{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:42:19Z","timestamp":1785901339687,"version":"3.56.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16ek0109099"],"award-info":[{"award-number":["16ek0109099"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16ek0109098h0002"],"award-info":[{"award-number":["16ek0109098h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12185-019-02738-3","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T14:25:18Z","timestamp":1571235918000},"page":"131-136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis"],"prefix":"10.1007","volume":"111","author":[{"given":"Motoshi","family":"Sonoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-6566","authenticated-orcid":false,"given":"Masataka","family":"Ishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhide","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirosuke","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"issue":"1","key":"2738_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1053\/j.semperi.2007.01.003","volume":"31","author":"DW Kimberlin","year":"2007","unstructured":"Kimberlin DW. Herpes simplex virus infections of the newborn. Semin Perinatol. 2007;31(1):19\u201325.","journal-title":"Semin Perinatol"},{"issue":"4","key":"2738_CR2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.blre.2014.03.002","volume":"28","author":"GE Janka","year":"2014","unstructured":"Janka GE, Lehmberg K. Hemophagocytic syndromes\u2014an update. Blood Rev. 2014;28(4):135\u201342.","journal-title":"Blood Rev"},{"issue":"3","key":"2738_CR3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1086\/422325","volume":"190","author":"J Kawada","year":"2004","unstructured":"Kawada J, Kimura H, Ito Y, Ando Y, Tanaka-Kitajima N, Hayakawa M, et al. Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection. J Infect Dis. 2004;190(3):494\u20138.","journal-title":"J Infect Dis"},{"issue":"2","key":"2738_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jpeds.2009.02.050","volume":"155","author":"N Suzuki","year":"2009","unstructured":"Suzuki N, Morimoto A, Ohga S, Kudo K, Ishida Y, Ishii E. Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan. J Pediatr. 2009;155(2):235\u20138.","journal-title":"J Pediatr"},{"issue":"2","key":"2738_CR5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12185-018-02572-z","volume":"109","author":"R Yanagisawa","year":"2019","unstructured":"Yanagisawa R, Nakazawa Y, Matsuda K, Yasumi T, Kanegane H, Ohga S, et al. Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan. Int J Hematol. 2019;109(2):206\u201313.","journal-title":"Int J Hematol"},{"key":"2738_CR6","first-page":"146","volume":"9","author":"M Nakayama","year":"2017","unstructured":"Nakayama M, Oda H, Nakagawa K, Yasumi T, Kawai T, Izawa K, et al. Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq. Biochem Biophys Rep. 2017;9:146\u201352.","journal-title":"Biochem Biophys Rep"},{"issue":"3","key":"2738_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1442-200X.2011.03428.x","volume":"54","author":"K Kojima","year":"2012","unstructured":"Kojima K, Takahashi N, Yada Y, Koike Y, Matano M, Kono Y, et al. White-matter damage in a neonate with disseminated herpes simplex virus infection. Pediatr Int. 2012;54(3):409\u201312.","journal-title":"Pediatr Int"},{"issue":"1","key":"2738_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1620\/tjem.214.1","volume":"214","author":"K Yamada","year":"2008","unstructured":"Yamada K, Yamamoto Y, Uchiyama A, Ito R, Aoki Y, Uchida Y, et al. Successful treatment of neonatal herpes simplex-type 1 infection complicated by hemophagocytic lymphohistiocytosis and acute liver failure. Tohoku J Exp Med. 2008;214(1):1\u20135.","journal-title":"Tohoku J Exp Med"},{"issue":"2","key":"2738_CR9","first-page":"e89","volume":"5","author":"S Maeba","year":"2015","unstructured":"Maeba S, Hasegawa S, Shimomura M, Ichimura T, Takahashi K, Motoyama M, et al. Successful treatment of corticosteroid with antiviral therapy for a neonatal liver failure with disseminated herpes simplex virus infection. AJP Rep. 2015;5(2):e89\u201392.","journal-title":"AJP Rep"},{"issue":"5","key":"2738_CR10","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/ped.12817","volume":"58","author":"K Otsubo","year":"2016","unstructured":"Otsubo K, Fukumura A, Hirayama M, Morimoto T, Kato M, Mochizuki H. Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: successful treatment with dexamethasone palmitate. Pediatr Int. 2016;58(5):390\u20133.","journal-title":"Pediatr Int"},{"issue":"5","key":"2738_CR11","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1442-200X.2011.03421.x","volume":"53","author":"Y Wada","year":"2011","unstructured":"Wada Y, Kai M, Tanaka H, Shimizu N, Shimatani M, Oshima T. Computed tomography findings of the liver in a neonate with Herpes simplex virus-associated hemophagocytic lymphohistiocytosis. Pediatr Int. 2011;53(5):773\u20136.","journal-title":"Pediatr Int"},{"issue":"3","key":"2738_CR12","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1093\/jpids\/piv005","volume":"4","author":"IA Vladescu","year":"2015","unstructured":"Vladescu IA, Browning WL, Thomsen IP. Massive ferritin elevation in neonatal herpes simplex virus infection: hemophagocytic lymphohistiocytosis or herpes simplex virus alone? J Pediatric Infect Dis Soc. 2015;4(3):e48\u201352.","journal-title":"J Pediatric Infect Dis Soc"},{"key":"2738_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fped.2016.00077","volume":"4","author":"ES Halstead","year":"2016","unstructured":"Halstead ES, Rajasekaran S, Fitzgerald JC, Weiss SL. Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention? Front Pediatr. 2016;4:77.","journal-title":"Front Pediatr"},{"issue":"2","key":"2738_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48(2):124\u201331.","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"2738_CR15","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/bjh.13461","volume":"170","author":"T Yasumi","year":"2015","unstructured":"Yasumi T, Hori M, Hiejima E, Shibata H, Izawa K, Oda H, et al. Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis. Br J Haematol. 2015;170(4):532\u20138.","journal-title":"Br J Haematol"},{"issue":"5","key":"2738_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00431-005-1636-9","volume":"164","author":"S Imashuku","year":"2005","unstructured":"Imashuku S, Ueda I, Teramura T, Mori K, Morimoto A, Sako M, et al. Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients. Eur J Pediatr. 2005;164(5):315\u20139.","journal-title":"Eur J Pediatr"},{"issue":"1","key":"2738_CR17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/eji.200636945","volume":"38","author":"MA Fernandez","year":"2008","unstructured":"Fernandez MA, Evans IAC, Hassan EH, Carbone FR, Jones CA. Neonatal CD8(+) T cells are slow to develop into lytic effectors after HSV infection in vivo. Eur J Immunol. 2008;38(1):102\u201313.","journal-title":"Eur J Immunol"},{"issue":"5","key":"2738_CR18","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1086\/427339","volume":"191","author":"EA Kurt-Jones","year":"2005","unstructured":"Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, Chan M, et al. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005;191(5):746\u20138.","journal-title":"J Infect Dis"},{"key":"2738_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jns.2016.11.034","volume":"372","author":"R Verma","year":"2017","unstructured":"Verma R, Bharti K. Toll like receptor 3 and viral infections of nervous system. J Neurol Sci. 2017;372:40\u20138.","journal-title":"J Neurol Sci"},{"issue":"10","key":"2738_CR20","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1084\/jem.20101568","volume":"208","author":"Y Guo","year":"2011","unstructured":"Guo Y, Audry M, Ciancanelli M, Alsina L, Azevedo J, Herman M, et al. Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity. J Exp Med. 2011;208(10):2083\u201398.","journal-title":"J Exp Med"},{"issue":"5844","key":"2738_CR21","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1126\/science.1139522","volume":"317","author":"SY Zhang","year":"2007","unstructured":"Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, Romero P, et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science. 2007;317(5844):1522\u20137.","journal-title":"Science"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02738-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-019-02738-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02738-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T23:25:32Z","timestamp":1600730732000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-019-02738-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2738"],"URL":"https:\/\/doi.org\/10.1007\/s12185-019-02738-3","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,23]]},"assertion":[{"value":"7 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare they have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}