{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:41:59Z","timestamp":1740120119026,"version":"3.37.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expansion of large granular lymphocytes (LGLs) is sometimes observed in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and is reported to be associated with a favorable transplant outcome. LGLs are also observed after autologous HSCT, but their clinical implications have not been well investigated. We retrospectively reviewed peripheral blood smears of consecutive autologous HSCT recipients. LGL lymphocytosis was defined as the observation of LGLs in the peripheral blood (&gt;\u200920% white blood cells) in at least two consecutive blood tests. We evaluated the clinical impact of LGL lymphocytosis on autologous HSCT recipients. LGL lymphocytosis was observed in 18 of 197 patients (9.1%) who received autologous HSCT, at a median of 49\u00a0days after transplantation, with a median duration of 120.5\u00a0days. Incidence of cytomegalovirus reactivation was significantly higher in patients with LGL lymphocytosis than those without (16.7% vs. 3.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). No significant difference in survival rates was observed between groups (3\u00a0year OS 90.9% vs. 90.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.793 for lymphoma; 100 vs. 92.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.328 for myeloma). LGL lymphocytosis was observed in almost 10% of autologous HSCT recipients. In contrast to allogeneic HSCT, the duration of LGL was shorter and no significant improvement in survival was observed.<\/jats:p>","DOI":"10.1007\/s12185-023-03540-y","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T10:04:42Z","timestamp":1676109882000},"page":"839-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expansion of large granular lymphocytes after autologous hematopoietic stem cell transplantation"],"prefix":"10.1007","volume":"117","author":[{"given":"Mina","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Taoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Maki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Masamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Jona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-2422","authenticated-orcid":false,"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,11]]},"reference":[{"issue":"12","key":"3540_CR1","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/ajh.20981","volume":"82","author":"D Rossi","year":"2007","unstructured":"Rossi D, Franceschetti S, Capello D, De Paoli L, Lunghi M, Conconi A, et al. Transient monoclonal expansion of CD8+\/CD57+ T-cell large granular lymphocytes after primary cytomegalovirus infection. Am J Hematol. 2007;82(12):1103\u20135.","journal-title":"Am J Hematol"},{"issue":"8","key":"3540_CR2","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/leu.2009.46","volume":"23","author":"S Mustjoki","year":"2009","unstructured":"Mustjoki S, Ekblom M, Arstila TP, Dybedal I, Epling-Burnette PK, Guilhot F, et al. Clonal expansion of T\/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia. 2009;23(8):1398\u2013405.","journal-title":"Leukemia"},{"issue":"11","key":"3540_CR3","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/j.bbmt.2012.07.007","volume":"18","author":"S Nann-R\u00fctti","year":"2012","unstructured":"Nann-R\u00fctti S, Tzankov A, Cantoni N, Halter J, Heim D, Tsakiris D, et al. Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome. Biol Blood Marrow Transplant. 2012;18(11):1765\u201370.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"10","key":"3540_CR4","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1038\/sj.leu.2402645","volume":"16","author":"M Mohty","year":"2002","unstructured":"Mohty M, Faucher C, Vey N, Chabannon C, Sainty D, Arnoulet C, et al. Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis. Leukemia. 2002;16(10):2129\u201333.","journal-title":"Leukemia"},{"issue":"8","key":"3540_CR5","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/bmt.2013.5","volume":"48","author":"D Kim","year":"2013","unstructured":"Kim D, Al-Dawsari G, Chang H, Panzarella T, Gupta V, Kuruvilla J, et al. Large granular lymphocytosis and its impact on long-term clinical outcomes following allo-SCT. Bone Marrow Transplant. 2013;48(8):1104\u201311.","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"3540_CR6","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/sj.leu.2402488","volume":"16","author":"R Costello","year":"2002","unstructured":"Costello R, Sivori S, Mallet F, Sainty D, Arnoulet C, Reviron D, et al. A novel mechanism of antitumor response involving the expansion of CD3+\/CD56+ large granular lymphocytes triggered by a tumor-expressed activating ligand. Leukemia. 2002;16(5):855\u201360.","journal-title":"Leukemia"},{"issue":"12","key":"3540_CR7","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1007\/s00277-017-3108-5","volume":"96","author":"K Matsuda","year":"2017","unstructured":"Matsuda K, Taoka K, Jona M, Masuda A, Arai S, Nakamura F, et al. Clinical features of hematological disorders with increased large granular lymphocytes (LGLs): a retrospective study. Ann Hematol. 2017;96(12):2113\u20135.","journal-title":"Ann Hematol"},{"issue":"2","key":"3540_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1309\/AJCP1T0JPBLSLAQF","volume":"139","author":"KL Wolniak","year":"2013","unstructured":"Wolniak KL, Goolsby CL, Chen Y-H, Chenn A, Singhal S, Mehta J, et al. Expansion of a clonal CD8+CD57+ large granular lymphocyte population after autologous stem cell transplant in multiple myeloma. Am J Clin Pathol. 2013;139(2):231\u201341.","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"3540_CR9","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1182\/blood.V98.3.579","volume":"98","author":"LF Porrata","year":"2001","unstructured":"Porrata LF, Gertz MA, Inwards DJ, Litzow MR, Lacy MQ, Tefferi A, et al. 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Bone Marrow Transplant. 2005;35(9):835\u201357.","journal-title":"Bone Marrow Transplant"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03540-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-023-03540-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03540-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T12:03:18Z","timestamp":1685275398000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-023-03540-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3540"],"URL":"https:\/\/doi.org\/10.1007\/s12185-023-03540-y","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"type":"print","value":"0925-5710"},{"type":"electronic","value":"1865-3774"}],"subject":[],"published":{"date-parts":[[2023,2,11]]},"assertion":[{"value":"26 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"M.K. received lecture fees from MSD K.K. Y.M. received lecture fees from MSD K.K. The other authors declare that they have no conflicting financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants followed the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standard. Informed consent was obtained from all patients for being included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}