{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:17:40Z","timestamp":1769761060208,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI (21K16248)"],"award-info":[{"award-number":["KAKENHI (21K16248)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s12185-023-03589-9","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T04:03:02Z","timestamp":1680235382000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Severe systemic inflammation mimicking TAFRO syndrome following COVID-19"],"prefix":"10.1007","volume":"118","author":[{"given":"Misato","family":"Tane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kosako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-7476","authenticated-orcid":false,"given":"Hiroki","family":"Hosoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Hiroi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Mushino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sonoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"3589_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12185-019-02780-1","volume":"111","author":"Y Masaki","year":"2020","unstructured":"Masaki Y, Kawabata H, Takai K, Tsukamoto N, Fujimoto S, Ishigaki Y, et al. 2019 updated diagnostic criteria and disease severity classification for TAFRO syndrome. Int J Hematol. 2020;111:155\u20138.","journal-title":"Int J Hematol"},{"key":"3589_CR2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00277-022-04762-6","volume":"101","author":"Y Masaki","year":"2022","unstructured":"Masaki Y, Arita K, Sakai T, Takai K, Aoki S, Kawabata H. Castleman disease and TAFRO syndrome. Ann Hematol. 2022;101:485\u201390.","journal-title":"Ann Hematol"},{"key":"3589_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3075","author":"T Chen","year":"2022","unstructured":"Chen T, Feng C, Zhang X, Zhou J. TAFRO syndrome: a disease that known is half cured. Hematol Oncol. 2022. https:\/\/doi.org\/10.1002\/hon.3075.","journal-title":"Hematol Oncol"},{"key":"3589_CR4","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1182\/blood.2019000931","volume":"135","author":"A Dispenzieri","year":"2020","unstructured":"Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood. 2020;135:1353\u201364.","journal-title":"Blood"},{"key":"3589_CR5","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/ajh.25554","volume":"94","author":"S Fujimoto","year":"2019","unstructured":"Fujimoto S, Sakai T, Kawabata H, Kurose N, Yamada S, Takai K, et al. Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease? Am J Hematol. 2019;94:975\u201383.","journal-title":"Am J Hematol"},{"key":"3589_CR6","first-page":"4703608","volume":"2016","author":"M Simons","year":"2016","unstructured":"Simons M, Apor E, Butera JN, Treaba DO. TAFRO syndrome associated with EBV and successful triple therapy treatment: case report and review of the literature. Case Rep Hematol. 2016;2016:4703608.","journal-title":"Case Rep Hematol"},{"key":"3589_CR7","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","volume":"26","author":"A Gupta","year":"2020","unstructured":"Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26:1017\u201332.","journal-title":"Nat Med"},{"key":"3589_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109428","volume":"113","author":"Y Nazerian","year":"2022","unstructured":"Nazerian Y, Ghasemi M, Yassaghi Y, Nazerian A, Hashemi SM. Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: molecular pathways and potential therapeutic options. Int Immunopharmacol. 2022;113: 109428.","journal-title":"Int Immunopharmacol"},{"key":"3589_CR9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2007575","volume":"382","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. Coagulopathy and antiphospholipid antibodies in patients with covid-19. N Engl J Med. 2020;382: e38.","journal-title":"N Engl J Med"},{"key":"3589_CR10","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1056\/NEJMc2009191","volume":"382","author":"G Toscano","year":"2020","unstructured":"Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain-barre syndrome associated with SARS-CoV-2. N Engl J Med. 2020;382:2574\u20136.","journal-title":"N Engl J Med"},{"key":"3589_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102506","volume":"114","author":"Y Rodriguez","year":"2020","unstructured":"Rodriguez Y, Novelli L, Rojas M, De Santis M, Acosta-Ampudia Y, Monsalve DM, et al. Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. J Autoimmun. 2020;114: 102506.","journal-title":"J Autoimmun"},{"key":"3589_CR12","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1007\/s10067-020-05310-1","volume":"39","author":"E Mantovani Cardoso","year":"2020","unstructured":"Mantovani Cardoso E, Hundal J, Feterman D, Magaldi J. Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology. Clin Rheumatol. 