{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:46:28Z","timestamp":1776951988029,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Japanese Agency for Medical Research and Development","award":["22ek0109612h0001"],"award-info":[{"award-number":["22ek0109612h0001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 45-year-old man who was a sibling donor for allogeneic peripheral blood stem cell transplantation (allo-PBSCT) was administered 7.2\u00a0mg of pegfilgrastim for stem cell collection. Peripheral blood stem cells were collected 4\u00a0days after administration of pegfilgrastim (Day 4) and 4.32\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> \/kg of CD34-positive cells per recipient body weight were obtained. Fever of 38 \u2103 or higher and left submandibular pain appeared on Day 6. Ultrasonography and contrast-enhanced computed tomography (CT) showed wall thickening of the carotid artery and the abdominal aorta. We carefully excluded the possibilities of cardiovascular and autoimmune diseases by thorough examination, and ultimately diagnosed pegfilgrastim-induced aortitis. The patient\u2019s fever resolved rapidly after treatment with prednisolone (PSL) 1\u00a0mg\/kg. We began to taper PSL after eight days. Sixty-one days after starting PSL, we confirmed that abdominal aortic wall thickening had improved by contrast-enhanced CT. We continued to taper off PSL and stopped 141\u00a0days later with no relapse thereafter. This is the first case report of pegfilgrastim-induced aortitis in an allo-PBSCT donor. Careful monitoring is warranted when administering pegfilgrastim to donors even without past medical history.<\/jats:p>","DOI":"10.1007\/s12185-023-03649-0","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T14:02:11Z","timestamp":1692021731000},"page":"772-775","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aortitis after administration of pegfilgrastim to a healthy donor for peripheral blood stem cell collection"],"prefix":"10.1007","volume":"118","author":[{"given":"Yu","family":"Uemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aika","family":"Fuseya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akane","family":"Hosokai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8275-5372","authenticated-orcid":false,"given":"Ayako","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"3649_CR1","doi-asserted-by":"publisher","unstructured":"Rafael G, Grau., Drug-Induced Vasculitis: New Insights and a Changing Lineup of Suspects. Curr Rheumatol Rep, 2015. 17(12): 71. Doi: https:\/\/doi.org\/10.1007\/s11926-015-0545-9","DOI":"10.1007\/s11926-015-0545-9"},{"key":"3649_CR2","doi-asserted-by":"publisher","unstructured":"Sang Yoon Lee., et al., The incidence and clinical features of PEGylated filgrastim-induced acute aortitis in patients with breast cancer. Sci Rep, 2020. 10(1): 18647. doi: https:\/\/doi.org\/10.1038\/s41598-020-75620-6.","DOI":"10.1038\/s41598-020-75620-6"},{"issue":"6","key":"3649_CR3","first-page":"224","volume":"77","author":"K Yukawa","year":"2019","unstructured":"Yukawa K, et al. Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor. Neth J Med. 2019;77(6):224\u20136.","journal-title":"Neth J Med"},{"issue":"1","key":"3649_CR4","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1186\/s12885-019-6403-9","volume":"19","author":"H Hoshina","year":"2019","unstructured":"Hoshina H, Takei H. Granulocyte-colony stimulating factor-associated aortitis in a woman with advanced breast cancer: a case report and review of the literature. BMC Cancer. 2019;19(1):1217. https:\/\/doi.org\/10.1186\/s12885-019-6403-9.","journal-title":"BMC Cancer"},{"issue":"2","key":"3649_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1537-2995.2010.02863.x","volume":"51","author":"D Lys\u00e1k","year":"2011","unstructured":"Lys\u00e1k D, et al. Changes of cytokine levels during granulocyte-colony-stimulating factor stem cell mobilization in healthy donors: association with mobilization efficiency and potential predictive significance. Transfusion. 2011;51(2):319\u201327.","journal-title":"Transfusion"},{"key":"3649_CR6","doi-asserted-by":"crossref","unstructured":"Magali Noval Rivas., Moshe Arditi., Kawasaki disease: pathophysiology and insights from mouse models. Nat Rev Rheumatol, 2020. 16(7): 391\u2013405.","DOI":"10.1038\/s41584-020-0426-0"},{"issue":"3","key":"3649_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s12016-015-8495-6","volume":"50","author":"P Renauer","year":"2016","unstructured":"Renauer P, et al. Epigenetics and vasculitis: a comprehensive review. Clin Rev Allergy Immunol. 2016;50(3):357\u201366.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"5","key":"3649_CR8","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s12185-010-0730-6","volume":"92","author":"B Nasilowska-Adamska","year":"2010","unstructured":"Nasilowska-Adamska B, et al. Acute glomerulonephritis in a donor as a side effect of allogeneic peripheral blood stem cell mobilization with granulocyte colony-stimulating factor. Int J Hematol. 2010;92(5):765\u20138.","journal-title":"Int J Hematol"},{"key":"3649_CR9","unstructured":"Arimura, K., et al., Acute lung Injury in a healthy donor during mobilization of peripheral blood stem cells using granulocyte-colony stimulating factor alone. Haematologica, 2005. 90(3): ECR10."}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03649-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-023-03649-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03649-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T15:12:50Z","timestamp":1700838770000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-023-03649-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["3649"],"URL":"https:\/\/doi.org\/10.1007\/s12185-023-03649-0","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]},"assertion":[{"value":"18 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}