{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:59:45Z","timestamp":1790459985244,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s12185-021-03229-0","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T10:06:13Z","timestamp":1632996373000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment of hepatosplenic T-cell lymphoma with fludarabine, high-dose cytarabine and subsequent unrelated umbilical cord blood transplantation"],"prefix":"10.1007","volume":"115","author":[{"given":"Takaya","family":"Honda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko Mikami","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-0946","authenticated-orcid":false,"given":"Masaharu","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"3229_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.critrevonc.2011.10.001","volume":"83","author":"AJM Ferrei","year":"2012","unstructured":"Ferrei AJM, Govi S, Pileri SA. Hepatosplenic gamma-delta T-cell lymphoma. Crit Rev Oncol Hematol. 2012;83:283\u201392.","journal-title":"Crit Rev Oncol Hematol"},{"key":"3229_CR2","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.humpath.2011.01.034","volume":"42","author":"C Lu","year":"2011","unstructured":"Lu C, Tang Y, Yang Q, Wang M, Zhao S, Bi C, et al. Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of 17 Chinese cases. Human Pathol. 2011;42:1965\u201378.","journal-title":"Human Pathol"},{"key":"3229_CR3","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1097\/01.mph.0000187431.37369.f5","volume":"27","author":"JA Domm","year":"2005","unstructured":"Domm JA, Thompson M, Kuttesch JF, Acra S, Frangoul H. Allogenic bone marrow transplantation for chemotherapy-refractory hepatosplenic \u03b3\u03b4 T-cell lymphoma. J Pediatr Hematol Oncol. 2005;27:607\u201310.","journal-title":"J Pediatr Hematol Oncol"},{"key":"3229_CR4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s12185-018-2440-4","volume":"108","author":"H Takahashi","year":"2018","unstructured":"Takahashi H, Kajiwara R, Kato M, Hasegawa D, Tomizawa D, Nogichi Y, et al. Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children\u2019s Cancer Study Group (TCCSG) study L04-16. Int J Hematol. 2018;108:98\u2013108.","journal-title":"Int J Hematol"},{"key":"3229_CR5","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1200\/JCO.1994.12.4.671","volume":"12","author":"E Estey","year":"1994","unstructured":"Estey E, Thall P, Andreeff M, Beran M, Kantarjian H, O\u2019Brien S, et al. Use of granulocyte colony-stimulating factor before, during, and after fludarabine plus cytarabine induction therapy of newly diagnosed acute myelogenous leukemia or myelodysplastic syndromes: comparison with fludarabine plus cytarabine without granulocyte colony-stimulating factor. J Clin Oncol. 1994;12:671\u20138.","journal-title":"J Clin Oncol"},{"key":"3229_CR6","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1182\/blood-2007-05-088310","volume":"111","author":"N Kawamata","year":"2008","unstructured":"Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki K, et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide genomic microarray. Blood. 2008;111:776\u201384.","journal-title":"Blood"},{"key":"3229_CR7","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1158\/0008-5472.CAN-05-0465","volume":"65","author":"Y Nannya","year":"2005","unstructured":"Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, et al. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res. 2005;65:6071\u20139.","journal-title":"Cancer Res"},{"key":"3229_CR8","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1086\/518809","volume":"81","author":"G Yamamoto","year":"2007","unstructured":"Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata N, et al. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet. 2007;81:114\u201326.","journal-title":"Am J Hum Genet"},{"key":"3229_CR9","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukemia. Nature. 2007;446:758\u201364.","journal-title":"Nature"},{"key":"3229_CR10","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1182\/blood.2019004118","volume":"136","author":"B Pro","year":"2020","unstructured":"Pro B, Allen P, Behdad A. Hepatosplenic T-cell lymphoma: a rare but challenging entity. Blood. 