2020;39:2811\u20135.","journal-title":"Clin Rheumatol"},{"key":"3589_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0030-4220(74)90417-4","volume":"37","author":"JS Greenspan","year":"1974","unstructured":"Greenspan JS, Daniels TE, Talal N, Sylvester RA. The histopathology of Sjogren\u2019s syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974;37:217\u201329.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"3589_CR14","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/ard.61.6.554","volume":"61","author":"C Vitali","year":"2002","unstructured":"Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554\u20138.","journal-title":"Ann Rheum Dis"},{"key":"3589_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, et al. 2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sjogren\u2019s Syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol. 2017;69:35\u201345.","journal-title":"Arthritis Rheumatol"},{"key":"3589_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12185-021-03159-x","volume":"114","author":"H Kawabata","year":"2021","unstructured":"Kawabata H, Fujimoto S, Sakai T, Yanagisawa H, Kitawaki T, Nara K, et al. Patient\u2019s age and D-dimer levels predict the prognosis in patients with TAFRO syndrome. Int J Hematol. 2021;114:179\u201388.","journal-title":"Int J Hematol"},{"key":"3589_CR17","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1080\/10428194.2022.2074992","volume":"63","author":"A Sakaki","year":"2022","unstructured":"Sakaki A, Hosoi H, Kosako H, Furuya Y, Iwamoto R, Hiroi T, et al. Successful combination treatment with rituximab, steroid pulse therapy, plasma exchange and romiplostim for very severe TAFRO syndrome. Leuk Lymphoma. 2022;63:2499\u2013502.","journal-title":"Leuk Lymphoma"},{"key":"3589_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41584-021-00608-z","volume":"17","author":"M Ramos-Casals","year":"2021","unstructured":"Ramos-Casals M, Brito-Zeron P, Mariette X. Systemic and organ-specific immune-related manifestations of COVID-19. Nat Rev Rheumatol. 2021;17:315\u201332.","journal-title":"Nat Rev Rheumatol"},{"key":"3589_CR19","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020;383:2255\u201373.","journal-title":"N Engl J Med"},{"key":"3589_CR20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3324\/haematol.2019.229781","volume":"105","author":"I Yakoub-Agha","year":"2020","unstructured":"Yakoub-Agha I, Chabannon C, Bader P, Basak GW, Bonig H, Ciceri F, et al. Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica. 2020;105:297\u2013316.","journal-title":"Haematologica"},{"key":"3589_CR21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1001\/jama.2021.11330","volume":"326","author":"M Shankar-Hari","year":"2021","unstructured":"Shankar-Hari M, Vale CL, Godolphin PJ, Fisher D, Higgins JPT, Group WHOREAfC-TW, et al. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis. JAMA. 2021;326:499\u2013518.","journal-title":"JAMA"},{"key":"3589_CR22","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","volume":"42","author":"R Karki","year":"2021","unstructured":"Karki R, Kanneganti TD. The \u201ccytokine storm\u201d: molecular mechanisms and therapeutic prospects. Trends Immunol. 2021;42:681\u2013705.","journal-title":"Trends Immunol"},{"key":"3589_CR23","doi-asserted-by":"publisher","first-page":"e276","DOI":"10.1016\/S1473-3099(20)30651-4","volume":"20","author":"L Jiang","year":"2020","unstructured":"Jiang L, Tang K, Levin M, Irfan O, Morris SK, Wilson K, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020;20:e276\u201388.","journal-title":"Lancet Infect Dis"},{"key":"3589_CR24","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1016\/j.vaccine.2021.01.054","volume":"39","author":"TP Vogel","year":"2021","unstructured":"Vogel TP, Top KA, Karatzios C, Hilmers DC, Tapia LI, Moceri P, et al. Multisystem inflammatory syndrome in children and adults (MIS-C\/A): case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2021;39:3037\u201349.","journal-title":"Vaccine"},{"key":"3589_CR25","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","volume":"395","author":"S Riphagen","year":"2020","unstructured":"Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607\u20138.","journal-title":"Lancet"},{"key":"3589_CR26","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.15585\/mmwr.mm6940e1","volume":"69","author":"SB Morris","year":"2020","unstructured":"Morris SB, Schwartz NG, Patel P, Abbo L, Beauchamps L, Balan S, et al. Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection\u2013United Kingdom and United States, March-August 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1450\u20136.