{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:58:15Z","timestamp":1786982295527,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s12185-020-03067-6","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T10:02:35Z","timestamp":1609495355000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-7074","authenticated-orcid":false,"given":"Norimichi","family":"Hattori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misuzu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Uesugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Watanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Uto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Phillip","family":"Koeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Iezumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"3067_CR1","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1182\/blood.2018894618","volume":"133","author":"P La Ros\u00e9e","year":"2019","unstructured":"La Ros\u00e9e P, Horne A, Hines M, von Bahr GT, Machowicz R, Berliner N, et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019;133:2465\u201377.","journal-title":"Blood"},{"key":"3067_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.blre.2016.05.001","volume":"30","author":"A Hayden","year":"2016","unstructured":"Hayden A, Park S, Giustini D, Lee AY, Chen LY. Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: a systematic scoping review. Blood Rev. 2016;30:411\u201320.","journal-title":"Blood Rev"},{"key":"3067_CR3","first-page":"29","volume":"18","author":"JI Henter","year":"1991","unstructured":"Henter JI, Elinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society. Semin Oncol. 1991;18:29\u201333.","journal-title":"Semin Oncol."},{"key":"3067_CR4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0925-5710(96)00560-9","volume":"65","author":"H Tsuda","year":"1997","unstructured":"Tsuda H. Hemophagocytic syndrome (HPS) in children and adults. Int J Hematol. 1997;65:215\u201326.","journal-title":"Int J Hematol"},{"key":"3067_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0925-5710(97)00584-7","volume":"66","author":"S Imashuku","year":"1997","unstructured":"Imashuku S. Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment. Int J Hematol. 1997;66:135\u201351.","journal-title":"Int J Hematol"},{"key":"3067_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/bmt.2011.95","volume":"47","author":"N Imahashi","year":"2012","unstructured":"Imahashi N, Inamoto Y, Ito M, Koyama D, Goto T, Onodera K, et al. Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT. Bone Marrow Transplant. 2012;47:387\u201394.","journal-title":"Bone Marrow Transplant"},{"key":"3067_CR7","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/j.1365-2141.2009.07863.x","volume":"147","author":"S Takagi","year":"2009","unstructured":"Takagi S, Masuoka K, Uchida N, Ishiwata K, Araoka H, Tsuji M, et al. High incidence of haemophagocytic syndrome following umbilical cord blood transplantation for adults. Br J Haematol. 2009;147:543\u201353.","journal-title":"Br J Haematol"},{"key":"3067_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124\u201331.","journal-title":"Pediatr Blood Cancer"},{"key":"3067_CR9","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.3324\/haematol.2017.186627","volume":"103","author":"E Gars","year":"2018","unstructured":"Gars E, Purington N, Scott G, Chisholm K, Gratzinger D, Martin BA, et al. Bone marrow histomorphological criteria can accurately diagnose hemophagocytic lymphohistiocytosis. Haematologica. 2018;103:1635\u201341.","journal-title":"Haematologica"},{"key":"3067_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbmt.2019.10.022","volume":"26","author":"N Hattori","year":"2020","unstructured":"Hattori N, Saito B, Matsui T, Nakata A, Sasaki Y, Shimada S, et al. Comparative study of tacrolimus and short-term methotrexate: 2-day versus 3-day methotrexate as graft-versus-host-disease prophylaxis after umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant. 2020;26:367\u201372.","journal-title":"Biol Blood Marrow Transplant"},{"key":"3067_CR11","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1182\/blood-2005-05-2004","volume":"106","author":"ML Sorror","year":"2005","unstructured":"Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106:2912\u20139.","journal-title":"Blood"},{"key":"3067_CR12","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1182\/blood-2014-01-552984","volume":"123","author":"P Armand","year":"2014","unstructured":"Armand P, Kim HT, Logan BR, Wang Z, Alyea EP, Kalaycio ME, et al. Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood. 2014;123:3664\u201371.","journal-title":"Blood"},{"key":"3067_CR13","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/pbc.21423","volume":"50","author":"CE Allen","year":"2008","unstructured":"Allen CE, Yu X, Kozinetz CA, McClain KL. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008;50:1227\u201335.","journal-title":"Pediatr Blood Cancer"},{"key":"3067_CR14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ajh.1141","volume":"68","author":"U Emmenegger","year":"2001","unstructured":"Emmenegger U, Frey U, Reimers A, Fux C, Semela D, Cottagnoud P, et al. Hyperferritinemia as indicator for intravenous immunoglobulin treatment in reactive macrophage activation syndromes. Am J Hematol. 