{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:59:11Z","timestamp":1785131951910,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s12185-026-04198-y","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:35:20Z","timestamp":1773927320000},"page":"270-282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cord blood versus matched related donor transplantation in AML not in remission: role of pre-engraftment immune reactions"],"prefix":"10.1007","volume":"124","author":[{"given":"Tatsuro","family":"Hirao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-7029","authenticated-orcid":false,"given":"Hisashi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoya","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Taya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Asano-Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"4198_CR1","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1182\/blood.2021011583","volume":"139","author":"AE Perl","year":"2022","unstructured":"Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E, et al. Follow-up of patients with R\/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial. Blood. 2022;139:3366\u201375. https:\/\/doi.org\/10.1182\/blood.2021011583.","journal-title":"Blood"},{"key":"4198_CR2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/ejh.14046","volume":"111","author":"DT Kristensen","year":"2023","unstructured":"Kristensen DT, Br\u00f8ndum RF, \u00d8rskov AD, Marcher CW, Sch\u00f6llkopf C, S\u00f8rensen ALT, et al. Venetoclax-based therapy for relapsed or refractory acute myeloid leukaemia following intensive induction chemotherapy. Eur J Haematol. 2023;111:573\u201382. https:\/\/doi.org\/10.1111\/ejh.14046.","journal-title":"Eur J Haematol"},{"key":"4198_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1182\/blood.2023022481","volume":"143","author":"F Thol","year":"2024","unstructured":"Thol F, D\u00f6hner H, Ganser A. How I treat refractory and relapsed acute myeloid leukemia. Blood. 2024;143:11\u201320. https:\/\/doi.org\/10.1182\/blood.2023022481.","journal-title":"Blood"},{"key":"4198_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/bmt.2016.188","volume":"52","author":"J Magenau","year":"2017","unstructured":"Magenau J, Westervelt P, Khaled S, McGuirk J, Hari P, Eapen M, et al. A multicenter trial of myeloablative clofarabine and busulfan conditioning for relapsed or primary induction failure AML not in remission at the time of allogeneic hematopoietic stem cell transplantation. Bone Marrow Transpl. 2017;52:59\u201365. https:\/\/doi.org\/10.1038\/bmt.2016.188.","journal-title":"Bone Marrow Transpl"},{"key":"4198_CR5","doi-asserted-by":"publisher","first-page":"215.e1","DOI":"10.1016\/j.jtct.2023.12.002","volume":"30","author":"T Konuma","year":"2024","unstructured":"Konuma T, Yamasaki S, Ishiyama K, Mizuno S, Hayashi H, Uchida N, et al. Comparison of allogeneic transplant outcomes between matched sibling donors and alternative donors in patients over 50 years of age with acute myeloid leukemia: 8\/8 allele-matched unrelated donors and unrelated cord blood provide better leukemia-free survival compared with matched sibling donors during nonremission status. Transplant Cell Ther. 2024;30:215.e1-215.e18. https:\/\/doi.org\/10.1016\/j.jtct.2023.12.002.","journal-title":"Transplant Cell Ther"},{"key":"4198_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13045-017-0498-8","volume":"10","author":"E Brissot","year":"2017","unstructured":"Brissot E, Labopin M, Stelljes M, Ehninger G, Schwerdtfeger R, Finke J, et al. Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. J Hematol Oncol. 2017;10:130. https:\/\/doi.org\/10.1186\/s13045-017-0498-8.","journal-title":"J Hematol Oncol"},{"key":"4198_CR7","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/s41375-021-01474-0","volume":"36","author":"Y Shimomura","year":"2022","unstructured":"Shimomura Y, Sobue T, Hirabayashi S, Kondo T, Mizuno S, Kanda J, et al. Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia. Leukemia. 2022;36:1132\u20138. https:\/\/doi.org\/10.1038\/s41375-021-01474-0.","journal-title":"Leukemia"},{"key":"4198_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/bjh.13926","volume":"173","author":"KK Ballen","year":"2016","unstructured":"Ballen KK, Lazarus H. Cord blood transplant for acute myeloid leukaemia. Br J Haematol. 2016;173:25\u201336. https:\/\/doi.org\/10.1111\/bjh.13926.","journal-title":"Br J Haematol"},{"key":"4198_CR9","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1182\/blood-2008-03-147041","volume":"113","author":"Y Atsuta","year":"2009","unstructured":"Atsuta Y, Suzuki R, Nagamura-Inoue T, Taniguchi S, Takahashi S, Kai S, et al. Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood. 2009;113:1631\u20138. https:\/\/doi.org\/10.1182\/blood-2008-03-147041.","journal-title":"Blood"},{"key":"4198_CR10","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.bbmt.2015.10.006","volume":"22","author":"S Terakura","year":"2016","unstructured":"Terakura S, Atsuta Y, Tsukada N, Kobayashi T, Tanaka M, Kanda J, et al. Comparison of outcomes of 8\/8 and 7\/8 allele-matched unrelated bone marrow transplantation and single-unit cord blood transplantation in adults with acute leukemia. Biol Blood Marrow Transpl. 2016;22:330\u20138. https:\/\/doi.org\/10.1016\/j.bbmt.2015.10.006.","journal-title":"Biol Blood Marrow Transpl"},{"key":"4198_CR11","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1056\/NEJMoa1602074","volume":"375","author":"F Milano","year":"2016","unstructured":"Milano F, Gooley T, Wood B, Woolfrey A, Flowers ME, Doney K, et al. Cord-blood transplantation in patients with minimal residual disease. N Engl J Med. 2016;375:944\u201353. https:\/\/doi.org\/10.1056\/NEJMoa1602074.","journal-title":"N Engl J Med"},{"key":"4198_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.tp.0000163289.20406.86","volume":"80","author":"Y Kishi","year":"2005","unstructured":"Kishi Y, Kami M, Miyakoshi S, Kanda Y, Murashige N, Teshima T, et al. Early immune reaction after reduced-intensity cord-blood transplantation for adult patients. Transplantation. 2005;80:34\u201340. https:\/\/doi.org\/10.1097\/01.tp.0000163289.20406.86.","journal-title":"Transplantation"},{"key":"4198_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.bbmt.2009.10.022","volume":"16","author":"KJ Patel","year":"2010","unstructured":"Patel KJ, Rice RD, Hawke R, Abboud M, Heller G, Scaradavou A, et al. Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2010;16:435\u201340. https:\/\/doi.org\/10.1016\/j.bbmt.2009.10.022.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"key":"4198_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/bjh.12097","volume":"160","author":"N Matsuno","year":"2013","unstructured":"Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, et al. Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation. Br J Haematol. 2013;160:255\u20138. https:\/\/doi.org\/10.1111\/bjh.12097. (Wiley).","journal-title":"Br J Haematol"},{"key":"4198_CR15","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.bbmt.2017.07.020","volume":"23","author":"T Konuma","year":"2017","unstructured":"Konuma T, Kohara C, Watanabe E, Mizukami M, Nagai E, Oiwa-Monna M, et al. Cytokine profiles of pre-engraftment syndrome after single-unit cord blood transplantation for adult patients. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2017;23:1932\u20138. https:\/\/doi.org\/10.1016\/j.bbmt.2017.07.020.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"key":"4198_CR16","doi-asserted-by":"publisher","first-page":"1084901","DOI":"10.3389\/fimmu.2023.1084901","volume":"14","author":"X Zhao","year":"2023","unstructured":"Zhao X, Wang W, Nie S, Geng L, Song K, Zhang X, et al. Dynamic comparison of early immune reactions and immune cell reconstitution after umbilical cord blood transplantation and peripheral blood stem cell transplantation. Front Immunol. 2023;14:1084901. https:\/\/doi.org\/10.3389\/fimmu.2023.1084901.","journal-title":"Front Immunol"},{"key":"4198_CR17","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1002\/ajh.70094","volume":"100","author":"M Sakurai","year":"2025","unstructured":"Sakurai M, Kataoka K, Mizuno K, Mori T, Shirane S, Sakaguchi H, et al. Risk factors for and impact of pre-engraftment syndrome on outcomes following single-unit cord blood transplantation in adults. Am J Hematol. 2025;100:2248\u201360. https:\/\/doi.org\/10.1002\/ajh.70094.","journal-title":"Am J Hematol"},{"key":"4198_CR18","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","volume":"5","author":"MM Oken","year":"1982","unstructured":"Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649\u201355.","journal-title":"Am J Clin Oncol"},{"key":"4198_CR19","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transpl. 1995;15:825\u20138.","journal-title":"Bone Marrow Transpl"},{"key":"4198_CR20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","volume":"21","author":"MH Jagasia","year":"2015","unstructured":"Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. the 2014 diagnosis and staging working group report. Biol Blood Marrow Transpl. 