{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:59:01Z","timestamp":1767142741376,"version":"build-2238731810"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08351"],"award-info":[{"award-number":["18K08351"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08321"],"award-info":[{"award-number":["18K08321"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12185-019-02741-8","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T05:09:27Z","timestamp":1569388167000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning"],"prefix":"10.1007","volume":"111","author":[{"name":"The Nagoya Blood and Marrow Transplantation Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-8046","authenticated-orcid":false,"given":"Seitaro","family":"Terakura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Onizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yachiyo","family":"Kuwatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiyasu","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Miyamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Naoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"2741_CR1","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1182\/blood.V89.8.3055","volume":"89","author":"JT Slattery","year":"1997","unstructured":"Slattery JT, Clift RA, Buckner CD, Radich J, Storer B, Bensinger WI, et al. Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation. Blood. 1997;89:3055\u201360.","journal-title":"Blood"},{"key":"2741_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2165\/00003088-200039020-00005","volume":"39","author":"JS McCune","year":"2000","unstructured":"McCune JS, Gibbs JP, Slattery JT. Plasma concentration monitoring of busulfan: does it improve clinical outcome? Clin Pharmacokinet. 2000;39:155\u201365.","journal-title":"Clin Pharmacokinet"},{"key":"2741_CR3","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.bbmt.2007.03.012","volume":"13","author":"JS McCune","year":"2007","unstructured":"McCune JS, Batchelder A, Deeg HJ, Gooley T, Cole S, Phillips B, et al. Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality. Biol Blood Marrow Transplant. 2007;13:853\u201362.","journal-title":"Biol Blood Marrow Transplant"},{"key":"2741_CR4","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1111\/j.1349-7006.2012.02342.x","volume":"103","author":"Y Kuwatsuka","year":"2012","unstructured":"Kuwatsuka Y, Kohno A, Terakura S, Saito S, Shimada K, Yasuda T, et al. Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy. Cancer Sci. 2012;103:1688\u201394.","journal-title":"Cancer Sci"},{"key":"2741_CR5","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/sj.onc.1209373","volume":"25","author":"CC McIlwain","year":"2006","unstructured":"McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene. 2006;25:1639\u201348.","journal-title":"Oncogene"},{"key":"2741_CR6","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/sj.onc.1209377","volume":"25","author":"C Rodriguez-Antona","year":"2006","unstructured":"Rodriguez-Antona C, Ingelman-Sundberg M. Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006;25:1679\u201391.","journal-title":"Oncogene"},{"key":"2741_CR7","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1056\/NEJM199810223391701","volume":"339","author":"T Sasazuki","year":"1998","unstructured":"Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med. 1998;339:1177\u201385.","journal-title":"N Engl J Med"},{"key":"2741_CR8","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1182\/blood.V99.11.4200","volume":"99","author":"Y Morishima","year":"2002","unstructured":"Morishima Y, Sasazuki T, Inoko H, Juji T, Akaza T, Yamamoto K, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200\u20136.","journal-title":"Blood"},{"key":"2741_CR9","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"2741_CR10","first-page":"250","volume":"28","author":"KM Sullivan","year":"1991","unstructured":"Sullivan KM, Agura E, Anasetti C, Appelbaum F, Badger C, Bearman S, et al. Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol. 1991;28:250\u20139.","journal-title":"Semin Hematol"},{"key":"2741_CR11","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","volume":"44","author":"RJ Jones","year":"1987","unstructured":"Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation. 1987;44:778\u201383.","journal-title":"Transplantation"},{"key":"2741_CR12","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3414\/ME11-01-0071","volume":"51","author":"H Tsuruta","year":"2012","unstructured":"Tsuruta H, Fukumoto M, Bax L, Kohno A, Morishita Y. Limited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method. Methods Inf Med. 2012;51:383\u201394.","journal-title":"Methods Inf Med"},{"key":"2741_CR13","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.bmt.1705257","volume":"37","author":"S Terakura","year":"2006","unstructured":"Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Morishima Y, et al. Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Bone Marrow Transplant. 2006;37:381\u20136.","journal-title":"Bone Marrow Transplant"},{"key":"2741_CR14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2165\/00129785-200202030-00005","volume":"2","author":"MM Shi","year":"2002","unstructured":"Shi MM. Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes. Am J Pharmacogenom. 2002;2:197\u2013205.","journal-title":"Am J Pharmacogenom"},{"key":"2741_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00008571-200204000-00010","volume":"12","author":"CR Lee","year":"2002","unstructured":"Lee CR, Goldstein JA, Pieper JA. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. 2002;12:251\u201363.","journal-title":"Pharmacogenetics"},{"key":"2741_CR16","doi-asserted-by":"publisher","first-page":"913","DOI":"10.2165\/00003088-200241120-00002","volume":"41","author":"Z Desta","year":"2002","unstructured":"Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet. 2002;41:913\u201358.","journal-title":"Clin Pharmacokinet"},{"key":"2741_CR17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"DR Cox","year":"1972","unstructured":"Cox DR. Regression models and life-tables. J R Stat Soc Ser B (Methodological). 1972;34:187\u2013220.","journal-title":"J R Stat Soc Ser B (Methodological)"},{"key":"2741_CR18","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496\u2013509.","journal-title":"J Am Stat Assoc"},{"key":"2741_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cca.2005.12.011","volume":"368","author":"M Kusama","year":"2006","unstructured":"Kusama M, Kubota T, Matsukura Y, Matsuno K, Ogawa S, Kanda Y, et al. Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfan. Clin Chim Acta. 2006;368:93\u20138.","journal-title":"Clin Chim Acta"},{"key":"2741_CR20","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.bbmt.2010.12.708","volume":"17","author":"SD Kim","year":"2011","unstructured":"Kim SD, Lee JH, Hur EH, Lee JH, Kim DY, Lim SN, et al. Influence of GST gene polymorphisms on the clearance of intravenous busulfan in adult patients undergoing hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2011;17:1222\u2013300.","journal-title":"Biol Blood Marrow Transplant"},{"key":"2741_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/00008571-199710000-00011","volume":"7","author":"K Nasu","year":"1997","unstructured":"Nasu K, Kubota T, Ishizaki T. Genetic analysis of CYP2C9 polymorphism in a Japanese population. Pharmacogenetics. 1997;7:405\u20139.","journal-title":"Pharmacogenetics"},{"key":"2741_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1097\/FPC.0b013e328045c4fb","volume":"17","author":"M Nakajima","year":"2007","unstructured":"Nakajima M, Komagata S, Fujiki Y, Kanada Y, Ebi H, Itoh K, et al. Genetic polymorphisms of CYP2B6 affect the pharmacokinetics\/pharmacodynamics of cyclophosphamide in Japanese cancer patients. Pharmacogenet Genom. 2007;17:431\u201345.","journal-title":"Pharmacogenet Genom"},{"key":"2741_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0009-8981(03)00200-6","volume":"333","author":"A Pastore","year":"2003","unstructured":"Pastore A, Federici G, Bertini E, Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 2003;333:19\u201339.","journal-title":"Clin Chim Acta"},{"key":"2741_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.clnu.2012.10.008","volume":"32","author":"SA Dello","year":"2013","unstructured":"Dello SA, Neis EP, de Jong MC, van Eijk HM, Kicken CH, Olde Damink SW, et al. Systematic review of ophthalmate as a novel biomarker of hepatic glutathione depletion. Clin Nutr. 2013;32:325\u201330.","journal-title":"Clin Nutr"},{"key":"2741_CR25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.beha.2008.02.002","volume":"21","author":"A Tichelli","year":"2008","unstructured":"Tichelli A, Gratwohl A. Vascular endothelium as 'novel' target of graft-versus-host disease. Best Pract Res Clin Haematol. 2008;21:139\u201348.","journal-title":"Best Pract Res Clin Haematol"},{"key":"2741_CR26","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12185-019-02684-0","volume":"110","author":"T Takachi","year":"2019","unstructured":"Takachi T, Arakawa Y, Nakamura H, Watanabe T, Aoki Y, Ohshima J, et al. Personalized pharmacokinetic targeting with busulfan in allogeneic hematopoietic stem cell transplantation in infants with acute lymphoblastic leukemia. Int J Hematol. 2019;110:355\u201363.","journal-title":"Int J Hematol"},{"key":"2741_CR27","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1182\/blood-2003-11-3778","volume":"104","author":"A Srivastava","year":"2004","unstructured":"Srivastava A, Poonkuzhali B, Shaji RV, George B, Mathews V, Chandy M, et al. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004;104:1574\u20137.","journal-title":"Blood"},{"key":"2741_CR28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","volume":"45","author":"JD Hayes","year":"2005","unstructured":"Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51\u201388.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"228\u201342","key":"2741_CR29","first-page":"e6","volume":"28","author":"T Habtetsion","year":"2018","unstructured":"Habtetsion T, Ding ZC, Pi W, Li T, Lu C, Chen T, et al. Alteration of tumor metabolism by CD4+ T cells leads to TNF-alpha-dependent intensification of oxidative stress and tumor cell death. Cell Metab. 2018;28(228\u201342):e6.","journal-title":"Cell Metab"}],"updated-by":[{"DOI":"10.1007\/s12185-019-02783-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000}}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12185-019-02741-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-019-02741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T20:54:08Z","timestamp":1721768048000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12185-019-02741-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2741"],"URL":"https:\/\/doi.org\/10.1007\/s12185-019-02741-8","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"19 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2019","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original article of Terakura et al., the COI disclosure were missing.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}