcin\/21.3.485","volume":"21","author":"S Lowe","year":"2000","unstructured":"Lowe S, Lin A. Apoptosis in cancer. Carcinogenesis. 2000;21(3):485\u201395.","journal-title":"Carcinogenesis"},{"key":"2175_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1756-9966-30-87","volume":"30","author":"R Wong","year":"2011","unstructured":"Wong R. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Res. 2011;30:87.","journal-title":"J Exp Clin Res"},{"key":"2175_CR5","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1096\/fj.00-058rev","volume":"15","author":"C Oberholzer","year":"2001","unstructured":"Oberholzer C, Oberholzer A, Clare-Salzler M, Moldawer L. Apoptosis in sepsis: a new target for therapeutic exploration. Faseb J. 2001;15:879\u201392.","journal-title":"Faseb J"},{"key":"2175_CR6","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2007.04.031","volume":"129","author":"M Peter","year":"2007","unstructured":"Peter M, Budd R, Desbarats J, Hedrick S, Hueber A, Karen M, et al. The CD95 receptor: apoptosis revisited. Cell. 2007;129:447\u201350.","journal-title":"Cell"},{"key":"2175_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4049\/jimmunol.181.1.5","volume":"181","author":"J Vick","year":"2008","unstructured":"Vick J. First demonstration of the role of tnf in the pathogenesis of disease. J Immunol. 2008;181:5\u20136.","journal-title":"J Immunol"},{"key":"2175_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1189\/jlb.0102006","volume":"74","author":"SC Chun","year":"2003","unstructured":"Chun SC, Song G, Lomas J, Simms H, Chaudry I, Ayala A. Inhibition of Fas\/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol. 2003;74:344\u201351.","journal-title":"J Leukoc Biol"},{"key":"2175_CR9","first-page":"35","volume":"43","author":"L Dougthy","year":"1998","unstructured":"Dougthy L, Clark R, Carcillo J. Soluble Fas receptor and Fas ligand in sepsis-induced multiple organ failure. Pediatr Res. 1998;43:35.","journal-title":"Pediatr Res"},{"key":"2175_CR10","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1378\/chest.125.6.2238","volume":"125","author":"I Freitas De","year":"2004","unstructured":"De Freitas I, Fernandez SM, Essenfeld SA, Cardier J. Serum levels of the apoptosis-associated molecules, tumor necrosis factor \u03b1\/tumor necrosis factor type-1 receptor and Fas\/FasL, in sepsis. Chest. 2004;125:2238\u201346.","journal-title":"Chest"},{"key":"2175_CR11","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1164\/ajrccm.163.6.16362a","volume":"163","author":"M Konstadoulakis","year":"2001","unstructured":"Konstadoulakis M, Messaris E. Are cancer patients adequate candidates for studying apoptosis in septic and ARDS models? Am J Resp Crit Care Med. 2001;163:1501.","journal-title":"Am J Resp Crit Care Med"},{"key":"2175_CR12","doi-asserted-by":"crossref","unstructured":"Regueira T, Andresen M, Djafarzadeh S. Disfunci\u00f3n mitocondrial en sepsis, impacto y posible papel regulador del factor inducible por hipoxia (HIF-1alfa). Med Intensiv (revista en la internet). 2009 (citado 2015 Mayo 13) 33(8):385\u201392. http:\/\/scielo.isciii.es\/scielo.php?script=sci_arttext&pid=S0210-56912009000800004&lng=es .","DOI":"10.1016\/j.medin.2008.10.002"},{"key":"2175_CR13","doi-asserted-by":"publisher","unstructured":"Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013; 50(1):23\u201336.","DOI":"10.3109\/10408363.2013.764490"},{"issue":"1","key":"2175_CR14","first-page":"46","volume":"113","author":"FJ Reyna","year":"2015","unstructured":"Reyna FJ, Lagunas MA, Mart\u00ednez MP, Madrid MV. Procalcitonin as a diagnostic biomarker of sepsis in children with cancer, fever and neutropenia: literature review. Arch Argent Pediatr. 