{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:26:07Z","timestamp":1787318767929,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12185-025-03937-x","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T02:10:12Z","timestamp":1738635012000},"page":"706-711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myelodysplastic neoplasms with repeating TAFRO syndrome-like symptoms"],"prefix":"10.1007","volume":"121","author":[{"given":"Kenta","family":"Hayashino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-7768","authenticated-orcid":false,"given":"Nobuharu","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Hashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Seike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ennishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"3937_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12185-019-02780-1","volume":"111","author":"Y Masaki","year":"2020","unstructured":"Masaki Y, Kawabata H, Takai K, Tsukamoto N, Fujimoto S, Ishigaki Y, et al. 2019 Updated diagnostic criteria and disease severity classification for TAFRO syndrome. Int J Hematol. 2020;111:155\u20138.","journal-title":"Int J Hematol"},{"key":"3937_CR2","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1007\/s00277-023-05435-8","volume":"102","author":"X Wu","year":"2023","unstructured":"Wu X, Zhang X, Qian S, Shi C, Li X, Feng X, et al. The experience of diagnosis and treatment for TAFRO syndrome. Ann Hematol. 2023;102:3515\u201320.","journal-title":"Ann Hematol"},{"key":"3937_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.hoc.2017.09.009","volume":"32","author":"T Igawa","year":"2018","unstructured":"Igawa T, Sato Y. TAFRO syndrome. Hematol Oncol Clin North Am. 2018;32:107\u201318.","journal-title":"Hematol Oncol Clin North Am"},{"key":"3937_CR4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ajh.24242","volume":"91","author":"N Iwaki","year":"2016","unstructured":"Iwaki N, Fajgenbaum DC, Nabel CS, Gion Y, Kondo E, Kawano M, et al. Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease. Am J Hematol. 2016;91:220\u20136.","journal-title":"Am J Hematol"},{"key":"3937_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/JBM.S127822","volume":"9","author":"K Sakashita","year":"2018","unstructured":"Sakashita K, Murata K, Takamori M. TAFRO syndrome: current perspectives. J Blood Med. 2018;9:15\u201323.","journal-title":"J Blood Med"},{"key":"3937_CR6","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1007\/s00277-018-3472-9","volume":"97","author":"E Grignano","year":"2018","unstructured":"Grignano E, Jachiet V, Fenaux P, Ades L, Fain O, Mekinian A. Autoimmune manifestations associated with myelodysplastic syndromes. Ann Hematol. 2018;97:2015\u201323.","journal-title":"Ann Hematol"},{"key":"3937_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/jha2.609","volume":"4","author":"H Mizumaki","year":"2023","unstructured":"Mizumaki H, Ishiyama K, Aoki J, Mori J, Mizuno S, Doki N, et al. Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10). EJHaem. 2023;4:251\u20137.","journal-title":"EJHaem"},{"key":"3937_CR8","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/bjh.17473","volume":"194","author":"M Matsunawa","year":"2021","unstructured":"Matsunawa M, Inoue Y, Yagihashi K, Aida Y, Uchida A, Uemura Y, et al. The clinicopathological analysis of organising pneumonia in myelodysplastic syndrome: high frequency in der(1;7)(q10; p10). Br J Haematol. 2021;194:214\u20137.","journal-title":"Br J Haematol"},{"key":"3937_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1046\/j.0902-4441.2003.00191.x","volume":"72","author":"C Yoshida","year":"2004","unstructured":"Yoshida C, Kojima H, Ishigaki T, Katsura Y, Kaneko S, Suzukawa K, et al. Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10). Eur J Haematol. 2004;72:149\u201353.","journal-title":"Eur J Haematol"},{"key":"3937_CR10","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1182\/hematology.2022000350","volume":"2022","author":"JD Gonzalez-Lugo","year":"2022","unstructured":"Gonzalez-Lugo JD, Verma A. Targeting inflammation in lower-risk MDS. Hematology. 2022;2022:382\u20137.","journal-title":"Hematology"},{"key":"3937_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3892\/ol.2023.13681","volume":"25","author":"N Kalitin","year":"2023","unstructured":"Kalitin N, Dudina G, Kostritsa N, Sivirinova A, Karamysheva A. Evaluation of VEGF and VEGFR gene expression as prognostic markers in low and intermediate-1 risk patients with myelodysplastic syndromes. Oncol Lett. 2023;25:95.","journal-title":"Oncol Lett"},{"key":"3937_CR12","doi-asserted-by":"publisher","DOI":"10.7326\/aimcc.2023.1018","volume":"3","author":"I Drici-Tani","year":"2024","unstructured":"Drici-Tani I, Grange L, Killian M, Gaultier J-B, P\u00e9oc\u2019h M, Sapet M, et al. Chronic myelomonocytic leukemia associated with TAFRO syndrome-like symptoms. Ann Intern Med Clin Cases. 