{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:23:16Z","timestamp":1792819396997,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12185-024-03896-9","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:14:11Z","timestamp":1734311651000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4021","authenticated-orcid":false,"given":"Kazuma","family":"Yamakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ikezoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Iba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Totoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidesaku","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Uchiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineji","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Madoiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Mayumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Committee of the Clinical Practice Guidelines for Management of Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"1","key":"3896_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.thromres.2009.08.017","volume":"125","author":"H Wada","year":"2010","unstructured":"Wada H, Asakura H, Okamoto K, Iba T, Uchiyama T, Kawasugi K, et al. Expert consensus for the treatment of disseminated intravascular coagulation in Japan. Thromb Res. 2010;125(1):6\u201311.","journal-title":"Thromb Res"},{"issue":"4","key":"3896_CR2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.thromres.2014.07.033","volume":"134","author":"H Wada","year":"2014","unstructured":"Wada H, Okamoto K, Iba T, Kushimoto S, Kawasugi K, Gando S, et al. Addition of recommendations for the use of recombinant human thrombomodulin to the \u201cExpert consensus for the treatment of disseminated intravascular coagulation in Japan.\u201d Thromb Res. 2014;134(4):924\u20135.","journal-title":"Thromb Res"},{"issue":"1","key":"3896_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","volume":"145","author":"M Levi","year":"2009","unstructured":"Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009;145(1):24\u201333.","journal-title":"Br J Haematol"},{"issue":"5","key":"3896_CR4","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1016\/j.thromres.2011.08.028","volume":"129","author":"M Di Nisio","year":"2012","unstructured":"Di Nisio M, Baudo F, Cosmi B, D\u2019Angelo A, De Gasperi A, Malato A, et al. Diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res. 2012;129(5):e177\u201384.","journal-title":"Thromb Res"},{"issue":"4","key":"3896_CR5","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1111\/jth.12155","volume":"11","author":"H Wada","year":"2013","unstructured":"Wada H, Thachil J, Di Nisio M, Mathew P, Kurosawa S, Gando S, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013;11(4):761\u20137.","journal-title":"J Thromb Haemost"},{"key":"3896_CR6","unstructured":"Minds Manual Developing Committee. Minds manual for guideline development 2020 ver. 3.0. Tokyo: Japan Council for Quality Health Care; 2021."},{"issue":"5","key":"3896_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1055\/s-0037-1616068","volume":"86","author":"FB Taylor Jr","year":"2001","unstructured":"Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M. Scientific subcommittee on disseminated intravascular coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH): towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327\u201330.","journal-title":"Thromb Haemost"},{"issue":"3","key":"3896_CR8","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/01.CCM.0000202209.42491.38","volume":"34","author":"S Gando","year":"2006","unstructured":"Gando S, Iba T, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006;34(3):625\u201331.","journal-title":"Crit Care Med"},{"issue":"11","key":"3896_CR9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1055\/s-0044-1786808","volume":"124","author":"K Yamakawa","year":"2024","unstructured":"Yamakawa K, Umemura Y, Mochizuki K, Matsuoka T, Wada T, Hayakawa M, et al. Proposal and validation of a clinically relevant modification of the Japanese association for acute medicine disseminated intravascular coagulation diagnostic criteria for sepsis. Thromb Haemost. 2024;124(11):1003\u201312.","journal-title":"Thromb Haemost"},{"issue":"8","key":"3896_CR10","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1111\/jth.14482","volume":"17","author":"T Iba","year":"2019","unstructured":"Iba T, Levy JH, Yamakawa K, Thachil J, Warkentin TE, Levi M, et al. Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation. J Thromb Haemost. 