{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:35:28Z","timestamp":1791858928827,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12185-026-04162-w","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T18:04:15Z","timestamp":1769364255000},"page":"924-934","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical correlation between plasma biomarker levels and post-transplant complications of allogeneic hematopoietic stem cell transplantation in children"],"prefix":"10.1007","volume":"123","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoquan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"issue":"7","key":"4162_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3760\/cma.j.issn.0253-2727.2020.07.001","volume":"41","author":"Stem Cell Application Group, Chinese Society of Hematology, Chinese Medical Association","year":"2020","unstructured":"Stem Cell Application Group, Chinese Society of Hematology, Chinese Medical Association. [Chinese consensus of allogeneic hematopoietic stem cell transplantation for hematological disease (\u2162) -acute graft-versus-host disease (2020)]. Zhonghua Xue Ye Xue Za Zhi. 2020;41(7):529\u201336. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2020.07.001.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"3","key":"4162_CR2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3760\/cma.j.issn.0253-2727.2021.03.001","volume":"42","author":"Hematopoietic Stem Cell Application Group, Chinese Society of Hematology, Chinese Medical Association","year":"2021","unstructured":"Hematopoietic Stem Cell Application Group, Chinese Society of Hematology, Chinese Medical Association. Chinese consensus on the diagnosis and management of transplant-associated thrombotic microangiopathy (2021. Zhonghua Xue Ye Xue Za Zhi. 2021;42(3):177\u201384. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2021.03.001.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"6","key":"4162_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMoa1213299","volume":"369","author":"MT Vander Lugt","year":"2013","unstructured":"Vander Lugt MT, Braun TM, Hanash S, Ritz J, Ho VT, Antin JH, et al. ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med. 2013;369(6):529\u201339. https:\/\/doi.org\/10.1056\/NEJMoa1213299.","journal-title":"N Engl J Med"},{"issue":"25","key":"4162_CR4","doi-asserted-by":"publisher","first-page":"6702","DOI":"10.1182\/blood-2011-08-375006","volume":"118","author":"JL Ferrara","year":"2011","unstructured":"Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, et al. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood. 2011;118(25):6702\u20138. https:\/\/doi.org\/10.1182\/blood-2011-08-375006.","journal-title":"Blood"},{"issue":"9","key":"4162_CR5","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/14728222.2021.1992383","volume":"25","author":"H Choe","year":"2021","unstructured":"Choe H, Ferrara JLM. New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD). Expert Opin Ther Targets. 2021;25(9):761\u201371. https:\/\/doi.org\/10.1080\/14728222.2021.1992383.","journal-title":"Expert Opin Ther Targets"},{"key":"4162_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1064203","volume":"13","author":"ML Schoettler","year":"2023","unstructured":"Schoettler ML, Bhatt H, Vasu S. A systematic review of diagnostic, prognostic, and risk blood and urine biomarkers of transplant-associated thrombotic microangiopathy. Front Immunol. 2023;13:1064203. https:\/\/doi.org\/10.3389\/fimmu.2022.1064203.","journal-title":"Front Immunol"},{"issue":"5","key":"4162_CR7","doi-asserted-by":"publisher","first-page":"e0178423","DOI":"10.1128\/mbio.01784-23","volume":"14","author":"F Baccianti","year":"2023","unstructured":"Baccianti F, Masson C, Delecluse S, Li Z, Poirey R, Delecluse H-J, et al. Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response. mBio. 2023;14(5):e0178423. https:\/\/doi.org\/10.1128\/mbio.01784-23.","journal-title":"mBio"},{"issue":"3","key":"4162_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/v15030651","volume":"15","author":"DA Dom\u00ednguez-Mart\u00ednez","year":"2023","unstructured":"Dom\u00ednguez-Mart\u00ednez DA, Fontes-Lemus JI, Garc\u00eda-Regalado A, Ju\u00e1rez-Flores \u00c1, Fuentes-Panan\u00e1 EM. IL-8 secreted by gastric epithelial cells infected with Helicobacter pylori\u00a0CagA positive strains is a chemoattractant for epstein-barr virus infected B lymphocytes. Viruses. 