{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:26:04Z","timestamp":1763713564967,"version":"3.45.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12185-025-04052-7","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:52:53Z","timestamp":1755100373000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute hemolytic crises and clinical course in a Japanese family with Hb Santander: a detailed case report"],"prefix":"10.1007","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-8755","authenticated-orcid":false,"given":"Sayaka","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Hosoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miku","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Maegaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihito","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hatayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Hosoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"4052_CR1","unstructured":"Globin Gene Server home page. https:\/\/globin.bx.psu.edu\/."},{"key":"4052_CR2","first-page":"437","volume":"59","author":"Y Hattori","year":"2001","unstructured":"Hattori Y, Harano A. Abnormal hemoglobin and thalassemia. Nippon Rinsho. 2001;59:437\u201351.","journal-title":"Nippon Rinsho"},{"key":"4052_CR3","doi-asserted-by":"publisher","first-page":"a011858","DOI":"10.1101\/cshperspect.a011858","volume":"3","author":"CS Thom","year":"2013","unstructured":"Thom CS, Dickson CF, Gell DA, Weiss MJ. Hemoglobin variants: biochemical properties and clinical correlates. Cold Spring Harb Perspect Med. 2013;3: a011858.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4052_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1081\/HEM-100104026","volume":"25","author":"H Wajcman","year":"2001","unstructured":"Wajcman H, Pr\u00e9hu C, Bardakdjian-Michau J, Prom\u00e9 D, Riou J, Godart C, et al. Abnormal hemoglobins: laboratory methods. Hemoglobin. 2001;25:169\u201381.","journal-title":"Hemoglobin"},{"key":"4052_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1081\/HEM-120016378","volume":"27","author":"A Villegas","year":"2003","unstructured":"Villegas A, Ropero P, Nogales A, Gonz\u00e1lez FA, Mateo M, Mazo E, et al. Hb Santander [beta34(B16)Val\u2192Asp (GTC\u2192GAC)]: a new unstable variant found as a de novo mutation in a Spanish patient. Hemoglobin. 2003;27:31\u20135.","journal-title":"Hemoglobin"},{"key":"4052_CR6","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/0005-2795(80)90088-4","volume":"624","author":"Y Blouquit","year":"1980","unstructured":"Blouquit Y, Braconnier F, Cohen-Solal M, F\u00f6ldi J, Arous N, Ankri A, et al. Hemoglobin Pitie-salpetriere beta 34 (B16) Val replaced by Phe. A new high oxygen affinity variant associated with familial erythrocytosis. Biochim Biophys Acta. 1980;624:473\u20138.","journal-title":"Biochim Biophys Acta"},{"key":"4052_CR7","first-page":"221","volume":"71","author":"T Uchida","year":"2000","unstructured":"Uchida T, Kinoshita T, Hirabayashi N, Saito H, Harano K, Harano T. Hemoglobin Piti\u00e9-Salp\u00e9tri\u00e8re [beta 34 (B16) Val\u2192Phe] showing erythrocytosis and mild hemolysis in a Japanese man. Int J Hematol. 2000;71:221\u20136.","journal-title":"Int J Hematol"},{"key":"4052_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1080\/03630269.2021.1943430","volume":"45","author":"J Tavakoli","year":"2021","unstructured":"Tavakoli J, Ho G, Kavecansky J, Pai AP. A new high affinity hemoglobin variant: Hb San Francisco-KP (HBB: c.104T>C). Hemoglobin. 2021;45:154\u20136.","journal-title":"Hemoglobin"},{"key":"4052_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1081\/HEM-120023384","volume":"27","author":"H Wajcman","year":"2003","unstructured":"Wajcman H, Bardakdjian-Michau J, Riou J, Pr\u00e9hu C, Kister J, Baudin-Creuza V, et al. Two new hemoglobin variants with increased oxygen affinity: Hb Nantes [beta34(B16)Val\u2192Leu] and Hb Vexin [beta116(G18)His\u2192Leu]. Hemoglobin. 2003;27:191\u20139.","journal-title":"Hemoglobin"},{"key":"4052_CR10","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1110\/ps.16401","volume":"10","author":"JS Kavanaugh","year":"2001","unstructured":"Kavanaugh JS, Weydert JA, Rogers PH, Arnone A, Hui HL, Wierzba AM, et al. Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces. Protein Sci. 2001;10:1847\u201355.","journal-title":"Protein Sci"},{"key":"4052_CR11","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1182\/bloodadvances.2019000527","volume":"3","author":"AM Dosunmu-Ogunbi","year":"2019","unstructured":"Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC. Decoding the role of SOD2 in sickle cell disease. Blood Adv. 2019;3:2679\u201387.","journal-title":"Blood Adv"},{"key":"4052_CR12","first-page":"41","volume":"27","author":"CC Winterbourn","year":"1990","unstructured":"Winterbourn CC. Oxidative denaturation in congenital hemolytic anemias: the unstable hemoglobins. Semin Hematol. 1990;27:41\u201350.","journal-title":"Semin Hematol"},{"key":"4052_CR13","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1592\/phco.22.8.656.33216","volume":"22","author":"GE Sklar","year":"2002","unstructured":"Sklar GE. Hemolysis as a potential complication of acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. Pharmacotherapy. 2002;22:656\u20138.","journal-title":"Pharmacotherapy"},{"key":"4052_CR14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.2344\/0003-3006-56.3.86","volume":"56","author":"AR Elyassi","year":"2009","unstructured":"Elyassi AR, Rowshan HH. Perioperative management of the glucose-6-phosphate dehydrogenase deficient patient: a review of literature. Anesth Prog. 2009;56:86\u201391.","journal-title":"Anesth Prog"},{"key":"4052_CR15","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1097\/00043426-200312000-00009","volume":"25","author":"H Tamary","year":"2003","unstructured":"Tamary H, Aviner S, Freud E, Miskin H, Krasnov T, Schwarz M, et al. High incidence of early cholelithiasis detected by ultrasonography in children and young adults with hereditary spherocytosis. J Pediatr Hematol Oncol. 2003;25:952\u20134.","journal-title":"J Pediatr Hematol Oncol"},{"key":"4052_CR16","doi-asserted-by":"publisher","first-page":"9527","DOI":"10.3390\/ijms24119527","volume":"24","author":"K Paschoudi","year":"2023","unstructured":"Paschoudi K, Yannaki E, Psatha N. Precision editing as a therapeutic approach for \u03b2-hemoglobinopathies. Int J Mol Sci. 2023;24:9527.","journal-title":"Int J Mol Sci"},{"key":"4052_CR17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.stem.2021.01.001","volume":"28","author":"CM Drysdale","year":"2021","unstructured":"Drysdale CM, Nassehi T, Gamer J, Yapundich M, Tisdale JF, Uchida N. Hematopoietic-stem-cell-targeted gene-addition and gene-editing strategies for \u03b2-hemoglobinopathies. Cell Stem Cell. 2021;28:191\u2013208.","journal-title":"Cell Stem Cell"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-025-04052-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-025-04052-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-025-04052-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:23:46Z","timestamp":1763713426000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-025-04052-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["4052"],"URL":"https:\/\/doi.org\/10.1007\/s12185-025-04052-7","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"type":"print","value":"0925-5710"},{"type":"electronic","value":"1865-3774"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"8 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}