{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:32:09Z","timestamp":1793295129179,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T00:00:00Z","timestamp":1540598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T00:00:00Z","timestamp":1540598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2019,2,20]]},"DOI":"10.1007\/s12185-018-2552-x","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T03:00:31Z","timestamp":1540609231000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epstein\u2013Barr virus-related diffuse large B-cell lymphoma in mogamulizumab-treated adult T-cell leukemia with incomplete T-cell reconstitution"],"prefix":"10.1007","volume":"109","author":[{"given":"Kazuharu","family":"Kamachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-6151","authenticated-orcid":false,"given":"Takero","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Kitaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadasu","family":"Shin-I","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,27]]},"reference":[{"issue":"4","key":"2552_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/S1473-3099(07)70081-6","volume":"7","author":"K Verdonck","year":"2007","unstructured":"Verdonck K, Gonzalez E, Van Dooren S, Vandamme AM, Vanham G, Gotuzzo E. Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect Dis. 2007;7(4):266\u201381.","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"2552_CR2","first-page":"639","volume":"78","author":"T Katsuki","year":"1987","unstructured":"Katsuki T, Katsuki K, Imai J, Hinuma Y. Immune suppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-I): impairment of T-cell control of Epstein-Barr virus-infected B-cells. Jpn J Cancer Res. 1987;78(7):639\u201342.","journal-title":"Jpn J Cancer Res"},{"issue":"1","key":"2552_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1440-1827.1998.tb03831.x","volume":"48","author":"Y Sadahira","year":"1998","unstructured":"Sadahira Y, Nishihara H, Shimizu M, Hirokawa M, Wada H, Yamada O, et al. Epstein-Barr virus-associated Hodgkin\u2019s disease in HTLV-I seropositive patients: a report of two cases. Pathol Int. 1998;48(1):67\u201373.","journal-title":"Pathol Int"},{"issue":"10","key":"2552_CR4","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1182\/blood.V97.10.3177","volume":"97","author":"J Yasunaga","year":"2001","unstructured":"Yasunaga J, Sakai T, Nosaka K, Etoh K, Tamiya S, Koga S, et al. Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state. Blood. 2001;97(10):3177\u201383.","journal-title":"Blood"},{"issue":"2","key":"2552_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/intimm\/dxh366","volume":"18","author":"S Chen","year":"2006","unstructured":"Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, Ndhlovu LC, et al. Regulatory T cell-like activity of Foxp3 + adult T cell leukemia cells. Int Immunol. 2006;18(2):269\u201377.","journal-title":"Int Immunol"},{"issue":"8","key":"2552_CR6","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1200\/JCO.2011.37.3472","volume":"30","author":"T Ishida","year":"2012","unstructured":"Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol. 2012;30(8):837\u201342.","journal-title":"J Clin Oncol"},{"key":"2552_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.21037\/sci.2016.09.13","volume":"3","author":"S Fuji","year":"2016","unstructured":"Fuji S, Shindo T. Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia\/lymphoma. Stem Cell Investig. 2016;3:70.","journal-title":"Stem Cell Investig"},{"issue":"8","key":"2552_CR8","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1158\/2326-6066.CIR-15-0303","volume":"4","author":"H Ureshino","year":"2016","unstructured":"Ureshino H, Shindo T, Nishikawa H, Watanabe N, Watanabe E, Satoh H, et al. Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T-cell leukemia. Cancer Immunol Res. 2016;4(8):644\u20139.","journal-title":"Cancer Immunol Res"},{"issue":"3","key":"2552_CR9","doi-asserted-by":"publisher","first-page":"e1405204","DOI":"10.1080\/2162402X.2017.1405204","volume":"7","author":"T Shindo","year":"2017","unstructured":"Shindo T, Kitaura K, Ureshino H, Kamachi K, Miyahara M, Doi K, et al. Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. Oncoimmunol. 2017;7(3):e1405204.","journal-title":"Oncoimmunol"},{"issue":"11","key":"2552_CR10","first-page":"1741","volume":"18","author":"MH Ellman","year":"1991","unstructured":"Ellman MH, Hurwitz H, Thomas C, Kozloff M. Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol. 1991;18(11):1741\u20133.","journal-title":"J Rheumatol"},{"issue":"5","key":"2552_CR11","doi-asserted-by":"publisher","first-page":";529","DOI":"10.1002\/ajh.24370","volume":"91","author":"JJ Castillo","year":"2016","unstructured":"Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM. EBV-positive diffuse large B-cell lymphoma of the elderly: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol. 2016;91(5):;529\u201337.","journal-title":"Am J Hematol"},{"key":"2552_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00277-013-1765-6","volume":"93","author":"Y Ohyama","year":"2014","unstructured":"Ohyama Y, Kumode T, Eguchi G, Yamaguchi T, Maeda Y. Induction of molecular remission by using anti-CC-chemokine receptor 4 (anti-CCR4) antibodies for adult T cell leukemia: a risk of opportunistic infection after treatment with anti-CCR4 antibodies. Ann Hematol. 2014;93:169\u201371.","journal-title":"Ann Hematol"},{"key":"2552_CR13","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s12185-015-1750-z","volume":"101","author":"H Totani","year":"2015","unstructured":"Totani H, Kusumoto S, Ishida T, Masuda A, Yoshida T, Ito A, et al. Reactivation of hepatitis B virus (HBV) infection in adult T-cell leukemia-lymphoma patients with resolved HBV infection following systemic chemotherapy. Int J Hematol. 