2019;17(8):1265\u20138.","journal-title":"J Thromb Haemost"},{"key":"3896_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12959-016-0117-x","volume":"14","author":"H Asakura","year":"2016","unstructured":"Asakura H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, et al. Proposal for new diagnostic criteria for DIC from the Japanese society on thrombosis and hemostasis. Thromb J. 2016;14:42.","journal-title":"Thromb J"},{"key":"3896_CR12","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1378\/chest.104.3.882","volume":"104","author":"F Fourrier","year":"1993","unstructured":"Fourrier F, Chopin C, Huart JJ, Runge I, Caron C, Goudemand J. Double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. Chest. 1993;104:882\u20138.","journal-title":"Chest"},{"key":"3896_CR13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/00024382-199711000-00003","volume":"8","author":"D Inthorn","year":"1997","unstructured":"Inthorn D, Hoffmann JN, Hartl WH, M\u00fchlbayer D, Jochum M. Antithrombin III supplementation in severe sepsis: beneficial effects on organ dysfunction. Shock. 1997;8:328\u201334.","journal-title":"Shock"},{"key":"3896_CR14","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s001340050576","volume":"24","author":"F Baudo","year":"1998","unstructured":"Baudo F, Caimi TM, de Cataldo F, Ravizza A, Arlati S, Casella G, et al. Antithrombin III (ATIII) replacement therapy in patients with sepsis and\/or postsurgical complications: a controlled double-blind, randomized, multicenter study. Intensive Care Med. 1998;24:336\u201342.","journal-title":"Intensive Care Med"},{"key":"3896_CR15","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1538-7836.2005.01697.x","volume":"4","author":"J Kienast","year":"2006","unstructured":"Kienast J, Juers M, Wiedermann CJ, Hoffmann JN, Ostermann H, Strauss R, et al. Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J Thromb Haemost. 2006;4:90\u20137.","journal-title":"J Thromb Haemost"},{"key":"3896_CR16","doi-asserted-by":"publisher","first-page":"R297","DOI":"10.1186\/cc13163","volume":"17","author":"S Gando","year":"2013","unstructured":"Gando S, Saitoh D, Ishikura H, Ueyama M, Otomo Y, Oda S, et al. A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Crit Care. 2013;17:R297.","journal-title":"Crit Care"},{"key":"3896_CR17","unstructured":"https:\/\/endpointhealth.com\/news\/endpoint-health-enters-into-global-collaboration-and-licensing-agreement-with-grifols\/"},{"key":"3896_CR18","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1097\/CCM.0b013e31828e9b03","volume":"41","author":"JL Vincent","year":"2013","unstructured":"Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013;41:2069\u201379.","journal-title":"Crit Care Med"},{"key":"3896_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012850","volume":"6","author":"A Hagiwara","year":"2016","unstructured":"Hagiwara A, Tanaka N, Uemura T, Matsuda W, Kimura A. Can recombinant human thrombomodulin increase survival among patients with severe septic-induced disseminated intravascular coagulation: a single-centre, open-label, randomised controlled trial. BMJ Open. 2016;6: e012850.","journal-title":"BMJ Open"},{"key":"3896_CR20","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3390\/jcm8101553","volume":"8","author":"S Mori","year":"2019","unstructured":"Mori S, Ai T, Sera T, Ochiai K, Otomo Y. Human soluble recombinant thrombomodulin, ART-123, resolved early phase coagulopathies, but did not significantly alter the 28 day outcome in the treatment of DIC associated with infectious systemic inflammatory response syndromes. J Clin Med. 2019;8:1553.","journal-title":"J Clin Med"},{"key":"3896_CR21","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1001\/jama.2019.5358","volume":"321","author":"JL Vincent","year":"2019","unstructured":"Vincent JL, Francois B, Zabolotskikh I, Daga MK, Lascarrou JB, Kirov MY, et al. Effect of a recombinant human soluble thrombomodulin on mortality in patients with sepsis-associated coagulopathy: the SCARLET randomized clinical trial. JAMA. 2019;321:1993\u20132002.","journal-title":"JAMA"},{"issue":"1","key":"3896_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13054-021-03524-6","volume":"25","author":"T Ito","year":"2021","unstructured":"Ito T, Kakuuchi M, Maruyama I. Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation. Crit Care. 2021;25(1):95.","journal-title":"Crit Care"},{"key":"3896_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12959-018-0178-0","volume":"16","author":"T Arishima","year":"2018","unstructured":"Arishima T, Ito T, Yasuda T, Yashima N, Furubeppu H, Kamikokuryo C, et al. Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin. Thromb J. 2018;16:24.","journal-title":"Thromb J"},{"issue":"1","key":"3896_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.thromres.2014.04.015","volume":"134","author":"T Iba","year":"2014","unstructured":"Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I. Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats. Thromb Res. 2014;134(1):169\u201373.","journal-title":"Thromb Res"},{"issue":"1","key":"3896_CR25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12959-023-00579-z","volume":"22","author":"T Totoki","year":"2024","unstructured":"Totoki T, Makino Y, Yamakawa K, Koami H, Wada T, Ito T, et al. Effects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis. Thromb J. 2024;22(1):10.","journal-title":"Thromb J"},{"issue":"1","key":"3896_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.659","volume":"8","author":"M Egi","year":"2021","unstructured":"Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, et al. The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020). Acute Med Surg. 2021;8(1): e659.","journal-title":"Acute Med Surg"},{"issue":"3","key":"3896_CR27","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3892\/etm.2013.1466","volume":"7","author":"XL Liu","year":"2014","unstructured":"Liu XL, Wang XZ, Liu XX, Hao D, Jaladat Y, Lu F, et al. Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: a prospective clinical study. Exp Ther Med. 2014;7(3):604\u20138.","journal-title":"Exp Ther Med"},{"issue":"10","key":"3896_CR28","first-page":"20074","volume":"9","author":"C Yang","year":"2016","unstructured":"Yang C, Chen X, Zheng D, Chen L, Ding Y, Xie W. Impacts of early anticoagulant therapy on tissue perfusion in patients with sepsis. Int J Clin Exp Med. 2016;9(10):20074\u20139.","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"3896_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12871-021-01545-w","volume":"22","author":"S Fu","year":"2022","unstructured":"Fu S, Yu S, Wang L, Ma X, Li X. Unfractionated heparin improves the clinical efficacy in adult sepsis patients: a systematic review and meta-analysis. BMC Anesthesiol. 2022;22(1):28.","journal-title":"BMC Anesthesiol"},{"issue":"3","key":"3896_CR30","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.21037\/apm-21-169","volume":"10","author":"X Li","year":"2021","unstructured":"Li X, Liu Z, Luo M, Xi Y, Li C, Wang S, et al. Therapeutic effect of low-molecular-weight heparin on adult sepsis: a meta-analysis. Ann Palliat Med. 2021;10(3):3115\u201327.","journal-title":"Ann Palliat Med"},{"issue":"5","key":"3896_CR31","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/jth.14810","volume":"18","author":"J Thachil","year":"2020","unstructured":"Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020;18(5):1023\u20136.","journal-title":"J Thromb Haemost"},{"issue":"9","key":"3896_CR32","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1111\/jth.14975","volume":"18","author":"T Iba","year":"2020","unstructured":"Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost. 2020;18(9):2103\u20139.","journal-title":"J Thromb Haemost"},{"key":"3896_CR33","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1097\/00003246-200005000-00027","volume":"28","author":"T Nishiyama","year":"2000","unstructured":"Nishiyama T, Matsukawa T, Hanaoka K. Is protease inhibitor a choice for the treatment of pre- or mild disseminated intravascular coagulation? Crit Care Med. 2000;28:1419\u201322.","journal-title":"Crit Care Med"},{"key":"3896_CR34","first-page":"678","volume":"103","author":"JT Hsu","year":"2004","unstructured":"Hsu JT, Chen HM, Chiu DF, Chen JC, Huang CJ, Hwang TL, et al. Efficacy of gabexate mesylate on disseminated intravascular coagulation as a complication of infection developing after abdominal surgery. J Formos Med Assoc. 2004;103:678\u201384.","journal-title":"J Formos Med Assoc"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-024-03896-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-024-03896-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-024-03896-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:48:28Z","timestamp":1745318908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-024-03896-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3896"],"URL":"https:\/\/doi.org\/10.1007\/s12185-024-03896-9","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"17 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Kazuma Yamakawa has received research grants from the Japan Blood Products Organization and Asahi Kasei Pharma. Yoshinobu Seki was involved in clinical trials conducted by Chugai Pharmaceutical. Takashi Ito has received lecture fees and research grants from Asahi Kasei Pharma. Toshiaki Iba received a research grant from JIMRO. Hiroyasu Ishikura has received lecture fees from Asahi Kasei Pharma. Hideo Wada received a research grant from I.L. Japan. Hidesaku Asakura is editor of International Journal of Hematology. None of the authors have any potential conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}