2023;15(3):651. https:\/\/doi.org\/10.3390\/v15030651.","journal-title":"Viruses"},{"issue":"7","key":"4162_CR9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/tri.13601","volume":"33","author":"A Lawitschka","year":"2020","unstructured":"Lawitschka A, Lucchini G, Strahm B, Dalle JH, Balduzzi A, Gibson B, et al. Pediatric acute graft-versus-host disease prophylaxis and treatment: surveyed real-life approach reveals dissimilarities compared to published recommendations. Transpl Int. 2020;33(7):762\u201372. https:\/\/doi.org\/10.1111\/tri.13601.","journal-title":"Transpl Int"},{"issue":"11","key":"4162_CR10","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1038\/s41409-018-0204-7","volume":"53","author":"HM Schoemans","year":"2018","unstructured":"Schoemans HM, Lee SJ, Ferrara JL, Wolff D, Levine JE, Schultz KR, et al. EBMT-NIH-CIBMTR task force position statement on standardized terminology & guidance for graft-versus-host disease assessment. Bone Marrow Transplant. 2018;53(11):1401\u201315. https:\/\/doi.org\/10.1038\/s41409-018-0204-7.","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"4162_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.blre.2014.11.001","volume":"29","author":"S Jodele","year":"2015","unstructured":"Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, et al. A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev. 2015;29(3):191\u2013204. https:\/\/doi.org\/10.1016\/j.blre.2014.11.001.","journal-title":"Blood Rev"},{"issue":"2","key":"4162_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.transci.2016.04.007","volume":"54","author":"S Jodele","year":"2016","unstructured":"Jodele S, Dandoy CE, Myers KC, El-Bietar J, Nelson A, Wallace G, et al. New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Transfus Apher Sci. 2016;54(2):181\u201390. https:\/\/doi.org\/10.1016\/j.transci.2016.04.007.","journal-title":"Transfus Apher Sci"},{"issue":"4","key":"4162_CR13","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.19746\/j.cnki.issn.1009-2137.2021.04.051","volume":"29","author":"AP Zhang","year":"2021","unstructured":"Zhang AP, Xiong H, Wang Z, Yang L, Qi SS, Nie YM, et al. The relationship between plasma sST2\/Reg3\u03b1 levels and acute graft-versus-host disease in children after allogeneic hematopoietic stem cell transplantation. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021;29(4):1334\u20139. https:\/\/doi.org\/10.19746\/j.cnki.issn.1009-2137.2021.04.051.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi."},{"issue":"4","key":"4162_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2022.101400","volume":"35","author":"N Spyrou","year":"2022","unstructured":"Spyrou N, Levine JE, Ferrara JLM. Acute GVHD: new approaches to clinical trial monitoring. Best Pract Res Clin Haematol. 2022;35(4):101400. https:\/\/doi.org\/10.1016\/j.beha.2022.101400.","journal-title":"Best Pract Res Clin Haematol"},{"issue":"17","key":"4162_CR15","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1200\/JCO.20.00619","volume":"39","author":"R Reshef","year":"2021","unstructured":"Reshef R, Saber W, Bola\u00f1os-Meade J, Chen G, Chen YB, Ho VT, et al. Acute GVHD diagnosis and adjudication in a multicenter trial: a report from the BMT CTN 1202 biorepository study. J Clin Oncol. 2021;39(17):1878\u201387. https:\/\/doi.org\/10.1200\/JCO.20.00619.","journal-title":"J Clin Oncol"},{"issue":"12","key":"4162_CR16","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1182\/bloodadvances.2023011049","volume":"8","author":"A Etra","year":"2024","unstructured":"Etra A, El Jurdi N, Katsivelos N, Kwon D, Gergoudis S, Morales G, et al. Amphiregulin, ST2, and REG3\u03b1 biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD. Blood Adv. 2024;8(12):3284\u201392. https:\/\/doi.org\/10.1182\/bloodadvances.2023011049.","journal-title":"Blood Adv"},{"issue":"25","key":"4162_CR17","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1056\/NEJMoa2215943","volume":"388","author":"J Bola\u00f1os-Meade","year":"2023","unstructured":"Bola\u00f1os-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, et al. Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis. N Engl J Med. 2023;388(25):2338\u201348. https:\/\/doi.org\/10.1056\/NEJMoa2215943.","journal-title":"N Engl J Med"},{"issue":"2","key":"4162_CR18","doi-asserted-by":"publisher","first-page":"513","DOI":"10.19746\/j.cnki.issn.1009-2137.2023.02.030","volume":"31","author":"YY Xiong","year":"2023","unstructured":"Xiong YY, Liu L, Chen JB, Tang XQ, Xiao Q, Zhang HB, et al. Clinical study of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023;31(2):513\u201321. https:\/\/doi.org\/10.19746\/j.cnki.issn.1009-2137.2023.02.030.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi."},{"issue":"5","key":"4162_CR19","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1007\/s00277-024-05707-x","volume":"103","author":"Y Umezawa","year":"2024","unstructured":"Umezawa Y, Yoshifuji K, Tanaka K, Nogami A, Nagano K, Tsuji A, et al. Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation. Ann Hematol. 2024;103(5):1737\u201344. https:\/\/doi.org\/10.1007\/s00277-024-05707-x.","journal-title":"Ann Hematol"},{"issue":"4","key":"4162_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14763","volume":"28","author":"T Tajima","year":"2024","unstructured":"Tajima T, Martinez OM, Bernstein D, Boyd SD, Gratzinger D, Lum G, et al. Epstein-Barr virus-associated post-transplant lymphoproliferative disorders in pediatric transplantation: a prospective multicenter study in the United States. Pediatr Transplant. 2024;28(4):e14763. https:\/\/doi.org\/10.1111\/petr.14763.","journal-title":"Pediatr Transplant"},{"issue":"6","key":"4162_CR21","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/bjh.16497","volume":"192","author":"S Paczesny","year":"2021","unstructured":"Paczesny S. Post-haematopoietic cell transplantation outcomes: why ST2 became a \u201cgolden nugget\u201d biomarker. Br J Haematol. 2021;192(6):951\u201367. https:\/\/doi.org\/10.1111\/bjh.16497.","journal-title":"Br J Haematol"},{"key":"4162_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1057694","volume":"13","author":"B Watkins","year":"2022","unstructured":"Watkins B, Williams KM. Controversies and expectations for the prevention of GVHD: a biological and clinical perspective. Front Immunol. 2022;13:1057694. https:\/\/doi.org\/10.3389\/fimmu.2022.1057694.","journal-title":"Front Immunol"},{"issue":"4","key":"4162_CR23","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1182\/bloodadvances.2021004933","volume":"6","author":"S Vasu","year":"2022","unstructured":"Vasu S, Bostic M, Zhao Q, Sharma N, Puto M, Knight S, et al. Acute GVHD, BK virus hemorrhagic cystitis and age are risk factors for transplant-associated thrombotic microangiopathy in adults. Blood Adv. 2022;6(4):1342\u20139. https:\/\/doi.org\/10.1182\/bloodadvances.2021004933.","journal-title":"Blood Adv"},{"issue":"11","key":"4162_CR24","doi-asserted-by":"publisher","first-page":"4970","DOI":"10.1172\/JCI99261","volume":"128","author":"D Zhao","year":"2018","unstructured":"Zhao D, Kim YH, Jeong S, Greenson JK, Chaudhry MS, Hoepting M, et al. Survival signal REG3\u03b1 prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. J Clin Invest. 2018;128(11):4970\u20139. https:\/\/doi.org\/10.1172\/JCI99261.","journal-title":"J Clin Invest"},{"issue":"12","key":"4162_CR25","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1182\/bloodadvances.2022007296","volume":"6","author":"A Etra","year":"2022","unstructured":"Etra A, Gergoudis S, Morales G, Spyrou N, Shah J, et al. Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification. Blood Adv. 2022;6(12):3707\u201315. https:\/\/doi.org\/10.1182\/bloodadvances.2022007296.","journal-title":"Blood Adv"},{"issue":"6","key":"4162_CR26","doi-asserted-by":"publisher","first-page":"603.e1","DOI":"10.1016\/j.jtct.2024.03.022","volume":"30","author":"M Qayed","year":"2024","unstructured":"Qayed M, Kapoor U, Gillespie S, Westbrook A, Aguayo-Hiraldo P, Ayuk FA, et al. A validated risk stratification that incorporates MAGIC biomarkers predicts long-term outcomes in pediatric patients with acute GVHD. Transplant Cell Ther. 2024;30(6):603.e1-603.e11. https:\/\/doi.org\/10.1016\/j.jtct.2024.03.022.","journal-title":"Transplant Cell Ther"},{"issue":"1","key":"4162_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/jha2.26","volume":"1","author":"B Balakrishnan","year":"2020","unstructured":"Balakrishnan B, Illangeswaran RSS, Rajamani BM, Pai AA, Raj IX, Paul DZ, et al. Prognostic plasma biomarkers of early complications and graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation. EJHaem. 