{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:15:27Z","timestamp":1792444527096,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s12185-019-02726-7","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T07:02:55Z","timestamp":1566198175000},"page":"591-598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of Survivin and Cyclin D1 in chronic myeloid leukemia cells"],"prefix":"10.1007","volume":"110","author":[{"given":"Kenta","family":"Moriyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-1406","authenticated-orcid":false,"given":"Toshiyuki","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"2726_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s12185-018-2519-y","volume":"108","author":"A Inoue","year":"2018","unstructured":"Inoue A, Kobayashi CI, Shinohara H, Miyamoto K, Yamauchi N, Yuda J, et al. Chronic myeloid leukemia stem cells and molecular target therapies for overcoming resistance and disease persistence. Int J Hematol. 2018;108:365\u201370.","journal-title":"Int J Hematol"},{"key":"2726_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00277-015-2325-z","volume":"94","author":"B Chereda","year":"2015","unstructured":"Chereda B, Melo JV. Natural course and biology of CML. Ann Hematol. 2015;94:107\u201321.","journal-title":"Ann Hematol"},{"key":"2726_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/emmm.201000062","volume":"2","author":"A Hoelbl","year":"2010","unstructured":"Hoelbl A, Schuster C, Kovacic B, Zhu B, Wickre M, Hoelzl MA, et al. Stat5 is indispensable for the maintenance of bcr\/abl -positive leukaemia: stat5 in leukaemia maintenance. EMBO Mol Med. 2010;2:98\u2013110.","journal-title":"EMBO Mol Med"},{"key":"2726_CR4","doi-asserted-by":"publisher","first-page":"5868","DOI":"10.1038\/sj.onc.1205724","volume":"21","author":"A Klejman","year":"2002","unstructured":"Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene. 2002;21:5868\u201376.","journal-title":"Oncogene"},{"key":"2726_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S1535-6108(02)00074-0","volume":"1","author":"M Sattler","year":"2002","unstructured":"Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, et al. Critical role for Gab2 in transformation by BCR\/ABL. Cancer Cell. 2002;1:479\u201392.","journal-title":"Cancer Cell"},{"key":"2726_CR6","doi-asserted-by":"publisher","first-page":"8075","DOI":"10.1038\/sj.onc.1206008","volume":"21","author":"MB Wilson","year":"2002","unstructured":"Wilson MB, Schreiner SJ, Choi H-J, Kamens J, Smithgall TE. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002;21:8075\u201388.","journal-title":"Oncogene"},{"key":"2726_CR7","doi-asserted-by":"publisher","first-page":"ra18","DOI":"10.1126\/scisignal.2001314","volume":"4","author":"L Rubbi","year":"2011","unstructured":"Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, et al. Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling src signaling. Sci Signal. 2011;4:ra18.","journal-title":"Sci Signal"},{"key":"2726_CR8","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"B Zhao","year":"2011","unstructured":"Zhao B, Tumaneng K, Guan K-L. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011;13:877\u201383.","journal-title":"Nat Cell Biol"},{"key":"2726_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14228","volume":"519","author":"K Taniguchi","year":"2015","unstructured":"Taniguchi K, Wu L-W, Grivennikov SI, de Jong PR, Lian I, Yu F-X, et al. A gp130\u2013Src\u2013YAP module links inflammation to epithelial regeneration. Nature. 2015;519:57\u201362.","journal-title":"Nature"},{"key":"2726_CR10","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1101\/gad.274951.115","volume":"30","author":"P Li","year":"2016","unstructured":"Li P, Silvis MR, Honaker Y, Lien W-H, Arron ST, Vasioukhin V. \u03b1E-catenin inhibits a Src\u2013YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway. Genes Dev. 2016;30:798\u2013811.","journal-title":"Genes Dev"},{"key":"2726_CR11","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1073\/pnas.1620290114","volume":"114","author":"K Taniguchi","year":"2017","unstructured":"Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, et al. YAP\u2013IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci. 2017;114:1643\u20138.","journal-title":"Proc Natl Acad Sci"},{"key":"2726_CR12","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1158\/1541-7786.MCR-18-0158","volume":"16","author":"T Sugihara","year":"2018","unstructured":"Sugihara T, Werneburg NW, Hernandez MC, Yang L, Kabashima A, Hirsova P, et al. YAP tyrosine phosphorylation and nuclear localization in cholangiocarcinoma cells are regulated by LCK and independent of LATS activity. Mol Cancer Res. 2018;16:1556\u201367.","journal-title":"Mol Cancer Res"},{"key":"2726_CR13","doi-asserted-by":"publisher","first-page":"9540","DOI":"10.1073\/pnas.92.21.9540","volume":"92","author":"DE Afar","year":"1995","unstructured":"Afar DE, McLaughlin J, Sherr CJ, Witte ON, Roussel MF. Signaling by ABL oncogenes through cyclin D1. Proc Natl Acad Sci. 1995;92:9540\u20134.","journal-title":"Proc Natl Acad Sci"},{"key":"2726_CR14","doi-asserted-by":"publisher","first-page":"8224","DOI":"10.1158\/0008-5472.CAN-05-0303","volume":"65","author":"Z Wang","year":"2005","unstructured":"Wang Z, Sampath J, Fukuda S, Pelus