{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:00:05Z","timestamp":1774476005759,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Ministry of Health, Labor, and Welfare"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12185-017-2323-0","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T19:03:07Z","timestamp":1504724587000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction"],"prefix":"10.1007","volume":"107","author":[{"given":"Hirokazu","family":"Kurahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Numoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-2857","authenticated-orcid":false,"given":"Akihisa","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"2323_CR1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.48.1.182","volume":"48","author":"A Beydoun","year":"1997","unstructured":"Beydoun A, Sackellares JC, Shu V. Safety and efficacy of divalproate sodium monotherapy in partial epilepsy: a double-blind, concentration\u2013response design clinical trial. Neurology. 1997;48:182\u20138.","journal-title":"Neurology"},{"key":"2323_CR2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1528-1167.2007.01429.x","volume":"49","author":"W Nasreddine","year":"2008","unstructured":"Nasreddine W, Beydoun A. Valproate-induced thrombocytopenia: a prospective monotherapy study. Epilepsia. 2008;49:438\u201345.","journal-title":"Epilepsia"},{"key":"2323_CR3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2004.04987.x","volume":"126","author":"C Briggs","year":"2004","unstructured":"Briggs C, Kunka S, Hart D, Oguni S, Machin SJ. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol. 2004;126:93\u20139.","journal-title":"Br J Haematol"},{"key":"2323_CR4","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1515\/cclm-2013-0252","volume":"51","author":"L Meintker","year":"2013","unstructured":"Meintker L, Haimerl M, Ringwald J, Krause SW. Measurement of immature platelets with Abbott CD-Sapphire and Sysmex XE-5000 in haematology and oncology patients. Clin Chem Lab Med. 2013;51:2125\u201332.","journal-title":"Clin Chem Lab Med"},{"key":"2323_CR5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/pbc.22907","volume":"57","author":"G Strau\u00df","year":"2011","unstructured":"Strau\u00df G, Vollert C, von Stackelberg A, Weimann A, Gaedicke G, Schulze H. Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatr Blood Cancer. 2011;57:641\u20137.","journal-title":"Pediatr Blood Cancer"},{"key":"2323_CR6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2141.2008.07485.x","volume":"144","author":"M Cremer","year":"2009","unstructured":"Cremer M, Paetzold J, Schmalisch G, Hammer H, Loui A, Dame C, et al. Immature platelet fraction as novel laboratory parameter predicting the course of neonatal thrombocytopenia. Br J Haematol. 2009;144:619\u201321.","journal-title":"Br J Haematol"},{"key":"2323_CR7","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/pbc.24484","volume":"60","author":"LW Have","year":"2013","unstructured":"Have LW, Hasle H, Vestergaard EM, Kjaersgaard M. Absolute immature platelet count may predict imminent platelet recovery in thrombocytopenic children following chemotherapy. Pediatr Blood Cancer. 2013;60:1198\u2013203.","journal-title":"Pediatr Blood Cancer"},{"key":"2323_CR8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3109\/09537104.2014.969220","volume":"26","author":"AA Adly","year":"2015","unstructured":"Adly AA, Ragab IA, Ismail EA, Farahat MM. Evaluation of the immature platelet fraction in the diagnosis and prognosis of childhood immune thrombocytopenia. Platelets. 2015;26:645\u201350.","journal-title":"Platelets"},{"key":"2323_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/2249-4847.123095","volume":"2","author":"S Yuko","year":"2013","unstructured":"Yuko S, Takeda T, Hirota A, Hisaeda Y, Amakata S, Nakao A, et al. Examination of the percentage of immature platelet fraction in term and preterm infants at birth. J Clin Neonatol. 2013;2:173\u20138.","journal-title":"J Clin Neonatol"},{"key":"2323_CR10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","volume":"30","author":"Commission on Classification and Terminology of the International","year":"1989","unstructured":"Commission on Classification and Terminology of the International. League against epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389\u201399.","journal-title":"Epilepsia"},{"key":"2323_CR11","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/jclinpath-2012-200930","volume":"65","author":"C Briggs","year":"2012","unstructured":"Briggs C, Longair I, Kumar P, Singh D, Machin SJ. Performance evaluation of the Sysmex haematology XN modular system. J Clin Pathol. 2012;65:1024\u201330.","journal-title":"J Clin Pathol"},{"key":"2323_CR12","doi-asserted-by":"crossref","first-page":"e85465","DOI":"10.1371\/journal.pone.0085465","volume":"9","author":"H Hong","year":"2014","unstructured":"Hong H, Xiao W, Maitta RW. Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage. PLoS One. 2014;9:e85465.","journal-title":"PLoS One"},{"key":"2323_CR13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/trf.12912","volume":"55","author":"H Hong","year":"2015","unstructured":"Hong H, Xiao W, Stempak LM, Sandhaus LM, Maitta RW. Absolute immature platelet count dynamics in diagnosing and monitoring the clinical course of thrombotic thrombocytopenic purpura. Transfusion. 2015;55:756\u201365.","journal-title":"Transfusion"},{"key":"2323_CR14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"R Kanda","year":"2013","unstructured":"Kanda R. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"2323_CR15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.jcp.0000088911.24613.0d","volume":"23","author":"D Berardis De","year":"2003","unstructured":"De Berardis D, Campanella D, Matera V, Gambi F, La Rovere R, Sepede G, et al. Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder. J Clin Psychopharmacol. 2003;23:451\u20138.","journal-title":"J Clin Psychopharmacol"},{"key":"2323_CR16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0887-8994(96)00052-5","volume":"14","author":"IN Allarakhia","year":"1996","unstructured":"Allarakhia IN, Garofalo EA, Komarynski MA, Robertson PL. Valproic acid and thrombocytopenia in children: a case-controlled retrospective study. Pediatr Neurol. 1996;14:303\u20137.","journal-title":"Pediatr Neurol"},{"key":"2323_CR17","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1111\/epi.12952","volume":"56","author":"ML Zighetti","year":"2015","unstructured":"Zighetti ML, Fontana G, Lussana F, Chiesa V, Vignoli A, Canevini MP, et al. Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis. Epilepsia. 2015;56:e49\u201352.","journal-title":"Epilepsia"},{"key":"2323_CR18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1176\/appi.ajp.158.1.128","volume":"158","author":"TJ Trannel","year":"2001","unstructured":"Trannel TJ, Ahmed I, Goebert D. Occurrence of thrombocytopenia in psychiatric patients taking valproate. Am J Psychiatry. 2001;158:128\u201330.","journal-title":"Am J Psychiatry"},{"key":"2323_CR19","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3109\/09537104.2010.513748","volume":"21","author":"N Schweinfurth","year":"2010","unstructured":"Schweinfurth N, Hohmann S, Deuschle M, Lederbogen F, Schloss P. Valproic acid and all trans retinoic acid differentially induce megakaryopoiesis and platelet-like particle formation from the megakaryoblastic cell line MEG-01. Platelets. 2010;21:648\u201357.","journal-title":"Platelets"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-017-2323-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-017-2323-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-017-2323-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T12:48:16Z","timestamp":1513774096000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-017-2323-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2323"],"URL":"https:\/\/doi.org\/10.1007\/s12185-017-2323-0","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]}}}