{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:42:05Z","timestamp":1740120125548,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ek0109210h0001","20ek0109481h0001"],"award-info":[{"award-number":["17ek0109210h0001","20ek0109481h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s12185-023-03699-4","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:01:56Z","timestamp":1705428116000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anticoagulant effects of protein C, protein S, and antithrombin levels on the protein C pathway in young children"],"prefix":"10.1007","volume":"119","author":[{"given":"Takashi","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-6915","authenticated-orcid":false,"given":"Kenichi","family":"Ogiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tonegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Nishikubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"issue":"4","key":"3699_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1055\/s-2007-1000655","volume":"21","author":"M Andrew","year":"1995","unstructured":"Andrew M. Developmental hemostasis: relevance to hemostatic problems during childhood. Semin Thromb Hemost. 1995;21(4):341\u201356.","journal-title":"Semin Thromb Hemost"},{"issue":"Suppl 1","key":"3699_CR2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/ijlh.12531","volume":"38","author":"P Toulon","year":"2016","unstructured":"Toulon P. Developmental hemostasis: laboratory and clinical implications. Int J Lab Hematol. 2016;38(Suppl 1):66\u201377.","journal-title":"Int J Lab Hematol"},{"issue":"10","key":"3699_CR3","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1111\/jth.12372","volume":"11","author":"C Attard","year":"2013","unstructured":"Attard C, van der Straaten T, Karlaftis V, Monagle P, Ignjatovic V. Developmental hemostasis: age-specific differences in the levels of hemostatic proteins. J Thromb Haemost. 2013;11(10):1850\u20134.","journal-title":"J Thromb Haemost"},{"issue":"2","key":"3699_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.blre.2009.12.001","volume":"24","author":"P Monagle","year":"2010","unstructured":"Monagle P, Ignjatovic V, Savoia H. Hemostasis in neonates and children: pitfalls and dilemmas. Blood Rev. 2010;24(2):63\u20138.","journal-title":"Blood Rev"},{"issue":"1","key":"3699_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12519-021-00492-3","volume":"18","author":"Y Rey","year":"2022","unstructured":"Rey Y, Formoso V, Barreto Mota R, Soares H. Developmental hemostasis in the neonatal period. World J Pediatr. 2022;18(1):7\u201315.","journal-title":"World J Pediatr"},{"issue":"3","key":"3699_CR6","doi-asserted-by":"publisher","first-page":"780","DOI":"10.3390\/nu12030780","volume":"12","author":"S Araki","year":"2020","unstructured":"Araki S, Shirahata A. Vitamin K deficiency bleeding in infancy. Nutrients. 2020;12(3):780.","journal-title":"Nutrients"},{"key":"3699_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.562495","volume":"9","author":"H Eliwan","year":"2022","unstructured":"Eliwan H, Omer M, McKenna E, Kelly LA, Nolan B, Regan I, et al. Protein C pathway in paediatric and neonatal Sepsis. Front Pediatr. 2022;9: 562495.","journal-title":"Front Pediatr"},{"issue":"3","key":"3699_CR8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/hae.12097","volume":"19","author":"S Ohga","year":"2013","unstructured":"Ohga S, Kang D, Kinjo T, Ochiai M, Doi T, Ishimura M, et al. Paediatric presentation and outcome of congenital protein C deficiency in Japan. Haemophilia. 2013;19(3):378\u201384.","journal-title":"Haemophilia"},{"issue":"1","key":"3699_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.thromres.2008.11.017","volume":"124","author":"P Toulon","year":"2009","unstructured":"Toulon P, Smirnov M, Triscott M, Safa O, Biguzzi E, Bouziane K, et al. A new chromogenic assay (HemosIL ThromboPath) is sensitive to major prothrombotic risk factors affecting the protein C pathway. Results of a multicenter study. Thromb Res. 2009;124(1):137\u201343.","journal-title":"Thromb Res"},{"issue":"6","key":"3699_CR10","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0049-3848(97)00179-5","volume":"87","author":"K Ruzicka","year":"1997","unstructured":"Ruzicka K, Kapiotis S, Quehenberger P, Handler S, Pabinger-Fasching I, Mannhalter C, et al. Evaluation of a new screening assay ProC Global for identification of defects in the protein C\/protein S anticoagulant pathway. Thromb Res. 1997;87(6):501\u201310.","journal-title":"Thromb Res"},{"issue":"1","key":"3699_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/ejh.13777","volume":"109","author":"N Hashimoto","year":"2022","unstructured":"Hashimoto N, Ogiwara K, Shimonishi N, Nakagawa T, Nakajima Y, Furukawa S, et al. Screening of the protein C pathway abnormality-related thrombophilia by using thrombomodulin-mediated tissue factor-triggered clot waveform analysis. Eur J Haematol. 2022;109(1):100\u20138.","journal-title":"Eur J Haematol"},{"issue":"1","key":"3699_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14741","volume":"64","author":"H Aoki","year":"2022","unstructured":"Aoki H, Ogiwara K, Hasegawa M, Nogami K. Hemostatic rebalance in neonatal intrahepatic cholestasis with citrin deficiency. Pediatr Int. 2022;64(1): e14741.","journal-title":"Pediatr Int"},{"issue":"6","key":"3699_CR13","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s12185-019-02645-7","volume":"109","author":"K Ogiwara","year":"2019","unstructured":"Ogiwara K, Nogami K, Mizumachi K, Nakagawa T, Noda N, Ohga S, et al. Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency. Int J Hematol. 2019;109(6):650\u20136.","journal-title":"Int J Hematol"},{"key":"3699_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.thromres.2019.03.021","volume":"178","author":"P Rogalski","year":"2019","unstructured":"Rogalski P, Rogalska-Plonska M, Wroblewski E, Kostecka-Roslen I, Dabrowska M, Swidnicka-Siergiejko A, et al. Laboratory evidence for hypercoagulability in cirrhotic patients with history of variceal bleeding. Thromb Res. 2019;178:41\u20136.","journal-title":"Thromb Res"},{"issue":"3","key":"3699_CR15","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/bjh.18239","volume":"198","author":"DJ Arachchillage","year":"2022","unstructured":"Arachchillage DJ, Mackillop L, Chandratheva A, Motawani J, MacCallum P, Laffan M. Thrombophilia testing: a British Society for Haematology guideline. Br J Haematol. 2022;198(3):443\u201358.","journal-title":"Br J Haematol"},{"issue":"6","key":"3699_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/MBC.0000000000001148","volume":"33","author":"N Hashimoto","year":"2022","unstructured":"Hashimoto N, Ogiwara K, Matsumoto T, Furukawa S, Takeyama M, Nogami K. Characterization of thrombophilia-related plasmas evaluated by anticoagulants-mediated thrombin and plasmin generation assays. Blood Coagul Fibrinolysis. 2022;33(6):327\u201336.","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03699-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-023-03699-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-023-03699-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T14:34:09Z","timestamp":1706711649000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-023-03699-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["3699"],"URL":"https:\/\/doi.org\/10.1007\/s12185-023-03699-4","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"type":"print","value":"0925-5710"},{"type":"electronic","value":"1865-3774"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"11 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}