{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:56:42Z","timestamp":1758819402176,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The National Cancer Center Research and Development Fund","award":["2020-A-15"],"award-info":[{"award-number":["2020-A-15"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s12185-023-03539-5","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T09:03:31Z","timestamp":1674810211000},"page":"933-940","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nelarabine-induced myelopathy in patients undergoing allogeneic hematopoietic cell transplantation: a report of three cases"],"prefix":"10.1007","volume":"117","author":[{"given":"Takanori","family":"Fukuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-0850","authenticated-orcid":false,"given":"Takashi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Isahaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaishi","family":"Satomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitose","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Inamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"3539_CR1","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1200\/JCO.2005.03.199","volume":"23","author":"J Kurtzberg","year":"2005","unstructured":"Kurtzberg J, Ernst TJ, Keating MJ, Gandhi V, Hodge JP, Kisor DF, et al. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol. 2005;23:3396\u2013403.","journal-title":"J Clin Oncol"},{"key":"3539_CR2","doi-asserted-by":"publisher","first-page":"3376","DOI":"10.1200\/JCO.2005.03.426","volume":"23","author":"SL Berg","year":"2005","unstructured":"Berg SL, Blaney SM, Devidas M, Lampkin TA, Murgo A, Bernstein M, et al. Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children\u2019s Oncology Group. J Clin Oncol. 2005;23:3376\u201382.","journal-title":"J Clin Oncol"},{"key":"3539_CR3","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1182\/blood-2006-11-056754","volume":"109","author":"DJ DeAngelo","year":"2007","unstructured":"DeAngelo DJ, Yu D, Johnson JL, Coutre SE, Stone RM, Stopeck AT, et al. Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood. 2007;109:5136\u201342.","journal-title":"Blood"},{"key":"3539_CR4","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1182\/blood-2011-01-329441","volume":"118","author":"N G\u00f6kbuget","year":"2011","unstructured":"G\u00f6kbuget N, Basara N, Baurmann H, Beck J, Br\u00fcggemann M, Diedrich H, et al. High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia\/lymphoma offers curative option with subsequent stem cell transplantation. Blood. 2011;118:3504\u201311.","journal-title":"Blood"},{"key":"3539_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ajh.24947","volume":"93","author":"Y Abaza","year":"2018","unstructured":"Abaza Y, Kantarjian HM, Faderl S, Jabbour E, Jain N, Thomas D, et al. Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma. Am J Hematol. 2018;93:91\u20139.","journal-title":"Am J Hematol"},{"key":"3539_CR6","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1200\/JCO.20.00256","volume":"38","author":"KP Dunsmore","year":"2020","unstructured":"Dunsmore KP, Winter SS, Devidas M, Wood BL, Esiashvili N, Chen Z, et al. Children\u2019s Oncology Group AALL0434: a phase III randomized clinical trial testing nelarabine in newly diagnosed T-cell acute lymphoblastic leukemia. J Clin Oncol. 2020;38:3282\u201393.","journal-title":"J Clin Oncol"},{"key":"3539_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17474086.2017.1262757","volume":"10","author":"TM Kadia","year":"2017","unstructured":"Kadia TM, Gandhi V. Nelarabine in the treatment of pediatric and adult patients with T-cell acute lymphoblastic leukemia and lymphoma. Expert Rev Hematol. 2017;10:1\u20138.","journal-title":"Expert Rev Hematol"},{"key":"3539_CR8","doi-asserted-by":"publisher","first-page":"e327","DOI":"10.1200\/JCO.2012.45.4728","volume":"31","author":"RP Gollard","year":"2013","unstructured":"Gollard RP, Selco S. Irreversible myelopathy associated with nelaribine in T-cell acute lymphoblastic leukemia. J Clin Oncol. 2013;31:e327\u201331.","journal-title":"J Clin Oncol"},{"key":"3539_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jocn.2015.12.014","volume":"29","author":"SG Dua","year":"2016","unstructured":"Dua SG, Jhaveri MD. MR imaging in nelarabine-induced myelopathy. J Clin Neurosci. 2016;29:205\u20136.","journal-title":"J Clin Neurosci"},{"key":"3539_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/jns.12173","volume":"21","author":"P Alberti","year":"2016","unstructured":"Alberti P, Parma M, Pioltelli P, Pogliani EM, Terruzzi E, Stasia A, et al. Severe, reversible nelarabine-induced neuropathy and myelopathy. J Peripher Nerv Syst. 2016;21:154\u20136.","journal-title":"J Peripher Nerv Syst"},{"key":"3539_CR11","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/ped.13303","volume":"59","author":"T Kanayama","year":"2017","unstructured":"Kanayama T, Imamura T, Nakagawa N, Osone S, Hosoi H. Pediatric T-ALL complicated by irreversible nelarabine neurotoxicity. Pediatr Int. 2017;59:843\u20135.","journal-title":"Pediatr Int"},{"key":"3539_CR12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1212\/WNL.0000000000011343","volume":"96","author":"AA Madhavan","year":"2021","unstructured":"Madhavan AA, Carr CM, Alkhateeb H, Staff NP, Naddaf E. Nelarabine-induced myelotoxicity. Neurology. 2021;96:175\u20136.","journal-title":"Neurology"},{"key":"3539_CR13","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1002\/ajh.23550","volume":"88","author":"B Hartz","year":"2013","unstructured":"Hartz B, L\u00f6bel U, Hagel C, Escherich G. Fatal neurological side-effects with necrosis of spinal cord following nelarabine treatment in a child with relapsed T-cell acute lymphoblastic leukemia. Am J Hematol. 