2020;136:2018\u201326.","journal-title":"Blood"},{"key":"3229_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/ajh.25674","volume":"95","author":"FM Foss","year":"2020","unstructured":"Foss FM, Horwitz SM, Civallero M, Bellei M, Marcheselli L, Kim WS, et al. Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas. Am J Hematol. 2020;95:151\u20135.","journal-title":"Am J Hematol"},{"key":"3229_CR12","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1097\/PAS.0000000000000614","volume":"40","author":"M Yabe","year":"2016","unstructured":"Yabe M, Medeiros LJ, Tang G, Wang SA, Ahmed S, Nieto Y, et al. Prognostic factors of hepatosplenic T-cell lymphoma: clinicopathologic study of 28 cases. Am J Surg Pathol. 2016;40:676\u201388.","journal-title":"Am J Surg Pathol"},{"key":"3229_CR13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.anndiagpath.2016.10.005","volume":"26","author":"M Yabe","year":"2017","unstructured":"Yabe M, Medeiro LJ, Daneshbod Y, Davanlou M, Bueso-Ramos CE, Moran E, et al. Hepatosplenic T-cell lymphoma arising in patients with immunodysregulatory disorders: a study of 7 patients who did not receive tumor necrosis factor-\u03b1 inhibitor therapy and literature review. Ann Diagn Pathol. 2017;26:16\u201322.","journal-title":"Ann Diagn Pathol"},{"key":"3229_CR14","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1182\/blood-2003-05-1675","volume":"102","author":"K Belhadj","year":"2003","unstructured":"Belhadj K, Reyes F, Farcet JP, Tilly H, Bastard C, Angonin R, et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood. 2003;102:4261\u20139.","journal-title":"Blood"},{"key":"3229_CR15","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1093\/annonc\/mdn751","volume":"10","author":"GS Falchook","year":"2009","unstructured":"Falchook GS, Vega F, Dang NH, Samaniego F, Rodriguez MA, Champlin RE, et al. Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment. Ann Oncol. 2009;10:1080\u20135.","journal-title":"Ann Oncol"},{"key":"3229_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.clml.2012.09.002","volume":"13","author":"MH Voss","year":"2013","unstructured":"Voss MH, Lunning MA, Maragulia JC, Papadopoulos EB, Goldberg J, Zelenetz A, et al. Intensive induction chemotherapy followed by early high-dose therapy and hematopoietic stem cell transplantation results in improved outcome for patients with hepatosplenic T-cell lymphoma: a single institution experience. Clin Lymphoma Myeloma Leukemia. 2013;13:8\u201314.","journal-title":"Clin Lymphoma Myeloma Leukemia"},{"key":"3229_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00000478-200103000-00002","volume":"25","author":"WR Macon","year":"2001","unstructured":"Macon WR, Levy NB, Kurtin PJ, Salhany KE, Elkhalifa MY, Casey TT, et al. Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol. 2001;25:285\u201396.","journal-title":"Am J Surg Pathol"},{"key":"3229_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1440-1827.2006.02027.x","volume":"56","author":"R Hassan","year":"2006","unstructured":"Hassan R, Franco SA, Stefanoff CG, Romano SO, Diamond HR, Franco LGP, et al. Hepatosplenic gammadelta T-cell lymphoma following seven malaria infections. Pathol Int. 2006;56:668\u201373.","journal-title":"Pathol Int"},{"key":"3229_CR19","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/annonc\/mdf293","volume":"13","author":"T Saito","year":"2002","unstructured":"Saito T, Matsuno Y, Tanosaki R, Watanabe T, Kobayashi Y, Tobinai K. Gamma delta T-cell neoplasms: a clinicopathological study of 11 cases. Ann Oncol. 2002;13:1792\u20138.","journal-title":"Ann Oncol"},{"key":"3229_CR20","doi-asserted-by":"publisher","first-page":"e318","DOI":"10.1038\/bcj.2015.43","volume":"5","author":"A Rashidi","year":"2015","unstructured":"Rashidi A, Cashen AF. Outcomes of allogenic stem cell transplantation in hepatosplenic T-cell lymphoma. Blood Cancer J. 2015;5:e318.","journal-title":"Blood Cancer J"},{"key":"3229_CR21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/j.1365-2141.1995.tb05221.x","volume":"90","author":"F Garcia-Sanchez","year":"1995","unstructured":"Garcia-Sanchez F, Menarguez J, Cristobal E, Cantalejo A, Gil J, Vicario JL. Hepatosplenic gamma-delta T-cell malignant lymphoma: report of the first case in childhood, including molecular minimal residual disease follow-up. Br J Haematol. 