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The aim of this study was to investigate the effect of food on iron absorption following ferric citrate hydrate administration in patients with iron deficiency anemia. A randomized, open-label, two-cohort, two-period, single-dose crossover study was conducted to assess the effect of food on iron absorption when 500\u00a0mg ferric citrate hydrate (approximately 120\u00a0mg of ferric iron) was administered under fasted and fed (immediately after a meal) conditions. Twelve patients aged 20\u201345\u00a0years with iron deficiency anemia (hemoglobin: male 8.0\u201313.0\u00a0g\/dL, female 8.0\u201312.0\u00a0g\/dL; serum ferritin\u2009&lt;\u200912\u00a0ng\/mL; transferrin saturation\u2009\u2264\u200916%), participated. The maximum serum iron concentration change was defined as \u0394C\n                    <jats:sub>max<\/jats:sub>\n                    , and the area under the serum iron concentration change versus time curve from baseline to 24\u00a0h after administration as \u0394AUC\n                    <jats:sub>0-24<\/jats:sub>\n                    . Serum iron levels increased regardless of fasting or fed conditions, and the \u0394C\n                    <jats:sub>max<\/jats:sub>\n                    and \u0394AUC\n                    <jats:sub>0-24<\/jats:sub>\n                    values were 39% and 29% higher, respectively, under fed versus fasting conditions. No adverse events were reported. In conclusion, food had no notable effect on iron absorption following ferric citrate hydrate administration in patients with iron deficiency anemia.\n                  <\/jats:p>","DOI":"10.1007\/s12185-025-04108-8","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:14:18Z","timestamp":1763140458000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of food on iron absorption in patients with iron deficiency anemia treated with ferric citrate hydrate"],"prefix":"10.1007","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-9126","authenticated-orcid":false,"given":"Norio","family":"Komatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-4429","authenticated-orcid":false,"given":"Kyoko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5020-8944","authenticated-orcid":false,"given":"Kojo","family":"Arita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-8561","authenticated-orcid":false,"given":"Yuko","family":"Mitobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"4108_CR1","first-page":"2790","volume":"109","author":"K Pantopoulos","year":"2024","unstructured":"Pantopoulos K. 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Norio Komatsu received consulting fees from JT and Torii. Kyoko Ito and Yuko Mitobe are employees of Torii, and Kojo Arita and Hironori Mitsui are employees of JT.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the Declaration of Helsinki and ethical guidelines. The study protocol was approved by the institutional review boards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}