2015;113(1):46\u201352.","journal-title":"Arch Argent Pediatr"},{"key":"2175_CR15","doi-asserted-by":"publisher","unstructured":"Dhainaut JF, Claessens YE, Janes J, Nelson D. Underlying disorders and their impact on the host response to infection. CID 2005; 41(Suppl 7):S481\u20139.","DOI":"10.1086\/432001"},{"issue":"5","key":"2175_CR16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/CDLI.5.1.28-32.1998","volume":"1","author":"U Sack","year":"1998","unstructured":"Sack U, Burkhardt U, Borte M, Schadlich H, Berg K, Emmrich F. Age-dependent levels of select immunological mediators in sera of healthy children. Clin Diagn Lab Immunol. 1998;1(5):28\u201332.","journal-title":"Clin Diagn Lab Immunol"},{"issue":"1","key":"2175_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4067\/S0716-10182015000200014","volume":"37","author":"FJ Reyna","year":"2015","unstructured":"Reyna FJ, Lagunas MA, Fern\u00e1ndez BMF, Ortiz IFJ, Madrid MV. Sepsis en el ni\u00f1o con c\u00e1ncer: problemas en su identificaci\u00f3n y retos para su disminuci\u00f3n. Rev Chilena Infectol. 2015;37(1):97\u2013104.","journal-title":"Rev Chilena Infectol"},{"key":"2175_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1749-6632.1997.tb46207.x","volume":"824","author":"D Schuler","year":"1997","unstructured":"Schuler D, Szende B. Apoptosis and acute lymphotic leukemia in children. Ann N Y Acad Sci. 1997;824:28\u201337.","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"2175_CR19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.leukres.2011.08.005","volume":"36","author":"Q Wu","year":"2012","unstructured":"Wu Q, Chen H, Xie W, Hong M, Xia L. Elevated Fas\/FasL system and endotelial cell microparticles are involved in endotelial damage in acute graft-versus-host diseases: a clinical analysis. Leuk Res. 2012;36(3):275\u201380.","journal-title":"Leuk Res"},{"issue":"277","key":"2175_CR20","first-page":"2","volume":"19","author":"C Santos dos","year":"2015","unstructured":"dos Santos C. Shedding metaboligth on the search for sepsis biokmarkers. Crit Care. 2015;19(277):2\u20133.","journal-title":"Crit Care"},{"key":"2175_CR21","doi-asserted-by":"publisher","unstructured":"Oberholzer C, Oberholzer A, Clare C, Moldawer I. Apoptosis in sepsis: a new target for therapeutic exploration Faseb J 2001; 15:879\u201392.","DOI":"10.1096\/fj.00-058rev"},{"key":"2175_CR22","first-page":"155","volume":"8","author":"RP Rastogi","year":"2009","unstructured":"Rastogi RP, Sinha R, Sinha RP. Apoptosis: molecular mechanisms and pathogenicity. EXCLI J. 2009;8:155\u201381.","journal-title":"EXCLI J"},{"issue":"4","key":"2175_CR23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","volume":"7","author":"T Aoyagi","year":"2015","unstructured":"Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol. 2015;7(4):17\u201329.","journal-title":"World J Gastrointest Oncol"},{"issue":"4","key":"2175_CR24","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.it.2015.02.006","volume":"36","author":"SB Coffelt","year":"2015","unstructured":"Coffelt SB, de Visser KE. Immune-mediated mechanisms influencing the efficacy of anticancer therapies. Trends Immunol. 2015;36(4):198\u2013216.","journal-title":"Trends Immunol"},{"key":"2175_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/1110-1067.124843","volume":"39","author":"N Nosair","year":"2014","unstructured":"Nosair N, Abd El Bar E, Taha A, Gawaly A. Fas (CD95) expression as a prognostic marker in acute leukemia and blastic transformation phase in chronic myeloid leukemia. Egypt J Hematol. 