2001;68:4\u201310.","journal-title":"Am J Hematol"},{"key":"3067_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"3067_CR16","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1182\/blood-2014-10-602607","volume":"125","author":"AM Schram","year":"2015","unstructured":"Schram AM, Campigotto F, Mullally A, Fogerty A, Massarotti E, Neuberg D, et al. Marked hyperferritinemia does not predict for HLH in the adult population. Blood. 2015;125:1548\u201352.","journal-title":"Blood"},{"key":"3067_CR17","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/pbc.21441","volume":"50","author":"A Gupta","year":"2008","unstructured":"Gupta A, Weitzman S, Abdelhaleem M. The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008;50:192\u20134.","journal-title":"Pediatr Blood Cancer"},{"key":"3067_CR18","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.amjmed.2014.04.034","volume":"127","author":"S Rivi\u00e8re","year":"2014","unstructured":"Rivi\u00e8re S, Galicier L, Coppo P, Marzac C, Aumont C, Lambotte O, et al. Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients. Am J Med. 2014;127:1118\u201325.","journal-title":"Am J Med"},{"key":"3067_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s12185-019-02672-4","volume":"110","author":"H Yamamoto","year":"2019","unstructured":"Yamamoto H. Single cord blood transplantation in Japan; expanding the possibilities of CBT. Int J Hematol. 2019;110:39\u201349.","journal-title":"Int J Hematol"},{"key":"3067_CR20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/1097-0142(197909)44:3<993::AID-CNCR2820440329>3.0.CO;2-5","volume":"44","author":"RJ Risdall","year":"1979","unstructured":"Risdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH Jr, Simmons RL, et al. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979;44:993\u20131002.","journal-title":"Cancer"},{"key":"3067_CR21","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1182\/bloodadvances.2017012310","volume":"1","author":"A Hayden","year":"2017","unstructured":"Hayden A, Lin M, Park S, Pudek M, Schneider M, Jordan MB, et al. Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH. Blood Adv. 2017;1:2529\u201334.","journal-title":"Blood Adv"},{"key":"3067_CR22","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/ejh.13433","volume":"105","author":"L Naymagon","year":"2020","unstructured":"Naymagon L, Tremblay D, Troy K, Mascarenhas J. Soluble interleukin-2 receptor (sIL-2r) level is a limited test for the diagnosis of adult secondary hemophagocytic lymphohistiocytosis. Eur J Haematol. 2020;105:255\u201361.","journal-title":"Eur J Haematol."},{"key":"3067_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1053\/j.seminhematol.2009.10.009","volume":"47","author":"P Szabolcs","year":"2010","unstructured":"Szabolcs P, Cairo MS. Unrelated umbilical cord blood transplantation and immune reconstitution. Semin Hematol. 2010;47:22\u201336.","journal-title":"Semin Hematol"},{"key":"3067_CR24","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1182\/blood-2014-07-589176","volume":"124","author":"I Politikos","year":"2014","unstructured":"Politikos I, Boussiotis VA. The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation. Blood. 2014;124:3201\u201311.","journal-title":"Blood"},{"key":"3067_CR25","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1182\/bloodadvances.2019000898","volume":"3","author":"SR Goldsmith","year":"2019","unstructured":"Goldsmith SR, Saif Ur Rehman S, Shirai CL, Vij K, DiPersio JF. Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1\/2 inhibitor ruxolitinib. Blood Adv. 2019;3:4131\u20135.","journal-title":"Blood Adv."},{"key":"3067_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02999-3","author":"R Ono","year":"2020","unstructured":"Ono R, Ashiarai M, Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, et al. Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis. Int J Hematol. 2020. https:\/\/doi.org\/10.1007\/s12185-020-02999-3.","journal-title":"Int J Hematol."},{"issue":"19","key":"3067_CR27","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1056\/NEJMoa1911326","volume":"382","author":"F Locatelli","year":"2020","unstructured":"Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, et al. Emapalumab in children with primary hemophagocytic lymphohistiocytosis. N Engl J Med. 2020;382(19):1811\u201322.","journal-title":"N Engl J Med"},{"key":"3067_CR28","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.255620","author":"F Tucci","year":"2020","unstructured":"Tucci F, Gallo V, Barzaghi F, Ferrua F, Migliavacca M, Calbi V, et al. Treatment with emapalumab in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis. Haematologica. 2020. https:\/\/doi.org\/10.3324\/haematol.2020.255620.","journal-title":"Haematologica"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-020-03067-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-020-03067-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-020-03067-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T06:05:42Z","timestamp":1620194742000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-020-03067-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3067"],"URL":"https:\/\/doi.org\/10.1007\/s12185-020-03067-6","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"22 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliances with ethical standards"}},{"value":"The authors declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}