1995;90:943\u20136.","journal-title":"Br J Haematol"},{"key":"3229_CR22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/00043426-200202000-00020","volume":"24","author":"HC Rossbach","year":"2002","unstructured":"Rossbach HC, Chamizo W, Dumont DP, Barbosa JL, Sutcliffe MJ. Hepatosplenic gamma\/delta T-cell lymphoma with isochromosome 7q, translocation t(7;21), and tetrasomy 8 in a 9-year-old girl. J Pediatr Hematol Oncol. 2002;24:154\u20137.","journal-title":"J Pediatr Hematol Oncol"},{"key":"3229_CR23","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00043426-200406000-00008","volume":"26","author":"M Chin","year":"2004","unstructured":"Chin M, Mugishima H, Takamura M, Nagata T, Shichino H, Shimada T, et al. Hemophagocytic syndrome and hepatosplenic \u03b3\u03b4 T-cell lymphoma with isochromosome 7q and 8 trisomy. J Pediatr Hematol Oncol. 2004;26:375\u20138.","journal-title":"J Pediatr Hematol Oncol"},{"key":"3229_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/ajh.10466","volume":"75","author":"A Gassas","year":"2004","unstructured":"Gassas A, Kirby M, Weitzman S, Ngan B, Abla O, Doyle JJ. Hepatosplenic gammadelta T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantation. Am J Hematol. 2004;75:113\u20134.","journal-title":"Am J Hematol"},{"key":"3229_CR25","doi-asserted-by":"publisher","first-page":"e13213","DOI":"10.1111\/petr.13213","volume":"22","author":"SS McThenia","year":"2018","unstructured":"McThenia SS, Rawwas J, Olivera JL, Khan SP, Rodriguez V. Hepatosplenic \u03b3\u03b4 T-cell lymphoma of two adolescents: case report and retrospective literature review in children, adolescent, and young adults. Pediatr Transpl. 2018;22:e13213.","journal-title":"Pediatr Transpl"},{"key":"3229_CR26","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.6004\/jnccn.2020.0053","volume":"18","author":"SM Horwitz","year":"2020","unstructured":"Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Clemens MW, et al. NCCN guidelines insights: T-cell lymphomas, Version 1.2021. J Natl Compr Cancer Netw. 2020;18:1460\u20137.","journal-title":"J Natl Compr Cancer Netw"},{"key":"3229_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1158\/2159-8290.CD-16-0330","volume":"7","author":"M McKinney","year":"2017","unstructured":"McKinney M, Moffitt AB, Gaulard P, Travert M, De Leval L, Nicolae A, et al. The genetic basis of hepatosplenic T-cell lymphoma. Cancer Discov. 2017;7:369\u201379.","journal-title":"Cancer Discov"},{"key":"3229_CR28","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1038\/s41375-019-0473-1","volume":"33","author":"Y Watatani","year":"2019","unstructured":"Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, et al. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia. 2019;33:2867\u201383.","journal-title":"Leukemia"},{"key":"3229_CR29","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ccr.2014.03.016","volume":"25","author":"C Chen","year":"2014","unstructured":"Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, et al. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014;25:652\u201365.","journal-title":"Cancer Cell"},{"key":"3229_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.humpath.2015.11.010","volume":"50","author":"M Yabe","year":"2016","unstructured":"Yabe M, Medeiros LJ, Tang G, Wang SA, Patel PK, Routbort M, et al. Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients. Human Pathol. 2016;50:109\u201317.","journal-title":"Human Pathol"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-021-03229-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-021-03229-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-021-03229-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T12:05:32Z","timestamp":1642334732000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-021-03229-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3229"],"URL":"https:\/\/doi.org\/10.1007\/s12185-021-03229-0","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"assertion":[{"value":"21 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}