2014;39:25\u201331.","journal-title":"Egypt J Hematol"},{"key":"2175_CR26","doi-asserted-by":"crossref","unstructured":"Papathanassoglou ED, Mpouzika MD, Giannakopoulou M, Bozas E, Middleton N, Boti S, Karabinis A. Pilot investigation of the association between serum stress neuropeptide levels and lymphocyte expression of Fas and Fas ligand in critical illness. Biol Res Nurs. 2014 (Epub ahead of print).","DOI":"10.1177\/1099800414542871"},{"key":"2175_CR27","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1016\/0090-1229(92)90036-N","volume":"62","author":"CE Spooner","year":"1992","unstructured":"Spooner CE, Markowitz NP, Saravolatz LD. The role of tumor necrosis factor in sepsis Clin Immunol Immunopathol. 1992;62:S11\u20137.","journal-title":"The role of tumor necrosis factor in sepsis Clin Immunol Immunopathol"},{"issue":"5","key":"2175_CR28","doi-asserted-by":"publisher","first-page":"e1000879","DOI":"10.1371\/journal.ppat.1000879","volume":"6","author":"MW Vliet Van","year":"2010","unstructured":"Van Vliet MW, Hermie JM, Harmsen H. The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 2010;6(5):e1000879.","journal-title":"PLoS Pathog"},{"key":"2175_CR29","doi-asserted-by":"crossref","unstructured":"Lin CW, Lo S, Hsu C, Hsieh CH, Chang YF, Hou BS, et al. T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis. PLoS One. 2014; 16 9(7):e102066.","DOI":"10.1371\/journal.pone.0102066"},{"issue":"3","key":"2175_CR30","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1093\/sleep\/33.3.319","volume":"33","author":"D Gozal","year":"2010","unstructured":"Gozal D, Serpero L, Kheirandish L, Sans O, Khalyfa A, Tauman R. Sleep measures and morning plasma TNF-\u03b1 levels in children with sleep-disordered breathing. Sleep. 2010;33(3):319\u201325.","journal-title":"Sleep"},{"issue":"1","key":"2175_CR31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1210\/jc.2009-0435","volume":"95","author":"M Tsaoussoglou","year":"2010","unstructured":"Tsaoussoglou M, Bixler E, Calhoun S, Chrousos G, Sauder K, Vgontzas A. Sleep-disordered breathing in obese children is associated with prevalent excessive daytime sleepiness, inflamation, and metabolic abnormalities. J Clin Endocrinol Metab. 2010;95(1):143\u201350.","journal-title":"J Clin Endocrinol Metab"},{"key":"2175_CR32","first-page":"335","volume":"29","author":"BA Cunha","year":"2004","unstructured":"Cunha BA. Fever in malignant disorders. Infect Dis Pract. 2004;29:335\u20136.","journal-title":"Infect Dis Pract"},{"key":"2175_CR33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/sj.cdd.4400823","volume":"8","author":"GN Barber","year":"2001","unstructured":"Barber GN. Host defense, viruses and apoptosis. Cell Death Differ. 2001;8:113\u201326.","journal-title":"Cell Death Differ"},{"key":"2175_CR34","doi-asserted-by":"publisher","unstructured":"O\u00b4Brien V. Viruses and apoptosis J Gen Virol 1998, 79:1833\u201345.","DOI":"10.1099\/0022-1317-79-8-1833"},{"key":"2175_CR35","doi-asserted-by":"publisher","unstructured":"Fransson J, Tornberg UC, Borrebaeck CA, Carlsson R, Frend\u00e9us B. Rapid induction of apoptosis in B-cell lymphoma by functionally isolated human antibodies. Int J Cancer 2006; 119(2):349\u201358.","DOI":"10.1002\/ijc.21829"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2175-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-016-2175-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-016-2175-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T06:30:44Z","timestamp":1601533844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-016-2175-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["2175"],"URL":"https:\/\/doi.org\/10.1007\/s12185-016-2175-z","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}