2015;21:389-401.e1. https:\/\/doi.org\/10.1016\/j.bbmt.2014.12.001.","journal-title":"Biol Blood Marrow Transpl"},{"key":"4198_CR21","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1182\/blood.2022016867","volume":"140","author":"H D\u00f6hner","year":"2022","unstructured":"D\u00f6hner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140:1345\u201377. https:\/\/doi.org\/10.1182\/blood.2022016867.","journal-title":"Blood"},{"key":"4198_CR22","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1080\/10428194.2017.1357173","volume":"59","author":"M Yanada","year":"2018","unstructured":"Yanada M, Mori J, Aoki J, Harada K, Mizuno S, Uchida N, et al. Effect of cytogenetic risk status on outcomes for patients with acute myeloid leukemia undergoing various types of allogeneic hematopoietic cell transplantation: an analysis of 7812 patients. Leuk Lymphoma. 2018;59:601\u20139. https:\/\/doi.org\/10.1080\/10428194.2017.1357173.","journal-title":"Leuk Lymphoma"},{"key":"4198_CR23","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","volume":"15","author":"A Bacigalupo","year":"2009","unstructured":"Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens\u202f: working definitions. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2009;15:1628. https:\/\/doi.org\/10.1016\/j.bbmt.2009.07.004.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"key":"4198_CR24","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1038\/leu.2015.98","volume":"29","author":"A Ruggeri","year":"2015","unstructured":"Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, et al. Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia. Leuk Nat Publ Gr. 2015;29:1891\u2013900. https:\/\/doi.org\/10.1038\/leu.2015.98.","journal-title":"Leuk Nat Publ Gr"},{"key":"4198_CR25","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1182\/blood-2015-06-654780","volume":"126","author":"P Hiwarkar","year":"2015","unstructured":"Hiwarkar P, Qasim W, Ricciardelli I, Gilmour K, Quezada S, Saudemont A, et al. Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells. Blood. 2015;126:2882\u201391. https:\/\/doi.org\/10.1182\/blood-2015-06-654780.","journal-title":"Blood"},{"key":"4198_CR26","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.bbmt.2019.02.007","volume":"25","author":"M Isobe","year":"2019","unstructured":"Isobe M, Konuma T, Kato S, Tanoue S, Mizusawa M, Oiwa-Monna M, et al. Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myelogenous leukemia after single cord blood transplantation. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2019;25:1187\u201396. https:\/\/doi.org\/10.1016\/j.bbmt.2019.02.007.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"key":"4198_CR27","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/bmt.2014.296","volume":"50","author":"TR Spitzer","year":"2015","unstructured":"Spitzer TR. Engraftment syndrome: double-edged sword of hematopoietic cell transplants. Bone Marrow Transpl. 2015;50:469\u201375. https:\/\/doi.org\/10.1038\/bmt.2014.296.","journal-title":"Bone Marrow Transpl"},{"key":"4198_CR28","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1158\/1078-0432.CCR-20-4856","volume":"27","author":"T Konuma","year":"2021","unstructured":"Konuma T, Kanda J, Kuwatsuka Y, Yanada M, Kondo T, Hirabayashi S, et al. Differential effect of graft-versus-host disease on survival in acute leukemia according to donor type. Clin Cancer Res. 2021;27:4825\u201335. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-4856.","journal-title":"Clin Cancer Res"},{"key":"4198_CR29","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/leu.2016.288","volume":"31","author":"J Kanda","year":"2017","unstructured":"Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, et al. Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation. Leukemia. 2017;31:663\u20138. https:\/\/doi.org\/10.1038\/leu.2016.288.","journal-title":"Leukemia"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-026-04198-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12185-026-04198-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12185-026-04198-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:04:32Z","timestamp":1785128672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12185-026-04198-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4198"],"URL":"https:\/\/doi.org\/10.1007\/s12185-026-04198-y","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"14 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}