{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:34:26Z","timestamp":1793284466940,"version":"4.5.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Nagoya Pediatric Cancer Fund"},{"name":"Nagoya University","id":[{"id":"https:\/\/ror.org\/04chrp450","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    T-cell lymphoblastic lymphoma (T-LBL) is an aggressive malignancy that comprises 20% of pediatric non-Hodgkin lymphoma cases. Most T-LBLs harbor\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    point mutations or small indels, which are generally associated with favorable outcomes. In contrast, the clinical impact of structural rearrangements involving\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    remains poorly understood. We describe the case of a 6-year-old boy with T-LBL carrying a\n                    <jats:italic>MIR142HG::NOTCH1<\/jats:italic>\n                    fusion from a t(9;17)(q34;q23) translocation, resulting in a truncated, constitutively active NOTCH1 protein. The patient experienced an aggressive course and died shortly after cord blood transplantation. Literature review suggests that 9q34 translocations in T-LBL portend poor prognosis, highlighting truncated\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1007\/s12185-026-04263-6","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:59:26Z","timestamp":1788371966000},"page":"747-751","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric T-cell lymphoblastic lymphoma with t(9;17)(q34;q23)-associated N-terminally truncated NOTCH1 activation: a case report"],"prefix":"10.1007","volume":"124","author":[{"given":"Ayako","family":"Yamamori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Sajiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahito","family":"Hama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Wakamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-0021","authenticated-orcid":false,"given":"Hideki","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"4","key":"4263_CR1","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1111\/bjh.70053","volume":"207","author":"M Te Vrugt","year":"2025","unstructured":"Te Vrugt M, Newman H, Teachey DT, Burkhardt B. T-cell lymphoblastic lymphoma in children, adolescents and young adults. Br J Haematol. 2025;207(4):1213\u201321.","journal-title":"Br J Haematol"},{"key":"4263_CR2","doi-asserted-by":"crossref","unstructured":"Ferrando AA. The role of NOTCH1 signaling in T-ALL. Hematol Am Soc Hematol Educ Program. 2009:353\u201361.","DOI":"10.1182\/asheducation-2009.1.353"},{"issue":"11","key":"4263_CR3","first-page":"745","volume":"2","author":"Y Kaneko","year":"1988","unstructured":"Kaneko Y, Frizzera G, Maseki N, Sakurai M, Komada Y, Sakurai M, et al. A novel translocation, t(9;17)(q34;q23), in aggressive childhood lymphoblastic lymphoma. Leukemia. 1988;2(11):745\u20138.","journal-title":"Leukemia"},{"issue":"3","key":"4263_CR4","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/1097-0142(19920801)70:3<714::AID-CNCR2820700329>3.0.CO;2-Z","volume":"70","author":"T Shikano","year":"1992","unstructured":"Shikano T, Ishikawa Y, Naito H, Kobayashi R, Nakadate H, Hatae Y, et al. 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