2013;88:1096\u20137.","journal-title":"Am J Hematol"},{"key":"3539_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/ajh.23502","volume":"88","author":"M Kawakami","year":"2013","unstructured":"Kawakami M, Taniguchi K, Yoshihara S, Ishii S, Kaida K, Ikegame K, et al. Irreversible neurological defects in the lower extremities after haploidentical stem cell transplantation: possible association with nelarabine. Am J Hematol. 2013;88:853\u20137.","journal-title":"Am J Hematol"},{"key":"3539_CR15","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/ajh.21719","volume":"85","author":"C Papayannidis","year":"2010","unstructured":"Papayannidis C, Iacobucci I, Abbenante MC, Curti A, Paolini S, Parisi S, et al. Complete paraplegia after nelarabine treatment in a T-cell acute lymphoblastic leukemia adult patient. Am J Hematol. 2010;85:608.","journal-title":"Am J Hematol"},{"key":"3539_CR16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.currproblcancer.2016.11.005","volume":"41","author":"C Lalayanni","year":"2017","unstructured":"Lalayanni C, Baldoumi E, Papayiannopoulos S, Tziola K, Saloum R, Anagnostopoulos A. Nelarabine-associated reversible Guillain\u2013Barr\u00e9-like syndrome or myelopathy in an adult patient with primary refractory T-lymphoblastic lymphoma. Curr Probl Cancer. 2017;41:138\u201343.","journal-title":"Curr Probl Cancer"},{"key":"3539_CR17","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/bjh.14877","volume":"179","author":"M Kuhlen","year":"2017","unstructured":"Kuhlen M, Bleckmann K, M\u00f6ricke A, Schrappe M, Vieth S, Escherich G, et al. Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy. Br J Haematol. 2017;179:272\u201383.","journal-title":"Br J Haematol"},{"key":"3539_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11060-012-0962-9","volume":"110","author":"AM Delios","year":"2012","unstructured":"Delios AM, Rosenblum M, Jakubowski AA, DeAngelis LM. Central and peripheral nervous system immune mediated demyelinating disease after allogeneic hemopoietic stem cell transplantation for hematologic disease. J Neurooncol. 2012;110:251\u20136.","journal-title":"J Neurooncol"},{"key":"3539_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/sj.bmt.1705716","volume":"40","author":"S Suzuki","year":"2007","unstructured":"Suzuki S, Mori T, Mihara A, Aisa Y, Ikeda Y, Suzuki N, et al. Immune-mediated motor polyneuropathy after hematopoietic stem cell transplantation. Bone Marrow Transpl. 2007;40:289\u201391.","journal-title":"Bone Marrow Transpl"},{"key":"3539_CR20","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.bbmt.2019.04.021","volume":"25","author":"X-Y Ren","year":"2019","unstructured":"Ren X-Y, Liu X, Huang Q-S, Wang Q-M, He Y, Zhu X-L, et al. Incidence, risk factors, and outcome of immune-mediated neuropathies (IMNs) following haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2019;25:1629\u201336.","journal-title":"Biol Blood Marrow Transpl"},{"key":"3539_CR21","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12185-017-2347-5","volume":"107","author":"T Ueki","year":"2018","unstructured":"Ueki T, Hoshi K, Hiroshima Y, Sumi M, Ichikawa N, Ogata M, et al. Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations. Int J Hematol. 2018;107:363\u201372.","journal-title":"Int J Hematol"},{"key":"3539_CR22","first-page":"3100","volume":"62","author":"CO Rodriguez Jr","year":"2002","unstructured":"Rodriguez CO Jr, Mitchell BS, Ayres M, Eriksson S, Gandhi V. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res. 2002;62:3100\u20135.","journal-title":"Cancer Res"},{"key":"3539_CR23","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1007\/s00415-012-6596-1","volume":"259","author":"SA Moore","year":"2012","unstructured":"Moore SA, Kumar N, Gavrilova RH. Leukoencephalopathy with brain stem and spinal cord involvement (and high lactate): raising the bar for diagnosis. J Neurol. 2012;259:2494\u20137.","journal-title":"J Neurol"},{"key":"3539_CR24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3174\/ajnr.A6910","volume":"42","author":"C Alves","year":"2021","unstructured":"Alves C, Goldstein A, Teixeira SR, Martin-Saavedra JS, de Barcelos IP, Fadda G, et al. Involvement of the spinal cord in primary mitochondrial disorders: a neuroimaging mimicker of inflammation and ischemia in children. AJNR Am J Neuroradiol. 2021;42:389\u201396.","journal-title":"AJNR Am J Neuroradiol"},{"key":"3539_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.braindev.2012.05.007","volume":"35","author":"S Yamashita","year":"2013","unstructured":"Yamashita S, Miyake N, Matsumoto N, Osaka H, Iai M, Aida N, et al. Neuropathology of leukoencephalopathy with brainstem and spinal cord involvement and high lactate caused by a homozygous mutation of DARS2. Brain Dev. 2013;35:312\u20136.","journal-title":"Brain Dev"},{"key":"3539_CR26","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jtct.2022.05.038","volume":"28","author":"GDE Cuvelier","year":"2022","unstructured":"Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, et al. Toward a better understanding of the atypical features of chronic graft-versus-host disease: a report from the 2020 national institutes of health consensus project task force. Transpl Cell Ther. 2022;28:426\u201345.","journal-title":"Transpl Cell Ther"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03539-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-023-03539-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03539-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T12:03:15Z","timestamp":1685275395000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-023-03539-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3539"],"URL":"https:\/\/doi.org\/10.1007\/s12185-023-03539-5","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"type":"print","value":"0925-5710"},{"type":"electronic","value":"1865-3774"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"13 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}