2024;3: e231018.","journal-title":"Ann Intern Med Clin Cases."},{"key":"3937_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3960\/jslrt.22029","volume":"63","author":"H Iizuka-Honma","year":"2023","unstructured":"Iizuka-Honma H, Takizawa H, Nitta H, Mitsumori T, Noguchi M. Development of rapidly fatal TAFRO syndrome-like features in a patient with essential thrombocythemia. J Clin Exp Hematop. 2023;63:32\u20136.","journal-title":"J Clin Exp Hematop"},{"key":"3937_CR14","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1086\/342290","volume":"71","author":"RR Graham","year":"2002","unstructured":"Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, et al. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet. 2002;71:543\u201353.","journal-title":"Am J Hum Genet"},{"key":"3937_CR15","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1212\/WNL.0b013e3181e24124","volume":"74","author":"L Handunnetthi","year":"2010","unstructured":"Handunnetthi L, Ramagopalan SV, Ebers GC. Multiple sclerosis, vitamin D, and HLA-DRB1*15. Neurology. 2010;74:1905\u201310.","journal-title":"Neurology"},{"key":"3937_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.humimm.2008.02.001","volume":"69","author":"ML Lombardi","year":"2008","unstructured":"Lombardi ML, Terrazzano G, Cosentini E, Gargiulo L, Risitano A, Camerlingo R, et al. Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population. Hum Immunol. 2008;69:202\u20136.","journal-title":"Hum Immunol"},{"key":"3937_CR17","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3389\/fimmu.2017.00984","volume":"8","author":"EM Scholz","year":"2017","unstructured":"Scholz EM, Marcilla M, Daura X, Arribas-Layton D, James EA, Alvarez I. Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires. Front Immunol. 2017;8:984.","journal-title":"Front Immunol"},{"key":"3937_CR18","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.3324\/haematol.2012.083345","volume":"99","author":"RS Komrokji","year":"2014","unstructured":"Komrokji RS, Mailloux AW, Chen DT, Sekeres MA, Paquette R, Fulp WJ, et al. A phase II multicenter rabbit anti-thymocyte globulin trial in patients with myelodysplastic syndromes identifying a novel model for response prediction. Haematologica. 2014;99:1176\u201383.","journal-title":"Haematologica"},{"key":"3937_CR19","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1200\/JCO.2003.10.503","volume":"21","author":"D Cilloni","year":"2003","unstructured":"Cilloni D, Gottardi E, Messa F, Fava M, Scaravaglio P, Bertini M, et al. Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes. J Clin Oncol. 2003;21:1988\u201395.","journal-title":"J Clin Oncol"},{"key":"3937_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1532\/LH96.06047","volume":"13","author":"JY Han","year":"2007","unstructured":"Han JY, Theil KS. Karyotypic identification of abnormal clones preceding morphological changes or occurring with no definite morphological features of myelodysplastic syndrome: a preliminary study. Lab Hematol. 2007;13:17\u201321.","journal-title":"Lab Hematol"},{"key":"3937_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1517\/14728214.2012.736487","volume":"17","author":"PK Epling-Burnette","year":"2012","unstructured":"Epling-Burnette PK, McDaniel J, Wei S, List AF. Emerging immunosuppressive drugs in myelodysplastic syndromes. Expert Opin Emerg Drugs. 2012;17:519\u201341.","journal-title":"Expert Opin Emerg Drugs"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-025-03937-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-025-03937-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-025-03937-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T06:48:43Z","timestamp":1745304523000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-025-03937-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3937"],"URL":"https:\/\/doi.org\/10.1007\/s12185-025-03937-x","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"23 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in the study were in accordance with the ethical standards of the institutional and\/or national research committee and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The use of rituximab, bortezomib, and tocilizumab in this case was approved by the Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflicts of interests. Daisuke Ennishi is editor of International Journal of Hematology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}}]}}