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Here we present the case of a 65-year-old woman with acute myeloid leukemia who successfully underwent HSCT, but developed AdV-HC followed by adenovirus viremia. Marked prolongation of activated partial thromboplastin time (APTT) was observed, along with a decrease in all coagulation factors except prothrombin, raising suspicion of a coagulation factor deficiency. A workup including the APTT cross-mixing test, diluted Russell\u2019s viper venom time, and phospholipid neutralization assays revealed the presence of lupus anticoagulant (LA), indicating a thrombotic tendency due to LA associated with artifactual lowering of coagulation factors. Based on these findings, no hemostatic agents were used to manage macroscopic hematuria, and all coagulation test results spontaneously normalized with the resolution of adenovirus viremia, without any thrombus formation. Patients with AdV-HC and prolonged APTT should be screened for LA to avoid inappropriate use of hemostatic agents.<\/jats:p>","DOI":"10.1007\/s12185-025-04020-1","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:55:34Z","timestamp":1749120934000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transient lupus anticoagulant induced by adenovirus cystitis in a bone marrow transplant recipient"],"prefix":"10.1007","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-7368","authenticated-orcid":false,"given":"Tatsuya","family":"Imi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidesaku","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yoroidaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Zaimoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyo","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"issue":"4","key":"4020_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1053\/sarh.2002.28303","volume":"31","author":"IW Uthman","year":"2002","unstructured":"Uthman IW, Gharavi AE. 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The funders had no role in the preparation of the manuscript, or decision to publish. HA and HY are editorial members of the International Journal of Hematology and therefore have a conflict of interest in peer review.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}