2015;101:398\u2013404.","journal-title":"Int J Hematol"},{"issue":"20","key":"2552_CR14","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.2169\/internalmedicine.8781-16","volume":"56","author":"H Tanaka","year":"2017","unstructured":"Tanaka H, Aoki H, Sugita Y, Shimizu R, Kiko K, Mochida H, et al. Development of Epstein-Barr Virus-related primary diffuse large B-cell lymphoma of the central nervous system in a patient with peripheral T-cell lymphoma, not otherwise specified after mogamulizumab treatment. Intern Med. 2017;56(20):2759\u201363.","journal-title":"Intern Med"},{"issue":"1","key":"2552_CR15","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12865-016-0177-5","volume":"17","author":"K Kitaura","year":"2016","unstructured":"Kitaura K, Shini T, Matsutani T, Suzuki R. A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) \u03b1 and \u03b2 repertoires and identifying potential new invariant TCR \u03b1 chains. BMC Immunol. 2016;17(1):38.","journal-title":"BMC Immunol"},{"issue":"65","key":"2552_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/1097-0142(19900115)65:2<327::AID-CNCR2820650224>3.0.CO;2-W","volume":"15","author":"T Teshima","year":"1990","unstructured":"Teshima T, Akashi K, Shibuya T, Taniguchi S, Okamura T, Harada M, et al. Central nervous system involvement in adult T-cell leukemia\/lymphoma. Cancer. 1990;15(65):327\u201332.","journal-title":"Cancer"},{"key":"2552_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0925-5710(95)00350-2","volume":"61","author":"C Kawasaki","year":"1995","unstructured":"Kawasaki C, Ikeda H, Fukumoto T. Cerebral mass lesions associated with adult T-cell leukemia\/lymphoma. Int J Hematol. 1995;61:97\u2013102.","journal-title":"Int J Hematol"},{"key":"2552_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1750-9378-4-10","volume":"4","author":"B Beltran","year":"2009","unstructured":"Beltran B, Salas R, Quinons P, Morales D, Hurtado F, Cotrina E, et al. EBV-positive diffuse large B-cell lymphoma in a human T-lymphotropic virus type 1 carrier. Infect Agent Cancer. 2009;4:10.","journal-title":"Infect Agent Cancer"},{"key":"2552_CR19","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/0145-2126(91)90468-9","volume":"15","author":"K Tobinai","year":"1991","unstructured":"Tobinai K, Ohtsu T, Hayashi M, Kinoshita T, Matsuno Y, Mukai K, et al. Epstein-Barr virus (EBV) genome carrying monoclonal B-cell lymphoma in a patient with adult T-cell leukemia-lymphoma. Leuk Res. 1991;15:837\u201346.","journal-title":"Leuk Res"},{"key":"2552_CR20","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1346-8138.2010.01120.x","volume":"38","author":"M Amano","year":"2011","unstructured":"Amano M, Marutsuka K, Sugimoto T, Todaka T, Setoyama M. Epstein-Barr virus-associated primary central nervous system lymphoma in a patient with adult T-cell leukemia\/lymphoma. J Dermatol. 2011;38:575\u201380.","journal-title":"J Dermatol"},{"issue":"4","key":"2552_CR21","doi-asserted-by":"publisher","first-page":";1458","DOI":"10.1182\/blood.V99.4.1458","volume":"99","author":"K Talvensaari","year":"2002","unstructured":"Talvensaari K, Clave E, Douay C, Rabian C, Garderet L, Busson M, et al. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood. 2002;99(4):;1458\u201364.","journal-title":"Blood"},{"key":"2552_CR22","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.4049\/jimmunol.1302064","volume":"192","author":"OV Britanova","year":"2014","unstructured":"Britanova OV, Putintseva EV, Shugay M, Merzlyak EM, Turchaninova MA, Staroverov DB, et al. Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling. J Immunol. 2014;192:2689\u201398.","journal-title":"J Immunol"},{"key":"2552_CR23","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.3389\/fmicb.2016.02111","volume":"7","author":"W Tu","year":"2016","unstructured":"Tu W, Rao S. Mechanisms Underlying T cell immunosenescence: aging and cytomegalovirus infection. Front Microbiol. 2016;7:2111.","journal-title":"Front Microbiol."},{"key":"2552_CR24","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1084\/jem.20071140","volume":"205","author":"EJ Yager","year":"2008","unstructured":"Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med. 2008;205:711\u201323.","journal-title":"J Exp Med"},{"key":"2552_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/neup.12435","volume":"38","author":"Y Sugita","year":"2018","unstructured":"Sugita Y, Furuta T, Ohshima K, Komaki S, Miyoshi J, Morioka M, et al. The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: the role of programmed cell death 1 and programmed cell death ligand 1. Neuropathology. 2018;38:125\u201334.","journal-title":"Neuropathology"},{"key":"2552_CR26","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3899\/jrheum.140533","volume":"42","author":"A Hashimoto","year":"2015","unstructured":"Hashimoto A, Chiba N, Tsuno H, Komiya A, Furukawa H, Matsui T, et al. Incidence of malignancy and the risk of lymphoma in Japanese patients with rheumatoid arthritis compared to the general population. J Rheumatol. 2015;42:564\u201371.","journal-title":"J Rheumatol"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-018-2552-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-018-2552-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-018-2552-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T12:15:41Z","timestamp":1659096941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-018-2552-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,27]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,20]]}},"alternative-id":["2552"],"URL":"https:\/\/doi.org\/10.1007\/s12185-018-2552-x","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,27]]},"assertion":[{"value":"23 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author(s) declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}