LM. Disruption of the Inhibitor of apoptosis protein survivin sensitizes Bcr-abl\u2013Positive cells to STI571-induced apoptosis. Cancer Res. 2005;65:8224\u201332.","journal-title":"Cancer Res"},{"key":"2726_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/sj.leu.2403999","volume":"20","author":"J Rangatia","year":"2006","unstructured":"Rangatia J, Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia. 2006;20:68\u201376.","journal-title":"Leukemia"},{"key":"2726_CR16","doi-asserted-by":"publisher","first-page":"181ra52","DOI":"10.1126\/scitranslmed.3004387","volume":"5","author":"Y Saito","year":"2013","unstructured":"Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, et al. A pyrrolo-pyrimidine derivative targets human primary aml stem cells in vivo. Sci Transl Med. 2013;5:181ra52.","journal-title":"Sci Transl Med"},{"key":"2726_CR17","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1182\/blood.V97.7.1999","volume":"97","author":"Y Kano","year":"2001","unstructured":"Kano Y. In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents. Blood. 2001;97:1999\u20132007.","journal-title":"Blood"},{"key":"2726_CR18","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jcp.1041400219","volume":"140","author":"T Kitamura","year":"1989","unstructured":"Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol. 1989;140:323\u201334.","journal-title":"J Cell Physiol"},{"key":"2726_CR19","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.exphem.2007.03.007","volume":"35","author":"L Gu","year":"2007","unstructured":"Gu L, Chiang K-Y, Zhu N, Findley HW, Zhou M. Contribution of STAT3 to the activation of survivin by GM-CSF in CD34\u2009+\u2009cell lines. Exp Hematol. 2007;35:957\u201366.","journal-title":"Exp Hematol"},{"key":"2726_CR20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1093\/carcin\/bgq254","volume":"32","author":"T Muramatsu","year":"2011","unstructured":"Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, et al. YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis. 2011;32:389\u201398.","journal-title":"Carcinogenesis"},{"key":"2726_CR21","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1158\/0008-5472.CAN-14-3396","volume":"75","author":"W Zhang","year":"2015","unstructured":"Zhang W, Gao Y, Li F, Tong X, Ren Y, Han X, et al. YAP promotes malignant progression of Lkb1 -deficient lung adenocarcinoma through downstream regulation of survivin. Cancer Res. 2015;75:4450\u20137.","journal-title":"Cancer Res"},{"key":"2726_CR22","doi-asserted-by":"publisher","first-page":"5117","DOI":"10.1038\/onc.2012.5","volume":"31","author":"T Mizuno","year":"2012","unstructured":"Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene. 2012;31:5117\u201322.","journal-title":"Oncogene"},{"key":"2726_CR23","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1016\/j.cub.2015.09.072","volume":"25","author":"N Vlahov","year":"2015","unstructured":"Vlahov N, Scrace S, Soto MS, Grawenda AM, Bradley L, Pankova D, et al. Alternate RASSF1 transcripts control src activity, E-cadherin contacts, and YAP-mediated invasion. Curr Biol. 2015;25:3019\u201334.","journal-title":"Curr Biol"},{"key":"2726_CR24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","volume":"29","author":"D Levy","year":"2008","unstructured":"Levy D, Adamovich Y, Reuven N, Shaul Y. Yap1 phosphorylation by c-Abl Is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell. 2008;29:350\u201361.","journal-title":"Mol Cell"},{"key":"2726_CR25","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/ng1343","volume":"36","author":"Y Hu","year":"2004","unstructured":"Hu Y, Liu Y, Pelletier S, Buchdunger E, Warmuth M, Fabbro D, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet. 2004;36:453\u201361.","journal-title":"Nat Genet"},{"key":"2726_CR26","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1038\/s41375-018-0111-3","volume":"32","author":"E Donato","year":"2018","unstructured":"Donato E, Biagioni F, Bisso A, Caganova M, Amati B, Campaner S. YAP and TAZ are dispensable for physiological and malignant haematopoiesis. Leukemia. 2018;32:2037\u201340.","journal-title":"Leukemia"},{"key":"2726_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0414-z","author":"H Li","year":"2016","unstructured":"Li H, Huang Z, Gao M, Huang N, Luo Z, Shen H, et al. Inhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo. J Exp Clin Cancer Res. 2016. \n                    https:\/\/doi.org\/10.1186\/s13046-016-0414-z\n                    \n                  .","journal-title":"J Exp Clin Cancer Res"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02726-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-019-02726-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02726-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T23:45:10Z","timestamp":1597707910000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-019-02726-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,19]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["2726"],"URL":"https:\/\/doi.org\/10.1007\/s12185-019-02726-7","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,19]]},"assertion":[{"value":"3 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"We declare that we have no competing interests in this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}