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This highlights a need for region-specific guidance on the diagnosis and management of AA in Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Asian Aplastic Anemia Working Group consisted of 10 experts from across Asia (South Korea, Japan, China, Hong Kong, Malaysia, Taiwan, and Thailand) who met virtually twice and developed 16 thematic statements on the diagnosis and management of AA. Using an e-Delphi method, members voted asynchronously on these statements using a 5-point Likert scale. Consensus was predefined as \u201c\u2265\u200980% level of agreement among the Delphi participants.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen thematic statements and 54 sub-statements were developed. The first three statements addressed AA definition, presentation, and causes; the next four focused on diagnosis and prognosis; and the remaining nine covered management, including clonal evolution, supportive care, and special populations. Fifteen statements reached consensus after the first voting round. However, one statement on the management of severe AA did not achieve consensus in the first round.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This e-Delphi method has, for the first time, generated Asian, expert-derived, consensus recommendations for the diagnosis and management of AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12185-026-04240-z","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:40:37Z","timestamp":1784713237000},"page":"521-537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence- and opinion-based consensus from Delphi round 1 of the Asian aplastic anemia recommendation development"],"prefix":"10.1007","volume":"124","author":[{"given":"Jun Ho","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yok Lam","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surapol","family":"Issaragrisil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeu-Chin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeung-Chul","family":"Mun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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Yok Lam Kwong received honoraria for lectures from Amgen, Astellas, Bayer, BeiGene, Bristol Myers Squibb, Celgene, Janssen, Merck, Otsuka, Novartis, Roche, and Takeda; and participated in advisory boards for Amgen, Astellas, Bayer, BeiGene, Bristol Myers Squibb, Celgene, Janssen, Merck, Otsuka, Novartis, Roche, and TakedaSupport for attending EBMT meetings 2024 and 2025 was received from Sanofi. Surapol Issaragrisil is the editor of International Journal of Hematology. Kohei Hosokawa received honoraria for lectures from Alexion Pharmaceuticals, Inc.; Chugai Pharmaceutical Co., Ltd.; Novartis Pharma K.K.; Kyowa Kirin Co., Ltd.; and Bristol-Myers Squibb K.K., and served an unpaid leadership role as a board member of the International PNH Interest Group (IPIG). Yeu-Chin Chen received speaker fees from Bayer, Chugai, CSL Behring, Kirin, Sanofi, AstraZeneca, BeiGene, Bristol Myers Squibb, Kirin, Novartis, PharmaEssential, Roche, and Takeda and received grant support by Shire and Sanofi. Lily Wong participated in the Aplastic Anemia Advisory Board. Shinji Nakao received honoraria for lectures from Novartis Pharma K.K., Kyowa Kirin Co., Ltd., Asahi Kasei Co., SymBio Pharmaceuticals Inc., and Alexion Pharmaceuticals, Inc. Ming Yao, Yeung-Chul Mun, and Zhang FK declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}