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"3589_CR27","doi-asserted-by":"publisher","first-page":"e741","DOI":"10.1093\/cid\/ciab936","volume":"75","author":"ED Belay","year":"2022","unstructured":"Belay ED, Godfred Cato S, Rao AK, Abrams J, Wyatt Wilson W, Lim S, et al. Multisystem inflammatory syndrome in adults after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Clin Infect Dis. 2022;75:e741\u20138.","journal-title":"Clin Infect Dis"},{"key":"3589_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.hrtlng.2022.03.007","volume":"54","author":"S Kunal","year":"2022","unstructured":"Kunal S, Ish P, Sakthivel P, Malhotra N, Gupta K. The emerging threat of multisystem inflammatory syndrome in adults (MIS-A) in COVID-19: a systematic review. Heart Lung. 2022;54:7\u201318.","journal-title":"Heart Lung"},{"key":"3589_CR29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ajh.24242","volume":"91","author":"N Iwaki","year":"2016","unstructured":"Iwaki N, Fajgenbaum DC, Nabel CS, Gion Y, Kondo E, Kawano M, et al. Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease. Am J Hematol. 2016;91:220\u20136.","journal-title":"Am J Hematol"},{"key":"3589_CR30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1046\/j.1440-1827.2001.01266.x","volume":"51","author":"T Suda","year":"2001","unstructured":"Suda T, Katano H, Delsol G, Kakiuchi C, Nakamura T, Shiota M, et al. HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman\u2019s disease. Pathol Int. 2001;51:671\u20139.","journal-title":"Pathol Int"},{"key":"3589_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinpr.2022.100158","volume":"16","author":"K Oshima","year":"2022","unstructured":"Oshima K, Kanamori H, Takei K, Baba H, Tokuda K. Severe coronavirus disease 2019 in a patient with TAFRO syndrome: a case report. Clin Infect Pract. 2022;16: 100158.","journal-title":"Clin Infect Pract"},{"key":"3589_CR32","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.jiac.2022.04.005","volume":"28","author":"M Yamada","year":"2022","unstructured":"Yamada M, Sada RM, Kashihara E, Okubo G, Matsushita S, Manabe A, et al. TAFRO syndrome with a fatal clinical course following BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccination: a case report. J Infect Chemother. 2022;28:1008\u201311.","journal-title":"J Infect Chemother"},{"key":"3589_CR33","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/ajh.26292","volume":"96","author":"Y Nishimura","year":"2021","unstructured":"Nishimura Y, Fajgenbaum DC, Pierson SK, Iwaki N, Nishikori A, Kawano M, et al. Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease. Am J Hematol. 2021;96:1241\u201352.","journal-title":"Am J Hematol"},{"key":"3589_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102883","volume":"20","author":"H Zacharias","year":"2021","unstructured":"Zacharias H, Dubey S, Koduri G, D\u2019Cruz D. Rheumatological complications of Covid 19. Autoimmun Rev. 2021;20: 102883.","journal-title":"Autoimmun Rev"},{"key":"3589_CR35","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1093\/rheumatology\/keaa748","volume":"60","author":"P Brito-Zeron","year":"2021","unstructured":"Brito-Zeron P, Melchor S, Seror R, Priori R, Solans R, Kostov B, et al. SARS-CoV-2 infection in patients with primary Sjogren syndrome: characterization and outcomes of 51 patients. Rheumatology (Oxford). 2021;60:2946\u201357.","journal-title":"Rheumatology (Oxford)"},{"key":"3589_CR36","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/art.42030","volume":"74","author":"R Conway","year":"2022","unstructured":"Conway R, Grimshaw AA, Konig MF, Putman M, Duarte-Garcia A, Tseng LY, et al. SARS-CoV-2 infection and COVID-19 outcomes in rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Rheumatol. 2022;74:766\u201375.","journal-title":"Arthritis Rheumatol"},{"key":"3589_CR37","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009220","volume":"96","author":"S Fujimoto","year":"2017","unstructured":"Fujimoto S, Kawabata H, Kurose N, Kawanami-Iwao H, Sakai T, Kawanami T, et al. Sjogren\u2019s syndrome manifesting as clinicopathological features of TAFRO syndrome: a case report. Medicine (Baltimore). 2017;96: e9220.","journal-title":"Medicine (Baltimore)"},{"key":"3589_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103137","volume":"21","author":"L Grange","year":"2022","unstructured":"Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, et al. TAFRO syndrome: a severe manifestation of Sjogren\u2019s syndrome? A systematic review Autoimmun Rev. 2022;21: 103137.","journal-title":"A systematic review Autoimmun Rev"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-023-03589-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T15:28:33Z","timestamp":1691681313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-023-03589-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["3589"],"URL":"https:\/\/doi.org\/10.1007\/s12185-023-03589-9","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"19 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were carried out in accordance with the ethical standards of the relevant institutional and\/or national research committees and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}