2020;1(1):219\u201329. https:\/\/doi.org\/10.1002\/jha2.26.","journal-title":"EJHaem"},{"issue":"1","key":"4162_CR28","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bbmt.2019.08.025","volume":"26","author":"R Yamada","year":"2020","unstructured":"Yamada R, Nemoto T, Ohashi K, Tonooka A, Horiguchi SI, Motoi T, et al. Distribution of transplantation-associated thrombotic microangiopathy (TA-TMA) and comparison between renal TA-TMA and intestinal TA-TMA: autopsy study. Biol Blood Marrow Transplant. 2020;26(1):178\u201388. https:\/\/doi.org\/10.1016\/j.bbmt.2019.08.025.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"20","key":"4162_CR29","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1182\/blood-2014-10-606830","volume":"125","author":"DK Reichenbach","year":"2015","unstructured":"Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, et al. The IL-33\/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125(20):3183\u201392. https:\/\/doi.org\/10.1182\/blood-2014-10-606830.","journal-title":"Blood"},{"issue":"12","key":"4162_CR30","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1056\/NEJMc1700185","volume":"376","author":"SJ Rotz","year":"2017","unstructured":"Rotz SJ, Dandoy CE, Davies SM. ST2 and endothelial injury as a link between GVHD and microangiopathy. N Engl J Med. 2017;376(12):1189\u201390. https:\/\/doi.org\/10.1056\/NEJMc1700185.","journal-title":"N Engl J Med"},{"key":"4162_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02432","volume":"9","author":"OS Kotsiou","year":"2018","unstructured":"Kotsiou OS, Gourgoulianis KI, Zarogiannis SG. IL-33\/ST2 axis in organ fibrosis. Front Immunol. 2018;9:2432. https:\/\/doi.org\/10.3389\/fimmu.2018.02432.","journal-title":"Front Immunol"},{"issue":"3","key":"4162_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jtct.2022.11.015","volume":"29","author":"ML Schoettler","year":"2023","unstructured":"Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, et al. Harmonizing definitions for diagnostic criteria and prognostic assessment of transplantation-associated thrombotic microangiopathy: a report on behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. Transplant Cell Ther. 2023;29(3):151\u201363. https:\/\/doi.org\/10.1016\/j.jtct.2022.11.015.","journal-title":"Transplant Cell Ther"},{"issue":"4","key":"4162_CR33","doi-asserted-by":"publisher","first-page":"308.e1","DOI":"10.1016\/j.jtct.2020.12.010","volume":"27","author":"A Li","year":"2021","unstructured":"Li A, Bhatraju PK, Chen J, Chung DW, Hilton T, Houck K, et al. Prognostic biomarkers for thrombotic microangiopathy after acute graft-versus-host disease: a nested case-control study. Transplant Cell Ther. 2021;27(4):308.e1-308.e8. https:\/\/doi.org\/10.1016\/j.jtct.2020.12.010.","journal-title":"Transplant Cell Ther"},{"issue":"8","key":"4162_CR34","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1038\/s41409-021-01283-0","volume":"56","author":"JA Young","year":"2021","unstructured":"Young JA, Pallas CR, Knovich MA. Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis. Bone Marrow Transplant. 2021;56(8):1805\u201317. https:\/\/doi.org\/10.1038\/s41409-021-01283-0.","journal-title":"Bone Marrow Transplant"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-026-04162-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-026-04162-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-026-04162-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:08:52Z","timestamp":1782468532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-026-04162-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,25]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4162"],"URL":"https:\/\/doi.org\/10.1007\/s12185-026-04162-w","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,25]]},"assertion":[{"value":"19 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}